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| 1 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 2 | Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders显示文摘孤独性光谱混乱(ASD ) 是有异构的病原学的许多人的神经病学的混乱。E3 ubiquitin (Ub ) 的活动过度 ligase UBE3A,不完全地源自 15q11-q13 拷贝数字变化,为世界范围的 ASD 盒子的 1%-3% 的报道,而是内在的机制遗体描绘了。这里,我们报导 ALDH1A2 的功能, retinoic 酸(RA ) 的限制率的酶合成,被 UBE3A 否定地以一种 ubiquitylation 依赖的方式调整。过多的 UBE3A 剂量被发现损害调停 RA 的 neuronal homeostatic synaptic 粘性。象 ASD 一样症状被 overexpressing UBE3A 在前额的外皮或由一个 ALDH1A 对手的管理在老鼠概括,而 RA 补充显著地减轻了过多的 UBE3A 导致剂量的象 ASD 一样显型。由识别在 ASD 作为内在的机制发信号的减少的 RA,显型连接了到 UBE3A 活动过度,我们的调查结果介绍 ASD 病原学的新远景并且对这逐渐地流行的疾病便于治疗学的开发的一个模式。 | Xingxing Xu Chuanyin Li Xiaobo Gao Kun Xia Hui Guo Yali Li ZijianHao Lei Zhang Daming Gao Chenfan Xu Huatai Xu Zhi-Qi Xiong Zilong Qiu Ling Mei Xiaoduo Xie Kangcheng Ruan Ronggui Hu | 2018 | Cell Research2018，28，1： | 13 |
| 3 | Trends in precipitation over the low latitude highlands of Yunnan, China显示文摘在西南中国的云南的低纬度高地的降水政体服从于在东方亚洲夏天季风和印度夏天之间的相互作用表面山志学的季风,和影响。在它的空间、时间的模式的变化的理解着急地为气候变化设计,水文学影响建模,和地区性、下游的水资源管理被需要。用在最后几十年( 1950s2007 )的低纬度高地的每日的 降水记录, 降水的一个时间系列索引,包括年度 降水,多雨的天的数字,吝啬的年度 降水紧张,雨季的发作的日期, 降水的度和时期季节的集中,最高1天、3天、7天的 降水,和 降水在不同紧张上面为 降水多雨的天总计并且数(例如 10 公里, 25 公里一没有趋势的预先增白的 Mann-Kendall 趋势测试然后被用来检测时间系列数据的趋势。结果证明在年度降水和越过低纬度高地的降水趋势的强壮的季节的区别没有重要趋势。弹簧和冬季正在变得更湿,夏天正在变得更干燥。秋天在东方正在变得更干燥并且在西方更湿。作为后果,降水的 seasonality 稍微正在变弱。雨季和最高的降水的时期的开始趋于更早。同时,低纬度高地也见证不太多雨的天,更强烈的降水,稍微更长中等、重的降水事件,和更经常的极端降水事件。另外,降水趋势的地区性的区别是显著的。这些变化可以与东方亚洲夏天季风变弱并且南方亚洲人夏天季风,以及特殊多山的地面的走廊障碍效果加强被联系。然而,包含的物理机制仍然需要以后被揭开。 | FAN Hui | 2013 | Journal of Geographical Sciences2013，23，6： | 9 |
| 4 | Transboundary eco-security and its regulation system in the Longitudinal Range-Gorge Region显示文摘这份报纸讨论了 transboundary eco 安全问题,他们的分发模式,特征和驱动力,和在纵的范围峡区域(LRGR ) 的规定系统。除了沙灰尘暴风雨,主要 transboundary eco 安全问题能在 LRGR 沿着中国的陆上的边阶区域被发现。直接驱动力包括了串联水力发出的电力水坝,高速公路和国际航行开发的构造,斜坡陆地耕作和矿物质探索。Transboundary eco 安全问题沿着国际水路在陆上的区域,和下游的国家影响附近的区域。在邻国的生态的变化在 LRGR 在国内方面上有效果,例如种类侵略。综合措施应该被考虑,包括边阶 eco 保护工程和 transboundary 自然保护区的构造,生态的阀值安装,种类侵略控制,监视平台的 eco 安全的建立,组成生态的赔偿机制和法律(规则) 并且机构,和能力大楼。在 LRGR 处理 transboundary 问题的最重要的任务是国际性地形成参与合作机制,为 transboundary eco 安全建立资金,实现生态的赔偿策略,并且开发信息交换站台和警告系统。 | HE DaMing LIU Jiang HU JinMing FEN Yan GAN Su | 2007 | Chinese Science Bulletin2007，52，A02： | 4 |
| 5 | Sodium tungsten bronze(Na_(x)WO_(3))-doped near-infrared-shielding bulk glasses for energy-saving applications显示文摘Tungsten bronze coatings and films have attracted global attention for their applications in near-infrared(NIR)-shielding windows.However,they are unstable in strong ultraviolet,humid heat,alkaline and/or oxidizing environments and are difficult to be coated on glass surfaces with complex shape.Here,we address these limitations by doping sodium tungsten bronze(Na_(x)WO_(3))into bulk glasses using a simple glass melting method.X-ray diffraction,Raman spectroscopy,X-ray photoelectron spectroscopy,TEM and SEM-EDS characterization confirmed the presence of sodium tungsten bronze(Na_(x)WO_(3))functional units inside the 34SiO_(2)-38B_(2)O_(3)-28NaF glass matrix.Because the functional units are well protected by the glass matrix,the fabricated glasses are stable under hot,humid,oxidizing conditions,as well as under ambient conditions,with no change after 360 days.The NIR-shielding performance of these glasses can be adjusted to as high as 100%by varying WO_(x)concentration(2-8 mol%)and quenching temperature(1000-1400℃).With a content of 6 mol%WO_(x)and a quenching temperature of 1000℃,the bulk glass shows 63%transmission of visible light and only 11%transmission of NIR light at 1100 nm.Thermal insulation experiments show that the NIR-shielding performance of the glasses are far superior to commercial soda lime window glass or indium-doped tin oxide(ITO)glass,and comparable to cesium tungsten bronze coated glass.The novel bulk glasses have higher stability,simpler processing,and can be easily made into complex shapes,making them excellent alternative materials for energy-saving glasses. | Guang Yang Yunhang Qi Daming Hu Haochen Wang Hongfei Chen Liangmiao Zhang Chuanxiang Cao Bin Liu Fang Xia Yanfeng Gao | 2021 | Journal of Materials Science & Technology2021，，30： | 3 |
| 6 | Solidification phases and their evolution during homogenization of a DC cast Al–8.35Zn–2.5Mg–2.25Cu alloy显示文摘 | Yan Liu Daming Jiang Wenlong Xie Jie Hu Boran Ma | 2014 | Materials Characterization2014，，： | 2 |
| 7 | Methane emissions from double-rice cropping system under conventional and no tillage in southeast China显示文摘 | Daming Li Manqiang Liu Yanhong Cheng Dong Wang Jiangtao Qin Jiaguo Jiao Huixin Li Feng Hu | 2011 | Soil & Tillage Research2011，，2： | 1 |
| 8 | Determination of Prometryne in water and soil by HPLC–UV using cloud-point extraction显示文摘 | Jihai Zhou Jiandong Chen Yanhong Cheng Daming Li Feng Hu Huixin Li | 2009 | Talanta2009，，2： | 1 |
| 9 | Science with the 2.5-meter Wide Field Survey Telescope(WFST)显示文摘The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky. | Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu Wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang Daming Wei Junjie Wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 1 |
| 10 | Suppression of antigen-specific CD4+ T cell activation by SRA/CD204 through reducing the immunostimulatory capability of antigen-presenting cell显示文摘 | Huanfa Yi Daming Zuo Xiaofei Yu Fanlei Hu Masoud Manjili Zhengliang Chen John Subjeck Xiang-Yang Wang | 2012 | Journal of Molecular Medicine2012，，4： | 1 |
| 11 | Methane emissions from double-rice cropping system under conventional and no tillage in southeast China显示文摘 | Daming Li Manqiang Liu Yanhong Cheng Dong Wang Jiangtao Qin Jiaguo Jiao Huixin Li Feng Hu | 2011 | Soil & Tillage Research2011，，2： | 1 |
| 12 | Heating aging behavior of Al–8.35Zn–2.5Mg–2.25Cu alloy显示文摘 | Yan Liu Daming Jiang Bingqing Li Tao Ying Jie Hu | 2014 | Materials and Design2014，，： | 1 |
| 13 | Effect of cooling aging on microstructure and mechanical properties of an Al–Zn–Mg–Cu alloy显示文摘 | Yan Liu Daming Jiang Bingqing Li Wenshu Yang Jie Hu | 2013 | Materials and Design2013，，： | 1 |
| 14 | Fish Assemblage Responses to a Low-head Dam Removal in the Lancang River显示文摘Dam removal is becoming an effective approach for aquatic biodiversity restoration in damming river in order to balance the aquatic ecosystem conservation with large-scale cascade damming. However, the effects of dam removal on fish communities in Asian mountainous rivers, which are dominated by Cypriniformes fishes, are still not well known. To determine whether dam removal on a mountainous river benefit restoration of fish diversity, we investigated the response of fish assemblage to dam removal using a before-after-control-impact design in two tributaries of the Lancang River(dam removal river: the Jidu River, and control river: the Fengdian River). Fish surveys were conducted one year prior to dam removal(2012) and three years(2013–2015) following dam removal. We observed rapidly and notably spatio-temporal changes in fish biodiversity metrics and assemblage structure, occurring in the Jidu River within the first year after dam removal. Overall, fish species richness, density and Shannon-Wiener diversity all increased immediately in above-and below-dam sites, and maintained a stable level in subsequent years, compared to unchanged situation in the control river. All sites in the Jidu River experienced shifts in fish composition after dam removal, with the greatest temporal changes occurred in sites below-and above-the former dam, resulting in a temporal homogenization tendency in the dam removed river. These findings suggest that dam removal can benefit the recovery of habitat conditions and fish community in Asian mountainous rivers, but the results should be further evaluated when apply to other dammed rivers since the dam age, fluvial geomorphology and situation of source populations could all affect the responses of fish assemblages. | DING Chengzhi JIANG Xiaoming WANG Lieen FAN Hui CHEN Liqiang HU Jinming WANG Hailong CHEN Yifeng SHI Xiaotao CHEN Hao PAN Bohui DING Liuyong ZHANG Chao HE Daming | 2019 | Chinese Geographical Science2019，29，1： | 1 |
| 15 | Distribution and Susceptibility Assessment of Collapses and Landslides in the Riparian Zone of the Xiaowan Reservoir显示文摘The southwest alpine gorge region is the major state base of hydropower energy development in China and hence planned many cascading hydropower stations. After the reservoir impoundment, the intense water level fluctuations under the interaction of cascade dams operating and the mountainous flooding, usually cause bank collapse, landslide and debris flow hazards. The Xiaowan reservoir(XWR), for example, as the ‘dragon head' meg reservoir located in the middle mainstream of Lancang River, have resulted in a series of geohazards during its building and operating. In this study, we investigated the number and surface area of collapses and landslides(CLs) occurred in the water level fluctuations zone(WLFZ) of XWR using remote sensing images of Gaofen-1 and Google Earth; evaluated the CLs susceptibility using information value method. The results presented that the total WLFZ area of 87.03 km2 and 804 CLs masses with a total area of 1.98 km2 were identified in the riparian zone of XWR. CLs mainly occurred at an elevation of 1190–1240 m, and the CLs density increased with an increase in altitude. The WLFZ with a slope gradient of 25°– 45° is the main CLs distribution area that accounts for more than half of the total CLs area. The susceptibility assessment revealed that high and very high susceptibility zones are generally distributed along zones with an elevation of 1210–1240 m, a slope degree of 25°–45° and a slope aspect perpendicular to the direction of Lancang River. Furthermore, these susceptible zones are close in distance to the dam site and tend to be in the riparian zones with the formation lithology of Silurian strata. These results provide a valuable contribution to prevent and control geohazards in the XWR area. Moreover, this study offers a constructive sample of geohazards assessment in the riparian zone of large reservoirs throughout the mountains of southwest China. | ZHONG Ronghua HE Daming HU Jinming DUAN Xingwu HUANG Jiangcheng CHENG Xupeng | 2019 | Chinese Geographical Science2019，29，1： | 1 |
| 16 | A Design of 220 kV Line Protection Action Deduction System Based on Numerical Simulation显示文摘Accurate conditions monitoring and early wrong action warnings of relay protection in the Smart Substation is the basic guarantee to realize the normal operation of primary and secondary system of the power grid.At present,the traditional operation and maintenance monitoring methods of relay protections have poor timeliness,while some automatic monitoring methods have insufficient early warning performance,and lack the online action deduction function independent of the actual device.In this paper,a design method of integrated action deduction system including protection logic reasoning and software and hardware operation condition is proposed.The system can receive real-time operation information of protection online,simulate different types of faults,and output the recording information of sub modules belongs to the action deduction system.It can realize the online monitoring of device faults such as deducing the correctness of setting values at a certain time in the future,giving the wrong action warnings and predicting the probability of them as well,which effectively improves the operation and maintenance efficiency of the secondary system in the intelligent substation. | Tiecheng Li Qingquan Liu Hui Fan Xianzhi Wang Daming Zhou Junan Guo Lee Li Kun Zhou Yujie Hu | 2022 | Energy Engineering2022，119，5： | 0 |
| 17 | Microstructure Evolution of Rapidly Solidified Ti_3Al-2Nb Alloy显示文摘It has been found from the analysis of X-ray diffraction and the observation of TEM that the metastable ordered orthorhombic martensite phase in the rapidly solidified Ti3Al-2Nb alloy transforms to various phases at different aging temperatures. When the alloy aged at temperature of 500℃ for 20 min, the phase decomposition into B2 and O phases is related to the stressin the alloy. When the aged temperature above 600℃, the phase transforms to α2 phase by both shearing and chemical | Rui XU Yuyou CUI Dong LI and Zhuangqi HU (State Key Lab. of RSA, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China)Daming XU and Qingchun LI (Dept. of Materials Science and Technology, Harbin Institute of Technology, Harb | 1996 | Journal of Materials Science & Technology1996，12，2： | 0 |
| 18 | Proteomics of adjacent-to-tumor samples uncovers clinically relevant biological events in hepatocellular carcinoma显示文摘Normal adjacent tissues(NATs)of hepatocellular carcinoma(HCC)differ from healthy liver tissues and their heterogeneity may contain biological information associated with disease occurrence and clinical outcome that has yet to be fully evaluated at the proteomic level.This study provides a detailed description of the heterogeneity of NATs and the differences between NATs and healthy livers and revealed that molecular features of tumor subgroups in HCC were partially reflected in their respective NATs.Proteomic data classified HCC NATs into two subtypes(Subtypes 1 and 2),and Subtype 2 was associated with poor prognosis and high-risk recurrence.The pathway and immune features of these two subtypes were characterized.Proteomic differences between the two NAT subtypes and healthy liver tissues were further investigated using data-independent acquisition mass spectrometry,revealing the early molecular alterations associated with the progression from healthy livers to NATs.This study provides a high-quality resource for HCC researchers and clinicians and may significantly expand the knowledge of tumor NATs to eventually benefit clinical practice. | Hongwen Zhu Youpei Lin Dayun Lu Shisheng Wang Yuejia Liu Liangqing Dong Qian Meng Jing Gao Yuqiu Wang Nixue Song Yuying Suo Li Ding Pei Wang Bing Zhang Daming Gao Jia Fan Qiang Gao Hu Zhou | 2023 | National Science Review2023，10，8： | 0 |
| 19 | Correlation of cooperatively localized rearrangement on the 'fluidized domain' in glass substances (or polymers) to their fragility Ⅲ:Theory of dynamic fragility at isochoric state显示文摘A set of universal equations on the reduced stress relaxation modulus with K-W-W stretched exponential function has been derived from the dynamics of α and β structural relaxation processes. In the present work, the K-W-W decay function is used to define the three types of relaxations (single α, single β relaxation and α-β co-relaxation), then their average times of relaxation are theoretically calculated from the reduced shear stress relaxation modulus and the relaxation time spectrum function H(τ). When the average time of co-relaxation, the reference temperatures (ficitive Tf and glass transition Tg) and the isostructural parameter achieved from the conditions of isostructural glass state are introduced into the reduced shear stress relaxation modulus (GT) under the equilibrium state, a set of correlations between isochoric fragility index (mvα, mvβ and mvαβ) and the coupling strength (α and β) under the reference temperatures are derived from the exact definition of isochoric fragility. So the theory of dynamic fragility for glass substances at isochoric state is developed. The theory can predict the following main features of structural relaxations and behavior of isochoric fragility: the temperature dependence of peak relaxation frequency exhibits a bifurcation with a pair of single α and single β relaxations; the temperature dependence of Stickel equation on 1/T exhibits two crossovers with VFTH(1) and VFTH(2) at the temperatures of Tf and Tg regime; there are two linear correlations between isochoric fragility index (mvα and mvβ) and the coupling strength. Fine agreements between the theoretical calculation and experimental results are obtained. | JIN Yan SONG MingShi HU GuiXian WU DaMing | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，3： | 0 |
| 20 | Flexible Strain Sensor Based on 3D Electrospun Carbonized Sponge显示文摘Flexible strain sensor has attracted much attention because of its potential application in human motion detection.In this work,the prepared strain sensor was obtained by encapsulating electrospun carbonized sponge(CS)with room temperature vulcanized silicone rubber(RTVS).In this paper,the formation mechanism of conductive sponge was studied.Based on the combination of carbonized sponge and RTVS,the strain sensing mechanism and piezoresistive properties are discussed.After research and testing,the CS/RTVS flexible strain sensor has excellent fast response speed and stability,and the maximum strain coefficient of the sensor is 136.27.In this study,the self-developed CS/RTVS sensor was used to monitor the movements of the wrist joint,arm elbow joint and fingers in real time.Research experiments show that CS/RTVS flexible strain sensor has good application prospects in the field of human motion monitoring. | He Gong Zilian Wang Zhiqiang Cheng Lin Chen Haohong Pan Daming Zhang Tianli Hu Thobela Louis Tyasi | 2022 | Computers, Materials & Continua2022，，12： | 0 |
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