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| 1 | Cyclooxygenase-2 and the inflammogenesis of breast cancer显示文摘Cohesive scientific evidence from molecular, animal, and human investigations supports the hypothesis that constitutive overexpression of cyclooxygenase-2(COX-2) is a ubiquitous driver of mammary carcinogenesis, and reciprocally, that COX-2 blockade has strong potential for breast cancer prevention and therapy. Key findings include the following:(1) COX-2 is constitutively expressed throughout breast cancer development and expression intensifies with stage at detection, cancer progression and metastasis;(2) essential features of mammary carcinogenesis(mutagenesis, mitogenesis, angiogenesis, reduced apoptosis, metastasis and immunosuppression) are linked to COX-2-driven prostaglandin E2(PGE-2) biosynthesis;(3) upregulation of COX-2 and PGE-2 expression induces transcription of CYP-19 and aromatase-catalyzed estrogen biosynthesis which stimulates unbridled mitogenesis;(4) extrahe-patic CYP-1B1 in mammary adipose tissue converts paracrine estrogen to carcinogenic quinones with mutagenic impact; and(5) agents that inhibit COX-2 reduce the risk of breast cancer in women without disease and reduce recurrence risk and mortality in women with breast cancer. Recent sharp increases in global breast cancer incidence and mortality are likely driven by chronic inflammation of mammary adipose and upregulation of COX-2 associated with the obesity pandemic. The totality of evidence clearly supports the supposition that mammary carcinogenesis often evolves as a progressive series of highly specific cellular and molecular changes in response to induction of constitutive overexpression of COX-2 and the prostaglandin cascade in the 'inflammogenesis of breast cancer'. | Randall E Harris Bruce C Casto Zachary M Harris | 2014 | World Journal of Clinical Oncology2014，5，4： | 15 |
| 2 | 全球研究型图书馆发展战略——2008年GRL2020会议各参会机构未来发展宣言书:1.华盛顿大学2020年未来发展宣言书显示文摘GRL2020(Global Research Library 2020)会议是面向未来数字图书馆发展,旨在建立和形成未来图书馆发展愿景的国际研讨会,为各图书馆提供一个平台,通过讨论交流,明确图书馆未来发展方向和所要采取的必要的计划。GRL2020计划每年在世界的一个大洲举办一次研讨会,2007年的第一届研讨会在北美洲的美国华盛顿举办,2008年在欧洲的意大利举办,2009年的GRL2020在亚洲的中国台湾举办。 | Harry Bruce 鲁超(编译) 尚玮娇(编译) | 2009 | 图书情报工作动态2009，，2： | 7 |
| 3 | Using ecological diversity measures with bacterial communities显示文摘 | Tom C.J. Hill Kerry A. Walsh James A. Harris Bruce F. Moffett | 2003 | FEMS Microbiology Ecology2003，，1： | 3 |
| 4 | Diffusion tensor imaging (DTI) detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome (IBS)显示文摘 | Benjamin M. Ellingson Emeran Mayer Robert J. Harris Cody Ashe-McNally Bruce D. Naliboff Jennifer S. Labus Kirsten Tillisch | 2013 | Pain2013，，： | 2 |
| 5 | Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals显示文摘 | Harry Olson Graham Betton Denise Robinson Karluss Thomas Alastair Monro Gerald Kolaja Patrick Lilly James Sanders Glenn Sipes William Bracken Michael Dorato Koen Van Deun Peter Smith Bruce Berger Allen Heller | 2000 | Regulatory Toxicology and Pharmacology2000，，1： | 1 |
| 6 | Candidatus “Scalindua brodae”, sp. nov., Candidatus “Scalindua wagneri”, sp. nov., Two New Species of Anaerobic Ammonium Oxidizing Bacteria显示文摘 | Markus Schmid Kerry Walsh Rick Webb W. Irene Rijpstra Katinka van de Pas-Schoonen Mark Jan Verbruggen Thomas Hill Bruce Moffett John Fuerst Stefan Schouten Jaap S. Sinninghe Damsté James Harris Phil Shaw Mike Jetten Marc Strous | 2003 | Systematic and Applied Microbiology2003，，4： | 1 |
| 7 | Cognitive impact of subcortical vascular and Alzheimer’s disease pathology显示文摘 | Helena C.Chui ChrisZarow Wendy J.Mack William G.Ellis LingZheng William J.Jagust DanMungas Bruce R.Reed Joel H.Kramer Charles C.DeCarli Michael W.Weiner Harry V.Vinters | 2006 | Ann Neurol2006，，6： | 1 |
| 8 | Comparison of three simulation-based training methods for management of medical emergencies 显示文摘 | Harry Owen Bruce Mugford | 2006 | Resuscitation2006，71，2： | 1 |
| 9 | Investigation of fundo-antral reflex in human beings显示文摘AIM: To examine the sensory and motor response(s)of the stomach following fundic distention and to assess whether cholinergic mechanisms influence these responses.METHODS: Fundic tone, gastric sensory responses and antral motility were evaluated in eight healthy volunteers after a probe with two sensors was placed in the antrum and a highly compliant balloon in the fundus. Isobaric balloon distentions were performed with a barostat.Study was repeated in six volunteers after intravenous atropine was given.RESULTS: Fundic distention induced large amplitude antral contractions in all subjects. The area under the curve was higher (P<0.05) during fundic distention.First sensation was reported at 12±4 mmHg,moderate sensation at 18±4 mmHg and discomfort at 21±4 mmHg. Discomfort was associated with a decrease in antral motility. After atropine was given, the area under the curve of pressure waves and fundic tone decreased (P<0.05). Sensory thresholds were not affected.CONCLUSIONS: Fundic balloon distention induces an antral motor response, the fundo-antral reflex, which in part may be mediated by cholinergic mechanisms. | Satish SC Rao Anjana Kumar Brent Harris Bruce Brown Konrad S Schulze | 2005 | World Journal of Gastroenterology2005，11，42： | 1 |
| 10 | Monitoring organichlorines with semi-permeable membrane devices (SPMDs) and mussels (Mytilus edulis) in Corio Bay,Victoria,Australia显示文摘 | HARRY F P BRUCE J R LISA A J | 1995 | Marine Pollution Bulletin1995，30，8： | 1 |
| 11 | Neuropathological basis of magnetic resonance images in aging and dementia显示文摘 | William J.Jagust LingZheng Danielle J.Harvey Wendy J.Mack Harry V.Vinters Michael W.Weiner William G.Ellis ChrisZarow DanMungas Bruce R.Reed Joel H.Kramer NorbertSchuff CharlesDeCarli Helena C.Chui | 2008 | Ann Neurol2008，，： | 1 |
| 12 | Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial显示文摘 | Derek J Hausenloy Peter K Mwamure Vinod Venugopal Joanne Harris Matthew Barnard Ernie Grundy Elizabeth Ashley Sanjeev Vichare Carmelo Di Salvo Shyam Kolvekar Martin Hayward Bruce Keogh Raymond J MacAllister Derek M Yellon | 2007 | The Lancet2007，，9587： | 1 |
| 13 | Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals显示文摘 | Harry Olson Graham Betton Denise Robinson Karluss Thomas Alastair Monro Gerald Kolaja Patrick Lilly James Sanders Glenn Sipes William Bracken Michael Dorato Koen Van Deun Peter Smith Bruce Berger Allen Heller | 2000 | Regulatory Toxicology and Pharmacology2000，，1： | 1 |
| 14 | Models and regulatory considerations for transient temperature rise during diagnostic ultrasound pulses显示文摘 | Bruce A Herman Gerald R Harris | 2002 | Ultrasound in Medicine & Biology2002，，9： | 1 |
| 15 | Con- ceptual Frameworks in Information Behavior 显示文摘 | Karen E Pettigrew Raya Fidel Harry Bruce | 2001 | Annum Review of Information Science and Tech- nology2001，，35： | 1 |
| 16 | Australian academic use of the Internet: implications for university administrators显示文摘 | Ann Applebee Peter Clayton Celina Pascoe Harry Bruce | 2000 | Internet Research2000，，2： | 1 |
| 17 | The influence of infiltrating lobular carcinoma on the outcome of patients treated with breast-conserving surgery and radiation therapy显示文摘 | Gloria Peiro Bruce A. Bornstein James L. Connolly Rebecca Gelman Stella Hetelekidis Asa J. Nixon Abram Recht Barbara Silver Jay R. Harris Stuart J. Schnitt | 2000 | Breast Cancer Research and Treatment2000，，1： | 1 |
| 18 | Inflammatory Markers and Incident Heart Failure Risk in Older Adults显示文摘 | Andreas Kalogeropoulos Vasiliki Georgiopoulou Bruce M. Psaty Nicolas Rodondi Andrew L. Smith David G. Harrison Yongmei Liu Udo Hoffmann Douglas C. Bauer Anne B. Newman Stephen B. Kritchevsky Tamara B. Harris Javed Butler | 2010 | Journal of the American College of Cardiology2010，，19： | 1 |
| 19 | Teriparatide for acceleration of fracture repair in humans: A prospective, randomized, double‐blind study of 102 postmenopausal women with distal radial fractures显示文摘 | PerAspenberg Harry KGenant TorstenJohansson Antonio JNino KyoungahSee KellyKrohn Pedro AGarcía‐Hernández Christopher PRecknor Thomas AEinhorn Gail PDalsky Bruce HMitlak AnkeFierlinger Mark CLakshmanan | 2010 | J Bone Miner Res2010，，2： | 1 |
| 20 | A comparison of day 5 and day 6 blastocyst transfers显示文摘 | Bruce S Shapiro Kevin S Richter Dee C Harris Said T Daneshmand | 2001 | Fertility and Sterility2001，，6： | 1 |
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