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| 1 | 雾霾对来京旅游者风险感知及旅游体验的影响——基于结构方程模型的中外旅游者对比研究显示文摘2013年以来,中国雾霾业已成为国际性议题。文章从旅游者感知的视角出发,探究雾霾对旅游的影响,设计了旅游者雾霾风险感知量表,并借助SEM模型验证了雾霾感知、风险感知、满意度和忠诚度间的结构关系,且在通过模型稳定性检验的基础上,利用均值结构模型比较了中、外旅游者的雾霾感知、风险感知、满意度及忠诚度水平。结果证实:旅游者对雾霾旅游损害的感知主要体现在危害健康、破坏情绪、损害照片品质、降低景点吸引力和可游性等方面。雾霾风险感知会提升旅游风险感知的整体水平,并降低满意度;高旅游风险感知对满意度有负面影响;满意度对忠诚度的积极贡献在雾霾情境中得以验证;同时,雾霾感知和风险感知都借由中介变量间接削弱忠诚度。另外,除了满意度水平无显著差异外,外国旅游者的雾霾感知、风险感知和忠诚度水平均低于中国人。 | 李静 Philip L.PEARCE 吴必虎 Alastair M.MORRISON | 2015 | 旅游学刊2015,30,10: | 77 |
| 2 | 高原鼠兔生境选择的初步研究显示文摘在石渠县西区的高山草甸和高山灌丛草甸分布区采用卫星照片(1∶100000)结合样线法,在草地(雅砻江及其支流两边)每隔150m设置一个样方,其他环境则每隔100m设置一个样方,样方面积为5×5m2,记录样方所在地的海拔高度、坡度、坡向、生境位置、样方内植被的盖度、阔叶植物盖度、阔叶植物高度、灌丛盖度、土壤质地、离水源的距离以及鼠兔洞数量.共设置样方312个,样方内的高原鼠兔洞数量最多为80个,最少为0,平均为13.7±15个.统计结果显示:影响高原鼠兔生境选择的主要因子依次是生境位置、土壤质地、离水源的距离、灌丛植物盖度和阔叶植物高度.分析表明,高原鼠兔选择的最优生境为下坡位、土质松软、离水源的距离小于50m、阔叶植物高度小于等于5cm,没有灌丛的环境. | 王淯 王小明 王正寰 Patrick Giraudoux Kenichi Takahashi Graham Alastair | 2004 | 四川大学学报(自然科学版)2004,41,5: | 37 |
| 3 | 国家视角下的目的地形象模型——基于来华国际游客的实证研究显示文摘国家形象和目的地形象因其对消费者行为和决策的重要影响,分别发展成为国际商务领域和旅游营销领域的重要概念和研究热点,虽然两者具有十分密切的内在联系,但学界对它们的研究却相对独立,缺少交叉研究。该研究在对两个领域的文献和理论模型进行整理后,将目的地形象放置到国家尺度下重新审视,试图揭示一个国家的综合国家形象与其作为旅游目的地的形象之间的互动机制,并尝试引入'熟悉度'等概念建立整合模型。最后以中国大陆为案例地,以来华国际游客为调查对象,通过结构方程模型进行实证检验和修正。结论指出:(1)熟悉度对目的地形象有正向影响;(2)国家形象与目的地形象之间具有双向且正向的影响;(3)国家形象通过目的地形象对游客的忠诚度产生间接影响。 | 张静儒 陈映臻 曾祺 吴必虎 Alastair M.MORRISON | 2015 | 旅游学刊2015,30,3: | 27 |
| 4 | Acupuncture for irritable bowel syndrome: A blinded placebo-controlled trial显示文摘AIM: Irritable bowel syndrome (IBS) is a common disorder and many patients fail to find adequate relief from conventional therapies for their symptoms. This study tests the claim that acupuncture is effective for a majority of these patients.METNODS: A prospective, blinded, sham acupuncturecontrolled trial of traditional Chinese acupuncture was performed at a single postgraduate teaching hospital in Europe. Sixty patients with well-established IBS were recruited. The blinded comparator was sham acupuncture administered by the second of two acupuncturists who alone was aware of the randomization, and who otherwise followed the prescription of the first. The primary endpoint was a defined fall in the symptom score at 13 wk (by intention to treat). The prior expectation was a 30%placebo response, and a response rate of 70% from acupuncture, for which the study was adequately powered.RESULTS: Patients in treated and sham groups improved significantly during the study-mean improvement in scores being equal (minus 1.9) and significant for both (P<0.05;one-tailed t test). There was a small numeric but nonsignificant difference between the response rate in patients receiving acupuncture (40.7%) and sham treatment (31.2%). Several secondary end-points marginally favored active treatment, but an improved symptom score of any degree of magnitude occurred more often with sham therapy (65.6% vs 59.2%). For no criterion was statistical significance approached.CONCLUSION: Traditional Chinese acupuncture is relatively ineffective in IBS in the European hospital setting,and the magnitude of any effect appears insufficient to warrant investment in acupuncture services. | Alastair Forbes Sue Jackson Clare Walter Shafi Quraishi Meron Jacyna Max Pitcher | 2005 | World Journal of Gastroenterology2005,11,26: | 22 |
| 5 | 全球旅游研究格局的综合分析(2003—2012)显示文摘基于Mill&Morrison的旅游系统理论,文章构建了由6个主类和61个亚类组成的旅游研究系统分类框架(The tourism research system categorization framework),选取31本国际旅游期刊在2003—2012年期间的10058篇文章,从而提取出13669个关键词(其出现频次为41624)并进行归类,运用演绎分析和统计方法对旅游研究主题进行大数据整理。文章识别出旅游学研究的跨学科特征和各个旅游研究主题的受关注程度:从主类来看,最受关注的是'目的地'领域,其次是'需求'和'营销'领域;从亚类来看,最受关注的是'市场细分'和'吸引物和节庆'领域,而'基础设施'、'交通(旅游目的地内部)'和'旅游客流'等领域受关注度最少。最后,本文试图寻求与旅游学学科树进行理论对话,重新检验了近10年国际旅游研究在国内分类框架的学科特征与演变趋势。 | 朴志娜 吴必虎 Alastair M.MORRISON 沈晔 李梦姣 | 2015 | 旅游学刊2015,30,7: | 14 |
| 6 | Sessile serrated adenoma/polyps: Where are we at in 2016?显示文摘It is currently known that colorectal cancers(CRC) arise from 3 different pathways: the adenoma to carcinoma chromosomal instability pathway(50%-70%); the mutator 'Lynch syndrome' route(3%-5%); and the serrated pathway(30%-35%). The World Health Organization has classified serrated polyps into three types of lesions: hyperplastic polyps(HP),sessile serrated adenomas/polyps(SSA/P) and traditional serrated adenomas(TSA),the latter two strongly associated with development of CRCs. HPs do not cause cancer and TSAs are rare. SSA/P appear to be the responsible precursor lesion for the development of cancers through the serrated pathway. Both HPs and SSA/Ps appear morphologically similar. SSA/P are difficult to detect. The margins are normally inconspicuous. En bloc resection of these polyps can hence be troublesome. A careful examination of borders,submucosal injection of a dye solution(for larger lesions) and resection of a rim of normal tissue around the lesion may ensure total eradication of these lesions. | Rajvinder Singh Leonardo Zorrón Cheng Tao Pu Doreen Koay Alastair Burt | 2016 | World Journal of Gastroenterology2016,22,34: | 13 |
| 7 | 中国旅游目的地定位与品牌化仍很滞后显示文摘大约自1998年开始,西方国家的旅游学者与旅游市场营销从业人员对目的地品牌化表现出极大的兴趣。令人遗憾的是,中国大陆的目的地管理机构(destination management organizations,DMO)往往只提出目的地"口号"和"标识",而不愿开展专业化的目的地品牌化开发。 | Alastair Morrison 李菲菲 | 2013 | 旅游学刊2013,28,2: | 11 |
| 8 | 身份认同视角下中国背包客的目的地选择偏好研究显示文摘近年来,随着我国城市化、现代化进程的不断加快,背包旅行作为一种后现代的生活方式迅速流行起来。中国背包客在本土化的过程中也形成了独特的目的地选择偏好。文章试图从身份认同的视角切入,分析背包客与目的地之间的关系。研究首先以背包客对其群体身份的认同度为依据,通过因子一聚类分析将背包客群体分为了两类——经验型和业余型;再通过t检验和卡方检验发现他们在目的地的选择上存在着不同的行为模式。文章最后指出,背包客群体本身具有异质性,不同的群体成员对于背包客身份的认同程度不同,而身份认同则是理解背包客不同行为特征新的切入点。 | 刘鲁 张静儒 吴必虎 Alastair M. MORRISON | 2018 | 旅游学刊2018,33,4: | 11 |
| 9 | 国际游客对中国的地理想象构建与旅游动机显示文摘文章提出的地理想象-旅游动机(G-M)模型,应用地理想象概念探究国际游客对旅游目的地的旅游动机意向,从地理学与心理学的角度提供来华国际游客的动机研究领域的新视角。研究选择了中国最主要的客源市场韩国游客为实证案例,在跨学科的文献综述与焦点小组讨论法的预调研基础上,探析了韩国游客对中国的地理想象构建。通过结构方程模型,研究还假设并验证了客源地与目的地之间的两国关系、形象与认知以及多种营销渠道对地理想象构建具有正面影响,而游客对目的地的地理想象会影响到他们的出游动机。分析结果显示,游客的地理想象并不是他们旅行到特定目的地之前产生的虚构或一次性的现象,而是会不断地更新及变化的真实概念。地理想象会不断地影响游客的重游行为,多次旅游经验还会持续地丰富他们对目的地的地理想象。作为一种社会结构与物理、心理设置相互作用的抽象意念,地理想象对中韩两国旅游交流与游客流动的分析具有重要意义。 | 朴志娜 江扬 吴必虎 Alastair M.MORRISON | 2018 | 旅游学刊2018,33,9: | 11 |
| 10 | 轨道车辆结构防碰撞性文献综述显示文摘重点介绍了最近已进行的轨道车辆防碰撞的研究,对英国现行的做法与世界各地最新的观点和研究进行了对比分析,提出了下一步工作建议。 | Alastair Erskine 阎锋 李东锋 | 2014 | 国外铁道车辆2014,,3: | 6 |
| 11 | 目的地管理与目的地营销:打造优质旅游目的地平台显示文摘为进一步提高本刊的学术水平和国际影响力,本栏目2013年起进行了全新改版,特邀请相关领域的专家学者担任本栏目的特邀责任编辑,由这些特邀责任编辑约请各自领域国内外有一定影响力的专家学者参与讨论。 | Alastair Morrison 邵隽 陈映臻 | 2013 | 旅游学刊2013,,1: | 5 |
| 12 | Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation显示文摘AIM: To investigate over-expression of Osteopontin(OPN) pathway expression and mechanisms of action in human alcoholic liver disease(ALD), in vivo and in vitro acute alcohol models. METHODS: OPN pathway was evaluated in livers from patients with progressive stages of human ALD and serum from drinkers with and without liver cirrhosis. In vitro stellate LX2 cells exposed to acute alcohol and in vivo in acute alcoholic steatosis mouse models were also investigated for OPN pathway expression and function. WT and OPN-/- mice were administered an acute dose of alcohol and extent of liver injury was examined by histopathology and liver biochemistry after 16-24 h. The causative role of OPN was studied in OPN knockout animals and in vitro in stellate LX2 cells, utilizing siRNA, aptamer and neutralizing antibodies to block OPN and OPN pathway. OPN pathway expression and downstream functional consequences were measured for signaling by Western blotting, plasmin activation by spectrophotometric assays and cell migration by confocal imaging and quantitation. RESULTS: OPN expression positively correlated with disease severity in patients with progressive stages of ALD. In vivo, associated with alcoholic steatosis, a single dose of acute alcohol significantly increased hepatic OPN mRNA and protein, and a cleaved OPN form in a dose dependent manner. OPN mRNA and secreted OPN also increased in parallel with activation of LX2 stellate cells within 4 h of a single dose of alcohol. Expression of OPN receptors, αvβ3-integrin and CD44, increased in human ALD, and in vivo and in vitro with alcohol administration. This was accompanied by downstream phosphorylation of Akt and Erk, increased mRNA expression of several fibrogenesis, fibrinolysis and extracellular matrix pathway genes, plasmin activation and hepatic stellate cell(HSC) migration. Inhibition of OPN and OPN-receptor mediated signaling partially inhibited alcohol-induced HSC activation, plasmin activity and cell migration. CONCLUSION: OPN is a key mediator of the alcoholinduced effects on hepatic stellate cell functions and liver fibrogenesis. | Devanshi Seth Alastair Duly Paul C Kuo Geoffrey W McCaughan Paul S Haber | 2014 | World Journal of Gastroenterology2014,20,36: | 5 |
| 13 | 新形势·新策略--网络药理学与中药新药研发显示文摘'网络药理学与生物医药发展国际论坛'于2018年8月23-25日在江苏省连云港市召开。本次论坛由中国科协海智办、国际药理学联合会天然药物药理学分会、中国药理学会、中国药学会、江苏省科学技术协会、江苏省食品药品监督管理局和连云港市人民政府共同主办,中国药理学会网络药理学专业委员会承办,江苏康缘药业股份有限公司协办,中国药理学会网络药理学专业委员会主任委员周文霞教授和常务委员、江苏康缘药业股份有限公司董事长肖伟教授共同担任论坛主席。有来自美国、澳大利亚、奥地利、中国大陆和中国澳门等多个国家和地区的97名代表出席本次论坛。国家卫生健康委员会科技教育司监察刘登峰专员应邀参会。论坛针对国际、国内网络药理学研究的现状、最新进展和发展前沿等有关问题进行了综合讨论,展示了该研究领域的新技术、新进展和新应用。为促进国内外学术交流,本文对部分专家的观点和意见进行了整理,以期为促进我国网络药理学和生物医药研究与发展起到积极的推动作用。 | 韩露 程肖蕊 伯晓晨 曹亮 陈纯 陈洛南 陈禹保 段大跃 方坚松 高丽 高莉 高耀 李美娜 李学军 刘艾林 刘骏 秦雪梅 Bauer RUDOLF 宋文婷 Alastair STEWART 孙蓉 孙妩弋 田俊生 王永华 王忠 魏伟 肖伟 徐峰 徐筱杰 张文娟 张媛媛 赵静 周文霞 张永祥 | 2018 | 中国药理学与毒理学杂志2018,0,11: | 5 |
| 14 | 神经干细胞体外分化抗原表达的研究显示文摘目的:观察体外神经干细胞向神经元分化过程中标志性抗原的表达,为进一步研究神经干细胞体外增殖分化的影响因素提供参照。方法:取12~14天胎鼠大脑皮层,体外培养神经干细胞;于第1次传代后第3天将培养的神经干细胞置于含有分化培养液的培养皿中进行分化;于不同分化时间点(1、4、7、10和14天)采用免疫细胞化学方法检测神经巢蛋白(nestin)、SOX2、doublecortin(DCX)、Tuj1、神经元核心抗原(NeuN)各抗原的表达。结果:nestin和SOX2在开始时表达量非常近似,几乎在所有的细胞中两者均同时表达,随时间的推移,两者表达量均逐渐下降,但SOX2表达时间相对nestin持续更长;DCX表达量在分化1周内较高且变化不大,随后开始下降,至分化14天时仅有少数细胞呈DCX阳性;Tuj1在分化7天时已有少量表达,随后逐渐增加,分化14天时有38.27%的细胞表达Tuj1;在贴壁分化的1周内未见NeuN阳性细胞,但至分化14天时,Ne-uN阳性细胞占21.11%;在贴壁分化第1天时即有大量GFAP阳性细胞,其表达量随分化时间延长而逐渐下降,但下降趋势较nestin缓和,至分化14天时仍有大量GFAP阳性细胞。结论:神经干细胞体外分化过程中抗原的表达是一个相互交错的过程,未分化状态标志性抗原表达的减少与分化状态标志性抗原表达的增加互相对应。 | 刘罡 吴毅 贾杰 汪洋 胡永善 Alastair I H Murchie | 2009 | 中国运动医学杂志2009,28,1: | 4 |
| 15 | 运动训练在缺血性脑梗死大鼠神经干细胞移植治疗中的作用显示文摘目的探讨运动训练对缺血性脑梗死大鼠神经干细胞移植后神经功能和缺血脑区超微结构的影响。方法建立Sprague-Dawley大鼠大脑中动脉缺血/再灌注模型,随机分为脑缺血对照组(对照组)、电动跑台训练组(运动组)、神经干细胞移植组(移植组)、神经干细胞移植联合运动训练组(联合组),每组6或10只。术后第5天将超顺磁氧化铁(SPIO)标记的神经干细胞移植到缺血侧纹状体区。术后第6天开始,运动组和联合组大鼠给予定量的电动跑台运动训练,运动训练期间对4组大鼠进行定期的神经功能评估。运动4周后处死大鼠,透射电镜观察SPIO标记的神经干细胞在宿主脑内存活迁徙以及宿主脑区超微结构变化情况。结果与对照组比较,运动训练2周后运动组和联合组的神经功能评分,差异有统计学意义(P〈0.05或0.01),移植组差异无统计学意义(P〉0.05)。联合组可见SPIO标记的神经干细胞密度较大,迁徙也相对广泛,宿主缺血脑区超微结构优于其他各组。结论运动训练可以促进神经干细胞移植对脑梗死大鼠的治疗作用,但其具体的机制还有待进一步研究。 | 刘罡 贾杰 吴毅 胡永善 汪洋 于惠贤 张峰 Alastair I H Murchie | 2008 | 中华物理医学与康复杂志2008,30,11: | 4 |
| 16 | Omics Approaches to Identify PotentialBiomarkers of Inflammatory Diseases in the FocalAdhesion Complex显示文摘Inflammatory diseases such as inflammatory bowel disease(IBD) require recurrent invasive tests, including blood tests, radiology, and endoscopic evaluation both to diagnose and assess disease activity, and to determine optimal therapeutic strategies. Simple ‘bedside' biomarkers could be used in all phases of patient management to avoid unnecessary investigation and guide further management. The focal adhesion complex(FAC) has been implicated in the pathogenesis of multiple inflammatory diseases, including IBD, rheumatoid arthritis, and multiple sclerosis. Utilizing omics technologies has proven to be an efficient approach to identify biomarkers from within the FAC in the field of cancer medicine. Predictive biomarkers are paving the way for the success of precision medicine for cancer patients, but inflammatory diseases have lagged behind in this respect. This review explores the current status of biomarker prediction for inflammatory diseases from within the FAC using omics technologies and highlights the benefits of future potential biomarker identification approaches. | Johanne Brooks Alastair Watson Tamas Korcsmaros | 2017 | Genomics, Proteomics & Bioinformatics2017,15,2: | 4 |
| 17 | Survival outcomes of cemented compared to uncemented stems in primary total hip replacement显示文摘Total hip replacement(THR) is a successful and reliable operation for both relieving pain and improving function in patients who are disabled with end stage arthritis.The ageing population is predicted to significantly increase the requirement for THR in patients who have a higher functional demand than those of the past. Uncemented THR was introduced to improve the long term results and in particular the results in younger, higher functioning patients. There has been controversy about the value of uncemented compared to cemented THR although there has been a world-wide trend towards uncemented fixation. Uncemented acetabular fixation has gained wide acceptance, as seen in the increasing number of hybrid THR in joint registries, but there remains debate about the best mode of femoral fixation.In this article we review the history and current worldwide registry data, with an in-depth analysis of the New Zealand Joint Registry, to determine the results of uncemented femoral fixation in an attempt to provide an evidence-based answer as to the value of this form of fixation. | Michael Wyatt Gary Hooper Christopher Frampton Alastair Rothwell | 2014 | World Journal of Orthopedics2014,5,5: | 4 |
| 18 | Methane Emissions from Grazing Holstein-Friesian Heifers at Different Ages Estimated Using the Sulfur Hexafluoride Tracer Technique显示文摘动物和日粮因素对牛肠道甲烷排放量影响的相关研究已经很普遍,但是关于放牧青年奶牛的甲烷排放量的可参考数据较少。本研究评估了荷斯坦奶牛在多年生黑麦草草地放牧时的生理状态对甲烷排放量的影响,分别进行了以下两个试验:试验1从2011年5月开始,为期11个星期,试验2从2011年8月开始,为期10个星期。在每个试验中,将荷斯坦奶牛分成三个处理组(每组12头),分别由小牛犊、一岁的母牛犊和妊娠母牛组成(平均年龄分别为8.5、14.5和20.5月龄)。在每个试验的最后一个星期利用六氟化硫示踪技术预估每头牛的甲烷排放量。干物质摄入量由代谢能需要量除以牧草中的代谢能含量计算而得。正如预期一样,活体重随年龄的增加而增加(P<0.001),然而试验1中三个分组的体增重没有差异,试验2中的体增重随着年龄增加有不同程度的减少(P<0.001)。在试验1中,妊娠母牛高于小牛犊的甲烷排放量(P<0.001),而一岁母牛犊的甲烷排放量最高(g·d^(-1))。当用单位活体重、干物质摄入量和总能摄入量表示甲烷排放量时,一岁母牛犊比小牛犊和妊娠母牛的排放速率更高(P<0.001)。在试验2中,甲烷排放量(g·d^(-1))随着年龄增加呈线性上升(P<0.001),但是这种差异在一岁母牛犊和妊娠母牛中并不显著。妊娠母牛的甲烷/活体重的比值低于另外两组(P<0.001),小牛犊的总能摄入量中甲烷能量输出的比值低于一岁母牛犊和妊娠母牛(P<0.05)。根据所有数据建立甲烷排放量的预测方程。所有关系均为显著(P<0.001),R2值的分布范围为0.630~0.682。这些模型表明:每增加1 kg活体重,甲烷排放量增加0.252 g·d^(-1);每增加1 kg·d^(-1)干物质摄入量,甲烷排放量增加14.9 g·d^(-1);每增加1 MJ·d^(-1)总能摄入量,甲烷能量输出增加0.046 MJ·d^(-1)。当实际甲烷排放量不可测时,这些结果为我们提供了预估放牧母牛甲烷排放量的另一种方法。 | Steven J. Morrisonn Judith McBride Alan W. Gordon Alastair R. G. Wylie Tianhai Yan | 2017 | Engineering2017,3,5: | 4 |
| 19 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 2: Current management显示文摘 | Axel Dignass James O. Lindsay Andreas Sturm Alastair Windsor Jean-Frederic Colombel Mathieu Allez Gert D’Haens André D’Hoore Gerassimos Mantzaris Gottfried Novacek Tom ?resland Walter Reinisch Miquel Sans Eduard Stange Severine Vermeire Simon Travis Gert | 2012 | Journal of Crohn’s and Colitis2012,,10: | 4 |
| 20 | Complications of intracerebral haemorrhage显示文摘 | Joyce S Balami Alastair M Buchan | 2012 | Lancet Neurology2012,,1: | 3 |