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| 1 | Efficacy and safety of tenofovir disoproxil fumarate in pregnancy for the prevention of vertical transmission of HBV infection显示文摘AIM:To evaluate the effects of tenofovir disoproxil fumarate(TDF)use during late pregnancy to reduce hepatitis B virus(HBV)transmission in highly viremic mothers.METHODS:This retrospective study included 45 pregnant patients with hepatitis B e antigen(+)chronic hepatitis B and HBV DNA levels>107copies/mL who received TDF 300 mg/d from week 18 to 27 of gestation(n=21).Untreated pregnant patients served as controls(n =24).All infants received 200 IU of hepatitis B immune globulin(HBIG)within 24 h postpartum and 20μg of recombinant HBV vaccine at 4,8,and 24 wk.Perinatal transmission rate was determined by hepatitis B surface antigen and HBV DNA results in infants at week 28.RESULTS:At week 28,none of the infants of TDFtreated mothers had immunoprophylaxis failure,whereas2(8.3%)of the infants of control mothers had immunoprophylaxis failure(P=0.022).There were no differences between the groups in terms of adverse events in mothers or congenital deformities,gestational age,height,or weight in infants.At postpartum week 28,significantly more TDF-treated mothers had levels of HBV DNA<250 copies/mL and normalized alanine aminotransferase compared with controls(62%vs none,P<0.001;82%vs 61%,P=0.012,respectively).CONCLUSION:TDF therapy during the second or third trimester reduced perinatal transmission rates of HBV and no adverse events were observed in mothers or infants. | Mustafa Kemal Celen Duygu Mert Müzeyyen Ay Tuba Dal Safak Kaya Necmettin Yildirim Serda Gulsun Tunga Barcin Sevgi Kalkanli Mehmet Sinan Dal Celal Ayaz | 2013 | World Journal of Gastroenterology2013，19，48： | 26 |
| 2 | Gallbladder function and dynamics of bile flow in asymptomatic gallstone disease显示文摘AIM:To investigate the effects of gallbladder stones on motor functions of the gallbladder and the dynamics of bile flow in asymptomatic gallstone disease.METHODS:Quantitative hepatobiliary scintigraphy was performed to detect the parameters of gallbladder motor function [gallbladder ejection fraction(GBEF),gallbladder visualization time(GBVT),gallbladder time to peak activity(GBTmax),gallbladder half emptying time(GBT1/2),and transit time of bile to duodenum(TTBD)] in 24 patients with asymptomatic cholelithiasis who were diagnosed incidentally during routine abdominal ultrasonographic examination and 20 healthy subjects with normal gallbladder.RESULTS:Even though there was no significant difference in the clinical and laboratory parameters between the patient and control groups,all parameters of gallbladder function except TTBD were found to differ significantly between the two groups.GBEF in the patient group was decreased(P=0.000) and GBVT,GBTmax,GBT1/2 in the patient group were longer(P=0.000,P=0.015,P=0.001,respectively).CONCLUSION:Our results showed that even if there were not any clinical and laboratory findings,gallbladder filling and emptying could be impaired in patients with gallstone disease. | Sevim Süreyya eri Feride Meltem zbek Celal eri Bahattin Baykal Hasan Erol Eroglu Zeynep Baykal Mustafa Yildiz Semahat Saglam Ahmet Yesildag | 2009 | World Journal of Gastroenterology2009，15，22： | 8 |
| 3 | Efficacy and safety of pegylated-interferon α-2a in hemodialysis patients with chronic hepatitis C显示文摘AIM: To evaluate the efficacy and safety of pegylated-interferon alpha-2a in hemodialysis patients with chronichepatitis C.METHODS: Thirty-six hemodialysis patients with chronichepatitis C were enrolled in a controlled and prospectivestudy. All patients were treatment naive, positivetested for anti-HCV antibodies, and positive tested forserum HCV-RNA. Twenty-two patients received 135 μgpeglyated-interferon a-2a weekly for 48 wk (group A).The remaining patients were left untreated, elevenrefused therapy, and three were not candidates forkidney transplantation and were allocated to the controlgroup (group B). At the end of the treatment biochemicaland virological response was evaluated, and 24 wk aftercompletetion of therapy sustained virological response(SVR) was assessed. Side effects were monitored.RESULTS: Of 22 hemodialysis patients, 12 were maleand 10 female, with a mean age of 35.2 ± 12.1 years.Virological end-of-treatment response was observed in14 patients (82.4%) in group A and in one patient (7.1%)in group B (P = 0.001). Sustained virological responsewas observed in 11 patients (64.7%) in group A and inone patient in group B (7.1%). Biochemical responseparameters normalized in 10/14 patients (71.4%) at theend of the treatment. ALT levels in group B were initiallyhigh in six patients and normalized in one of them (25%)at the end of the 48 wk. In five patients (22.7%) therapyhad to be stopped at mo 4 due to complications ofweakness, anemia, and bleeding.CONCLUSION: SVR could be achieved in 64.7% ofpatients on hemodialysis with chronic hepatitis C by atreatment with peglyated-interferon a-2a. Group A hada significantly better efficacy compared to the controlgroup B, but the side effects need to be concerned. | Celal Ayaz Mustafa Kemal Celen Ugur Nedim Yuce Mehmet Faruk Geyik | 2008 | World Journal of Gastroenterology2008，14，2： | 5 |
| 4 | Effect of Helicobacter pylori eradication on serum ghrelin and obestatin levels显示文摘AIM: To investigate changes in serum ghrelin and obestatin levels before and after Helicobacter pylori (H. pylori ) eradication. METHODS: A total of 92 patients presenting with symptoms of dyspepsia were enrolled in the study. Upper endoscopy was performed on all patients and used to diagnose H. pylori infection according to the presence of characteristic histopathological findings; seventy patients were diagnosed with H. pylori infection and the remaining 22 non-infected patients were classified as healthy controls. H. pylori eradication was accomplished by administering the classical triple therapy drug regimen, consisting of lansoprazole 30 mg bid , amoxicillin 1 g bid , and clarithromycin 500 mg tid for 14 d. The eradication of H. pylori was assessed with C14-urea breath test, which was performed at eight weeks after treatment. Levels of serum active ghrelin and obestatin were assessed at beginning of the study (prior to treatment) and after eight weeks. The levels were comparatively analyzed between the H. pylori negative control group, the H. pylori eradicated group, and the H. pylori non-eradicated group. RESULTS: A total of 92 patients, 50 females and 42 males with a mean age of 38.2 ± 11.9 years (range: 19-64), were analyzed. H. pylori eradication success was achieved in 74.3% (52/70) of H. pylori positive patients. The initial levels of ghrelin in the H. pylori positive and control cases were 63.6 ± 19.8 pg/mL and 65.1 ± 19.2 pg/mL (P=0.78), respectively, and initial obestatin levels were 771±427 pg/mL and 830 ± 296 pg/mL (P=0.19), respectively. The difference between the initial levels and the week 8 levels of ghrelin and obestatin in the control group was insignificant [4.5% (P=0.30) and -0.9% (P=0.65), respectively]. The difference between the initial and week 8 levels of ghrelin and obestatin in the H. pylori non-eradicated group were also insignificant [0.9% (P=0.64) and 5.3% (P=0.32), respectively]. The H. pylori eradicated group had a greater change in obestatin levels when compared to the control and the non-eradicated groups (148 ± 381 pg/mL vs -12±138 pg/mL and -72.8±203 pg/mL, respectively, P=0.015), while decreases in ghrelin levels were insignificant (-7.2 pg/mL vs -1.4 pg/mL and -1.9 pg/mL, respectively, P=0.52). The ghrelin/obestatin ratio for the initial and week 8 levels changed significantly in only the H. pylori eradicated group (0.11 vs 0.08, respectively, P=0.015). For overweight patients (as designated by body mass index), we observed significant increases in obestatin levels in the eradicated group as compared to non-eradicated group (201 ± 458 pg/mL vs -5 ± 81 pg/mL, respectively, P=0.02). In the H. pylori-eradicated group, the levels did not differ between the sexes for ghrelin (-6.3 ± 26.9 pg/mL vs -8.0 ± 24.0 pg/mL, respectively, P=0.97) or obestatin (210 ± 390 pg/mL vs 96 ± 372 pg/mL, respectively, P=0.23).CONCLUSION: Serum levels of ghrelin decreased while obestatin levels increased in H. pylori eradicated subjects, especially in overweight and male patients. | Celal Ulasoglu Banu Isbilen Levent Doganay Filiz Ozen Safak Kiziltas Ilyas Tuncer | 2013 | World Journal of Gastroenterology2013，19，15： | 5 |
| 5 | Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B显示文摘AIM: To investigate the effect of human leukocyte antigen(HLA) DRB1 and DQB1 alleles on the inactive and advanced stages of chronic hepatitis B.METHODS: Patient records at a single institution's hepatology clinic were reviewed. Demographic data, laboratory results, endoscopy results, virological parameters, biopsy scores and treatment statuses were recorded. In total, 355 patients were eligible for thestudy, of whom 226(63.7%) were male. Overall, 82(23.1%) were hepatitis B early antigen(HBeAg) positive, 87(24.5%) had cirrhosis, and 66(18.6%) had inactive disease. The presence of DQB1 and DRB1 alleles was determined by polymerase chain reaction with sequence-specific primers. The distribution of the genotyped alleles among patients with cirrhosis and patients with chronic active hepatitis was analyzed.RESULTS: The most frequent HLA DQB1 allele was DQB1*03:01(48.2%), and the most frequent HLA DRB1 allele was DRB1*13/14(51.8%). DQB1*05:01 was more frequent in patients with active disease than in inactive patients(27% vs 9.1%; P = 0.002, Pc = 0.026). DRB1*07 was rare in patients with cirrhosis compared with non-cirrhotics(3.4% vs 16%; P = 0.002, Pc = 0.022). Older age(P < 0.001) and male gender(P = 0.008) were the other factors that affected the presence of cirrhosis. In a multivariate logistic regression analysis, DRB1*07 remained a significant negative predictor of cirrhosis(P = 0.015). A bioinformatics analysis revealed that a polymorphic amino acid sequence in DRB1*07 may alter interaction with the T-cell recognition site.CONCLUSION: This study demonstrates that HLA alleles may influence cirrhosis development and disease activity in Turkish chronic hepatitis B patients. | Levent Doganay Arta Fejzullahu Seyma Katrinli Feruze Yilmaz Enc Oguzhan Ozturk Yasar Colak Celal Ulasoglu Ilyas Tuncer Gizem Dinler Doganay | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 6 | 板块构造学与造山运动:特提斯例析梗概显示文摘1 引言本文是作者的题为“二十五年来的板块构造学和造山运动研究:特提斯例析”长文的极简要梗概,原文发表于《地球科学论评》(1990,Vol.271 p.1—201,下文引用以“Sengor1990a”表示),笔者在撰写梗概过程中并未试图对原文作系统修改以使之反映最新的认识,但确实增加了一些内容,并对原文的一些错误进行了修正。为使读者了解所新增的内容,文中用方括弧来表示之;所有的修正均用楷体字表示; | A. M. Celal Sengor 周祖翼 丁晓 | 1992 | 海洋地质译丛1992，，1： | 2 |
| 7 | Determination of Some Trace Metals in Environmental Samples by Flame AAS Following Solid Phase Extraction with Amberlite XAD-2000 Resin after Complexing with 8-Hydroxyquinoline显示文摘为 Mn ( II )的 preconcentration 的一个过程, Fe ( II ),公司( II ), Cu ( II ), Cd ( II ), Zn ( II ), Pb ( II )和 Ni ( II )被火焰 AAS 为环境样品的分析基于他们有在列的 Amberlite XAD-2000 树脂上的 8-hydroxyquinoline ( HQ )的建筑群的保留建议。象 pH, eluent 类型,卷,集中,流动率和样品答案的体积那样的各种各样的参数,和金属离子的保留上的矩阵干扰效果被调查。为在问题的金属建筑群的保留的最佳 pHs 除了为其价值是 8 的 Mn2+ 是大约 6。为从在最佳条件下面的树脂的这些金属和他们的恢复的吸附物的装载能力在范围是 6.829.26 | DURAN, Celal SENTURK, H. Basri GUNDOGDU, Ali BULUT, V. Numan EICi, Latif SOYLAK, Mustafa TUFEKCI, Mehmet UYGUR, Yaprak | 2007 | Chinese Journal of Chemistry2007，25，2： | 2 |
| 8 | Assessment of endothelial function in patients with nonalcoholic fatty liver disease显示文摘 | Yasar Colak Ebubekir Senates Atakan Yesil Yusuf Yilmaz Oguzhan Ozturk Levent Doganay Ender Coskunpinar Ozlem Timirci Kahraman Banu Mesci Celal Ulasoglu Ilyas Tuncer | 2013 | Endocrine2013，，1： | 2 |
| 9 | Removal of Pb(II) ions from aqueous solution by a waste mud from copper mine industry: Equilibrium, kinetic and thermodynamic study显示文摘 | Duygu Ozdes Ali Gundogdu Baris Kemer Celal Duran Hasan Basri Senturk Mustafa Soylak | 2008 | Journal of Hazardous Materials2008，，2： | 2 |
| 10 | 热脱水钠硼解石在醋酸铵溶液中的溶解(英文)显示文摘钠硼解石含有大量的结晶水。采用煅烧法可以将固体组分中的一部水脱去,得到一种多孔结构物质,以提高浸出反应速率。采用醋酸铵作为浸出溶剂,研究煅烧钠硼解石样品在不同温度下的溶解情况。研究了反应参数对煅烧钠硼解石溶解的影响。研究发现,煅烧样品的溶解速率高于未煅烧样品的溶解速率。在煅烧温度低于150℃时,煅烧钠硼解石的溶解速率随着煅烧温度的升高而加快。钠硼解石的浸出反应速率符合化学反应控制模型。溶解过程中的活化能为41.5kJ/mol。 | Nizamettin DEMRKIRAN Nazli BAYRAKCI Celal ASN | 2013 | 中国有色金属学会会刊:英文版2013，23，6： | 2 |
| 11 | Mechanisties of nickel sorption by activated sludge显示文摘 | BETUL A CELAL F G ULKU Y | 2002 | Process Biochemistry2002，37，11： | 1 |
| 12 | The effect of HLA-DQB1 alleles on virologic breakthroughs during chronic hepatitis B treatment with genetically low barrier drugs显示文摘 | Levent Doganay Ilyas Tuncer Seyma Katrinli Feruze Yilmaz Enc Oguzhan Ozturk Yasar Colak Celal Ulasoglu Gizem Dinler | 2012 | Clinics and Research in Hepatology and Gastroenterology2012，，： | 1 |
| 13 | Low serum pancreatic enzyme levels predict mortality and are associated with malnutrition–inflammation–atherosclerosis syndrome in patients with chronic kidney disease显示文摘 | Abdullah Ozkok Omer Celal Elcioglu Tahsin Cukadar Ali Bakan Gulsah Sasak Kadir Gokhan Atilgan Sabahat Alisir Mehmet Kanbay Adrian Covic Ali Riza Odabas | 2013 | International Urology and Nephrology2013，，2： | 1 |
| 14 | Ruptured dissecting aneu- rysms arising from non-vertebral arteries of the posterior circulation: endovascular treatment perspective 显示文摘 | Ismail O Celal C Baki Y | 2009 | Diagn Interv Radiol2009，15，： | 1 |
| 15 | Cluster based wireless sensor network routing using artificial bee colony algorithm显示文摘 | Dervis Karaboga Selcuk Okdem Celal Ozturk | 2012 | Wireless Sensor Network2012，18，7： | 1 |
| 16 | Thermoelectric transport behaviours of n-type Mg2 (Si,Sn,Ge) quaternary solid solutions显示文摘Mg2X(X=Si,Sn,and Ge)based systems have attracted widespread attention owing to their various benefits in thermoelectric applications.In particular,to date,ternary Mg2X based solid solutions have become one of the most widely investigated thermoelectric systems.However,the investigation of temperature varied thermoelectric properties of Mg2X based quaternary systems is rather limited both theoretically and experimentally.Therefore,here,we report a rigorous theoretical work of thermoelectric properties for n-type Mg2Si0.55-z;Sn0.4Ge0.05Biz quaternary solid solutions(z=0.02,0.025,0.03,and 0.035)from 300 K to 850 K.By using nearly-free-electron model together with Fermi-Dirac statistics we define Fermi level both in extrinsic and intrinsic regimes as a function o f temperature.We follow Hicks and Dresselhaus,approach to calculate electronic transport properties.By performing the Debye's isotropic continuum model a detailed theoretical investigation of lattice thermal conductivity is presented among with various phonon relaxation rates.From our theoretical analysis the highest ZT is attained for Mg2Si0.53Sn0.4Ge0.05Bi0.02 solid solution as 1.14 at 850 K. | Ovgü Ceyda Yelgel Celal Yelgel | 2019 | Journal of Magnesium and Alloys2019，7，3： | 1 |
| 17 | Davidon least squares- based learning algorithm for feedforward neural networks 显示文摘 | Kasparian V Celal B Zhang H | 1994 | Neural Networks1994，7，4： | 1 |
| 18 | Coded OFDM with transmitter diversity for digital television terrestrial broadcasting显示文摘 | Celal Esli Hakan Deli | 2006 | IEEE Transactions on Broadcasting2006，3，3： | 1 |
| 19 | The evaluation of myomectomies performed dur- ing cesarean section in our clinic 显示文摘 | Celal K Hulya C | 2011 | Niger Med J2011，52，3： | 1 |
| 20 | Artificial bee colony (ABC) optimization algorithm for training feed - forward neural networks显示文摘 | Dervis K Bahriye A Celal O | 2007 | Modeling Decisions for Artificial Intelligence2007，，4617： | 1 |
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