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| 1 | Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters显示文摘AIM: To investigate the expression of Cyclooxygenase-2 (COX-2), proliferating cell nuclear antigen (PCNA), Ki-67 and p53 in gastrointestinal stromal tumors (GISTs) and its relationship with histopathological parameters. METHODS: Twenty-five GISTs were examined by light microscopy and immunohistochemistry. c-kit, CD34, SMA, S-100 protein, COX-2, PCNA, Ki-67 and p53 were detected immunohistochemically and the relationship was evaluated among histopathologic parameters such as mitotic index (MI), tumor grade, tumor size, COX-2, PCNA, Ki-67 and p53. RESULTS: COX-2 protein expression was found in 19 of 25 (76%) of the tumors, and expression was noted in the cytoplasm of the tumor cells. p53 was significantly related to MI and tumor grade but no relationship was found between COX-2, proliferation markers and MI, tumor grade and tumor size. CONCLUSION: COX-2 is expressed in most GISTs and it may play an important role in the proliferation and progression of these tumors or a useful marker to identify GIST. Although immunohistochemical assessment of p53 can be used for distinguishing the risk groups of GISTs, tumor size and mitotic rate should be considered at the same time. | Derya Gumurdulu Seyda Erdogan Fazilet Kayaselcuk Gulsah Seydaoglu Cem K Parsak Orhan Demircan Ilhan Tuncer | 2007 | World Journal of Gastroenterology2007，13，3： | 21 |
| 2 | Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer显示文摘Colorectal cancer(CRC) is the third most frequent cancer type and the incidence of this disease is increasing gradually per year in individuals younger than 50 years old. The current knowledge is that early-onset CRC(EOCRC) cases are heterogeneous population that includes both hereditary and sporadic forms of the CRC. Although EOCRC cases have some distinguishing clinical and pathological features than elder age CRC, the molecular mechanism underlying the EOCRC is poorly clarified. Given the significance of CRC in the world of medicine, the present review will focus on the recent knowledge in the molecular basis of genetic and epigenetic mechanism of the hereditary forms of EOCRC, which includes Lynch syndrome, Familial CRC type X, Familial adenomatous polyposis, Mut YH-associated polyposis, Juvenile polyposis syndrome, Peutz-Jeghers Syndrome and sporadic forms of EOCRC. Recent findings about molecular genetics and epigenetic basis of EOCRC gave rise to new alternative therapy protocols. Although exact diagnosis of these cases still remains complicated, the present review paves way for better predictions and contributes to more accurate diagnostic and therapeutic strategies into clinical approach. | gulcin tezcan berrin tunca secil ak gulsah cecener unal egeli | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 5 |
| 3 | Efficient,Secure,Dynamic Source Routing for Ad-Hoc Networks显示文摘 | MICHAEL W GULSAH A | 2006 | Network and Systems Management2006，14，4： | 1 |
| 4 | Low serum pancreatic enzyme levels predict mortality and are associated with malnutrition–inflammation–atherosclerosis syndrome in patients with chronic kidney disease显示文摘 | Abdullah Ozkok Omer Celal Elcioglu Tahsin Cukadar Ali Bakan Gulsah Sasak Kadir Gokhan Atilgan Sabahat Alisir Mehmet Kanbay Adrian Covic Ali Riza Odabas | 2013 | International Urology and Nephrology2013，，2： | 1 |
| 5 | Managerial competencies of female and maleconstruction managers显示文摘 | David A Gulsah B | | 0，，11： | 1 |
| 6 | Greedy algorithms and metaheuristics for a multiple runway combined arrival-departure aircraft sequencing problem显示文摘 | Gulsah Hancerliogullari Ghaith Rabadi Ameer H. Al-Salem Mohamed Kharbeche | 2013 | Journal of Air Transport Management2013，，： | 1 |
| 7 | Label-free voltammetric detection of Mi-croRNAs at multi-channel screen printed array of electrodes comparison to graphite sensors显示文摘 | Arzum E Gulsah C | | 0，，： | 1 |
| 8 | Risky anatomic variations of sphenoid sinus for surgery显示文摘 | Birsen Unal Gulsah Bademci Yasemin K. Bilgili Funda Batay Emel Avci | 2006 | Surgical and Radiologic Anatomy2006，，2： | 1 |
| 9 | Frailty significantly impairs the short term prognosis in elderly patients with heart failure显示文摘Background Frailty is a condition of elderly characterized by increased vulnerability to stressful events with high risk of adverse outcomes. The purpose of this study was to evaluate the association between frailty and adverse outcomes including death and hospitalization due to heart failure in elderly patients. Methods We included patients aged ≥ 65 years with the diagnosis of heart failure. The clinical and laboratory data, echocardiography and ECGs were recorded. Additionally, the frailty scores of the patients were evaluated according to Canadian Study of Health and Aging. All the patients were divided as frail or non-frail. The groups were compared for their characteristics and the occurrence of clinical outcomes. Results We included 86 eligible patients. The median follow-up time was four months. The mean age was 75 ± 6.5 years. Of these 86 patients, 17 (19.7%) patients encountered an event (death and/or hospitalization). Nine patients (10.4%) died during follow-up. Thirty patients (34.9%) were considered frail. Among the demographic, clinical and laboratory data, only total protein and albumin levels were found to be lower in frail patients (total protein level: 6.8 ± 0.6 g/dL in non-frails, 6.5 ± 0.9 g/dL in frails, P = 0.05;albumin level: 3.8 ± 0.4 g/dL in non-frails, 3.4 ± 0.6 g/dL in frails, P = 0.001). In multivariate analysis, frailty was found to be strongly associated with clinical outcomes in short term. Conclusions Being frail in an elderly heart failure patient is associated with death and/or hospitalization due to heart failure in short term. Therefore, frailty score should be evaluated for all elderly heart failure patients as a prognostic marker. | Ali Deniz Caglar Ozmen Ertugrul Bayram Gulsah Seydaoglu Ayhan Usal | 2018 | Journal of Geriatric Cardiology2018，15，11： | 1 |
| 10 | Perylene imide dyes for solid- state dye- sensitized solar cells : Spectroscopy, energy levels and photovoltaic performance 显示文摘 | Sule Erten-Ela Gulsah Turkmen | 2011 | Renew- able Energy2011，36，： | 1 |
| 11 | Operations Management Perspectives in the Air Transport Management显示文摘The area of operations management has had a substantial effect on the today’s air transportation management.Having moved with huge demand from management to obtain a competitive advantage in the market,the airlines are utilizing advanced optimization techniques to develop decision support systems for operations management and control.In order to provide a service with high quality and low cost,airlines spend a tremendous amount of resources and effort to generate profitable and cost-effective fare classes,flight schedules,fleet plans,aircraft routes,crew scheduling,gate assignment,etc.In this paper,the techniques and operations management applications that are used in the air transportation industry are reviewed including demand forecasting,fleet assignment,aircraft routing,crew scheduling,runway scheduling problem and gate assignment. | Gulsah Hancerliogullari Koksalmis | 2019 | Journal of Business Administration Research2019，2，1： | 1 |
| 12 | Organizational Career Growth and Turnover Intention:An Application in Audit Firms in Turkey显示文摘 | Karavardar Gulsah | 2014 | International Business Research2014，7，9： | 1 |
| 13 | Risky anatomic variations of sphenoid sinus for surgery显示文摘 | Birsen U Gulsah B Yasemin K | 2006 | Surg Radiol Anat2006，19，： | 1 |
| 14 | Prevalence of cag A and vac A genotypes of Helicobacter pylori isolated from Turkish patients with active or non-active chronic gastritis显示文摘 | Birol Safak Ihsan Hakki Ciftci Fatma Husniye Dilek Ihsan Uslan Zafer Cetinkaya Gulsah Asik Osman Nuri Dilek | 2010 | Scandinavian Journal of Infectious Diseases (-)2010，，6： | 1 |
| 15 | Synthesis and electrochemical, electrical and gas sensing properties of no- vel mononuclear metal-free, Zn(ⅡI ), Ni ( Ⅱ ), Co ( Ⅱ), Cu ( Ⅱ ), Lu ( Ⅱ) and double-decker Lu (Ⅱ ) phthalocyanines 显示文摘 | Gulsah Gumrukc Mahmure Ustun Ozgur | 2011 | Synth Metals2011，161，12： | 1 |
| 16 | Risky anatomic variations of sphenoid sinus for surgery显示文摘 | BIRSEN U GULSAH B YASEMIN K | 2006 | Surg Radiol Anat2006，19，： | 1 |
| 17 | Severity of injury resulting from pedestrian–vehicle crashes: What can we learn from examining the built environment?显示文摘 | Kelly J. Clifton Carolina V. Burnier Gulsah Akar | 2009 | Transportation Research Part D2009，，6： | 1 |
| 18 | Analysis of acute adult poisoning in a 6-year period and factors affecting the hospital stay显示文摘 | Salim Satar Gulsah Seydaoglu | 2005 | Advances in Therapy2005，，2： | 1 |
| 19 | The best immunohistochemical panel for differentiating hepatocellular carcinoma from metastatic adenocarcinoma显示文摘 | Ayca Karabork Gulsah Kaygusuz Cemil Ekinci | 2010 | Pathology - Research and Practice2010，，8： | 1 |
| 20 | Influence of individualperception and bicycle infrastructure on decision tobike显示文摘 | Gulsah Akar Kelly J Clifton | 2009 | Transportation Research Record: Journal of theTransportation Research Board2009，2140，： | 1 |
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