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| 1 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 2 | Abrasion characteristic analyses of solid-liquid two-phase centrifugal pump显示文摘Based on the solid-liquid two-phase mixture transportation test, the renormalization group (RNG) k-e turbulent model was utilized to simulate the solid-liquid two-phase turbulent flow in a centrifugal pump. By comparing the simulated and experimental results, inner flow features were revealed to improve the abrasion characteristic of the solid-liquid two-phase centrifugal pump. The influence of the solid phase on centrifugal pump abrasive performance is small when the particle volume fraction is less than 2.5%. The aggregation degree of the solid particles is enhanced as the particle diameter increases from 0.1 to 1 mm; however, the mixture density on the pressure side is reduced when the particle diameter increases to 1 mm for the impact of inertia. The wear on the hub is most severe for the shear stress on this position; it is also the largest. The wear characteristic is affected greatly by the parameters of the solid phase. The wear chracteristic can be optimized by decreasing the blade outlet angle. In the modified design, the blade angle is different, whereas the other geometric dimensions remain the same. The improved pump is simulated to contrast with the original pump. The results show that the values of mixture density and shear stress both decrease. The wear condition of the blade is improved to a certain extent. | LI Yi ZHU Zuchao HE Zhaohui HE Weiqiang | 2011 | Journal of Thermal Science2011，20，3： | 23 |
| 3 | The development and function of follicular helper T cells in immune responses显示文摘小囊的助手 T 房间(Tfh ) 作为提供帮助让 B 房间增殖并且在幼芽的中心经历抗体亲密关系成熟的一个系被提交了。证据支持了那个 Tfh 子集开发象另外的系一样,依赖于一个特别 transcriptional 节目被开始的微型环境。它为 Tfh 房间的开发和函数作为主人管理者被看了那 Bcl-6 和 IL-21 行为。Tfh dysregulation 涉及自体免疫的病理的发展,例如全身的豺狼座 erythematosus,风湿性关节炎和另外的自体免疫的疾病。现在的评论在在他们的开发和函数的 Tfh 房间和焦点的域里加亮最近的进展。 | Maogen Chen Zhiyong Guo Weiqiang Ju Bernhard Ryffel Xiaoshun He Song Guo Zheng | 2012 | Cellular & Molecular Immunology2012，9，5： | 18 |
| 4 | Nonintubated uniportal video-assisted thoracoscopic surgery for primary spontaneous pneumothorax显示文摘Objective:The objective of the current study was to evaluate the feasibility and safety of nonintubated uniportal video-assisted thoracoscopic surgery(VATS) for the management of primary spontaneous pneumothorax(PSP).Methods:From November 2011 to June 2013,32 consecutive patients with PSP were treated by nonintubated uniportal thoracoscopic bullectomy using epidural anaesthesia and sedation without endotracheal intubation.An incision 2 cm in length was made at the 6^(th) intercostal space in the median axillary line.The pleural space was entered by blunt dissection for placement of a soft incision protector.Instruments were then inserted through the incision protector to perform thoracoscopic bullectomy.Data were collected within a minimum follow-up period of 10 months.Results:The average time of surgery was 49.0 min(range,33-65 min).No complications were recorded.The postoperative feeding time was 6 h.The mean postoperative chest tube drainage and hospital stay were19.3 h and 41.6 h,respectively.The postoperative pain was mild for 30 patients(93.75%) and moderate for two patients(6.25%).No recurrences of pneumothorax were observed at follow-up.Conclusions:The initial results indicated that nonintubated uniportal video-assisted thoracoscopic operations are not only technically feasible,but may also be a safe and less invasive alternative for select patients in the management of PSP.This is the first report to include the use of a nonintubated uniportal technique in VATS for such a large number of PSP cases.Further work and development of instruments are needed to define the applications and advantages of this technique. | Shuben Li Fei Cui Jun Liu Xin Xu Wenlong Shao Weiqiang Yin Hanzhang Chen Jianxing He | 2015 | Chinese Journal of Cancer Research2015，27，2： | 15 |
| 5 | Safety and feasibility of video-assisted thoracoscopic surgery for stage IIIA lung cancer显示文摘Objective: The current study was prospectively designed to explore the application of video-assisted thoracoscopic surgery(VATS) radical treatment for patients with stage IIIA lung cancer, with the primary endpoints being the safety and feasibility of this operation and the second endpoints being the survival and complications after the surgery.Methods: A total of 51 patients with radiologically or mediastinoscopically confirmed stage IIIA lung cancer underwent VATS radical treatment, during which the standard pulmonary lobectomy and mediastinal lymph node dissection were performed after pre-operative assessment. The operative time, intraoperative blood loss/complications, postoperative recovery, postoperative complications, and lymph node dissection were recorded and analyzed. This study was regarded as successful if the surgical success rate reached 90% or higher.Results: A total of 51 patients with non-small cell lung cancer(NSCLC) were enrolled in this study from March 2009 to February 2010. The median post-operative follow-up duration was 50.5 months. Of these 51 patients, 41(80.4%) had N2 lymph node metastases. All patients underwent the thoracoscopic surgeries, among whom 50(98%) received pulmonary lobectomy and mediastinal lymph node dissection completely under the thoracoscope, 6 had their incisions extended to about 6 cm due to larger tumor sizes, and 1 had his surgery performed using a 12 cm small incision for handling the adhesions between lymph nodes and blood vessels. No patient was converted to conventional open thoracotomy. No perioperative death was noted. One patient received a second surgery on the second post-operative day due to large drainage(>1,000 mL), and the postoperative recovery was satisfactory. Up to 45 patients(88.2%) did not suffer from any perioperative complication, and 6(11.8%) experienced one or more complications.Conclusions: VATS radical treatment is a safe and feasible treatment for stage IIIA lung cancer. | Wenlong Shao Jun Liu Wehua Liang Hanzhang Chen Shuben Li Weiqiang Yin Xin Zhang Jianxing He | 2014 | Chinese Journal of Cancer Research2014，26，4： | 12 |
| 6 | Numerical Simulation and Experimental Research on the Influence of Solid-phase Characteristics on Centrifugal Pump Performance显示文摘The law governing the movement of particles in the centrifugal pump channel is complicated; thus, it is difficult to examine the solid-liquid two-phase turbulent flow in the pump. Consequently, the solid-liquid two-phase pump is designed based only on the unary theory. However, the obvious variety of centrifugal-pump internal flow appears because of the existence of solid phase, thus changing pump performance. Therefore, it is necessary to establish the flow characteristics of the solid-liquid two-phase pump. In the current paper, two-phase numerical simulation and centrifugal pump performance tests are carried out using different solid-particle diameters and two-phase mixture concentration conditions. Inner flow features are revealed by comparing the simulated and experimental results. The comparing results indicate that the influence of the solid-phase characteristics on centrifugal-pump performance is small when the flow rate is low, specifically when it is less than 2 m3/h. The maximum efficiency declines, and the best efficiency point tends toward the low flow-rate direction along with increasing solid-particle diameter and volume fraction, leading to reduced pump steady efficient range. The variation tendency of the pump head is basically consistent with that of the efficiency. The efficiency and head values of the two-phase mixture transportation are even larger than those of pure-water transportation under smaller particle diameter and volume fraction conditions at the low-flow-rate region. The change of the particle volume fraction has a greater effect on the pump performance than the change in the particle diameter. The experimental values are totally smaller than the simulated values. This research provides the theoretical foundation for the optimal design of centrifugal pump. | LI Yi ZHU Zuchao HE Weiqiang HE Zhaohui | 2012 | Chinese Journal of Mechanical Engineering2012，25，6： | 11 |
| 7 | Nonintubated thoracoscopic lobectomy plus lymph node dissection following segmentectomy for central type pulmonary masses显示文摘IntroductionLung cancer is the most common cancer worldwide.In the United States,it causes more cancer-related deaths than the next four causes(breast cancer,prostate cancer,colon cancer,and pancreatic cancer)of cancer-related mortality combined(1).About 30% of people have already | Wenlong Shao Wei Wang Weiqiang Yin Zhihua Guo Guilin Peng Ying Chen Jianxing He | 2013 | Chinese Journal of Cancer Research2013，25，1： | 7 |
| 8 | Developer social networks in software engineering:construction,analysis,and applications显示文摘With the increasing popularity of Internet,more and more developers are collaborating together for software development.During the collaboration,a lot of information related to software development,including communication and coordination information of developers,can be recorded in software repositories.The information can be employed to construct Developer Social Networks(DSNs)for facilitating tasks in software engineering.In this paper,we survey recent advances of DSNs and examine three fundamental steps of DSNs,namely construction,analysis,and applications.We summarize the state-of-the-art methods in the three steps and investigate the relationships among them.Furthermore,we discuss the main issues and point out the future opportunities in the study of DSNs. | ZHANG WeiQiang NIE LiMing JIANG He CHEN ZhenYu LIU Jia | 2014 | Science China(Information Sciences)2014，57，12： | 7 |
| 9 | Long-term survival outcomes of video-assisted thoracic surgery for patients with non-small cell lung cancer显示文摘Background: Video-assisted thoracic surgery(VATS) has been shown to be a safe alternative to conventional thoracotomy for patients with non-small cell lung cancer(NSCLC). However, popularization of this relatively novel technique has been slow, partly due to concerns about its long-term outcomes. The present study aimed to evaluate the long-term survival outcomes of patients with NSCLC after VATS, and to determine the significant prognostic factors on overall survival.Methods: Consecutive patients diagnosed with NSCLC referred to one institution for VATS were identified from a central database. Patients were treated by either complete-VATS or assisted-VATS, as described in previous studies. A number of baseline patient characteristics, clinicopathologic data and treatment-related factors were analyzed as potential prognostic factors on overall survival.Results: Between January 2000 and December 2007, 1,139 patients with NSCLC who underwent VATS and fulfilled a set of predetermined inclusion criteria were included for analysis. The median age of the entire group was 60 years, with 791 male patients(69%). The median 5-year overall survival for Stage I, II, III and IV disease according to the recently updated TNM classification system were 72.2%, 47.5%, 29.8% and 28.6%, respectively. Female gender, TNM stage, pT status, and type of resection were found to be significant prognostic factors on multivariate analysis.Conclusions: VATS offers a viable alternative to conventional open thoracotomy for selected patients with clinically resectable NSCLC. | Wenlong Shao Xinguo Xiong Hanzhang Chen Jun Liu Weiqiang Yin Shuben Li Xin Xu Xin Zhang Jianxing He | 2014 | Chinese Journal of Cancer Research2014，26，4： | 5 |
| 10 | Two-dimensional gel electrophoresis-based analysis provides global insights into the cotton ovule and fiber proteomes显示文摘Proteomic analysis of upland cotton was performed to profile the global detectable proteomes of ovules and fibers using two-dimensional electrophoresis(2DE).A total of 1,203 independent protein spots were collected from representative 2DE gels,which were digested with trypsin and identified by matrix-assisted laser desorption and ionization-time-offlight/time-of-flight(MALDI-TOF/TOF)mass spectrometry.The mass spectrometry or tandem mass spectrometry(MS or MS/MS)data were then searched against a local database constructed from Gossypium hirsutum genome sequences,resulting in successful identification of 975 protein spots(411 for ovules and 564 for fibers).Functional annotation analysis of the 975identified proteins revealed that ovule-specific proteins were mainly enriched in functions related to fatty acid elongation,sulfur amino acid metabolism and post-replication repair,while fiber-specific proteins were enriched in functions related to root hair elongation,galactose metabolism and D-xylose metabolic processes.Further annotation analysis of the most abundant protein spots showed that 28.96%of the total proteins in the ovule were mainly located in the Golgi apparatus,endoplasmic reticulum,mitochondrion and ribosome,whereas in fibers,27.02%of the total proteins were located in the cytoskeleton,nuclear envelope and cell wall.Quantitative real-time polymerase chain reaction(q RT-PCR)analyses of the ovule-specific protein spots P61,P93 and P198 and fiber-specific protein spots 230,477 and 511 were performed to validate the proteomics data.Protein-protein interaction network analyses revealed very different network cluster patterns between ovules and fibers.This work provides the largest protein identification dataset of 2DE-detectable proteins in cotton ovules and fibers and indicates potentially important roles of tissue-specific proteins,thus providing insights into the cotton ovule and fiber proteomes on a global scale. | Xiang Jin Limin Wang Liping He Weiqiang Feng Xuchu Wang | 2016 | Science China(Life Sciences)2016，59，2： | 3 |
| 11 | Prototype of multi-filament electron curtain accelerator显示文摘 | LI Guohua TANG Huaping LIU Jinsheng ZHANG Huayi LIU Yaohong ZHANG Dongsheng HE Yu LI Jian GUAN Weiqiang | 2013 | Nuclear Science and Techniques2013，24，B12： | 2 |
| 12 | Time-fre- quency cepstral feature and heteroscedastic linear dis- criminant analysis for language recognition显示文摘 | Zhang Weiqiang He Liang Deng Yan | | IEEE Trans on Audio Speech & Language Processing 201 10，19，2： | 1 |
| 13 | Digital Terrestrial Television Broadcasting in China显示文摘 | Liang Weiqiang Zhang Wenjun He Dazhi | 2007 | IEEE Multimeadia2007，14，3： | 1 |
| 14 | Time frequency cepstral features and heteroscedastic linear discriminant analysis of language recognition显示文摘 | Zhang Weiqiang He Liang Deng Yan | | 0，，02： | 1 |
| 15 | Polybenzimidazole functionalized electrolyte with Li-wetting and self-fluorination functionalities for practical Li metal batteries显示文摘Rough Li plating,low ionic conductivity,and low thermal stability of conventional electrolytes post-primary challenges for achieving reliable high-capacity rechargeable lithium batteries,for which lithiummetal is frequently proposed as themost promising anode material.Conventional low-polarity commercial polypropylene/polyethylene separators fail to support the application of high-energy-density Li anodes due to their rigid physicochemical properties and the high reactivity of Li metal,leading to fatal dendrite formation and vigorous exothermic reaction with electrolytes.Herein,we develop a Li-wetting,flame-retardant binary polymer electrolyte by functionalizing poly(vinylidene fluoride)(PVDF)separators with nonflammable polybenzimidazole(PBI)to build safe room-temperature solid-state electrolyte membranes.A dendrite-free LiFePO4 cell with the solid polymer electrolyte(SPE)delivers a discharge capacity of 127 mAh g^(-1) at 25℃ with a capacity retention of 87.5%after 500 cycles at 0.5℃(0.15 mA cm^(-2)).Phase-field simulations and density functional theory calculations demonstrate that the negatively charged benzimidazole chains of PBI own superior affinity to lithium bis(trifluoromethanesulfonyl)imide(LiTFSI),and shares overlapping electron density with Li anode,giving rise to accelerated Li^(+)conduction at room temperature and uniform Li electrodeposition at the electrolyte/Li metal interface.The SPE is also flame-retardant since heat-resistant polytetrafluoroethylene and a dense,heat-blocking graphitized carbon layer are formed in intense heat throughdehydrogenation/fluorination of PVDF under the catalysis of Lewis base imidazole rings and the decomposition of benzimidazole rings in PBI.No such fire-resistant mechanism is ever reported in conventional electrolytes. | Dongjiang Chen Yuanpeng Liu Chuan Xia Yupei Han Qingwei Sun Xuchang Wang Wei Chen Xian Jian Weiqiang Lv Jianyi Ma Weidong He | 2022 | InfoMat2022，4，5： | 1 |
| 16 | Study of the synergistic effect of a triazine-dithiocarbamate derivative with TCP in vegetable oil 显示文摘 | He Zhongyi Song Yuping Zhan Weiqiang | 2005 | Journal of Synthesis Lubrication2005，21，4： | 1 |
| 17 | Model for end-stage liver disease versus the Child-Pugh score in predicting the post-transplant 3-month and 1-year mortality in a cohort of Chinese recipients显示文摘 | Zhiyong Guo Xiaoshun He Linwei Wu Weiqiang Ju Anbin Hu Qiang Tai Dongping Wang Yi Ma Guodong Wang Xiaofeng Zhu Jiefu Huang | 2010 | Surgery Today2010，，1： | 1 |
| 18 | Effects of monsoon onset vortex on heat budget in the mixed layer of the Bay of Bengal显示文摘We investigated the effects of monsoon onset vortex(MOV)on the mixed layer heat budget in the Bay of Bengal(BOB)in spring 2003 using the reanalysis datasets.The results suggest that the solar radiation flux penetrating the mixed layer and the existence of barrier layer are both able to modulate the effects of MOV on the evolution of sea surface temperature(SST)in the BOB.Prior to the formation of BOB MOV,the local SST raised quickly due to mass of solar radiation reaching the sea surface under the clear-sky condition.Meanwhile,since the mixed layer was shallow before the onset of the Asian summer monsoon(ASM),some solar radiation flux could penetrate to directly heat the deeper water,which partly offset the warming effect of shortwave radiation.On the other hand,the in-situ SST started to cool due to the upwelling of cold water when the MOV generated over the BOB,along with the rapidly increased surface wind speed and its resultant deeper mixed layer.As the MOV developed and moved northward,the SST tended to decrease remarkably because of the strong upward surface latent heat flux over the BOB ascribed to the wind-evaporation mechanism.However,the MOV-related precipitation brought more fresh water into the upper ocean to produce a thicker barrier layer,whose thermal barrier effect damped the cooling effect of entrainment upwelling on the decrease tendency of the BOB SST.In other words,the thermal barrier effect could slow down the decreasing trend of the BOB SST even after the onset of ASM,which facilitated the further enhancement of the MOV. | Effects of monsoon onset vortex on heat budget in the mixed layer of the Bay of BengalXU Kang LIU Boqi LIU Yu WANG Weiqiang HE Zhuoqi | 2020 | Journal of Oceanology and Limnology2020，38，6： | 1 |
| 19 | Programmed 6-Step Approach of Improved Liposuction-Curettage for Axillary Bromhidrosis显示文摘Background Liposuction-curettage is a long-standing and effective treatment for axillary bromhidrosis.However,residual malodor and skin necrosis typically occur following this treatment.Therefore,we improved this method to ensure fewer complications and better outcomes.Here,we have presented our programmed 6-step approach of improved liposuction-curettage.Methods The programmed 6-step approach of improved liposuction-curettage was used to remove the axillary apocrine glands.We used pointed and obtuse cannulas designed for liposuction-curettage.Results Patients treated using the programmed 6-step approach of improved liposuctioncurettage did not experience any serious complications or residual malodor.Conclusion The programmed 6-step approach of improved liposuction-curettage was more effective than traditional surgery with respect to the treatment of axillary bromhidrosis. | Yanqi LIU Yanmeng PAN Minxia ZHANG Li CHEN Fawei XU Hongfang MA Xing HE Ying HU Guijuan HE Jiaqin CAI Weiqiang TAN | 2020 | Chinese Journal Of Plastic and Reconstructive Surgery2020，2，3： | 1 |
| 20 | Study of the synergistic effect of a triazine-dithiocarbamate derivative with TCP in vegetable oil显示文摘 | He Zhongyi Zhan Weiqiang | 2005 | Journal of Synthesis Lubrication2005，21，4： | 1 |
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