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| 1 | Landscape of DILI-related adverse drug reaction in China Mainland显示文摘Drug-induced liver injury(DILI)is a type of bizarre adverse drug reaction(ADR)damaging liver(L-ADR)which may lead to substantial hospitalizations and mortality.Due to the general low incidence,detection of L-ADR remains an unsolved public health challenge.Therefore,we used the data of 6.673 million of ADR reports from January 1st,2012 to December 31st,2016 in China National ADR Monitoring System to establish a new database of L-ADR reports for future investigation.Results showed that totally 114,357 ADR reports were retrieved by keywords searching of liver-related injuries from the original heterogeneous system.By cleaning and standardizing the data fields by the dictionary of synonyms and English translation,we resulted 94,593 ADR records reported to liver injury and then created a new database ready for computer mining.The reporting status of L-ADR showed a persistent 1.62-fold change over the past five years.The national population-adjusted reporting numbers of L-ADR manifested an upward trend with age increasing and more evident in men.The annual reporting rate of L-ADR in age group over 80 years old strikingly exceeded the annual DILI incidence rate in general population,despite known underreporting situation in spontaneous ADR reporting system.The percentage of herbal and traditional medicines(H/TM)L-ADR reports in the whole number was 4.5%,while 80.60%of the H/TM reports were new findings.There was great geographical disparity of reported agents,i.e.more cardiovascular and antineoplastic agents were reported in higher socio-demographic index(SDI)regions and more antimicrobials,especially antitubercular agents,were reported in lower SDI regions.In conclusion,this study presented a large-scale,unbiased,unified,and computer-minable L-ADR database for further investigation.Age-,sex-and SDI-related risks of L-ADR incidence warrant to emphasize the precise pharmacovigilance policies within China or other regions in the world. | Jiabo Wang Haibo Song Feilin Ge Peng Xiong Jing Jing Tingting He Yuming Guo Zhuo Shi Chao Zhou Zixin Han Yanzhong Han Ming Niu Zhaofang Bai Guangbin Luo Chuanyong Shen Xiaohe Xiao | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 12 |
| 2 | Quantitative method for evaluating detailed volatility of wind power at multiple temporal-spatial scales显示文摘With the increasing proportion of wind power integration, the volatility of wind power brings huge challenges to the safe and stable operation of the electric power system. At present, the indexes commonly used to evaluate the volatility of wind power only consider its overall characteristics, such as the standard deviation of wind power, the average of power variables, etc., while ignoring the detailed volatility of wind power, that is, the features of the frequency distribution of power variables. However, how to accurately describe the detailed volatility of wind power is the key foundation to reduce its adverse influences. To address this, a quantitative method for evaluating the detailed volatility of wind power at multiple temporal-spatial scales is proposed. First, the volatility indexes which can evaluate the detailed fluctuation characteristics of wind power are presented, including the upper confidence limit, lower confidence limit and confidence interval of power variables under the certain confidence level. Then, the actual wind power data from a location in northern China is used to illustrate the application of the proposed indexes at multiple temporal(year–season–month–day) and spatial scales(wind turbine–wind turbines–wind farm–wind farms) using the calculation time windows of 10 min, 30 min, 1 h, and 4 h. Finally, the relationships between wind power forecasting accuracy and its corresponding detailed volatility are analyzed to further verify the effectiveness of the proposed indexes. The results show that the proposed volatility indexes can effectively characterize the detailed fluctuations of wind power at multiple temporal-spatial scales. It is anticipated that the results of this study will serve as an important reference for the reserve capacity planning and optimization dispatch in the electric power system which with a high proportion of renewable energy. | Yongqian Liu Han Wang Shuang Han Jie Yan Li Li Zixin Chen | 2019 | Global Energy Interconnection2019，2，4： | 5 |
| 3 | Deep-red emitting Mg2Ti04:Mn^(4+)phosphor ceramics for plant lighting显示文摘In this study,deep-red emitting Mg2T i04:Mn4 phosphor ceramics were synthesized by the high temperature solid-state reaction method.The ceramics can be excited by the 465 nm blue light and had a narrow emission with a full width at half maximum(FWMH)value of 31 nm.The peak wavelength was located at 658 nm,which matched the demanded wavelength for photosynthesis.The crystal field strength(Dq)and the Racah parameters(B and C)were estimated by the Tanabe-Sugano diagram.The thermal conductivity of the Mg2Ti(0.999)O4:0.001Mn^(4+)ceramic was 7.535 W/(m·K)at room temperature,which was one order of magnitude higher than that of the traditional packaging method using the silicone gel.A set of phosphor converted LEDs were fabricated by mounting the phosphor ceramics onto the 460 nm blue LED chips and the CIE coordinates can move from the blue region to the purple light region with the thickness of the ceramic increasing.These results indicated that the Mg2Ti04:Mn^(4+)phosphor ceramic was suitable for plant lighting when combined with a blue LED chip. | Zixin WANG Hui LIN Dawei ZHANG Yiming SHEN Yang LI Ruijin HONG Chunxian TAO Zhaoxia HAN Lei CHEN Shengming ZHOU | 2021 | Journal of Advanced Ceramics2021，10，1： | 2 |
| 4 | SynBioEcoli: a comprehensive metabolism network of engineered E. coil in three dimensional visualization显示文摘设计 E 的一个全面新陈代谢网络。coli 在系统生物学是很重要的, metabolomics 学习。许多工具集中于二维的空格在新陈代谢的网络显示小径。然而,三维的可视化的用法可以帮助更好理解新陈代谢、规章的网络的复杂拓扑学。方法我们手工地从文学的大量试验性的数据(包括的小径,反应和代谢物) 与设计 E 的不同类型联系了的 curated。coli 然后利用了三维的可视化的一种新奇技术开发一个全面新陈代谢的网络命名 SynBioEcoli。结果 SynBioEoli 包含 740 条 biosynthetic 小径, 3,889 新陈代谢的反应, 2,255 化学药品手工地从与设计 E 的不同类型联系的大约 11,000 份新陈代谢出版物加重 curated。coli。而且, SynBioEcoli 与各种各样的信息科学技术集成。结论 SynBioEcoli 能被认为是设计 E 的全面 knowledgebase。coli 并且代表下一代细胞的新陈代谢网络可视化技术。它能经由浏览器被存取(例如 Google 铬) 支持 WebGL,在 http://gffzz849681930f04473chco5kupcxk50c6knf.ffgz.tsg.suse.edu.cn/synbioecoli/ 。 | Weizhong Tu Shaozhen Ding Ling Wu Zhe Deng Hui Zhu Xiaotong Xu Chen Lin Chaonan Ye Minlu Han Mengna Zhao Juan Liu Zixin Deng Junni Chen Dong-Qing Wei Qian-Nan Hu | 2017 | Frontiers of Electrical and Electronic Engineering in China2017，5，1： | 2 |
| 5 | Development of Streptomyces sp. FR-008 as an emerging chassis显示文摘Microbial-derived natural products are important in both the pharmaceutical industry and academic research.As the metabolic potential of original producer especially Streptomyces is often limited by slow growth rate,complicated cultivation profile,and unfeasible genetic manipulation,so exploring a Streptomyces as a super industrial chassis is valuable and urgent.Streptomyces sp.FR-008 is a fast-growing microorganism and can also produce a considerable amount of macrolide candicidin via modular polyketide synthase.In this study,we evaluated Streptomyces sp.FR-008 as a potential industrial-production chassis.First,PacBio sequencing and transcriptome analyses indicated that the Streptomyces sp.FR-008 genome size is 7.26 Mb,which represents one of the smallest of currently sequenced Streptomyces genomes.In addition,we simplified the conjugation procedure without heat-shock and pre-germination treatments but with high conjugation efficiency,suggesting it is inherently capable of accepting heterologous DNA.In addition,a series of promoters selected from literatures was assessed based on GusA activity in Streptomyces sp.FR-008.Compared with the common used promoter ermE*-p,the strength of these promoters comprise a library with a constitutive range of 60e860%,thus providing the useful regulatory elements for future genetic engineering purpose.In order to minimum the genome,we also target deleted three endogenous polyketide synthase(PKS)gene clusters to generate a mutant LQ3.LQ3 is thus an“updated”version of Streptomyces sp.FR-008,producing fewer secondary metabolites profiles than Streptomyces sp.FR-008.We believe this work could facilitate further development of Streptomyces sp.FR-008 for use in biotechnological applications. | Qian Liu Liping Xiao Yuanjie Zhou Kunhua Deng Gaoyi Tan Yichao Han Xinhua Liu Zixin Deng Tiangang Liu | 2016 | Synthetic and Systems Biotechnology2016，1，3： | 2 |
| 6 | Disease resistance conferred by components of essential chrysanthemum oil and the epigenetic regulation of OsTPS1显示文摘The sesquiterpene alpha-bisabolol is the predominant active ingredient in essential oils that are highly valued in the cosmetics industry due to its wound healing,anti-inflammatory,and skin-soothing properties.Alpha-bisabolol was thought to be restricted to Compositae plants.Here we reveal that alpha-bisabolol is also synthesized in rice,a non-Compositae plant,where it acts as a novel sesquiterpene phytoalexin.Overexpressing the gene responsible for the biosynthesis of alpha-bisabolol,Os TPS1,conferred bacterial blight resistance in rice.Phylogenomic analyses revealed that alpha-bisabolol-synthesizing enzymes in rice and Compositae evolved independently.Further experiments demonstrated that the natural variation in the disease resistance level was associated with differential transcription of Os TPS1 due to polymorphisms in its promoter.We demonstrated that Os TPS1 was regulated at the epigenetic level by JMJ705 through the methyl jasmonate pathway.These data reveal the cross-family accumulation and regulatory mechanisms of alpha-bisabolol production. | Chuansong Zhan Long Lei Hao Guo Shen Zhou Congping Xu Zixin Liu Zichen Wu Yuan Deng Yuanyuan Miao Yu Han Meng Zhang Hua Li Sishu Huang Chenkun Yang Feng Zhang Yufei Li Ling Liu Xianqing Liu Hafiz Muhammad Khalid Abbas Alisdair R.Fernie Meng Yuan Jie Luo | 2023 | Science China(Life Sciences)2023，66，5： | 1 |
| 7 | Few-layer Ti_(3)CN MXene for ultrafast photonics applications in visible band显示文摘Ti_(3)CN,as a typical hetero-MXene,has attracted tremendous attention for its unique properties.However,its ultrafast photonics applications are still rare.Here,the few-layer Ti_(3)CN MXene was successfully prepared by selective etching and molecular delamination technique.The nonlinear optical response of few-layer Ti_(3)CN MXene at 640 nm was studied using the open-aperture Z-scan technique.The asprepared Ti_(3)CN MXene sample exhibited excellent nonlinear saturable absorption characteristics,resulting in the nonlinear absorption coefficient b of4.05×10^(-2)cm/GW,which was one order of magnitude larger than that of black phosphorus(BP)and molybdenum disulfide(MoS_(2)).For the optical modulation applications of few-layer Ti_(3)CN MXene,passively Q-switched(PQS)solid-state visible lasers based on Ti_(3)CN saturable absorber(SA)at 522 nm,607 nm,639 nm,and 721 nm were successfully realized.Furthermore,a Ti_(3)CN-based stable passively mode-locked Pr:YLF red laser was also successfully achieved with a pulse duration of 30 ps,and the corresponding repetition rate was 73.1 MHz.The optical modulation device based on few-layer Ti_(3)CN MXene shows good performance.Our work demonstrates that the tremendous prospects of the few-layer Ti_(3)CN MXene as a visible optical modulation device in ultrafast photonics applications. | Zixin Yang Qi Yang Yulin Tian Xianghe Ren Chun Li Yuqian Zu Syed Zaheer Ud Din Lingfeng Gao Jian Wu Hualong Chen Han Zhang Jie Liu Jingliang He Abdullah GAl-Sehemi | 2023 | Journal of Materiomics2023，9，1： | 0 |
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