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| 1 | MicroRNAs:a new ray of hope for diabetes mellitus显示文摘Diabetes mellitus has become one of the most common chronic diseases,thereby posing a major challenge to global health.Characterized by high levels of blood glucose(hyperglycemia),diabetes usually results from a loss of insulin-producing β-cells in the pancreas,leading to a deficiency of insulin(type 1 diabetes),or loss of insulin sensitivity(type 2 diabetes).Both types of diabetes have serious secondary complications,such as microvascular abnormalities,cardiovascular dysfunction,and kidney failure.Various complex factors,such as genetic and environmental factors,are associated with the pathophysiology of diabetes.Over the past two decades,the role of small,single-stranded noncoding microRNAs in various metabolic disorders,especially diabetes mellitus and its complications,has gained widespread attention in the scientific community.Discovered first as an endogenous regulator of development in the nematode Caenorhabditis elegans,these small RNAs post-transcriptionally suppress mRNA target expression.In this review,we discuss the potential roles of different microRNAs in diabetes and diabetes-related complications. | Munish Kumar Sayantan Nath Himanshu K Prasad G D Sharma Yong Li | 2012 | Protein & Cell2012，3，10： | 14 |
| 2 | Fluoroscopy guided percutaneous renal access in prone position显示文摘Percutaneous nephrolithotomy is a very commonly done procedure for management of renal calculus disease. Establishing a good access is the first and probably themost crucial step of this procedure. A proper access is the gateway to success. However, this crucial step has the steepest learning curve for, in a fluoroscopy guided access, it involves visualizing a three dimensional anatomy on a two dimensional fluoroscopy screen. This review describes the anatomical basis of the renal access. It provides a literature review of all aspects of percutaneous renal access along with the advances that have taken place in this field over the years. The article describes a technique to determine the site of skin puncture, the angle and depth of puncture using a simple mathematical principle. It also reviews the common problems faced during the process of puncture and dilatation and describes the ways to overcome them. The aim of this article is to provide the reader a step by step guide for percutaneous renal access. | Gyanendra R Sharma Pankaj N Maheshwari Anshu G Sharma Reeta P Maheshwari Ritwik S Heda Sakshi P Maheshwari | 2015 | World Journal of Clinical Cases2015，3，3： | 5 |
| 3 | Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma显示文摘AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters.METHODS:β-actin is a housekeeping gene,frequently used as loading control,but,differentially expresses in cancer.In gastric cancer,an overall increased expression ofβ-actin has been reported using tissue disruptive techniques.At present,no histological data is available to indicate its cell type-specific expression and distribution pattern.In the present study,we analyzedβ-actin expression and distribution in paired normal and tumor tissue samples of gastric adenocarcinoma patients using immunohistochemistry(IHC),a tissue non-disruptive technique as well as tissue disruptive techniques like reverse transcriptase-polymerase chain reaction(RT-PCR)and western blotting.Correlation ofβ-actin level with clinicopathological parameters was done using univariate analysis.RESULTS:The results of this study showed significant overexpression,at both mRNA and protein level in tumor tissues as confirmed by RT-PCR(1.47±0.13 vs2.36±0.16;P<0.001)and western blotting(1.92±0.26 vs 2.88±0.32;P<0.01).IHC revealed thatβ-actin expression is majorly distributed between epithelial and inflammatory cells of the tissues.Inflammatory cells showed a significantly higher expression compared to epithelial cells in normal(2.46±0.13 vs 5.92±0.23,P<0.001),as well as,in tumor tissues(2.79±0.24 vs6.71±0.14,P<0.001).Further,comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpressβ-actin in tumor tissues,however,significant difference was observed only in inflammatory cells(5.92±0.23vs 6.71±0.14,P<0.01).Moreover,combined expression in epithelial and inflammatory cells also showed significant increase(4.19±0.15 vs 4.75±0.14,P<0.05)in tumor tissues.In addition,univariate analysis showed a positive correlation ofβ-actin level of inflammatory cells with tumor grade(P<0.05)while epithelial cells exhibited negative correlation(P>0.05).CONCLUSION:In gastric cancer,β-actin showed an overall higher expression predominantly contributed by inflammatory or tumor infiltrating immune cells of the tissue microenvironment and correlates with tumor grade. | Shafqat A Khan Monica Tyagi Ajit K Sharma Savio G Barreto Bhawna Sirohi Mukta Ramadwar Shailesh V Shrikhande Sanjay Gupta | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 4 | RRM1 and PTEN as prognostic parameters for overall and disease-free survival in patients with non-small-cell lung cancer显示文摘 | Bepler G Sharma S Cantor A | | 0，，10： | 2 |
| 5 | Toward operational space-based space surveillance显示文摘 | Sharma J Slokes G H Braun C | 2002 | Lincoln Lahoratory Journal2002，13，2： | 1 |
| 6 | In vitro propagation of an adult tree Wrightia lomentosa through enhanced axilliary branching显示文摘 | Purohit S D Kukda G Sharma P | 1994 | Plant Sci1994，103，： | 1 |
| 7 | Promoter hypermethylation of TMS1, BRCA1, ERa and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients 显示文摘 | Mirza S Sharma G Prasad CP | 2007 | Life Sciences2007，81，4： | 1 |
| 8 | Electricity consumption- growth nexus:The case of Malaysia显示文摘 | CHANDRAN V G R SHARMA S | 2010 | Energy Policy2010，38，1： | 1 |
| 9 | Human Toll-like receptor 4 polymorphisms TLR4 Asp299Gly and Thr399Ile influence suscepti- bility and severity of puhnonary tuberculosis in the Asian Indian population 显示文摘 | Najmi N Kaur G Sharma S K | 2010 | Tissue Antigens2010，76，2： | 1 |
| 10 | Hypoxia inducible factor-l: its potential role in cerebral ischemia显示文摘 | Singh N Sharma G Mishra V | 2012 | Cell Mol Neurobiol2012，32，4： | 1 |
| 11 | Phylogeny and genetic diversity of foot and mouth disease virus serotype Asial in India during 1964-2012 显示文摘 | Subramaniam S Mohapatra J K Sharma G K | 2013 | Vet Microbiol2013，167，34： | 1 |
| 12 | Disaggregation procedures for stochastic hydrology based on nonparametric density estimation 显示文摘 | TARBOTON D G SHARMA A LALL U | 2000 | Water Resources Research2000，34，1： | 1 |
| 13 | Design of biode- gradable nanoparticles for oral delivery of doxorubicin: in vivo pharmacokinetics and toxicity studies in rats 显示文摘 | Kalaria DR Sharma G Beniwal V | 2009 | Pharm Res2009，26，： | 1 |
| 14 | Feasibility and efficacy of molecular analysis- directed individualized therapy in advanced non - small - cell lung cancer显示文摘 | Simon G Sharma A Li X | 2007 | J Clin Oncol2007，25，19： | 1 |
| 15 | Studies on Spinel Cobaltites, FeCo2O4 and MgCo2O4 as Anodes for Li-ion Batteries显示文摘 | Sharma Y Sharma N Subba R G V | 2008 | Solid State lonics2008，179，： | 1 |
| 16 | Immunomodulatory Effects of MacrolideAntibiotics in Respiratory Disease: Therapeutic Implications for Asthma and Cystic Fibrosis显示文摘 | Sharma S Jaffe A Dixon G | 2007 | Paediatr Drugs2007，9，2： | 1 |
| 17 | Soil microbial population numbers and enzyme activities in relation to altitude and forest degradation显示文摘 | J HA D K SHARMA G D MISHRA R R | 1992 | Soil Bio Biochem1992，24，8： | 1 |
| 18 | Chemical diffusion in the bcc phase of the Zr-Ti alloy 显示文摘 | RAGHUNATHAN V R TIWARI G R SHARMA B D | 1972 | Metallurgical and Materials Transactions B1972，3，： | 1 |
| 19 | Effect of a dental water jet with orthodontic tip on plaque and bleeding in adolescent patients with fixed orthodontic appliances显示文摘 | SHARMA N C LYLE D M QAQISH J G | 2008 | Am J Orthod Dentofacial Orthop2008，133，4： | 1 |
| 20 | Lossless generalized-LSB data embedding显示文摘 | Celik M U Sharma G Tekalp A M | 2005 | IEEE Transactions on Image Processing2005，14，2： | 1 |
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