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| 1 | mRNA expression of DOK1-6 in human breast cancer显示文摘AIM:To examine the expression of downstream of tyrosine kinase(DOK)1-6 genes in normal and breast cancer tissue and correlated this with several clinicopathological and prognostic factors.METHODS:DOK1-6 m RNA extraction and reverse transcription were performed on fresh frozen breast cancer tissue samples(n = 112) and normal background breast tissue(n = 31). Tissues were collected between 1991 and 1996 at two centres and all patients underwent mastectomy and ipsilateral axillary node dissection. All tissues were randomly numbered and the details were only made known after all analyses were completed. Transcript levels of expression were determined using real-time polymerase chain reaction and analyzed against TNM stage, tumour grade and clinical outcome over a 10-year follow-up period.RESULTS:DOK-2 and DOK-6 expression decreased with increasing TNM stage. DOK-6 expression decreased with increasing Nottingham Prognostic Index(NPI) [NPI-1 vs NPI-3(mean copy number 15.4 vs 0.22, 95%CI:2.7-27.6, P = 0.018) and NPI-2 vs NPI-3(mean copy number 7.6 vs 0.22, 95%CI:0.1-14.6, P = 0.048)]. After a median follow up period of 10 years, higherlevels of DOK-2 expression were found among patients who remained disease-free compared to those who developed local or distant recurrence(mean copy number 3.94 vs 0.0000096, 95%CI:1.0-6.85, P = 0.0091), and distant recurrence(mean copy number 3.94 vs 0.0025, 95%CI:1.0-6.84, P = 0.0092). Patients who remained disease-free had higher levels of DOK-6 expression compared to those who died from breast cancer.CONCLUSION:Decreasing expression levels of DOK-2 and DOK-6 with increased breast tumour progression supports the notion that DOK-2 and DOK-6 behave as tumour suppressors in human breast cancer. | Tamara Ghanem James Bracken Abdul Kasem Wen G Jiang Kefah Mokbel | 2014 | World Journal of Clinical Oncology2014，5，2： | 3 |
| 2 | A randomized controlled trial of methylprednisolone or naloxone in the treat ment of acute spinal-cord injury: result of the Second National A cute Spinal Cord Injury Study显示文摘 | Bracken MB Shepard MJ Collins WF | 1990 | N Engl J Med1990，322，20： | 1 |
| 3 | Temperature dependence of intramolecular dynamics of the basic leu cine zipper of GCN4: Implications for the entropy of association with DNA显示文摘 | Bracken C Carr P A Cavanagh J | 1999 | J Mol Biol1999，285，5： | 1 |
| 4 | Methylprednisolone and acute spinal cord injury: an update of the randomized evidence显示文摘 | Bracken MB | 2001 | Spine ( Phila Pa 1976)2001，26，24： | 1 |
| 5 | Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury:results of the Third National Acute Spinal Cord Injury Study显示文摘 | Bracken MB Shepard MJ Holford TR | 1997 | JAMA1997，277，20： | 1 |
| 6 | Long-Term Exposure to House Dust Mite Leads to the Suppression of Allergic Airway Disease Despite Persistent Lung Inflammation显示文摘 | Bracken SJ Adami AJ Szczepanek SM | 2015 | International archives of allergy and immunology2015，166，4： | 1 |
| 7 | In-hospital neurologic deterioration following fractures of the ankylosed spine: a single-institution experience 显示文摘 | Sehiefer TK Milligan BD Bracken CD | 2015 | World Neurosurg2015，83，5： | 1 |
| 8 | Analyses of magnetic-field peak-exposure summary measures显示文摘 | Mezei G Bracken TD Senior R | 2006 | J Expo Sci Environ Epidemiol2006，16，6： | 1 |
| 9 | The Integration of Social-economic and Physical Resource Data for Applies Land Management Information System显示文摘 | | 1993 | Applied Geography1993，13，1： | 1 |
| 10 | Effect of timing on recovery of segmental and longhact neurologic function in NASCIS 2显示文摘 | Bracken MB Holford TR | 1993 | Neurosurg1993，79，4： | 1 |
| 11 | Measuring patient safety cli- mate : A review of Surveys 显示文摘 | Colla JB Bracken AC Kinney LM | 2005 | Qual Saf Health Care2005，14，5： | 1 |
| 12 | Neurological and functional status 1 year after acute spinal cord injury: estimates of functional recovery in National Acute Spinal Cord Injury Study U from results mod- eled in National Acute Spinal Cord Injury Study HI 显示文摘 | Bracken MB Holford TR | 2002 | J Neuro- surg2002，96，3： | 1 |
| 13 | Duration of intrapartum prophylaxis for neonatal group B streptococcal disease:a systematic review显示文摘 | Illuzzi JL Bracken MB | 2006 | Obstet Gynecol2006，108，5： | 1 |
| 14 | Cyclopenin, a nitrogen-containing metabolic product of Penicillium cyclopium Westling 显示文摘 | Bracken A Pocker A Raistrick H | 1954 | Biochem J1954，57，4： | 1 |
| 15 | The hypoxia - induc- ible factors: key transcriptional regulators of hypoxic re- sponses显示文摘 | Bracken CP Whitelaw ML Peet DJ | 2003 | Cell Mol Life Sci2003，60，7： | 1 |
| 16 | A duplex quantitative polymerase chain reaction assay based on quantification of alpha-methylacyl-coa racemase transcripts and prostate cancer antigen 3 in urine sediments improved diagnostic accuracy for prostate cancer显示文摘 | Ouyang B Bracken B Burke B | 2009 | J Urol2009，181，6： | 1 |
| 17 | Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals显示文摘 | Harry Olson Graham Betton Denise Robinson Karluss Thomas Alastair Monro Gerald Kolaja Patrick Lilly James Sanders Glenn Sipes William Bracken Michael Dorato Koen Van Deun Peter Smith Bruce Berger Allen Heller | 2000 | Regulatory Toxicology and Pharmacology2000，，1： | 1 |
| 18 | Efficacy of methylprednisolone in acute spinal cord injury显示文摘 | Bracken MB Collins WF Freeman DF | 1984 | JAMA1984，251，1： | 1 |
| 19 | International standards for neurological and functional classification of spinal cord injury显示文摘 | MAYNARD F M BRACKEN M B GREACEY G | 1992 | Spinal Cord1992，35，7： | 1 |
| 20 | International standards for neurological and functional classification of spinal cord injury显示文摘 | Maynard FM Jr Bracken MB Creasey G | 1997 | Spinal Cord1997，35，5： | 1 |
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