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| 1 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 2 | Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders显示文摘孤独性光谱混乱(ASD ) 是有异构的病原学的许多人的神经病学的混乱。E3 ubiquitin (Ub ) 的活动过度 ligase UBE3A,不完全地源自 15q11-q13 拷贝数字变化,为世界范围的 ASD 盒子的 1%-3% 的报道,而是内在的机制遗体描绘了。这里,我们报导 ALDH1A2 的功能, retinoic 酸(RA ) 的限制率的酶合成,被 UBE3A 否定地以一种 ubiquitylation 依赖的方式调整。过多的 UBE3A 剂量被发现损害调停 RA 的 neuronal homeostatic synaptic 粘性。象 ASD 一样症状被 overexpressing UBE3A 在前额的外皮或由一个 ALDH1A 对手的管理在老鼠概括,而 RA 补充显著地减轻了过多的 UBE3A 导致剂量的象 ASD 一样显型。由识别在 ASD 作为内在的机制发信号的减少的 RA,显型连接了到 UBE3A 活动过度,我们的调查结果介绍 ASD 病原学的新远景并且对这逐渐地流行的疾病便于治疗学的开发的一个模式。 | Xingxing Xu Chuanyin Li Xiaobo Gao Kun Xia Hui Guo Yali Li ZijianHao Lei Zhang Daming Gao Chenfan Xu Huatai Xu Zhi-Qi Xiong Zilong Qiu Ling Mei Xiaoduo Xie Kangcheng Ruan Ronggui Hu | 2018 | Cell Research2018，28，1： | 13 |
| 3 | Sodium tungsten bronze(Na_(x)WO_(3))-doped near-infrared-shielding bulk glasses for energy-saving applications显示文摘Tungsten bronze coatings and films have attracted global attention for their applications in near-infrared(NIR)-shielding windows.However,they are unstable in strong ultraviolet,humid heat,alkaline and/or oxidizing environments and are difficult to be coated on glass surfaces with complex shape.Here,we address these limitations by doping sodium tungsten bronze(Na_(x)WO_(3))into bulk glasses using a simple glass melting method.X-ray diffraction,Raman spectroscopy,X-ray photoelectron spectroscopy,TEM and SEM-EDS characterization confirmed the presence of sodium tungsten bronze(Na_(x)WO_(3))functional units inside the 34SiO_(2)-38B_(2)O_(3)-28NaF glass matrix.Because the functional units are well protected by the glass matrix,the fabricated glasses are stable under hot,humid,oxidizing conditions,as well as under ambient conditions,with no change after 360 days.The NIR-shielding performance of these glasses can be adjusted to as high as 100%by varying WO_(x)concentration(2-8 mol%)and quenching temperature(1000-1400℃).With a content of 6 mol%WO_(x)and a quenching temperature of 1000℃,the bulk glass shows 63%transmission of visible light and only 11%transmission of NIR light at 1100 nm.Thermal insulation experiments show that the NIR-shielding performance of the glasses are far superior to commercial soda lime window glass or indium-doped tin oxide(ITO)glass,and comparable to cesium tungsten bronze coated glass.The novel bulk glasses have higher stability,simpler processing,and can be easily made into complex shapes,making them excellent alternative materials for energy-saving glasses. | Guang Yang Yunhang Qi Daming Hu Haochen Wang Hongfei Chen Liangmiao Zhang Chuanxiang Cao Bin Liu Fang Xia Yanfeng Gao | 2021 | Journal of Materials Science & Technology2021，，30： | 3 |
| 4 | Key issues on watershed ecological security assessment显示文摘有关分水岭基于关键问题的分析包括评价的题目,内容,和方法论的生态的安全评价,这篇论文指出那生态的安全应该在不同层次动态地被估计(例如分水岭和生态系统层次) 与是的人一起主要评价题目。功能的安全和结构的安全必须在分水岭被认为生态的安全评价。以便反映分水岭的全面、及时的安全地位, PSR (pressure-state-response ) 方法应该被采用。纵的范围峡区域(LRGR ) 作为一个例子被研究。分水岭的一个索引系统生态的安全评价被建议了,它包括结构的索引,功能的索引,压力和反应索引,并且生态的安全的状态在云南为 LRGR 被分析省。 | GAO JiXI ZHANG XiangHui JIANG Yun OU XiaoKun HE DaMing SHI JianBin | 2007 | Chinese Science Bulletin2007，52，A02： | 3 |
| 5 | Phosphorylation of Rictor at Thr1135 impairs the Rictor/Cullin-1 complex to ubiquitinate SGK1显示文摘The Rictor/mTOR complex plays a pivotal role in a variety of cellular functions including cellular metabolism,cell proliferation and survival by phosphorylating Akt at Ser473 to fully activate the Akt kinase.However,its upstream regulatory pathways as well as whether it has additional function(s)remain largely unknown.We recently reported that Rictor contains a novel ubiquitin E3 ligase activity by forming a novel complex with Cullin-1,but not with other Cullin family members.Furthermore,we identified SGK1 as its downstream target.Interestingly,Rictor,but not Raptor or mTOR,promotes SGK1 ubiquitination.As a result,SGK1 expression is elevated in Rictor^(–/–)MEFs.We further defined that as a feedback mechanism,Rictor can be phosphorylated by multiple AGC family kinases including Akt,S6K and SGK1.Phosphorylation of Rictor at the Thr1135 site did not affect its kinase activity towards phosphorylating its conventional substrates including Akt and SGK1.On the other hand,it disrupted the interaction between Rictor and Cullin-1.Consequently,T1135E Rictor was defective in promoting SGK1 ubiquitination and destruction.This finding further expands our knowledge of Rictor’s function.Furthermore,our work also illustrates that Rictor E3 ligase activity could be governed by specific signaling kinase cascades,and that misregulation of this process might contribute to SGK overexpression which is frequently observed in various types of cancers. | Daming Gao Lixin Wan Wenyi Wei | 2010 | Protein & Cell2010，1，10： | 2 |
| 6 | Regulation of APC^cdh1 E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7显示文摘Fbw7 和 Cdh1 分别地是 SCF 类型和 APC 类型 E3 ubiquitin ligases 的底层识别子单元。新兴的证据由为破坏指向 oncoproteins 作为肿瘤 suppressors 正在建议那 Fbw7 和 Cdh1 功能。Fbw7 的损失,然而并非 Cdh1,经常在各种各样的人的肿瘤被观察。然而, Fbw7 怎么机械学地作为肿瘤 suppressor 工作并且是否在 Fbw7 和 Cdh1 之间有发信号的串音,仍然保持大部分未知。这里,我们报导那 Fbw7 缺乏的房间不仅显示 SCF Fbw7 底层包括 cyclin E,而且增加了各种各样的 APC Cdh1 底层。我们进一步把 cyclin E 定义为 Fbw7 由管理 APC Cdh1 活动,在 Fbw7 缺乏的房间的 cyclin E 的弄空导致 APC Cdh1 底层到比得上那些的层次在野类型(WT ) 房间。相反地, cyclin E 的宫外的表示概括异常 APC 在 Fbw7 缺乏的房间观察的 Cdh1 底层表示。更重要地,对 Cdk2/cyclin 电子 mediated phosphorylation 抵抗的 4A-Cdh1,然而并非 WT-Cdh1,颠倒了各种各样的 APC 在 Fbw7 缺乏的房间的 Cdh1 底层。4A-Cdh1 的 Overexpression 也导致了延迟的房间生长并且减少抛锚无关的殖民地形成。总的来说,我们识别了 Fbw7 以一种 cyclin 电子依赖者方式由管理 Cdh1 活动的新奇规章的机制。作为结果, Fbw7 的损失能在两 SCF Fbw7 和 APC Cdh1 底层。我们的学习提供 Fbw7 的肿瘤 suppressor 功能的更好的理解,并且建议禁止者能为治疗 Fbw7 缺乏的肿瘤作为有效治疗学的代理人服务的那 Cdk2/cyclin E。 | Alan WLau Hiroyuki Inuzuka Hidefumi Fukushima LixinWan Pengda Liu Daming Gao Yi Sun Wenyi Wei | 2013 | Cell Research2013，23，7： | 1 |
| 7 | Isobaric vapor-liquid equilibria for binary and ternary mixtures of propanal, propanol, and propanoic acid 显示文摘 | GAO Daming ZHU Dechun ZHANG Lingyun | 2010 | J Chem Eng Data2010，55，12： | 1 |
| 8 | Significant VectorLearning to Construct Sparse Kernel Regression Models显示文摘 | Gao Junbin Shi Daming Liu Xiaomao | 2007 | NeuralNetworks2007，20，7： | 1 |
| 9 | Obesity paradox: Clinical benefits not observed in obese patients with ST-segment elevation myocardial infarction: A multicenter, prospective, cohort study of the northern region of China显示文摘 | Yuze Li Chunwei Wu Yujiao Sun Daming Jiang Bo Zhang Lina Ren Yuan Gao Haijie Yu Guang Yang Qigang Guan Wen Tian Haishan Zhang Liang Guo Guoxian Qi | 2013 | International Journal of Cardiology2013，，： | 1 |
| 10 | Preparation of molecularly imprinted polymer nanoparticles for selective removal of fluoroquinolone antibiotics in aqueous solution 显示文摘 | Feng Tana Daming Sun Jinsuo Gao | 2013 | Journal of Hazardous Materials2013，，： | 1 |
| 11 | Proteomics of adjacent-to-tumor samples uncovers clinically relevant biological events in hepatocellular carcinoma显示文摘Normal adjacent tissues(NATs)of hepatocellular carcinoma(HCC)differ from healthy liver tissues and their heterogeneity may contain biological information associated with disease occurrence and clinical outcome that has yet to be fully evaluated at the proteomic level.This study provides a detailed description of the heterogeneity of NATs and the differences between NATs and healthy livers and revealed that molecular features of tumor subgroups in HCC were partially reflected in their respective NATs.Proteomic data classified HCC NATs into two subtypes(Subtypes 1 and 2),and Subtype 2 was associated with poor prognosis and high-risk recurrence.The pathway and immune features of these two subtypes were characterized.Proteomic differences between the two NAT subtypes and healthy liver tissues were further investigated using data-independent acquisition mass spectrometry,revealing the early molecular alterations associated with the progression from healthy livers to NATs.This study provides a high-quality resource for HCC researchers and clinicians and may significantly expand the knowledge of tumor NATs to eventually benefit clinical practice. | Hongwen Zhu Youpei Lin Dayun Lu Shisheng Wang Yuejia Liu Liangqing Dong Qian Meng Jing Gao Yuqiu Wang Nixue Song Yuying Suo Li Ding Pei Wang Bing Zhang Daming Gao Jia Fan Qiang Gao Hu Zhou | 2023 | National Science Review2023，10，8： | 0 |
| 12 | Exploring the underlying biology of cancer and potential therapeutic strategies:a special issue focused on mechanism-based studies显示文摘Cancer,commonly referred to as malignant tumors,is one of the deadliest human diseases.Every year,millions of people die from cancer,and almost as many are newly diagnosed with the disease.Due to its severe impact on both individuals and the economy,cancer research has become one of the most active areas of biomedical research in recent decades.As cancer originates from highly proliferative,invasive,and immune-suppressive transformed cells,understanding the molecular mechanisms that determine the malignant phenotype of cancer cells is crucial for the development of effective cancer therapy.This special issue comprises 10 reviews by experts in basic cancer research and aims at summarizing the up-todate advances in cancer biology from their own perspectives. | Daming Gao Gaoxiang Ge | 2023 | Acta Biochimica et Biophysica Sinica2023，55，6： | 0 |
| 13 | Comparison of spatial-temporal distribution characteristics of water temperatures between Lancang River and Mekong River显示文摘水温度(WT ) 是水身体物理性质的重要指示物之一。在河连续统在 WT 上理解空间时间的变化的特征将帮助开发合理 river-water-resource 利用,以避免可能的生态学危机,并且在深奥区域充分利用自然资源计划。作为在亚洲的最大的国际河连续统, Lancang 湄公河河分区(作为更大的湄公河分区知道,公克) 成为了著名经济、政治、生态的自然领土。这研究检验了 Lancang 河水的空间时间的分发特征。温度,用从 11 的 WT 价值的观察数据,水文学在 1960 年代驻扎。而且, Yunjinghong 水文学之间的 WT 差别驻扎(在中国的一个代表性的车站) 并且 Chiang Saen 水文学车站(在泰国的一个代表性的车站) 被分析。结果显示了那:1 ) 水温度比上面的部分在河连续统的更低的部分是更高的。纬度变化是主要影响因素。这效果比在雨季在旱季是更明显的,在冬季更明显比在夏天,和平均最小的 WT 明显的更多比平均最大的 WT , 2 )之间的 WT 差别上面并且河连续统的更低的部分在研究时期期间由于更低的部分( Chiang Saen 水文学车站)的上面的部分( Yunjinghong 水文学车站)和 WT 的明显的减少的 WT 的小增加是减少。因此, WT 的参数被纬度影响,并且Lancang湄公河河连续统躺在纵贯的方向因此热带水的动物例如热带水的鱼,不能在冬季季节在这河连续统的上面的部分幸存,当时在里面夏天季节,热带水的动物适当地游泳到上面的溪流。更低的湄公河河里的水温度被地区性的水温度和地区性的气候变化主要影响。 | ZHANG YiPing GAO FU HE DaMing LI ShaoJuan | 2007 | Chinese Science Bulletin2007，52，A02： | 0 |
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