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| 1 | Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters显示文摘AIM: To investigate the expression of Cyclooxygenase-2 (COX-2), proliferating cell nuclear antigen (PCNA), Ki-67 and p53 in gastrointestinal stromal tumors (GISTs) and its relationship with histopathological parameters. METHODS: Twenty-five GISTs were examined by light microscopy and immunohistochemistry. c-kit, CD34, SMA, S-100 protein, COX-2, PCNA, Ki-67 and p53 were detected immunohistochemically and the relationship was evaluated among histopathologic parameters such as mitotic index (MI), tumor grade, tumor size, COX-2, PCNA, Ki-67 and p53. RESULTS: COX-2 protein expression was found in 19 of 25 (76%) of the tumors, and expression was noted in the cytoplasm of the tumor cells. p53 was significantly related to MI and tumor grade but no relationship was found between COX-2, proliferation markers and MI, tumor grade and tumor size. CONCLUSION: COX-2 is expressed in most GISTs and it may play an important role in the proliferation and progression of these tumors or a useful marker to identify GIST. Although immunohistochemical assessment of p53 can be used for distinguishing the risk groups of GISTs, tumor size and mitotic rate should be considered at the same time. | Derya Gumurdulu Seyda Erdogan Fazilet Kayaselcuk Gulsah Seydaoglu Cem K Parsak Orhan Demircan Ilhan Tuncer | 2007 | World Journal of Gastroenterology2007，13，3： | 21 |
| 2 | 腹腔间室综合征:当前存在的问题和新的治疗策略显示文摘腹腔间室综合征(ACS)是一种处理起来十分棘手的疾病,ACS对病人的心血管、呼吸、肾脏及神经等系统的功能均有不良影响。ACS的临床过程中存在两个重要问题亟待解决:(1)病人早期生存的问题;(2)后期关闭腹部切口的问题。本研究根据腹内压(IAP)的高低来决定腹腔间室综合征病人是否需要剖腹减压处理,同时也分析了腹内压升高时病人的病理生理变化。作者对119例腹内压增高的原发性ACS病人进行了前瞻性研究。 | Parsak CK Seydaoglu G Sakman G 郑德华(摘) 邹一平(校) | 2009 | 中华肝胆外科杂志2009，15，2： | 2 |
| 3 | Prognostic value of thyroid hormone levels in acute myocardial infarction:Just an epiphenomenon 显示文摘 | Satar S Seydaoglu G Avci A | 2005 | Am Heart Hosp J2005，3，4： | 1 |
| 4 | Comparison of two misoprostol regimens for mid-trimester pregnancy terminations after FIGO s misoprostol dosage recommendation in 2012显示文摘 | Cetin C Buyukkurt S Seydaoglu G | 2016 | J Matern Fetal Neonatal Med2016，29，8： | 1 |
| 5 | Programmed death-1 ( PD-1),programmed death-ligand 1 ( PD-L1 ),and EBV-encodedRNA (EBER) expression in Hodgkin lymphoma 显示文摘 | Paydas S Bagir E Seydaoglu G | 2015 | Ann Hema-tol2015，94，9： | 1 |
| 6 | Prognostic significance of angiogenic/lymphangiogenic, anti-apoptotic, inflammatory and viral factors in 88 cases with diffuse large B cell lymphoma and review of the literature显示文摘 | Paydas S Ergin M Seydaoglu G | 2009 | Leuk Res2009，33，12： | 1 |
| 7 | Pronostic significance of angiogenic/lymphangiogenic, anti-apoptotic, inflammatory and Vi- ral factors in 88 cases with diffuse large B cell lymphoma and re- view of The literature显示文摘 | Paydas S Ergin M Seydaoglu G | 2009 | Leuk Res2009，33，12： | 1 |
| 8 | Prognostic significance of angiogenic lymphangiogenic, anti apoptotic, inflarmatory and viral factors in 88 cases with diffuse large B cell lymphoma and review of the literature显示文摘 | Paydas S Ergin M Seydaoglu G | 2009 | Leuk Res2009，33，12： | 1 |
| 9 | Diode laser for harvesting de- epithelialized palatal graft in the treatment of gingival recession defects: a randomized clinical trial显示文摘 | Ozcelik O Seydaoglu G Haytac CM | 2016 | Journal of ClinicalPeriodontology2016，43，1： | 1 |
| 10 | Abdominal compartment syndrome: current problems and new strategies显示文摘 | Parsak CK Seydaoglu G Sakman G | 2008 | World J Surg2008，32，1： | 1 |
| 11 | Prognostic significance of angiogenic / lymphangiogenic, anti-apop- totic, inflammatory and viral factors in 88 cases with diffuse large B cell lymphoma and review of the litera- ture 显示文摘 | Paydas S Ergin M Seydaoglu G | 2009 | Leuk Res2009，33，12： | 1 |
| 12 | Frailty significantly impairs the short term prognosis in elderly patients with heart failure显示文摘Background Frailty is a condition of elderly characterized by increased vulnerability to stressful events with high risk of adverse outcomes. The purpose of this study was to evaluate the association between frailty and adverse outcomes including death and hospitalization due to heart failure in elderly patients. Methods We included patients aged ≥ 65 years with the diagnosis of heart failure. The clinical and laboratory data, echocardiography and ECGs were recorded. Additionally, the frailty scores of the patients were evaluated according to Canadian Study of Health and Aging. All the patients were divided as frail or non-frail. The groups were compared for their characteristics and the occurrence of clinical outcomes. Results We included 86 eligible patients. The median follow-up time was four months. The mean age was 75 ± 6.5 years. Of these 86 patients, 17 (19.7%) patients encountered an event (death and/or hospitalization). Nine patients (10.4%) died during follow-up. Thirty patients (34.9%) were considered frail. Among the demographic, clinical and laboratory data, only total protein and albumin levels were found to be lower in frail patients (total protein level: 6.8 ± 0.6 g/dL in non-frails, 6.5 ± 0.9 g/dL in frails, P = 0.05;albumin level: 3.8 ± 0.4 g/dL in non-frails, 3.4 ± 0.6 g/dL in frails, P = 0.001). In multivariate analysis, frailty was found to be strongly associated with clinical outcomes in short term. Conclusions Being frail in an elderly heart failure patient is associated with death and/or hospitalization due to heart failure in short term. Therefore, frailty score should be evaluated for all elderly heart failure patients as a prognostic marker. | Ali Deniz Caglar Ozmen Ertugrul Bayram Gulsah Seydaoglu Ayhan Usal | 2018 | Journal of Geriatric Cardiology2018，15，11： | 1 |
| 13 | Frequency and mortality risk factors of acute adult poisoning in Adana,Turkey, 1997- 2002 显示文摘 | Seydaoglu G Satar S Alparstan N | 2005 | Mt Sinai J Med2005，72，6： | 1 |
| 14 | Abdominal compartment syn- drome:current problems and new strategies显示文摘 | Parsak CK Seydaoglu G Sakman G | 2008 | World J Surg2008，32，1： | 1 |
| 15 | Prognostic significance of angiogenic/lymphangiogenic, anti-apoptotic, inflammatory and viral factors in 88 cases with diffuse large B cell lymphoma and review of the literature 显示文摘 | Paydas S Ergin M Seydaoglu G | 2009 | Leuk Res2009，33，12： | 1 |
| 16 | Abdominal compartment syndrome:current problems and new strategies显示文摘 | Parsak CK Seydaoglu G Sakman G | 2008 | World J Surg2008，32，1： | 1 |
| 17 | Survivin and EPR-1 expression in acute leukemias:prognostic significance and review of the literature 显示文摘 | Oto OA Paydas S Tanriverdi K Seydaoglu G Yavuz S Disel U | 2007 | Leuk Res2007，31，11： | 1 |
| 18 | Validity, reli- ability, and comparison of the WOMAC osteoarthritis in- dex and Lequesne algofunctional index in Turkish patients with hip or knee osteoarthritis显示文摘 | Basaran S1 Guzel R Seydaoglu G | 2010 | Clin Rheumatol2010，29，7： | 1 |
| 19 | Abdominal compartment syndrome:current problems and new strategies显示文摘 | Related A Linksparsak CK Seydaoglu G | 2008 | World J Surg2008，32，1： | 1 |
| 20 | Immediate post-op- erative effects of different periodontal treatment modalities on oral health-related quality of life: a randomized clinical trial 显示文摘 | Ozcelik O Haytac MC Seydaoglu G | 2007 | J ClinPeriodontol2007，34，9： | 1 |
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