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| 1 | Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats显示文摘The aim of this study was to evaluate the effect of naringin on experimentally induced inflammatory bowel disease in rats.Naringin(20,40 and 80 mg/kg) was given orally for 7 days to Wistar rats before induction of colitis by intrarectal instillation of 2 mL of 4%(v/v) acetic acid solution.The degree of colonic mucosal damage was analyzed by examining mucosal damage,ulcer area,ulcer index and stool consistency.Intrarectal administration of 4%acetic acid resulted in significant modulation of serum alkaline phosphatase,lactate dehydrogenase,superoxide dismutase(SOD),glutathione(GSH),malondialdehyde(MDA) and myeloperoxidase(MPO) content along with colonic nitric oxide(NO),xanthine oxidase(XO) level and protein carbonyl content in the colonic tissue as well as in blood.Naringin(40 and 80 mg/kg) exerted a dose dependent(P < 0.05) ameliorative effect,as it significantly increased hematological parameter as well as colonic SOD and GSH.There was a significant(P < 0.05)and dose dependant inhibition of macroscopical score,ulcer area along with colonic MDA,MPO activity by the7 days of pretreatment of naringin(40 and 80 mg/kg).Biochemical studies revealed a significant(P < 0.05) dose dependant inhibition in serum alkaline phosphatase(ALP) and lactate dehydrogenase(LDH) levels by pretreatment of naringin.Increased levels of colonic NO,XO,protein carbonyl content and DNA damage were also significantly decreased by naringin pretreatment.The findings of the present investigation propose that naringin has an anti-inflammatory,anti-oxidant and anti-apoptotic potential effect at colorectal sites as it modulates the production and expression of oxidative mediators such as MDA,MPO,NO and XO,thus reducing DNA damage. | Venkatashivam Shiva Kumar Anuchandra Ramchandra Rajmane Mohammad Adil Amit Dattatraya Kandhare Pinaki Ghosh Subhash Laxman Bodhankar | 2014 | The Journal of Biomedical Research2014，28，2： | 8 |
| 2 | Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn.leaves in experimental colitis in rats显示文摘Objective:To elucidate the ameliorative effect of liydrualcuholic extract of leaves of Hibiscus rosa sinensis(HRS) in acetic acid induced experimental colitis in male wistar rats.Methods: The animals were administered with 2 mL acetic acid(4%) via intra rectal.The animals were divided into various treatment groups(n=6).Prednisolone was used as standard drug and HRS was administered at a dose of 50,100 and 200 mg/kg p.o.The control group of animals received 1 mL of vehicle(distilled water).Ulcer area,ulcer index,spleen weight,colon weight to length ratio, macroscopic score,haemalological parameters,colonic superoxide dismutase(SOD),glutathione(GSH),myeloperoxidase(MPO),malondialdchyde(MDA),tumor necrosis factor-α(TNK- α), nitric oxide(NO) and histological changes were recorded after the treatment regimen of 11 days. Results:Intrarectal instillation of acetic acid caused enhanced ulcer area,ulcer index,spleen weight,colon weight to length ratio,colonic MPO,MDA,NO and TNF-α It caused significant decreased level of SOD and GSH.Pretreatment with HRS for 7 days exhibited significant effect in lowering of oxidative stress,colonic NO,TNF- α and elevation of SOD and GSH at a dose of 100 and 200 mg/kg in acetic acid induced colilis.Conclusions:The present investigation demonstrates HRS is of potent therapeutic value in the amelioration of expcrimenlal colilis in laboralory animals by inhibiting the proinflammatory mediator like NO and TNK-α. | Amit D Kandhare Kiran S Raygude Pinaki Ghosh Arvindkumar E Ghule Tejas P Gosavi Sachin L Badole Subhash L Bodhankar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 2 |
| 3 | Ameliorative effects of standardized extract from Trigonella foenum-graecum L.seeds on painful peripheral neuropathy in rats显示文摘Objective:To evaluate the effects of the standardized extract of fenugreek(Trigonella foenumgraecum L.Family:Leguminasae) seed(IND01) in animal models of peripheral neuropathy. Methods:IND01 was prepared from fenugreek seeds and standardized by high performance liquid chromatography to a marker compound,trigonelline.The effects of daily oral administration of IND01(50,100 and 200 mg/kg) were studied in rats after partial sciatic nerve ligation(PSNL) and sciatic nerve crush injury(SNCI) during 30-days period.The measurements on thermal hyperalgesia(TH),motor function test(MFT) score and motor nerve conduction velocity (MNCV) were recorded.Results:IND01 offered sustained protection against TH and deranged MFT scores in both models from 7-day onwards.Fifteen days of daily oral administration of IND01 restored MNCV reduction in rats with SNCI but not with PSNL.Conclusions:IND01 was found to be effective in rat models of painful peripheral neuropathy. | Aashish S Morani Subhash L Bodhankar V Mohan Prasad A Thakurdesai | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，5： | 2 |
| 4 | In vitro antioxidant and antimicrobial activity cycloart-23-ene-3β,25-diol(B2) isolated from Pongamia pinnata(L.Pierre)显示文摘Objective:To evaluate the in-vitro antioxidant and antimicrobial activity of cvcloart-23- ene-3β,25-diol(called as B2) isolated from stem bark of Pongamia pinnata.Methods:In vitro antioxidant activity of B2 was determined by methods for determination of Dl’PH radical scavenging,reducing power,superoxide anion radical scavenging,hydroxyl radical scavenging, hydrogen peroxide scavenging,metal chelating and nitric oxide radical scavenging at the doses of 20.40.60.80 and 100μg/mL,respectively.3 -tocopherol with same concentration was used as a standard antioxidant.In vitro antimicrobial activity of B2 was determined by cup plate method in different concentration range of 10-100μg/mL.Results:The results indicated that dose dependent%reduction against DPPH radical,reducing power,superoxide anion radical scavenging,hydroxyl radical scavenging,metal chelating,hydrogen peroxide scavenging and nitric oxide radical scavenging by B2 andβ-tocopherol.Conclusions:It is concluded that cycloart 23-ene-3β,25 diol(B2) showed dose dependent antioxidant activity.B2 showed more DPPH radical scavenging,reducing power,superoxide scavenging,hydroxyl radical scavenging, metal chelating scavenging,hydrogen peroxide radical scavenging and nitric oxide radical scavenging activity thanβ-tocopherol and in case of antimicrobial activity B2 exhibited broad-spectrum activ ity against bacteria and strong activity against yeast type of fungi. | Sachin L Badole Anand A Zanwar Abhijeet N Khopade Subhash L Bodhankar | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 2 |
| 5 | Cardioprotective effect of Lagenaria sicerctria (LS) fruit powder in isoprenalin-inducedcardiotoxicity in rats显示文摘 | Mali V R Bodhankar S L | 2010 | European Journal of Integrative Medicine2010，2，： | 1 |
| 6 | Pharmacological Studies for the Aqueous Extract of Sapindus Trifoliatus on Centra Nervous System : Possible Antimigraine Mechanisms 显示文摘 | Aruluozhi D K Veeranjaneyulu A Bodhankar S L | 2005 | J Ethnophammcology2005，97，： | 1 |
| 7 | Superior mesenteric artery first combined with uncinate process approach versus uncinate process first approach in pancreatoduodenectomy: a comparative study evaluating perioperative outcomes 显示文摘 | Shrikhande SV Barreto SG Bodhankar YD | 2011 | Langenbecks Arch Surg2011，396，8： | 1 |
| 8 | Estrogen-induced pro-tection against experimental autoimmune encephalomyelitis is abro-gated in the absence of B cells显示文摘 | Bodhankar S Wang C Vandenbark AA | 2011 | Eur J Immunol2011，4，： | 1 |
| 9 | Early co-administration of vitamin E acetate and methylcobalamin improves thermal hyperalgesia and motor nerve conduction velocity following sciatic nerve crush injury in rats显示文摘 | Aashish S. Morani Subhash L. Bodhankar | 2010 | Pharmacological Reports2010，，： | 1 |
| 10 | Regenerative potential of pancreata in alloxan induced diabetic mice by 4-hydroxyisoleucine,comparision with pioglitazone显示文摘 | Shah S Bodhankar S Bhonde R | | 0，，： | 1 |
| 11 | NK cells interfere with the generation of resistance against mycoplasma respiratory infection following nasal-pulmonary immunization 显示文摘 | Bodhankar S Woolard MD Sun X | 2009 | J Immunol2009，183，4： | 1 |
| 12 | Metabolic effects of various antidiabetie and hypolipidaemie agents on a high-fat diet and multiple low-dose streptozoein (MLDS) mouse model of diabetes显示文摘 | Arulmozhi D K Kufian R Bodhankar S L | 2008 | J Pharm Pharmacol2008，60，9： | 1 |
| 13 | Neurobehavioral assessment of hydroalcoholic extract of trigonella foenum-graecum seeds in rodent models of Parkinson's disease显示文摘 | Gaur V Bodhankar S L Mohan V | | 0，，05： | 1 |
| 14 | Immunomodulatory activity of alcoholic extract ofMangifera indicaL in mice显示文摘 | Makare N Bodhankar S Rangari V | 2001 | J Ethnopharmacol2001，78，23： | 1 |
| 15 | Estrogen-induced protection against experimental autoimmune encephalomyelitis is abrogated in the absence orB cells显示文摘 | Bodhankar S Wang C Vandenbark AA | 2011 | EurJ Immunol2011，41，4： | 1 |
| 16 | Protective effect of aqueous extract of Feronia elephantum correa leaves on thioacetamide induced liver necrosis in diabetic rats显示文摘Objective:To evalueate hepatoprotective effects Feronia elephantum(F.elephantum)correa against thioacctamide(TA)induced liver necrosis in diabetic rats.Methods:Male wistar rats were made diabetic with alloxan(160 mg/kg)on day 0 of the study.They were intoxicated with hepatotoxicant(thioacetamide,300 mg/kg,ip)on day 9 of study to produce liver necrosis.Effects of 7 day daily once administration(day 2 to day 9)of EF(400 and 800 mg/kg,po)were evaluated on necorosis of liver in terms of mortality,liver volume,liver weight,serum aspartate aminotransferase(AST)and serum alanine transaminase(ALT),and histopathology of liver sections(for signs of necorosis and inflammation)on day-9 of the study.Separate groups of rats with treated only with alloxan(DA control),thioacetamide(TA control)and both(TA+DA control)were maintained.Results:FE significantly lowered the mortality rate and showed improvement in liver function parameters in TA-induced diabetic rats without change in liver weight,volume and serum glucose levels.Conclusions:FE showed promising activity against TA-induced liver necorsis in diabetic rats and so might be useful for prevention of liver complications in DM. | Prashant Sharma Subhash L Bodhankar Prasad A Thakurdesai | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，9： | 1 |
| 17 | Metabolic effects of various antidiabetic and hypolipidaemic agents on a high-fat diet and multiple low-dose streptozocin (MLDS) mousemodel of diabetes显示文摘 | Arulmozhi DK Kurian R Bodhankar SL | 2008 | J Pharm Pharmacol2008，60，9： | 1 |
| 18 | Migraine:cur- rent concepts and emerging therapies 显示文摘 | Arulmozhi DK Veeranjaneyulu A Bodhankar SL | 2005 | Vascul Pharmacol2005，43，3： | 1 |
| 19 | Immunomodulatory activity of alcoholic extract of Mangifera indical in mice显示文摘 | Makare N Bodhankar S Rangari V | 2001 | J Ethnopharmacol2001，78，23： | 1 |
| 20 | Estrogen - induced protection against experimental autoimmune encephalomyelitis is Abro- gated in the absence of B cells 显示文摘 | Bodhankar S Wang C Vandenbark AA | 2011 | Eur J Immunol2011，41，6： | 1 |
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