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| 1 | Antisense MMP-9 RNA inhibits malignant glioma cell growth in vitro and in vivo显示文摘The matrix-degrading metalloproteinases (MMPs), particularly MMP-9, play important roles in the pathogenesis and development of malignant gliomas. In the present study, the oncogenic role of MMP-9 in malignant glioma cells was investigated via antisense RNA blockade in vitro and in vivo. TJ905 malignant glioma cells were transfected with pcDNA3.0 vector expressing antisense MMP-9 RNA (pcDNA-AS-MMP9), which significantly decreased MMP-9 expression, and cell proliferation was assessed. For in vivo studies, U251 cells, a human malignant glioma cell line, were implanted subcutaneously into 4-to 6-week-old BALB/c nude mice. The mice bearing well-established U251 gliomas were treated with intratumoral pcDNA-AS-MMP9-Lipofectamine complex (AS-MMP-9-treated group), subcutaneous injection of endostatin (endostatin-treated group), or both (combined therapy group). Mice treated with pcDNA (empty vector)-Lipofectamine served as the control group. Four or eight weeks later, the volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity were assayed. We demonstrate that pcDNA-AS-MMP9 significantly decreased MMP-9 expression and inhibited glioma cell proliferation. Volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity in the antisense-MMP-9-treated and therapeutic alliance groups were significantly lower than those in the control group. The results suggest that MMP-9 not only promotes malignant glioma cell invasiveness, but also affects tumor cell proliferation. Blocking the expression of MMP-9 with antisense RNA substantially suppresses the malignant phenotype of glioma cells, and thus can be used as an effective therapeutic strategy for malignant gliomas. | Cuiyun Sun Qian Wang Hongxu Zhou Shizhu Yu Alain R. Simard Chunsheng Kang Yanyan Li Yanling Kong Tongling An Yanjun Wen Fudong Shi Junwei Hao | 2013 | Neuroscience Bulletin2013，29，1： | 14 |
| 2 | Iron-based oxygen carriers in chemical looping conversions:A review显示文摘A solid oxygen carrier is usually applied in a chemical looping conversion process to transfer oxygen from the gaseous oxygen source to the fuel,which can avoid the direct contact of these two reactants and hence decrease the energy penalty of separation.Among the solid oxygen carriers,iron-based oxygen carrier is an attractive option due to its inherent properties of low cost and environmentally-friendly.Several processes such as chemical looping combustion(CLC),chemical looping gasification(CLG),chemical looping reforming(CLR),and chemical looping hydrogen generation(CLHG)have been proposed and investigated based on the iron-based oxygen carrier.In this review,the relevant researches on the iron-based oxygen carrier are summarized,which include the characteristics of iron oxides,the preparations of the iron-based oxygen carrier based on the iron ores and some other low-cost iron contained materials,and their applications in the continuous operated chemical looping conversion processes.It is expected to provide a better understanding for the development and utilization of iron-based oxygen carrier in the practical chemical looping processes. | Zhongliang Yu Yanyan Yang Song Yang Qian Zhang Jiantao Zhao Yitian Fang Xiaogang Hao Guoqing Guan | 2019 | Carbon Resources Conversion2019，2，1： | 9 |
| 3 | World’s first spaceflight on-orbit demonstration of a flexible solar array system based on shape memory polymer composites显示文摘With a 10%reversible compressive strain in more than 10 deformation cycles,the shape memory polymer composites(SMPCs)could be used for deployable structure and releasing mechanism.In this paper,without traditional electro-explosive devices or motors/controllers,the deployable SMPC flexible solar array system(SMPC-FSAS)is studied,developed,ground-based tested,and finally on-orbit validated.The epoxy-based SMPC is used for the rolling-out variable-stiffness beams as a structural frame as well as an actuator for the flexible blanket solar array.The releasing mechanism is primarily made of the cyanate-based SMPC,which has a high locking stiffness to withstand 50 g gravitational acceleration and a large unlocking displacement of 10 mm.The systematical mechanical and thermal qualification tests of the SMPC-FSAS flight hardware were performed,including sinusoidal sweeping vibration,shocking,acceleration,thermal equilibrium,thermal vacuum cycling,and thermal cycling test.The locking function of the SMPC releasing mechanisms was in normal when launching aboard the SJ20 Geostationary Satellite on 27 Dec.,2019.The SMPC-FSAS flight hardware successfully unlocked and deployed on 5 Jan.,2020 on geostationary orbit.The triggering signal of limit switches returned to ground at the 139 s upon heating,which indicated the successful unlocking function of SMPC releasing mechanisms.A pair of epoxy-based SMPC rolled variable-stiffness tubes,which clapped the flexible blanket solar array,slowly deployed and finally approached an approximate 100%shape recovery ratio within 60 s upon heating.The study and on-orbit successful validation of the SMPC-FSAS flight hardware could accelerate the related study and associated productions to be used for the next-generation releasing mechanisms as well as space deployable structures,such as new releasing mechanisms with low-shocking,testability and reusability,and ultra-large space deployable solar arrays. | LAN Xin LIU LiWu ZHANG FengHua LIU ZhengXian WANG LinLin LI QiFeng PENG Fan HAO SiDa DAI WenXu WAN Xue TANG Yong WANG Mian HAO YanYan YANG Yang YANG Cheng LIU YanJu LENG JinSong | 2020 | Science China(Technological Sciences)2020，63，8： | 7 |
| 4 | Strongly secure identity-based authenticated key agreement protocols in the escrow mode显示文摘Escrowable identity-based authenticated key agreement(AKA) protocols are desirable under certain circumstances especially in certain closed groups applications.In this paper,we focus on two-party identitybased AKA schemes in the escrow mode,and present a strongly secure escrowable identity-based AKA protocol which captures all basic desirable security properties including perfect forward secrecy,ephemeral secrets reveal resistance and so on.The protocol is provably secure in the extended Canetti-Krawczyk model,and its security can be reduced to the standard computational bilinear Diffie-Hellman assumption in the random oracle model.Assuming no adversary can obtain the master private key for the escrow mode,our scheme is secure as long as each party has at least one uncompromised secret.Also,we present two strongly secure variants of the protocol,which are computationally more efficient than the original scheme. | NI Liang CHEN GongLiang LI JianHua HAO YanYan | 2013 | Science China(Information Sciences)2013，56，8： | 6 |
| 5 | Analysis of the ambiguity of log-constrained seismic impedance inversion显示文摘Although the ambiguity of seismic inversion is widely recognized in both theory and practice,so far as a concrete inversion example is concerned,there is not any objective,controllable method or any standard for how to evaluate and determine its ambiguity and reliability,especially for the high frequency components beyond the effective seismic frequency band.Taking log-constrained impedance inversion as an example,a new appraisal method is proposed on the basis of analyzing a simple geological model.Firstly,the inverted impedance model is transformed to a reflection coefficient series.Secondly,the maximum effective frequency of the real seismic data is chosen as a cutoff point and the reflection coefficient series is decomposed into two components by low-pass and high-pass filters.Thirdly,the geometrical reflection characteristics of the high-frequency components and that of the real seismic data are compared and analyzed.Then,the reliability of the inverted impedance model is appraised according to the similarity of geometrical characteristics between the high-frequency components and the real seismic data.The new method avoids some subjectivity in appraising the inverted result,and helps to enhance the reliability of reservoir prediction by impedance inversion technology. | Li Guofa Li Hao Ma Yanyan Xiong Jinliang | 2011 | Petroleum Science2011，8，2： | 5 |
| 6 | Recent Advancements on Photothermal Conversion and Antibacterial Applications over MXenes-Based Materials显示文摘The pernicious bacterial proliferation and emergence of super-resistant bacteria have already posed a great threat to public health,which drives researchers to develop antibiotic-free strategies to eradicate these fierce microbes.Although enormous achievements have already been achieved,it remains an arduous challenge to realize efficient sterilization to cut off the drug resistance generation.Recently,photothermal therapy(PTT)has emerged as a promising solution to efficiently damage the integrity of pathogenic bacteria based on hyperthermia beyond their tolerance.Until now,numerous photothermal agents have been studied for antimicrobial PTT.Among them,MXenes(a type of two-dimensional transition metal carbides or nitrides)are extensively investigated as one of the most promising candidates due to their high aspect ratio,atomic-thin thickness,excellent photothermal performance,low cytotoxicity,and ultrahigh dispersibility in aqueous systems.Besides,the enormous application scenarios using their antibacterial properties can be tailored via elaborated designs of MXenes-based materials.In this review,the synthetic approaches and textural properties of MXenes have been systematically presented first,and then the photothermal properties and sterilization mechanisms using MXenes-based materials are documented.Subsequently,recent progress in diverse fields making use of the photothermal and antibacterial performances of MXenes-based materials are well summarized to reveal the potential applications of these materials for various purposes,including in vitro and in vivo sterilization,solar water evaporation and purification,and flexible antibacterial fabrics.Last but not least,the current challenges and future perspectives are discussed to provide theoretical guidance for the fabrication of efficient antimicrobial systems using MXenes. | Shuyan Hao Hecheng Han Zhengyi Yang Mengting Chen Yanyan Jiang Guixia Lu Lun Dong Hongling Wen Hui Li Jiurong Liu Lili Wu Zhou Wang Fenglong Wang | 2022 | Nano-Micro Letters2022，14，11： | 4 |
| 7 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 8 | Systematic analysis of clinical relevance and molecular characterization of m^(6)A in COVID-19 patients显示文摘N6-methyladenosine(m6A)is the most prevalent post-transcriptional RNA modification in mRNA and long non-coding RNAs of eukaryotes,and its biological functions are mediated by m6A writers,erasers and readers.1 A nuclear methyltransferase complex consisting of METTL3,METTL14,WTAP,VIRMA,ZC3H13,RBM15(or RBM15B),YWHAG,TRA2A and CAPRIN1 catalyzes the m6A modifications,acting as m6A writers.1 m6A demethylase ALKBH5 as well as m6A demethylase FTO mediate the demethylation of m6As,acting as the m6A erasers. | Sanqi An Zhouhua Xie Yanyan Liao Junjun Jiang Wenyi Dong Fuqiang Yin Wen-Xing Li Li Ye Jianyan Lin Hao Liang | 2022 | Genes & Diseases2022，9，5： | 1 |
| 9 | Nonlinear Finite Element Analysis of Barge Collision with a Single Bridge Pier显示文摘 | Sha Yanyan Hao Hong | 2012 | Engineering Structures2012，41，： | 1 |
| 10 | Co_(2)N Nanoparticles Anchored on N-Doped Active Carbon as Catalyst for Oxygen Reduction Reaction in Zinc–Air Battery显示文摘The development of efficient catalytic electrode toward oxygen reduction reaction(ORR)is still a great challenge for the wide use of zinc–air batteries.Herein,Co_(2)N nanoparticles(NPs)anchored on N-doped carbon from cattail were verified with excellent catalytic performances for ORR.The onset and half-wave potentials over the optimal catalyst reach to 0.96 V and 0.84 V,respectively.Current retention rates of 96.8%after 22-h test and 98.8%after running 1600 s were obtained in 1 M methanol solution.Density functional theory simulation proposes an apparently increased electronic states of Co_(2)N in N-doped carbon layer close to the Fermi level.Higher charge density,favorable adsorption,and charge transfer of intermediates originate from the coexistence of Co_(2)N NPs and N atoms in carbon skeleton.The superior catalytic activity of composites also was confirmed in zinc–air batteries.This novel catalytic property and controllable preparation approach of Co_(2)Ncarbon composites provide a promising avenue to fabricate metal-containing catalytically active carbon from biomass. | Xianli Wu Guosheng Han Hao Wen Yanyan Liu Lei Han Xingyu Cui Jiajing Kou Baojun Li Jianchun Jiang | 2022 | Energy & Environmental Materials2022，5，3： | 1 |
| 11 | Strongly secure identity-based authenticated key agreement protocols显示文摘 | Liang Ni Gongliang Chen Jianhua Li Yanyan Hao | 2011 | Computers and Electrical Engineering2011，，2： | 1 |
| 12 | SmProt: A Reliable Repository with Comprehensive Annotation of Small Proteins Identified from Ribosome Profiling显示文摘Small proteins specifically refer to proteins consisting of less than 100 amino acids translated from small open reading frames(s ORFs),which were usually missed in previous genome annotation.The significance of small proteins has been revealed in current years,along with the discovery of their diverse functions.However,systematic annotation of small proteins is still insufficient.Sm Prot was specially developed to provide valuable information on small proteins for scientific community.Here we present the update of Sm Prot,which emphasizes reliability of translated s ORFs,genetic variants in translated s ORFs,disease-specific s ORF translation events or sequences,and remarkably increased data volume.More components such as non-ATG translation initiation,function,and new sources are also included.Sm Prot incorporated638,958 unique small proteins curated from 3,165,229 primary records,which were computationally predicted from 419 ribosome profiling(Ribo-seq)datasets or collected from literature and other sources from 370 cell lines or tissues in 8 species(Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Danio rerio,Saccharomyces cerevisiae,Caenorhabditis elegans,and Escherichia coli).In addition,small protein families identified from human microbiomes were also collected.All datasets in Sm Prot are free to access,and available for browse,search,and bulk downloads at http://gffzz47cba05b3f0c4ad7h5ow0nnkfn5bo6uuw.ffgz.tsg.suse.edu.cn/SmProt/. | Yanyan Li Honghong Zhou Xiaomin Chen Yu Zheng Quan Kang Di Hao Lili Zhang Tingrui Song Huaxia Luo Yajing Hao Runsheng Chen Peng Zhang Shunmin He | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 1 |
| 13 | New Subclasses of Biholomorphic Mappings and the Modified Roper-Suffridge Operator显示文摘The authors propose a new approach to construct subclasses of biholomorphic mappings with special geometric properties in several complex variables. The RoperSuffridge operator on the unit ball B^n in C^n is modified. By the analytical characteristics and the growth theorems of subclasses of spirallike mappings, it is proved that the modified Roper-Suffridge operator [Φ_(G,γ)(f)](z) preserves the properties of S_Ω~*(A, B), as well as strong and almost spirallikeness of type β and order α on B^n. Thus, the mappings in S_Ω~*(A, B), as well as strong and almost spirallike mappings, can be constructed through the corresponding functions in one complex variable. The conclusions follow some special cases and contain the elementary results. | Chaojun WANG Yanyan CUI Hao LIU | 2016 | Chinese Annals of Mathematics,Series B2016，37，5： | 1 |
| 14 | Randomized, three‐arm study to optimize lamivudine efficacy in hepatitis B e antigen‐positive chronic hepatitis B patients显示文摘 | Xieer Liang Jun Cheng Yongtao Sun Xinyue Chen Tong Li Hao Wang Jianning Jiang Xiaoping Chen Hui Long Hong Tang Yanyan Yu Jifang Sheng Shijun Chen Junqi Niu Hong Ren Junping Shi Xiaoguang Dou Mobin Wan Jiaji Jiang Qing Xie Guangfeng Shi Qin Ning Chengwei C | 2015 | J Gastroenterol Hepatol2015，，4： | 1 |
| 15 | NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma显示文摘Multiple myeloma(MM) is still an incurable hematologic malignancy, which is eagerly to the discovery of novel therapeutic targets and methods. N-acetyltransferase 10(NAT10) is the first reported regulator of mRNA acetylation that is activated in many cancers. However, the function of NAT10 in MM remains unclear. We found significant upregulation of NAT10 in MM patients compared to normal plasma cells, which was also highly correlated with MM poor outcome. Further enforced NAT10 expression promoted MM growth in vitro and in vivo, while knockdown of NAT10 reversed those effects. The correlation analysis of acetylated RNA immunoprecipitation sequencing(ac RIP-seq) and ribosome profiling sequencing(Ribo-seq) combined with RIP-PCR tests identified centrosomal protein 170(CEP170) as an important downstream target of NAT10. Interfering CEP170 expression in NAT10-OE cells attenuated the acceleration of cellular growth caused by elevated NAT10. Moreover,CEP170 overexpression promoted cellular proliferation and chromosomal instability(CIN) in MM.Intriguingly, remodelin, a selective NAT10 inhibitor, suppressed MM cellular growth, induced cellular apoptosis in vitro and prolonged the survival of 5TMM3VT mice in vivo. Collectively, our data indicate that NAT10 acetylates CEP170 mRNA to enhance CEP170 translation efficiency, which suggests that NAT10 may serve as a promising therapeutic target in MM. | Rongfang Wei Xing Cui Jie Min Zigen Lin Yanyan Zhou Mengjie Guo Xiaojuan An Hao Liu Siegfried Janz Chunyan Gu Hongbo Wang Ye Yang | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 1 |
| 16 | CATIRI:An Efficient Method for Content-and-Text Based Image Retrieval显示文摘The combination of visual and textual information in image retrieval remarkably alleviates the semantic gap of traditional image retrieval methods,and thus it has attracted much attention recently.Image retrieval based on such a combination is usually called the content-and-text based image retrieval(CTBIR).Nevertheless,existing studies in CTBIR mainly make efforts on improving the retrieval quality.To the best of our knowledge,little attention has been focused on how to enhance the retrieval efficiency.Nowadays,image data is widespread and expanding rapidly in our daily life.Obviously,it is important and interesting to investigate the retrieval efficiency.To this end,this paper presents an efficient image retrieval method named CATIRI(content-and-text based image retrieval using indexing).CATIRI follows a three-phase solution framework that develops a new indexing structure called MHIM-tree.The MHIM-tree seamlessly integrates several elements including Manhattan Hashing,Inverted index,and M-tree.To use our MHIM-tree wisely in the query,we present a set of important metrics and reveal their inherent properties.Based on them,we develop a top-k query algorithm for CTBIR.Experimental results based on benchmark image datasets demonstrate that CATIRI outperforms the competitors by an order of magnitude. | Mengqi Zeng Bin Yao Zhi-Jie Wang Yanyan Shen Feifei Li Jianfeng Zhang Hao Lin Minyi Guo | 2019 | Journal of Computer Science & Technology2019，34，2： | 0 |
| 17 | Etoposide,dexamethasone,and pegaspargase with sandwiched radiotherapy in early-stage natural killer/T-cell lymphoma:A randomized phase III study显示文摘Methotrexate,etoposide,dexamethasone,and pegaspargase(MESA)with sandwiched radiotherapy is known to be effective for early-stage extranodal natural killer/T-cell lymphoma,nasal type(NKTCL).We explored the efficacy and safety of reduced-intensity,non-intravenous etoposide,dexamethasone,and pegaspargase(ESA)with sandwiched radiotherapy.This multicenter,randomized,phase III trial enrolled patients aged between 14 and 70 years with newly diagnosed early-stage nasal NKTCL from 27 centers in China.Patients were randomly assigned(1:1)to receive ESA(pegaspargase 2,500 IU/m^(2)intramuscularly on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4)or MESA(methotrexate 1 g/m^(2)intravenously on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4,and pegaspargase 2,500 IU/m^(2)intramuscularly on day 5)regimen(four cycles),combined with sandwiched radiotherapy. | Huijuan Zhong Shu Cheng Xi Zhang Bing Xu Jiayi Chen Xufeng Jiang Jie Xiong Yu Hu Guohui Cui Juying Wei Wenbin Qian Xiaobing Huang Ming Hou Feng Yan Xin Wang Yongping Song Jianda Hu Yuanhua Liu Xuejun Ma Fei Li Chongyang Wu Junmin Chen Li Yu Ou Bai Jingyan Xu Zunmin Zhu Li Liu Xin Zhou Li Huang Yin Tong Ting Niu Depei Wu Hao Zhang Chaofu Wang Binshen Ouyang Hongmei Yi Qi Song Gang Cai Biao Li Jia Liu Zhifeng Li Rong Xiao Luqun Wang Yujie Jiang Yanyan Liu Xiaoyun Zheng Pengpeng Xu Hengye Huang Li Wang Saijuan Chen Weili Zhao | 2023 | The Innovation2023，4，3： | 0 |
| 18 | A Multi-Objective Optimization Approach for Heat Exchanger Network in Process Industries显示文摘To simultaneously improve the quantity and quality of heat recovery in a heat exchanger network(HEN),this study conducts a theory analysis based on the first and second laws of thermodynamics.Under the premise of maximizing the heat recovery quantity of HEN,Ġdiss is used as an evaluation index to optimize the quality of heat recovery.Meanwhile,the total annual cost(TAC)is considered as another optimization objective to ensure the economic feasibility of the HEN.A superstructure-based multi-objective mixed integer non-linear programming approach is put forward to solve the trade-off between minimizingĠdiss and minimizing TAC.This allows for the optimum HEN structure to be obtained.A well-studied example is solved to highlight the benefits of the proposed method. | Tan Qiang Chen Yuting Xu Yanyan Ye Shuang Xiao Hao Huang Weiguang | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，2： | 0 |
| 19 | Molecular engineering and biomedical applications of ultra-sensitive fluorescent probe for Ag^(+)显示文摘A series of probes KJ-x(x=1-3)with carbon chains of different lengths based on the matrix of rhodamine B were engineered to detect Ag^(+)in aqueous solution in this work.Among them,KJ-1 is selected as the best option after in vitro investigation in view of its most sensitive and rapid response to Ag^(+),whose possible sensing mechanism is studied by experimental investigation and theoretical calculation.To identify the practical application of the probe,the detection of Ag^(+)in nonantibiotic fungicide Silver&Health and differentiation between normal hepatocytes and hepatoma cells using confocal imaging was conducted. | Jianfei Kan Xiaonan Zhou Yanyan Sun Liyuan Sun Hao Chu Zhaosheng Qian Jin Zhou | 2021 | Chinese Chemical Letters2021，32，10： | 0 |
| 20 | Three doses of prototypic SARS-CoV-2 inactivated vaccine induce cross-protection against its variants of concern显示文摘Variants are globally emerging very quickly following pandemic prototypic SARS-CoV-2.To evaluate the cross-protection of prototypic SARS-CoV-2 vaccine against its variants,we vaccinated rhesus monkeys with three doses of prototypic SARS-CoV-2 inactivated vaccine,followed by challenging with emerging SARS-CoV-2 variants of concern(VOCs). | Tianhong Xie Shuaiyao Lu Zhanlong He Hongqi Liu Junbin Wang Cong Tang Ting Yang Wenhai Yu Hua Li Yun Yang Hao Yang Lei Yue Yanan Zhou Fengmei Yang Zhiwu Luo Yanyan Li Hong Xiang Yuan Zhao Jie Wang Haixuan Wang Runxiang Long Dexuan Kuang Wenjie Tan Xiaozhong Peng Qihan Li Zhongping Xie | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 0 |
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