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| 1 | Dendritic Cells Transduced with SOCS1 Gene Exhibit Regulatory DC Properties and Prolong Allograft Survival显示文摘SOCS1 is a key regulator of cytokine signaling and is important for maintaining balance in the immune system. It is thought to participate in negative feedback loops in cytokine signaling and may be an important signal for the regulation of dendritic cell (DC) maturation. However, it remains unclear whether DCs transduced with SOCS1 exhibit characteristics of regulatory DCs and induce allogeneic T-cell hyporesponsiveness. In this study, we constructed adenoviral vector coding SOCS1 (Ad-SOCS1) that can efficiently increase SOCS1 gene expression in bone marrow-derived dendritic cells. DCs transduced with Ad-SOCS1 (DC-SOCS1) expressed low levels of costimulatory and MHC molecules, were resistant to maturation and activation stimulation, induced allogeneic T-cell hyporesponsiveness, and promoted the generation of regulatory-like T cells in vitro. DC-SOCS1 pretreatment significantly prolonged the survival of allografts and led to a substantial increase in the generation of regulatory T cells. Our data suggest that SOCS1 inhibits DC maturation and induces regulatory DC generation, therefore possessing therapeutic potential to prevent rejection in organ transplantation. | Hong Fu Shaohua Song Fang Liu Zhijia Ni Xiaoyun Shen Liang Xiao Guoshan Ding Quanxing Wang | 2009 | Cellular & Molecular Immunology2009，6，2： | 20 |
| 2 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 3 | Energy sources identify metabolic phenotypes n pancreatic cancer显示文摘 | Chen Liang Yi Qin Bo Zhang Shunrong Ji Si Shi Wenyan Xu Jiang Liu Jinfeng Xiang Dingkong Liang Qiangsheng Hu Liang Liu Chen Liu Guopei Luo Quanxing Ni Jin xu Xianjun Yu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 3 |
| 4 | Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment显示文摘 | Feng Yang Chen Jin Dong Yang Yongjian Jiang Ji Li Yang Di Jianhua Hu Changchun Wang Quanxing Ni Deliang Fu | 2011 | European Journal of Cancer2011，，12： | 2 |
| 5 | Pancreatic adenocarcinoma: dynamic 64-slice helical CT with perfusion imaging显示文摘 | Jin Xu Zonghui Liang Sijie Hao Li Zhu Maskay Ashish Chen Jin Deliang Fu Quanxing Ni | 2009 | Abdominal Imaging2009，，6： | 2 |
| 6 | Meehansis of multipleorgan damages in acute necrotizing panereatitis显示文摘 | Ni Quanxing Caiduan | 2001 | Chinese Medical Jomal2001，114，7： | 1 |
| 7 | Metabolic tumor burden is associated with major oncogenomic alterations and serum tumor markers in patients with resected pancreatic cancer显示文摘 | Si Shi Shunrong Ji Yi Qin Jin Xu Bo Zhang Wenyan Xu Jiang Liu Jiang Long Chen Liu Liang Liu Quanxing Ni Xianjun Yu | 2015 | Cancer Letters2015，，2： | 1 |
| 8 | Mechanisms of multiple organ damages in acute necrotizing pancreatitis显示文摘 | Zhang Qunhai Ni Quanxing Cai Duan | 2001 | Chin Med J (Engl)2001，114，7： | 1 |
| 9 | Pancreatic adenocarcinoma: dynamic 64-slice helical CT with perfusion imaging显示文摘 | Jin Xu Zonghui Liang Sijie Hao Li Zhu Maskay Ashish Chen Jin Deliang Fu Quanxing Ni | 2009 | Abdominal Imaging2009，，6： | 1 |
| 10 | Blood Neutrophil–Lymphocyte Ratio Predicts Survival in Patients with Advanced Pancreatic Cancer Treated with Chemotherapy显示文摘 | Guopei Luo Meng Guo Zuqiang Liu Zhiwen Xiao Kaizhou Jin Jiang Long Liang Liu Chen Liu Jin Xu Quanxing Ni Xianjun Yu | 2015 | Annals of Surgical Oncology2015，，： | 1 |
| 11 | Molecular Mechanism Underlying Lymphatic Metastasis in Pancreatic Cancer显示文摘 | Zhiwen Xiao Guopei Luo Chen Liu Chuntao Wu Liang Liu Zuqiang Liu Quanxing Ni Jiang Long Xianjun Yu Sonshin Takao | 2014 | BioMed Research International2014，，： | 1 |
| 12 | Molecular Mechanism Underlying Lymphatic Metastasis in Pancreatic Cancer显示文摘 | Zhiwen Xiao Guopei Luo Chen Liu Chuntao Wu Liang Liu Zuqiang Liu Quanxing Ni Jiang Long Xianjun Yu Sonshin Takao | 2014 | BioMed Research International2014，，： | 1 |
| 13 | Glutamine deprivation induces ferroptosis in pancreatic cancer cells显示文摘Ferroptosis is a type of programmed cell death closely related to amino acid metabolism.Pancreatic cancer cells have a strong dependence on glutamine,which serves as a carbon and nitrogen substrate to sustain rapid growth.Glutamine also aids in self-protection mechanisms.However,the effect of glutamine on ferroptosis in pancreatic cancer remains largely unknown.Here,we aim to explore the association between ferroptosis and glutamine deprivation in pancreatic cancer.The growth of pancreatic cancer cells in culture media with or without glutamine is evaluated using Cell Counting Kit-8.Reactive oxygen species(ROS)are measured by 2′,7′-dichlorodihydrofluorescein diacetate staining.Ferroptosis is assessed by BODIPY-C11 dye using confocal microscopy and flow cytometry.Amino acid concentrations are measured using ultrahigh-performance liquid chromatography-tandem mass spectrometry.Isotope-labelled metabolic flux analysis is performed to track the metabolic flow of glutamine.Additionally,RNA sequencing is performed to analyse the genetic alterations.Glutamine deprivation inhibits pancreatic cancer growth and induces ferroptosis both in vitro and in vivo.Additionally,glutamine decreases ROS formation via glutathione production in pancreatic cancer cells.Interestingly,glutamine inhibitors(diazooxonorleucine and azaserine)promotes ROS formation and ferroptosis in pancreatic cancer cells.Furthermore,ferrostatin,a ferroptosis inhibitor,rescues ferroptosis in pancreatic cancer cells.Glutamine deprivation leads to changes in molecular pathways,including cytokine-cytokine receptor interaction pathways(CCL5,CCR4,LTA,CXCR4,IL-6R,and IL-7R).Thus,exogenous glutamine is required for the detoxification of ROS in pancreatic cancer cells,thereby preventing ferroptosis. | Zhiwen Xiao Shengming Deng He Liu Ruijie Wang Yu Liu Zhengjie Dai Wenchao Gu Quanxing Ni Xianjun Yu Chen Liu Guopei Luo | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
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