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| 1 | Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn.leaves in experimental colitis in rats显示文摘Objective:To elucidate the ameliorative effect of liydrualcuholic extract of leaves of Hibiscus rosa sinensis(HRS) in acetic acid induced experimental colitis in male wistar rats.Methods: The animals were administered with 2 mL acetic acid(4%) via intra rectal.The animals were divided into various treatment groups(n=6).Prednisolone was used as standard drug and HRS was administered at a dose of 50,100 and 200 mg/kg p.o.The control group of animals received 1 mL of vehicle(distilled water).Ulcer area,ulcer index,spleen weight,colon weight to length ratio, macroscopic score,haemalological parameters,colonic superoxide dismutase(SOD),glutathione(GSH),myeloperoxidase(MPO),malondialdchyde(MDA),tumor necrosis factor-α(TNK- α), nitric oxide(NO) and histological changes were recorded after the treatment regimen of 11 days. Results:Intrarectal instillation of acetic acid caused enhanced ulcer area,ulcer index,spleen weight,colon weight to length ratio,colonic MPO,MDA,NO and TNF-α It caused significant decreased level of SOD and GSH.Pretreatment with HRS for 7 days exhibited significant effect in lowering of oxidative stress,colonic NO,TNF- α and elevation of SOD and GSH at a dose of 100 and 200 mg/kg in acetic acid induced colilis.Conclusions:The present investigation demonstrates HRS is of potent therapeutic value in the amelioration of expcrimenlal colilis in laboralory animals by inhibiting the proinflammatory mediator like NO and TNK-α. | Amit D Kandhare Kiran S Raygude Pinaki Ghosh Arvindkumar E Ghule Tejas P Gosavi Sachin L Badole Subhash L Bodhankar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 2 |
| 2 | 显示文摘 | GOSAVI R K RAGHUNATHAN P STRAUSZ O P | 1985 | J Mol Struct: THEOCHEM1985，133，： | 1 |
| 3 | Molecular orbital studies of the spectral and structural properties of ehlorosilylidyne, SiC1 显示文摘 | Gosavi R K Strausz O P | 1986 | Chem Phys Lett1986，131，： | 1 |
| 4 | Efficient hydrogen supply through catalytic dehydrogenation of methylcyclohexane over Pt/metal oxide catalysts显示文摘 | SHUKLA A A GOSAVI P V PANDE J V KUMAR V P CHARY K V R BINIWALE R B | 2010 | Int J Hydrogen Energy2010，35，9： | 1 |
| 5 | In-situ citric acid crosslinking of alginate/polyvinyl alcohol electrospun nanofibers显示文摘 | STONE S A GOSAVI P ATHAUDA T J | 2013 | Materials Letters2013，112，12： | 1 |
| 6 | 显示文摘 | Sharma G Gosavi S W Lochab S P | 2012 | Journal of Lumi- nescence2012，10，132： | 1 |
| 7 | Conformational transi- tions in adenylate kinase allosteric communication reduces misligation 显示文摘 | Whifford P C Gosavi S Onuchic JN | 2008 | Journal of Biological Chemistry2008，283，4： | 1 |
| 8 | Solving Semi-Markov Decision Problems Using Average Reward Reinforcement Learning 显示文摘 | Das T P Gosavi A | 1999 | Management Science1999，45，4： | 1 |
| 9 | Sirenomelia with associated systemic anomalies: An autopsy pathologic il- lustration of a series of four cases显示文摘 | Chikannaiah P Mahadevan A Gosavi M | 2014 | Pathol Res Pract2014，210，7： | 1 |
| 10 | Sirenomelia with associated systemic anomalies: An autopsy pathologic il- lustration of a series of four cases显示文摘 | Chikkannaiah P Mahadevan A Gosavi M | 2014 | Pathol Res Pract2014，210，7： | 1 |
| 11 | Global supply chain management:a reinforcement learning approach显示文摘 | Pontrandolfo P Gosavi A Okogbaa O G | 2002 | International Journal of Production Research2002，40，6： | 1 |
| 12 | Sirenomelia with associated systemic anomalies: An autopsy pathologic il- lustration of a series of four cases显示文摘 | Chikkannaiah P Mahadevan A Gosavi M | 2014 | Pathol Res Pract2014，210，7： | 1 |
| 13 | Unwrapping homeopathic principles in the wake of research:serendipity,placebo or true therapeutic milestones显示文摘 | Gosavi TP Ghosh P Kandhare A Bodhankar SL | | 0，，： | 1 |
| 14 | Studies on Luminescence Properties and Energy Transfer in Ce/Dy Co-Doped CaS Nano-phosphors 显示文摘 | Sharma G Gosavi S W Lochab S P | 2012 | Journal of Luminescence2012，10，132： | 1 |
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