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| 1 | Occurrence and assessment of veterinary antibiotics in swine manures:A case study in East China显示文摘We investigated the occurrence of 14 selected antibiotics including five therapeutic classes of tetracyclines,sulfonamides,macrolides,fluoroquinolones and chloramphenicols in manures collected from four swine farms of different sizes in eastern China.Tetracyclines(tetracycline,oxytetracycline,chlortetracycline,and doxycycline) and sulfadiazine were the most prominent contaminants in the manure samples,with maximum concentrations reaching 98.2 × 10 3,354.0 × 10 3,139.4 × 10 3,37.2× 10 3,and 7.1× 10 3 μg/kg,respectively.The occurrence of these compounds was dependent on breeding scale,animal type,and breeding season.Manure storage and vermiculture were not able to effectively deplete the heavier contaminants(tetracyclines and sulfadiazine),resulting in high levels of these chemicals remaining in manures.Therefore,the occurrence of these antibiotics in agricultural soils(0.1-205.1 μg/kg) collected from four types of agricultural land(pear orchard,tea plantation,bamboo forest,and paddy field) near the studied farms,was a reflection of manure application.However,the extremely high concentrations of antibiotics in manures were unlikely from feed consumption,but from other direct forms of medicine application. | CHEN YongShan ZHANG HaiBo LUO YongMing SONG Jing | 2012 | Chinese Science Bulletin2012，57，6： | 29 |
| 2 | 2D materials via liquid exfoliation:a review on fabrication and applications显示文摘Since graphene was discovered, the study of two-dimensional(2D) materials with atomic thickness has become a hot spot. To prepare different 2D materials,different methods have been groped, such as mechanical exfoliation, chemical vapor deposition(CVD), liquid-phase exfoliation. This review mainly introduced the sonication liquid-phase exfoliation, an effective method to prepare 2D materials. Compared with mechanical exfoliation and CVD methods, liquid-phase exfoliation is convenient and costeffective and provides high yield. We focused on both theoretical and experimental details of this method. This method was reviewed according to the development of 2D materials from graphene, h-BN to transition metal chalcogenides(TMDs) and black phosphorus nanosheets.We discussed the applications of liquid-exfoliated 2D materials including micro- and nanoelectrical devices,photoelectric devices, and energy storage devices. | Chengxue Huo Zhong Yan Xiufeng Song Haibo Zeng | 2015 | Science Bulletin2015，60，23： | 20 |
| 3 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 4 | Predicting As,Cd and Pb uptake by rice and vegetables using field data from China显示文摘Plant uptake factor(PUF),single-variable regression of natural log-transformed concentrations in rice grain/vegetables versus natural log-transformed concentrations in soil and multiple-variable regression with soil concentrations and pH,was derived,validated and compared based on the paired crop and soil data collected from studies regarding As,Cd and Pb contaminated croplands in China.Results showed that the median value of PUF did not present deterministic prediction.But after natural logarithm transformation,the PUF followed Gaussian distribution which could be useful in risk assessment.The single-variable regression models were significant for As,Cd and Pb uptake both by rice and vegetables;however,the standard errors of all the regressions were comparatively large.Soil pH as a variable was generally significant but it only contributed positively to model fit for Cd uptake.After model comparison and selection,the upper 95% prediction limits of the multiple regression model for Cd uptake by rice was recommended to calculate screening value of Cd for paddy soil based on the limit for Cd concentration in rice grain. | Hongzhen Zhang Yongming Luo Jing Song Haibo Zhang Jiaqi Xia Qiguo Zhao | 2011 | Journal of Environmental Sciences2011，23，1： | 12 |
| 5 | Landscape of DILI-related adverse drug reaction in China Mainland显示文摘Drug-induced liver injury(DILI)is a type of bizarre adverse drug reaction(ADR)damaging liver(L-ADR)which may lead to substantial hospitalizations and mortality.Due to the general low incidence,detection of L-ADR remains an unsolved public health challenge.Therefore,we used the data of 6.673 million of ADR reports from January 1st,2012 to December 31st,2016 in China National ADR Monitoring System to establish a new database of L-ADR reports for future investigation.Results showed that totally 114,357 ADR reports were retrieved by keywords searching of liver-related injuries from the original heterogeneous system.By cleaning and standardizing the data fields by the dictionary of synonyms and English translation,we resulted 94,593 ADR records reported to liver injury and then created a new database ready for computer mining.The reporting status of L-ADR showed a persistent 1.62-fold change over the past five years.The national population-adjusted reporting numbers of L-ADR manifested an upward trend with age increasing and more evident in men.The annual reporting rate of L-ADR in age group over 80 years old strikingly exceeded the annual DILI incidence rate in general population,despite known underreporting situation in spontaneous ADR reporting system.The percentage of herbal and traditional medicines(H/TM)L-ADR reports in the whole number was 4.5%,while 80.60%of the H/TM reports were new findings.There was great geographical disparity of reported agents,i.e.more cardiovascular and antineoplastic agents were reported in higher socio-demographic index(SDI)regions and more antimicrobials,especially antitubercular agents,were reported in lower SDI regions.In conclusion,this study presented a large-scale,unbiased,unified,and computer-minable L-ADR database for further investigation.Age-,sex-and SDI-related risks of L-ADR incidence warrant to emphasize the precise pharmacovigilance policies within China or other regions in the world. | Jiabo Wang Haibo Song Feilin Ge Peng Xiong Jing Jing Tingting He Yuming Guo Zhuo Shi Chao Zhou Zixin Han Yanzhong Han Ming Niu Zhaofang Bai Guangbin Luo Chuanyong Shen Xiaohe Xiao | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 12 |
| 6 | Recent advances and prospects toward blue perovskite materials and light-emitting diodes显示文摘Perovskite based light-emitting diodes(PeLEDs)have become a powerful candidate for next-generation solid-state lightings and high-definition displays due to their high photoluminescence quantum yield(PLQY),tunable emission wavelength over the visible spectrum,and narrow emission linewidths.Over the past few years,the development of red-and green-emissive PeLEDs has rapidly increased,and the corresponding external quantum efficiencies(EQE)have exceeded 20%.However,the research progress of blue-emitting PeLEDs is limited by its poor material quality and inappropriate device structure.Currently,the maximum EQE of blue PeLED is only 6.2%,which is far from the industrialization requirements.In order to promote the development of blue PeLEDs,we summarize the recent research progress of blue perovskite materials and LEDs and discuss several fatal challenges,mainly embodied in low efficiency and poor stability.In order to overcome these challenges,detailed analysis and strategies are put forward in terms of the materials and devices.For the former,we summarize the feasible strategy for the preparation of efficient and stable blue-emissive perovskites using component engineering.For the latter,we analyze the advantages and limitations of the different strategies for blue-emissive perovskite in LEDs.At the end of the review,a comprehensive outlook is detailed,including future development directions and several technical problems to be solved.Thus,we aim to highlight the significance and promote the industrialization of PeLEDs. | Tao Fang Fengjuan Zhang Shichen Yuan Haibo Zeng Jizhong Song | 2019 | InfoMat2019，1，2： | 9 |
| 7 | Nanowire-based transparent conductors for flexible electronics and optoelectronics显示文摘As the necessary components for various modern electronic and optoelectronic devices, novel transparent electrodes(TEs) with the low cost, abundance features, and comparable performance of indium tin oxide(ITO) are inquired materials. Metal nanowires(NWs) with the excellent photoelectric properties as next-generation TE candidates have widely applications in smart optoelectronic devices such as electronic skins, wearable electronics, robotic skins, flexible and stretchable displays. This review describes the synthetic strategies for the preparation of metal NWs, the assemble process for metal NW films,and the practical aspects of metal NW films with the desired properties in various low-cost, flexible,and solution-based photoelectric devices. | Jie Xue Jizhong Song Yuhui Dong Leimeng Xu Jianhai Li Haibo Zeng | 2017 | Science Bulletin2017，62，2： | 8 |
| 8 | Perovskite light-emitting/detecting bifunctional fibres for wearable LiFi communication显示文摘Light fidelity(LiFi),which is emerging as a compelling technology paradigm shifting the common means of highcapacity wireless communication technologies,requires wearable and full-duplex compact design because of its great significance in smart wearables as well as the‘Internet of Things’.However,the construction of the key component of wearable full-duplex LiFi,light-emitting/detecting bifunctional fibres,is still challenging because of the conflicting process between carrier separation and recombination,as well as the highly dynamic film-forming process.Here,we demonstrate light-emitting/detecting bifunctional fibres enabled by perovskite QDs with hybrid components.The hybrid perovskite inks endow fibres with super-smooth QD films.This,combined with the small exciton binding energy and high carrier mobility of perovskite QDs,enables successful integration of electroluminescence and photodetection into monofilaments.The bifunctional fibres possess the narrowest electroluminescence full width at half maximum of ~19 nm and,more importantly,the capability for simultaneously transmitting and receiving information.The successful fabrication of narrow emission full-duplex LiFi fibres paves the way for the fabrication and integration of low crosstalk interoperable smart wearables. | Qingsong Shan Changting Wei Yan Jiang Jizhong Song Yousheng Zou Leimeng Xu Tao Fang Tiantian Wang Yuhui Dong Jiaxin Liu Boning Han Fengjuan Zhang Jiawei Chen Yongjin Wang Haibo Zeng | 2020 | Light(Science & Applications)2020，9，1： | 7 |
| 9 | Perovskite nanocrystals:synthesis,properties and applications显示文摘Halide perovskites have emerged as superstar materials for optoelectronic devices. Besides the fever of research in solar cells, these materials show great promise on light emitting diodes(LEDs), photodetectors and lasers as well. Rapid advances in bulk perovskite materials aroused universal interest for the development of perovskite nanocrystals, inspired by the great progress of classic colloidal semiconductor quantum dots. Perovskite nanocrystals have been synthesized based on solution process and exhibited high luminescence quantum yield, sharp emission peak, and emission color tunability. Significant progresses have been made about the application of perovskite nanocrystals for LED and lasers in recent years. In this paper, we will comprehensively introduce the synthesis strategies, physical and chemical characteristics, as well as their applications in optoelectronic devices. | Pengfei Fu Qingsong Shan Yuequn Shang Jizhong Song Haibo Zeng Zhijun Ning Jinkang Gong | 2017 | Science Bulletin2017，62，5： | 6 |
| 10 | Direct laser writing of volumetric gradient index lenses and waveguides显示文摘Direct laser writing(DLW)has been shown to render 3D polymeric optical components,including lenses,beam expanders,and mirrors,with submicrometer precision.However,these printed structures are limited to the refractive index and dispersive properties of the photopolymer.Here,we present the subsurface controllable refractive index via beam exposure(SCRIBE)method,a lithographic approach that enables the tuning of the refractive index over a range of greater than 0.3 by performing DLW inside photoresist-filled nanoporous silicon and silica scaffolds.Adjusting the laser exposure during printing enables 3D submicron control of the polymer infilling and thus the refractive index and chromatic dispersion.Combining SCRIBE’s unprecedented index range and 3D writing accuracy has realized the world’s smallest(15μm diameter)spherical Luneburg lens operating at visible wavelengths.SCRIBE’s ability to tune the chromatic dispersion alongside the refractive index was leveraged to render achromatic doublets in a single printing step,eliminating the need for multiple photoresins and writing sequences.SCRIBE also has the potential to form multicomponent optics by cascading optical elements within a scaffold.As a demonstration,stacked focusing structures that generate photonic nanojets were fabricated inside porous silicon.Finally,an all-pass ring resonator was coupled to a subsurface 3D waveguide.The measured quality factor of 4600 at 1550 nm suggests the possibility of compact photonic systems with optical interconnects that traverse multiple planes.SCRIBE is uniquely suited for constructing such photonic integrated circuits due to its ability to integrate multiple optical components,including lenses and waveguides,without additional printed supports. | Christian R.Ocier Corey A.Richards Daniel A.Bacon-Brown Qing Ding Raman Kumar Tanner J.Garcia Jorik van de Groep Jung-Hwan Song Austin J.Cyphersmith Andrew Rhode Andrea N.Perry Alexander J.Littlefield Jinlong Zhu Dajie Xie Haibo Gao Jonah F.Messinger Mark L.Brongersma Kimani C.Toussaint Jr Lynford L.Goddard Paul V.Braun | 2020 | Light(Science & Applications)2020，9，1： | 6 |
| 11 | Design of a Passive Gait‑based Ankle‑foot Exoskeleton with Self‑adaptive Capability显示文摘Propulsion during push-off is the key to realizing human locomotion.Humans have evolved a way of walking with high energy utilization,but it can be further improved.Drawing inspiration from the muscle-tendon unit,a passive spring-actuated ankle-foot exoskeleton is designed to assist with human walking and to lengthen walking duration by mechanically enhancing walking efficiency.Detection of the gait events is realized using a smart clutch,which is designed to detect the contact states between the shoe sole and the ground,and automatically switch its working state.The engagement of a suspended spring behind the human calf muscles is hence controlled and is in synchrony with gait.The device is completely passive and contains no external power source.Energy is stored and returned passively using the clutch.In our walking trials,the soleus electromyography activity is reduced by as much as 72.2%when the proposed ankle-foot exoskeleton is worn on the human body.The influence of the exoskeleton on walking habits is also studied.The results show the potential use of the exoskeleton in humans’daily life. | Xiangyang Wang Sheng Guo Bojian Qu Majun Song Haibo Qu | 2020 | Chinese Journal of Mechanical Engineering2020，33，3： | 5 |
| 12 | Biodegradation behavior of magnesium and ZK60 alloy in artificial urine and rat models显示文摘In this work, the biodegradable and histocompatibility properties of pure Mg and ZK60 alloy wereinvestigated as new temporary implants for urinary applications. The corrosion mechanism in artificialurine was proposed using electrochemical impedance spectroscopy and potentiodynamic polarizationtests. The corrosion potential of pure magnesium and ZK60 alloy were -1820 and -1561 mV, respectively,and the corrosion current densities were 59.66 ± 6.41 and 41.94 ± 0.53 μA cm^-2, respectively. Thein vitro degradation rates for pure Mg and ZK60 alloy in artificial urine were 0.382 and 1.023 mm/y,respectively, determined from immersion tests. The ZK60 alloy degraded faster than the pure Mg in bothartificial urine and in rat bladders (the implants of both samples are ø 3 mm × 5 mm). Histocompatibilityevaluations showed good histocompatibility for the pure Mg and ZK60 alloy during the 3 weeks postimplantationin rat bladders, and no harm was observed in the bladder, liver and kidney tissues. Theresults provide key information on the degradation properties and corrosion mechanism of pure Mg andZK60 alloy in the urinary system. | Shiying Zhang Yanze Bi Jianye Li Zhenguo Wang Jingmin Yan Jiawang Song Haibo Sheng Heqing Guo Yan Li | 2017 | Bioactive Materials2017，2，2： | 4 |
| 13 | LEO Enhanced Global Navigation Satellite System(LeGNSS):progress,opportunities,and challenges显示文摘With the completion of Chinese BeiDou Navigation Satellite System(BDS),the world has begun to enjoy the Positioning,Navigation,and Timing(PNT)services of four Global Navigation Satellite Systems(GNSS).In order to improve the GNSS performance and expand its applications,Low Earth Orbit(LEO)Enhanced Global Navigation Satellite System(LeGNSS)is being vigorously advocated.Combined with high-,medium-,and low-earth orbit satellites,it can improve GNSS performance in terms of orbit determination,Precise Point Positioning(PPP)convergence time,etc.This paper comprehensively reviews the current status of LeGNSS,focusing on analyzing its advantages and challenges for precise orbit and clock determination,PPP convergence,earth rotation parameter estimation,and global ionosphere modeling.Thanks to the fast geometric change brought by LEO satellites,LeGNSS is expected to fundamentally solve the problem of the long convergence time of PPP without any augmentation.The convergence time can be shortened within 1 minute if appropriate LEO constellations are deployed.However,there are still some issues to overcome,such as the optimization of LEO constellation as well as the real time LEO precise orbit and clock determination. | Haibo Ge Bofeng Li Song Jia Liangwei Nie Tianhao Wu Zhe Yang Jingzhe Shang Yanning Zheng Maorong Ge | 2022 | Geo-Spatial Information Science2022，25，1： | 4 |
| 14 | Metagenome analysis reveals potential microbial functions in topsoil of wheat-maize rotation system with five-year application of fertilizers显示文摘Fertilization mode affects soil quality and ecological health.The effects of four fertilization regimens on lignocellulose content,readily degradable carbohydrate decomposition,and potential microbial functions in the topsoil of a wheat-maize rotation system between 2012 and 2017 were investigated.The fertilization regimens of control(control NFNB),high chemical fertilizer(HCF),high biochar plus low chemical fertilizer(HBLCF),and biochar-based fertilizer(BBF)were compared on soil fundamental properties,microbial structure,and potential function in soil carbohydrate degradation based on metagenome analysis.The diversity of carbohydrate-active enzyme genes in the topsoil microbial consortia in the four trials was primarily distributed within the ten ecologically most dominant phyla.Application of BBF was associated with the lowest decline in total nitrogen and P2O5(2012-2017:6.5%and 28.1%,respectively)and the most effective carbohydrate decomposition(2015-2017:67.0%for cellulose and 59.9%for readily degradable carbohydrate).Carbohydrate transport and metabolism accounted for 6.0%of reads assigned functional classification under the BBF regimen.These findings reveal the ecologically functional diversity of topsoil microorganisms and suggest BBF application as a promising strategy for sustainable agriculture and beneficial to soil health. | Yujun Shen Lixin Zhao Haibo Meng Hongsheng Cheng Jingtao Ding Jiarui Wang Shanshan Dong Xi Zhang Liqiu Song Shengwei Zheng | 2019 | International Journal of Agricultural and Biological Engineering2019，12，6： | 3 |
| 15 | Development of an aero-thermal coupled through-flow method for cooled turbines显示文摘The influence of complicated interaction between the flow field and heat transfer in cooled turbines becomes more and more significant with the increasing turbine inlet temperature. However, classical through-flow methods did not take into account the influence of the interaction caused by air cooling. The aerodynamic design and cooling design of cooled turbines were carried out separately, and the iterations between the aerodynamic design and cooling design led to a long design period and raised the design cost. To shorten the design period and decrease the design cost, this paper proposes a concise aero-thermal coupled through-flow method for the design of cooled turbines, taking into account the influence of the complicated interaction between the flow field and heat transfer in cooled turbines. The governing equations, such as energy equation and continuity equation in classical through-flow method are re-derived theoretically by considering the historical influence of cooling with the same method that deals with viscous losses in this paper. A cooling model is developed in this method. The cooled blade is split into a number of heat transfer elements, and the heat transfer is studied element by element along both the span and the chord in detail. This paper applies the method in the design of a two-stage axial turbine, of which the first stator is cooled with convective cooling. With the prescribed blade temperature limitation and the knowledge of the flow variables of the mainstream at the turbine inlet, such as the total pressure, total temperature and mass flow rate, the convergence of the calculation is then obtained and the properties of the flow field, velocity triangles and coolant requirement are well predicted. The calculated results prove that the aero-thermal coupled through-flow method is a reliable tool for flow analysis and coolant requirement prediction in the design of cooled turbines. | GU ChunWei LI HaiBo SONG Yin | 2015 | Science China(Technological Sciences)2015，58，12： | 3 |
| 16 | Enhanced Damping Capacities of Mg–Ce Alloy by the Special Microstructure with Parallel Second Phase显示文摘Microstructure evolution and damping capacities of Mg–Ce binary alloys with three different Ce contents(0.5, 1, or 2 wt%) have been systematically investigated in this work. Numerous fine parallel second phases in Mg–2Ce alloy are obtained, as well as a large number of dislocations around them, but few dislocations appear around the reticular second phase in the Mg–1Ce alloy. Among the three alloys, two internal friction peaks(P_1 and P_2) are detected at about 78 and 167?C in both the Mg–0.5Ce and Mg–1Ce alloys.In addition, the alloy with special parallel second phase structure exhibits excellent damping capacity in both strain amplitude and temperature-dependent regions. These results may be ascribed to the stress concentration and the formation of abundant parallel and uniform dislocation configurations in the ?-Mg matrix without the influence of crystal orientation. The obtained results may provide a novel idea to prepare high-damping magnesium alloys by tailoring their microstructure. | Zhongshan Wu Jingfeng Wang Haibo Wang She Ma Song Huang Shun Li Fusheng Pan | 2017 | Journal of Materials Science & Technology2017，33，9： | 3 |
| 17 | Experimental and numerical investigation on surface quality for two-point incremental sheet forming with interpolator显示文摘The unsatisfied surface quality seriously impedes the wide application of incremental sheet forming(ISF)in industrial field.As a novel approach,the interpolator method is a promising strategy to enhance the surface quality in ISF.However,the mechanism for the improvement of surface quality and the influence of interpolator properties on surface roughness are not well understood.In this paper,the influences of process variables(i.e.tool diameter,step size and thickness of interpolators)on the forming process(e.g.surface roughness,forming force and geometric error)are investigated through a systematic experimental approach of central composite design(CCD)in two-point incremental sheet forming(TPIF).It is obtained that the increase in thickness of interpolators decreases the surface roughness in direction vertical to the tool path while increases the surface roughness in direction horizontal to the tool path.Nevertheless,the combined influence between thickness of interpolators and process parameters(tool diameter and step size)is limited.Meanwhile,the placement of interpolator has little influence on the effective forming force of blank.In addition,the geometric error enlarges with the increase of step size and thickness of interpolator while decreases firstly and then increase with an increase in tool diameter.Finally,the influencing mechanism of the interpolator method on surface quality can be attributed to the decrease of thecontact pressure due to the increase of contact area with the unchanged contact force.Meanwhile,the interpolator method eliminates the sliding friction on the surface of blank due to the stable relative position between the blank and the interpolator. | Xiaoqiang LI Kai HAN Xu SONG Haibo WANG Dongsheng LI Yanle LI Qing LI | 2020 | Chinese Journal of Aeronautics2020，33，10： | 3 |
| 18 | Essential training steps to achieving competency in the basic intraoperative transesophageal echocardiography examination for Chinese anesthesiologists显示文摘为检查定义的 intraoperative transesophageal echocardiography (T ) 的指南为医药专业人员的一个详细标准,特别地麻醉学者, T 考试怎么应该继续。多年以来, T 获得了实质的流行并且作为一种比较喜欢的监视形式出现了在血液动力学的不稳定性状况或批评照顾背景期间帮助 perioperative 管理和决策。T 训练小径和惯例指南很好在西方的国家和世界的许多区域被建立了。然而, T 为麻醉学者训练和实践信息缺乏中国。当创新技术发展,另外的教育模型出现了帮助在基本 T 考试获得才能。因此,在在中国为麻醉学者训练途径的理想的 T 上建立一致着急地被需要。开发能被合并到居民外套训练也是的麻醉学的有效课程对必要在基本 T 考试向才能提供知识和技巧。与演变,医药系统改革,增加为 intraoperative 要求提供外科的革新的血液动力学的监视,麻醉学专业人员逐渐地被强迫在他们的现在和将来的惯例执行 intraoperative T 考试。克服障碍并且在使用 TEE 形式在 intraoperative 管理和外科的决策帮助获得重要进步,出版为瓷器麻醉学者训练指南的基本 T 是一个重要努力。 | Yong G. Peng Haibo Song E. Wang Weipeng Wang Jin Liu | 2015 | Frontiers of Medicine2015，9，1： | 2 |
| 19 | Investigation and analysis of the linkage mechanism and whole process cost of livestock manure organic fertilizer显示文摘In recent years,the utilization of manure resources for livestock and poultry farming has attracted a widespread attention,and manure resources utilization models suitable for different regional characteristics have formed gradually.Among them,the production of organic fertilizer from animal manure is a vital utilization method.However,there are still some problems such as high production costs,difficult sales,and the unwillingness of farmers to use organic fertilizers which have affected the breeding cycle and the sustainability of manure treatment in livestock and poultry breeding.This article selected 371 organic fertilizer plants,related farms and farmers in China,focusing on the main links of the entire process of livestock manure-organic fertilizer-farm application,and studied the mode of animal manure collection by organic fertilizer plants.The costs of organic fertilizer production and farmland application were discussed.Moreover,suggestions were made for the promotion and implementation of large-scale organic fertilizers to make good utilization of manure resources in livestock and poultry farming. | Shanshan Dong Bin Sui Yujun Shen Haibo Meng Lixin Zhao Jingtao Ding Haibin Zhou Xi Zhang Hongsheng Cheng Jian Wang Ran Li Liqiu Song Pengxiang Xu Ji Li | 2020 | International Journal of Agricultural and Biological Engineering2020，13，2： | 2 |
| 20 | All-trans retinoic acid(ATRA)inhibits insufficient radiofrequency ablation(IRFA)-induced enrichment of tumor-initiating cells in hepatocellular carcinoma显示文摘Objective:Local recurrence of hepatocellular carcinoma(HCC)after radiofrequency ablation(RFA)treatment remains a serious problem.Tumor-initiating cells(TICs)are thought to be responsible for tumor relapse.Here,we investigated the effect of the TIC differentiation inducer,all-trans retinoic acid(ATRA),on RFA and explored the potential molecular mechanisms.Methods:The proportions of CD133+and epithelial cell adhesion molecule(Ep CAM);TICs in recurrent HCC after RFA and primary HCC were first determined in clinic.Then,the effect of heat intervention or insufficient RFA(IRFA)on the malignant potential of HCC cells,including cell migration,sphere formation ability,tumor growth,the proportion of CD133+and Ep CAM+TICs and expression of stem cell-related genes,was evaluated in vitro and in vivo.Finally,the effect of ATRA on the tumor growth and the proportion of TICs was evaluated.Results:In clinical data,a higher proportion of CD133+and Ep CAM+TICs was found in recurrent tumors than in primary tumors.In vitro heat intervention promoted the cell migration and sphere formation ability.Additionally,it increased the proportion of CD133+and Ep CAM+TICs and the expression of stem cell-related genes.In addition,after IRFA the residual tumors in xenografts grew faster and had more TICs than untreated tumors.ATRA remarkably inhibited residual tumor growth after IRFA by elimination of TICs though the PI3 K/AKT pathway.Combination treatment with ATRA resulted in longer survival outcomes in mouse xenografts than RFA alone.Conclusions:ATRA,as a TIC differentiation inducer,could help to improve the effect of RFA treatment,which was partially attributed to its effect against TICs.The data indicated its potential as an alternative drug in the development of better therapeutic strategies for use in combination with RFA. | Song Wang Jingtao Liu Hao Wu Anna Jiang Kun Zhao Kun Yan Wei Wu Haibo Han Yanhua Zhang Wei Yang | 2021 | Chinese Journal of Cancer Research2021，33，6： | 2 |
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