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| 1 | Relationship between the expression of iNOS,VEGF,tumor angiogenesis and gastric cancer显示文摘AIM:To in vestigate the relationship between the expression of inducible nitric oxide synthase(iNOS),vascular endothelial growth factor(VEGF),the microvascular density(MVD)and the pathological features and clinical staging of gastric cancer.METHODS:Immunohistochemical staining was used for detecting the expression of iNOS and VEGFin46resected specimens of gastric carcinoma;the monoclonal antibody against CD34 was used for displaying vascular endothelial cells,and MVD was detected by counting of CD34-positive vascular endothelial cells.RESULTS:Of 46resected specimens of gastric carcinoma,the rates of expressions of iNOS and VEGF were 58.70%and76.09%,respectively,and MVDaveraged55.59±19.39,Judged by the standard TNM criteria,the rate of expression of iNOS in stageⅣ(84.46%)was higher than those in stageⅠ,Ⅱ,Ⅲ(Fish exact probabilities test,P=0.019,0.023and 0.033,respectively);the rates of expression of VEGFin stage Ⅲ,Ⅳ(76.0%,92.31%,respectively)were higher than those in stageⅠ,Ⅱ(Fis exact probabilities test,P=0.031,0.017,0.022and0.019).MVDs in stageⅢ,Ⅳ(64.72±14.96,67.09±18.29,respectively)were higher than those in stageⅠ,Ⅱ(t\2.378,4.015,2.503and2.450,P<0.05,P<0.001,P<0.001,P<0.05,respectively),In37gastric carcinoma specimens with lymph node metastasis,MVD(68.69±18.07)and the rates of expression of iNOS and VEGF(70.27%,83.78%,respectively)were higher than those in the specimens with absence of metastasis(t=2.205,X^2=6.3587,X^2=6.2584,P<0.01,P<0.05,P<0.05,respectively),MVD and the expressions of iNOS and EGF were not correlated to the location,size or grade of tumor,nor with the depth of invasion of tumor;MVDs in the positive iNOS and VEGF specimens(59.88±18.02,58.39±17.73,repectively)were higher than those in the negative iNOS and VEGF specimens(X^2=6.3587and 6.1574,P<0.05,P<0.05,respectively);thus the expressions of iNOS and VEGF was correlated to MVD,but the expression of iNOS was not correlated to that of VEGF,In addition.of the 46 surviving patients,the 5-year survival rate of patients with positive iNOS or VEGF tumors was significantly less than that of patients with negative iNOS-or VEGF tumors(X^2=4.3842and 5.4073,P<0.05,P<0.05.respectively).CONCLUSION:The expressions of iNOS and VEGF are colosely related to tumor angiogenesis,and are involved in the advancement and the lymph node metastasis;thusMVD and the expressions of iNOS and EGF may serve indexes for evaluating staging of gastric carcinoma and forecasting its risk of metastasis,which will help establish a comprehensive therapeutical measure of post-operative patients and provide a new approach to tumor therapy. | Zheng-Jun Song Ping Gong Yu-E Wu Department of Gastroenterology,First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,ShaanXi Province,China | 2002 | World Journal of Gastroenterology2002，8，4： | 87 |
| 2 | Emission inventories of primary particles and pollutant gases for China显示文摘Detailed high-resolution emission inventories of primary particles(PM2.5,BC and OC) and pollutant gases(SO2,NOx,NH3,CO and VOCs) for China in 2007 were constructed on the basis of the latest fuel consumption data,mostly at the county level,and from socio-economic statistics and data on fossil and biomass fuels obtained from government agencies.New emission factors reflecting local features were also used.The calculated emissions were 13.212 Mt PM2.5,1.4 Mt BC,2.946 Mt OC,31.584 Mt SO2,23.248 Mt NOx,16.017 Mt NH3,164.856 Mt CO and 35.464 Mt VOCs.The national and regional emissions were gridded with 0.5°× 0.5° resolution for use in air quality models.Larger emissions were found in eastern and central China than in western China.The emissions estimated here are roughly equal to those obtained in previous studies,but with different contributions from because of seasonal changes in residential heating and biomass combustion.Finally,uncertainties in inventories were analyzed. | CAO GuoLiang ZHANG XiaoYe GONG SunLing AN XinQin WANG YaQiang | 2011 | Chinese Science Bulletin2011，56，8： | 64 |
| 3 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 4 | Assessment of duodenogastric reflux by combined continuous intragastric pH and bilirubin monitoring显示文摘AIM: To assess the diagnostic value of a combination of continuous intragastric pH and bilirubin monitoring in the detection of duodenogastric reflux (DGR), and the effects of diet on the bilirubin absorbance.METHODS: 30 healthy volunteers were divided into twogroups: standard diet group (Group 1) 18 cases, free diet group (Group 2) 12 cases. Each subjects were subjected to simultaneous 24 hour intragastric pH and spectrophotometric bilirubin concentration monitoring (Bilitec 2000).RESULTS: There was no difference of preprandial phasebilirubin absorbance between two groups. The absorbanceof postprandial phase was significantly increased in group 2than group 1. There was no difference between preprandialphase and postprandial phase absorbance in group 1.Postprandial phase absorbance was significantly higher ingroup 2. In a comparison of bile reflux with intragastric pHduring night time, there were 4 types of reflux:Simultaneous increase in absorbance and pH in only 19.6%, increase in bilirubin with unchanged pH 33. 3 %, pHincrease with unchanged absorbance 36. 3 %, and bothunchanged in 10. 8 %. Linear regression analysis showed nocorrelation between percertage total time of pH < 4 aridpercentage total time of absortance > 0. 14, r=0.068, P<0.05.CONCLUSION: Because of the dietary effect, highabsorbance fluids or foods should be avoided in detection.Intrsgastric pH and bilirubin monitoring separately predictthe presence of duodenal (and/or pancreatic) reflux and bilereflux. They can not substitute for each other. The detectionof DGR is improved if the two parameters are combinedsimultanoously. | Fei Dai Jun Gong Ru Zhang Jin-Yan Luo You-Ling Zhu Xue-Qin Wang,Department of Gastroenterology,Second Hospital of Xi’ an Jiaotong University,Xi’an 710004,Shaanxi Province,China | 2002 | World Journal of Gastroenterology2002，8，2： | 30 |
| 5 | Memetic computation based on regulation between neural and immune systems: the framework and a case study显示文摘Lamarckian learning has been introduced into evolutionary computation to enhance the ability of local search. The relevant research topic, memetic computation, has received significant amount of interest. In this study, a novel memetic computational framework is proposed by simulating the integrated regulation between neural and immune systems. The Lamarckian learning strategy of simulating the unidirectional regulation of neural system on immune system is designed. Consequently, an immune memetic algorithm based on the Lamarckian learning is proposed for numerical optimization. The proposed algorithm combines the advantages of immune algorithms and mathematical programming, and performs well in both global and local search. The simulation results based on ten low-dimensional and ten high-dimensional benchmark problems show that the immune memetic algorithm outperforms the basic genetic algorithm-based memetic algorithm in solving most of the test problems. | GONG MaoGuo , JIAO LiCheng, LIU Fang & YANG Jie Key Lab of Intelligent Perception and Image Understanding of Ministry of Education of China, Institute of Intelligent Information Processing, Xidian University, Xi’an 710071, China | 2010 | Science China(Information Sciences)2010，53，8： | 16 |
| 6 | Evaluation on the accuracy of digital elevation models显示文摘There is a growing interest in investigating the accuracy of digital elevation model (DEM). However people usually have an unbalanced view on DEM errors. They emphasize DEM sampling errors, but ignore the impact of DEM resolution and terrain roughness on the accuracy of terrain representation. This research puts forward the concept of DEM terrain representation error (Et) and then investigates the generation, factors, measurement and simulation of DEM terrain representation errors. A multi-resolution and multi-relief comparative approach is used as the major methodology in this research. The experiment reveals a quantitative relationship between the error and the variation of resolution and terrain roughness at a global level. Root mean square error (RMS Et) is regressed against surface profile curvature (V) and DEM resolution (R) at 10 resolution levels. It is found that the RMS Et may be expressed as RMS Et = (0.0061 ( V+ 0.0052) ( R - 0.022 ( V + 0.2415. This result may be very useful in forecasting DEM accuracy, as well as in determining the DEM resolution related to the accuracy requirement of particular application. | TANG Guo-an~1, Josef Strobl~2, GONG Jian-ya~3, ZHAO Mu-dan~1, CHEN Zhen-jiang~1 (1. Department of Geography, Northwest University, Xi’an 710069, China 2. Department of Geography and Geoinformation, Salzburg University, Hellbrunnerstr. 34, A-5020 Salzb | 2001 | Journal of Geographical Sciences2001，11，2： | 13 |
| 7 | Anti-HBV effect of TAT-HBV targeted ribonuclease显示文摘AIM: To prepare and purify TAT-HBV targeted ribonuclease fusion protein, evaluate its transduction activity and investigate its effect on HBV replication in 2.2.15 cells.METHODS: The prokaryotic expression vector pTAT containing TR gene was used in transforming E. coli BL21(DE3) LysS and TR was expressed with the induction of IPTG. The TAT-TR fusion protein was purified using Ni-NTA-agrose and PD-10 desalting columns, and analyzed by SDSPAGE. Transduction efficiency of TAT-TR was detected with immunofluorescence assay and the concentration of HBeAg in the supernatant of the 2.2.15 cells was determined via solid-phase radioimmunoassay (spRIA). MTT assay was used to detect the cytotoxicity of TAT-TR.RESULTS: The SDS-PAGE showed that the TAT-TR fusion protein was purified successfully, and the purity of TAT-TR was 90 %. The visualization of TAT-TR by immunofiuorescence assay indicated its high efficiency in transducing 2.2.15 cells.RIA result suggests that TAT-TR could inhibit the replication of HBV effectively, it didn′t affect cell growth and had no cytotoxicity.CONCLUSION: TAT-TR possesses a significant anti-HBV activity and the preparation of TAT-TR fusion protein has laid the foundation for the use of TR in the therapeutic trial of HBV infection. | Jin Ding Jun Liu Cai-Fang Xue Wei-Dong Gong Ying-Hui Li Ya Zhao Department of Etiology,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China | 2003 | World Journal of Gastroenterology2003，9，7： | 12 |
| 8 | 军队战时饮用水卫生标准显示文摘军队战时饮用水卫生标准(GJB651-89)规定了军队战时饮用的水质标准,及对水源选择、卫生防护、水质检验的要求。适用于军队战时饮水期为7天(军用毒剂染毒时3天以内)或90天以内各种给水方式的饮用水水质要求;也适用于军队平时行军、野营及其它野外条件的饮用水的水质要求。水质标准对27项指标规定了限量值,是按60kg体重的健康成人,每人每天饮水量为5L,饮水期限为7天或9o天而制定的。 | Hou Yue Jiang Xingjing Zhuo Jianbo Shi Peicai Gong Shuming(Department of Military Hygiene,The Fourth Military Medical University,Xi’an) | 1994 | 解放军预防医学杂志1994，12，2： | 10 |
| 9 | Total mesopancreas excision for pancreatic head cancer: analysis of 120 cases显示文摘Objective: To evaluate the feasibility and safety of total mesopancreas excision(TMpE) in the treatment of pancreatic head cancer. Methods: The clinical and pathological data of 120 patients with pancreatic head cancer who had undergone TMpE in our center from May 2010 to January 2014 were retrospectively analyzed. Results: The mean operative time was(275.0±50.2) min and the average intra-operative blood loss was(390.0±160.5) mL. Post-operative complications were reported in 45 patients, while no peri-operative death was noted. The specimen margins were measured in three dimensions, and 86 patients(71.6%) achieved R0 resection. Conclusions: TMpE is safe and feasible for pancreatic head cancer and is particularly helpful to increase the R0 resection rate. | Wenguang Wu Xu'an Wang Xiangsong Wu Maolan Li Hao Weng Yang Cao Ruifa Bao Sijun Su Jianhua Lu Wei Gong Weibin Shi Jun Gu Xuefeng Wang Yingbin Liu Zhiwei Quan Shuyou Peng | 2016 | Chinese Journal of Cancer Research2016，28，4： | 10 |
| 10 | Treatment of nutcracker syndrome with spermatic vein ligation and iliac vein anastomosis:Case report of three cases显示文摘Three patients with nutcracker syndrome(NCS) were enrolled in the study.Their clinical symptoms mainly included proteinuria and serious varicocele.Color Doppler ultrasound and computed tomography showed that the patients had constricted abdominal aortas,reduced superior mesenteric artery angles,and thinned left renal veins.Patients then underwent left spermatic vein ligation and iliac vein anastomosis.They were checked tliree months after their operation,and results showed that their sperms were improved and their proteinuria disappeared. The color Doppler ultrasound showed new cycle pathways.NCS clinical manifestations are complicated,and need combination diagnosis of symptoms and auxiliary examination to detennine surgical indications.Ligation of spermatic vein and vein anastomosis can be used to treat NCS. | Xiao-Yong Gong Wei Zheng Hong Du Yi Lei Ya-Hui Xue Chao-Hui Xue Xian-Chao An Gang Zheng | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，11： | 10 |
| 11 | Evidences for vagus nerve in-maintenance of immune balance and transmission of immune information from gut to brain in STM-infected rats显示文摘AIM:To determine whether salmonella Typhimurium(STM) in gastrointestinal tract can induce the functional activation of brain,whether the vagus nerve involves in signaling immune infomation from gastrointestinal tract to brain and how it influences the immune function under natural infection condition.METHODS:Animal model of gastrointestinal tract infection in the rat was established by an intuation of Salmonella Typhimurium(STM) into stomach to minic the condition of natural bacteria infection,Subdiagphragmatic vagotomy was performed in some of the animals 28 days before infection The changes of Fos expression visualized with immunohistochemistry technique in hypothalamic paraventricular nucleus(pVN) and superaoptic nuclesu (SON)were conted.Meanwhilie,the percentage and the Mean Intensities of Flurescent (MIFs)of CD4+ and CD8+ T cells in peripheral blood were measured by using flow cytometry(FCM),and the pathological changes in ileum and mesenteric lymph node were observed in HE stained sections.RESULTS:In bacteria-stimulated groups,inflammatory pathological changes were seen in ileum and mesenteric lymph node,The percentages of CD4+ T cells in peripheral blood were decreased from 43%±4.5%to 34%±4.9%(P<0.5)and MIFs of CD8+ T cells were also decreased from 2.9±0.39to 2.1±0.36(P<0.05)with STM stimulation.All of them proved that our STM-infection model was reliable Fos immunoreactive(Fos-ir) cells in PVN and SON incerased significantly with STM stimulation,from 189±41 to467±62(P<0.05)and from 64±21 to 282±47(P<0.05)individually,which suggested that STM in gastointestinal tract induced the functional activation of brain Subdiagphragmatic vagotomy attenuated FOs expression in PVN and SON induced by STM,from 467±62to 226±45(P<0.05)and from 282±47to 71±19(P<0.05)individually,and restored the decreased percentages of CD4+ T cells induced by STM from 34%±4.9% to original level 44%±6.0%(P<0.05).In addition,subdiagphragmatic vagotomy itself also decreased the percentages of CD8+ T cells (from 28%±3.0%to 21%±5.9%),P<0.05 and MIFs of CD4+(from 6.6±0.6to4.9±1.0P<0.05)and CD8+ T cells (from 2.9±0.39to 1.4±0.34,P<0.05).Both of them manifested the important role of vagus nerve in transmitting immune information from gut to brain and maintaining the immune balance of the organism.CONCLUSION:Vagus nerve dose involve in transmitting adbominal immune informaton into the brain in STM infection condition and play an important role in maintenance of the immune balance of the oranism. | Xi Wang Bai-Ren Wang Zhen Xu Yu-Qiang Ding Gong Ju,Institute of Neuroscience,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China Xi-Jing Zhang,Department of Anesthesiology,Xi Jing Hospital,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China | 2002 | World Journal of Gastroenterology2002，8，3： | 10 |
| 12 | Effect of a single oral dose of rabeprazole on nocturnal acid breakthrough and nocturnal alkaline amplitude显示文摘AIM: To study the effect of rabeprazole (RAB) on nocturnal acid breakthrough (NAB) and nocturnal alkaline amplitude (NAKA) and to compare it with omeprazole (OME) and pantoprazole (PAN).METHODS: By an open comparative study, forty patients with active peptic ulcer were randomly assigned to receive one of the three PPIs (proton pump inhibitor) with a single oral dose. They were divided into RAB group (10 mg), OME group(20 mg) and PAN group (40 mg). Twenty healthy volunteers were enrolled to the control group (without taking any drug). Intragastric pH monitoring was then performed 1 hour before and 24 hours after the dose was given.RESULTS: No clinically undesirable signs and symptoms possibly attributed to the administration of RAB or OME and PAN were recognizable throughout the study period. All subjects completed the study according to the protocol. All data were processed by a computer using the Student ttest or t' test followed by an analysis of covariance. P<0.05 was considered to have statistical significance. The intragastric pH of NAB was significantly higher in RAB group (1.84±0.55) than in either OME group (1.15±0.31) or PAN group (1.10±0.30) (both P<0.01). RAB produced a longer sustaining time (4.65±1.22 h) on NAKA than OME (3.22±1.89 h) (P<0.05),PAN (3.15±1.92 h) (P<0.05), and the sustaining time of NAKA in RAB group was longer than that in the healthy control group (P<0.01) too. In addition, RAB produced a much higher pH on NAKA (6.41±0.45) in comparison with PAN (6.01±0.92) (P<0.05).CONCLUSION: A single oral dose of 10 mg RAB may increase the pH of NAB and shorten the sustaining time of NAB, and it may increase the pH of NAKA as well as prolong the sustaining time of NAKA. | Jin-Yan Luo Chun-Yan Niu Xue-Qin Wang You-Ling Zhu Jun Gong, Department of Gastroenterology, The Second Hospital of Xi’an Jiaotong Uuniversity, Xi’an 710004, Shanxi Province, China | 2003 | World Journal of Gastroenterology2003，9，11： | 9 |
| 13 | A 'Yellow Cap' on Quaternary Red Clay in Jiujiang,Jiangxi Province显示文摘A thin layer of yellow-brown-colored earth was generally found on Quaternary red clay in Jiujiang,Jiangxi Province. A typical profile was established. Both particle size distribution and REE (rare earthelements) characteristics of the yellow-brown-colored earth of the profile fully suggested its aeolian origin andclose similarity to Naming Xiashu loess. The study also implied aeolian origin of the underlying Quaternaryred clap Compared with the red clay, the yellow- brown- colored earth was less weathered because of its lowercontent of free iron and higher mole ratios of SiO2/A12O3 and SiO2/(Fe2O3+A12O3 ) as well as its lessdeveloped chemical microtextures of quartz grains.In order to study the aged of the two deposits comparatively, the thermoluminescent dating method wasused. As a result, the bottom of the yellow-brown-colored esrth was dated to 6015 ka B. P. and the upperpart of the red clay 38854 ka B. P. It was suggested that the yellow- browm- colored earth was formed inthe Late Pleistocene and was probably the aeolian deposit of the Last Glacial, which corresponded with theMalan loess in the Loess Plateau of the northwestern part of China; while the underlying red clay was formedin the Middle Pleistocene.A 'yellow cap' on Quaternary red clay in Jiujiang implied a great climatic and environmental varistionin the beginning of the Late Pleistocene in the southern pot of China, especially in the middle and lowerreaches of the Yangtze River. The eveal not only halted the rubification, once dominating the region, butalso produced a widespread covering of aeolian deposit, as only occurred in the cold and dry environment. | HU XUEFENG GONG ZITONG(1State Key Laboratory of Loess and Quaternary Geology, the Chinese Academy of Sciences, P. O. Box: 17,xi’an 710054 (China))(2Institute of Soil Science, the Chinese Acodemy of Sciences, P. O. Box 821, Nanjing 210008 (China)) | 1999 | Pedosphere1999，9，4： | 9 |
| 14 | Heavy Ion Beams Induce Survivin Expression in Human Hepatoma SMMC-7721 Cells More Effectively than X-rays显示文摘高线性的精力转移(让)重离子放射在导致生物损坏比是更有效的低--让的X光或 y-rays.Heavy 离子横梁在批评癌症织物提供好剂量本地化(布拉格山峰)并且在房间越过剂量山峰杀死给更高相对的生物有效性,那么高--让的重离子横梁比在癌症 treatment.Survivin 的 low-LETradiation 优异作为 apoptosis 蛋白质家庭的禁止者的一个成员,可能帮助癌的房间克服 G_2/M apoptotic 检查点并且在暴露以后在人的 hepatoma SMMC-7721cell 线通过 mitosis.Survivin 表示赞成转变房间的异常前进到低--让的X光检查和高度--让的碳离子照耀在这研究被调查。与X光检查照耀相比,清楚地引起 G_2/M 拘捕并且在剂量依赖者 manner.Clonogenic 幸存试金支持了 survivin 基因的表示的碳离子横梁证明 SMMC-7721 房间对高度更对射线敏感--比到theX光线让碳离子,并且放射敏感度与特定的 survivin 在治疗以后被支持在 transcriptional 和翻译层次的短介入 RNA.Differential survivin 表示被作出对 SMMC-7721 房间列在后面有利的裁决低--并且高--让的照耀。过去 survivinin SMMC-7721 房间的表示可能是癌的房间有辐射抵抗到象高的稠密的电离那样的强壮的刺激的一个重要原因 -- 让的放射。然而,由高度的癌的房间上的直接杀死效果 -- 让的放射可能是比 apoptosis 抑制通过更重要的过去 survivin 的表示后面的重离子照耀。 | Li GONG Xiaodong JIN Qiang LI Jiangtao LIU Lizhe AN | 2007 | Acta Biochimica et Biophysica Sinica2007，39，8： | 9 |
| 15 | Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference显示文摘Mesenchymal stem cells(MSCs)are multipotent stem cells and capable of differentiating into multiple cell types including osteoblastic,chondrogenic and adipogenic lineages.We previously identified BMP9 as one of the most potent BMPs that induce osteoblastic differentiation of MSCs although exact molecular mechanism through which BMP9 regulates osteogenic differentiation remains to be fully understood.Here,we seek to develop a recombinant adenovirus system to optimally silence mouse BMP9 and then characterize the important role of BMP9 in osteogenic differentiation of MSCs.Using two different siRNA bioinformatic prediction programs,we design five siRNAs targeting mouse BMP9(or simB9),which are expressed under the control of the converging H1 and U6 promoters in recombinant adenovirus vectors.We demonstrate that two of the five siRNAs,simB9-4 and simB9-7,exhibit the highest efficiency on silencing exogenous mouse BMP9 in MSCs.Furthermore,simB9-4 and simB9-7 act synergistically in inhibiting BMP9-induced expression of osteogenic markers,matrix mineralization and ectopic bone formation from MSCs.Thus,our findings demonstrate the important role of BMP9 in osteogenic differentiation of MSCs.The characterized simB9 siRNAs may be used as an important tool to investigate the molecular mechanism behind BMP9 osteogenic signaling.Our results also indicate that recombinant adenovirus-mediated expression of siRNAs is efficient and sustained,and thus may be used as an effective delivery vehicle of siRNA therapeutics. | Shujuan Yan Ruyi Zhang Ke Wu Jing Cui Shifeng Huang Xiaojuan Ji Liping An Chengfu Yuan Cheng Gong Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Bo Liu Rex C.Haydon Michael J.Lee Russell R.Reid Jennifer Moriatis Wolf Qiong Shi Hue H.Luu Tong-Chuan He Yaguang Weng | 2018 | Genes & Diseases2018，5，2： | 8 |
| 16 | Fog Computing Dynamic Load Balancing Mechanism Based on Graph Repartitioning显示文摘Because of cloud computing's high degree of polymerization calculation mode, it can't give full play to the resources of the edge device such as computing, storage, etc. Fog computing can improve the resource utilization efficiency of the edge device, and solve the problem about service computing of the delay-sensitive applications. This paper researches on the framework of the fog computing, and adopts Cloud Atomization Technology to turn physical nodes in different levels into virtual machine nodes. On this basis, this paper uses the graph partitioning theory to build the fog computing's load balancing algorithm based on dynamic graph partitioning. The simulation results show that the framework of the fog computing after Cloud Atomization can build the system network flexibly, and dynamic load balancing mechanism can effectively configure system resources as well as reducing the consumption of node migration brought by system changes. | SONG Ningning GONG Chao AN Xingshuo ZHAN Qiang | 2016 | China Communications2016，13，3： | 8 |
| 17 | 安石榴苷对脂多糖诱导奶牛子宫内膜上皮细胞炎症损伤的保护作用(英文)显示文摘目的:评估安石榴苷对脂多糖诱导奶牛子宫内膜上皮细胞炎症损伤的保护作用,并初步探讨其作用机制。创新点:首次证明安石榴苷对脂多糖诱导奶牛子宫内膜上皮细胞炎症损伤具有保护作用,且此作用与核转录因子κB(NF-κB)和丝裂原活化蛋白激酶(MAPK)信号通路的抑制相关。方法:用不同浓度的脂多糖(1、10、30、50和100μg/ml)刺激奶牛子宫内膜上皮细胞3、6、9、12和18 h,筛选出建立炎症损伤的最佳作用浓度和时间。安石榴苷预处理细胞2 h后用脂多糖刺激12 h,用逆转录聚合酶链式反应(RT-PCR)检测炎症因子白细胞介素1β(IL-1β)、白细胞介素6(IL-6)、白细胞介素8(IL-8)及肿瘤坏死因子α(TNF-α)的表达。用蛋白质免疫印迹试验(Western blotting)的方法检测核因子κB抑制蛋白α(IκBα)、磷酸化的p65、p38、c-Jun氨基末端激酶(JNK)和细胞外调节蛋白激酶(ERK)的表达水平。结论:MTT结果显示,30μg/ml脂多糖刺激奶牛子宫内膜上皮细胞12 h能够造成细胞活力下降和形态改变(图2和3)。RT-PCR结果显示,安石榴苷预处理后炎症因子显著降低(图4)。Western blotting结果显示,安石榴苷预处理能显著抑制IκBα降解以及p65、p38、JNK和ERK的磷酸化表达水平(图5和6)。综上所述,安石榴苷对脂多糖诱导奶牛子宫内膜上皮细胞炎症损伤具有保护作用,在治疗奶牛子宫内膜炎中具有重要价值。 | An LYU Jia-jia CHEN Hui-chuan WANG Xiao-hong YU Zhi-cong ZHANG Ping GONG Lin-shu JIANG Feng-hua LIU | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，6： | 8 |
| 18 | Design of a titl angle measurement system based on ADXL345 sensor显示文摘设计了一种基于ADXL345三轴加速度传感器的倾角测量系统。阐述了系统的组成及工作原理,其控制芯片采用超低功耗、高性能单片机MSP430F149。系统通电后,ADXL345输出一个与加速度成正比的电压值,该电压值经传感器内部AD转换器转换成相应的数字信号,而数字信号经MSP430F149处理运算,可转化成倾角值显示在LCD显示屏上。实验表明:与传统的倾角仪相比,该系统结构简单、成本低、功耗小,使用方便,具有较高的灵敏度和响应速度,可满足实际工程应用要求。 | SU Yan-ping GONG Mao-fa AN Bin ZHANG Jian-yu ZHAO Xu-jie | 2014 | Journal of Measurement Science and Instrumentation2014，5，2： | 7 |
| 19 | Acoustic reflection of rib-stiffened double plates coated with a viscoelastic layer显示文摘To predict sound-absorbing performance of anechoic materials,the acoustic reflection problem of a viscoelastic layer backed with periodically rib-stiffened infinite double plates is studied in this paper.The reason why structural theories of plates are not applicable to viscoelastic plates is explained through comparing dispersion and attenuation curves of flexural waves with those of Lamb waves.As a result,(visco-)elastic theory is adopted to deal with(visco-)elastic plates,and ribs are treated by structural theories of plates.The coupling between ribs and plates are solved by Hull's method,and solution of the reflected field is obtained.The accuracy of present method is validated by comparing with the results by the structural theories of plates.The influence of a backing on the acoustic reflection of the viscoelatic layer is analyzed by computing reflection coefficients.Performances of different viscoelastic materials are evaluated by the average reflection coefficients.The computational results show that,influence of a backing on the acoustic reflection cannot be suppressed by the viscoelastic materials in low frequencies.The resonance is determined by the coupling of the fluid layer and the double plates.And ribs,which are coupled with the double plates,mainly reduce the acoustic reflection. | GONG Jiayuan AN Junying MA Li XU Haiting | 2014 | Chinese Journal of Acoustics2014，33，3： | 6 |
| 20 | Dynamic analysis of granite rockburst based on the PIV technique显示文摘This paper describes the deep rockburst simulation system to reproduce the granite instantaneous rockburst process.Based on the PIV(Particle Image Velocimetry)technique,quantitative analysis of a rockburst,the images of tracer particle,displacement and strain fields can be obtained,and the debris trajectory described.According to the observation of on-site tests,the dynamic rockburst is actually a gas–solid high speed flow process,which is caused by the interaction of rock fragments and surrounding air.With the help of analysis on high speed video and PIV images,the granite rockburst failure process is composed of six stages of platey fragment spalling and debris ejection.Meanwhile,the elastic energy for these six stages has been calculated to study the energy variation.The results indicate that the rockburst process can be summarized as:an initiating stage,intensive developing stage and gradual decay stage.This research will be helpful for our further understanding of the rockburst mechanism. | Wang Hongjian Liu Da'an Gong Weili Li Liyun | 2015 | International Journal of Mining Science and Technology2015，25，2： | 6 |
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