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| 1 | Reappraisement and refinement of zircon U-Pb isotope and trace element analyses by LA-ICP-MS显示文摘A protocol was established for simultaneous measurements of zircon U-Pb ages and trace elements by LA-ICP-MS at spot sizes of 16 32 μm.This was accomplished by introducing N 2 into ICP to increase the sensitivity.The obtained U-Pb ages for zircon standards GJ-1,TEMORA and SK10-2 are consistent with the preferred values within about 1% uncertainty (2σ) by simple external calibration against zircon standard 91500.Different data reduction softwares could yield different uncertainties for calculation of U-Pb ages.The commercially available program GLITTER4.4 could apply an improper uncertainty calculation strategy,but it may yield artificial high precisions for single analyses.Our trace element analyses indicate that Si is not an ideal internal standard for zircon when calibrated against the NIST glasses.Calibration against the NIST glasses using Si as an internal standard,a systematic deviation of 10% 30% was found for most trace elements including Zr.However,the trace element compositions of zircon can be accurately measured by calibration against multiple reference materials with natural compositions (e.g.,BCR-2G,BHVO-2G and BIR-1G),or calibration against NIST SRM 610 and using Zr as an internal standard.Analyses of two pieces of GJ-1 demonstrate that it is relatively homogenous for most trace elements (except for Ti). | LIU YongSheng HU ZhaoChu ZONG KeQing GAO ChangGui GAO Shan XU Juan CHEN HaiHong | 2010 | Chinese Science Bulletin2010，55，15： | 1011 |
| 2 | Structure of summer atmospheric boundary layer in the center of Arctic Ocean and its relation with sea ice extent change显示文摘The atmospheric vertical structure and changed characteristics of boundary layer parameters, as well as their relations with sea ice and temperature changes in the center of Arctic Ocean(80°–88°N) are presented by adopting GPS sounding data obtained by the 4th–6th Arctic expeditions of China and NCEP(National Centre for Environmental Prediction) reanalysis data. Obvious differences are observed regarding the tropopause, boundary layer height, temperature inversion, and vertical structure of wind speed and direction in the center Arctic Ocean in the summer of 2012, 2010, and 2014. These differences can be explained by the relations between temperature and changes in sea ice extent in September from 1979 to 2014. In September 2012, the Arctic sea ice extent decreased by 44% an with obvious warming process. In September 2010 and 2014, it decreased by 22.6% and 17% with an obvious cooling process, respectively. A comparison of the two processes shows that sea ice change has a significant influence on the structure of the atmospheric boundary layer. In the recent 30 years, the temperature changes of 1000 and 850 h Pa in the center of the Arctic Ocean have displayed an obvious warming trend and negative correlation with sea ice extent. These changes indicate that the continuous reduction of Arctic sea ice will continue the warming of the troposphere middle layer. | BIAN LinGen DING MingHu LIN Xiang LU ChangGui GAO ZhiQiu | 2016 | Science China Earth Sciences2016，59，5： | 4 |
| 3 | In situ analysis of major and trace elements of anhydrous minerals by LA-ICP-MS without applying an internal standard显示文摘 | Yongsheng Liu Zhaochu Hu Shan Gao Detlef Günther Juan Xu Changgui Gao Haihong Chen | 2008 | Chemical Geology2008，，1： | 3 |
| 4 | Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates显示文摘Emerging SARS-CoV-2 variants and the gradually decreasing neutralizing antibodies over time post vaccination have led to an increase in incidents of breakthrough infection across the world.To investigate the potential protective effect of the recombinant protein subunit COVID-19 vaccine targeting receptor-binding domain(RBD)(PS-RBD)and whole inactivated virus particle vaccine(IV)against the variant strains,in this study,rhesus macaques were immunized with PS-RBD or IV vaccine,followed by a Beta variant(B.1.351)challenge.Although neutralizing activity against the Beta variant was reduced compared with that against the prototype,the decreased viral load in both upper and lower respiratory tracts,milder pathological changes,and downregulated inflammatory cytokine levels in lung tissues after challenge demonstrated that PS-RBD and IV still provided effective protection against the Beta variant in the macaque model.Furthermore,PS-RBD-induced macaque sera possessed general binding and neutralizing activity to Alpha,Beta,Delta,and Omicron variants in our study,though the neutralizing antibody(NAb)titers declined by varying degrees,demonstrating potential protection of PS-RBD against current circulating variants of concern(VOCs).Interestingly,although the IV vaccine-induced extremely low neutralizing antibody titers against the Beta variant,it still showed reduction for viral load and significantly alleviated pathological change.Other correlates of vaccine-induced protection(CoP)like antibody-dependent cellular cytotoxicity(ADCC)and immune memory were both confirmed to be existing in IV vaccinated group and possibly be involved in the protective mechanism. | Qian He Qunying Mao Xiaozhong Peng Zhanlong He Shuaiyao Lu Jialu Zhang Fan Gao Lianlian Bian Chaoqiang An Wenhai Yu Fengmei Yang Yanan Zhou Yun Yang Yanyan Li Yadi Yuan Xujia Yan Jinghuan Yang Xing Wu Weijin Huang Changgui Li Junzhi Wang Zhenglun Liang Miao Xu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 5 | Clinical and functional comparison of dynamic hip screws and intramedullary nails for treating proximal femur metastases in older individuals显示文摘Objective:To compare the outcomes of dynamic hip screws(DHS)and intramedullary nailing(IMN)in the treatment of extra-capsular metastatic carcinoma of the proximal femur.Methods:A retrospective case analysis method was used to examine data of patients with proximal metastatic cancer of the femur who were treated with internal fixation in Department of Orthopaedics,Beijing Friendship Hospital,from January 2007 to December 2018.Blood loss,postoperative pain,functional score,length of stay,and survival rates were compared,and postoperative complications were assessed.Results:Complete follow-up data were available for 33 patients.The mean follow-up period was 12.2±3.6(range:9-32)months and the average age was 72.3±4.7(range:59-83)years old.There were 20 females and 13 males.Twenty-three patients had undergone IMN and 10 DHS,according to bone defects and the patient’s overall condition.The median survival time was 10 months in the IMN group and 11 months in the DHS group.Duration of surgery(t=-7.366,P<0.001)and length of hospital stay(t=-3.509,P<0.001)differed significantly between the two groups.There was one case of breakage of internal fixation in the IMN group.Conclusions:There was no significant difference between DHS and IMN in terms of surgical efficacy.IMN and DHS were different in terms of surgical time and hospital stay.However,due to the limited number of cases in this study,multi-factor analysis has not been performed and needs to be further verified in future analysis.When developing a surgical plan,it is recommended to consider the patient’s condition and the surgeon’s experience. | Hua Gao Xiaodong Bai Wentao Chen Yadong Li Liang Zhao Changgui Liu Zhenyu Liu Baojun Wang | 2020 | Chinese Journal of Cancer Research2020，32，3： | 2 |
| 6 | In situ analysis of major and trace elements of anhydrous minerals by LA-ICP-MS without applying an internal standard显示文摘 | Liu Yongsheng Hu Zhaochu Gao Shan Ganther D Xu Juan Gao Changgui Chen Haibong | | 0，，： | 1 |
| 7 | In situ U -Pb dating and trace element analysis of zircons in thin sections of eclo- gite:refining constraints on the ultra high-pressure metamorphism of the Sulu terrane, China 显示文摘 | Zong Keqing Liu Yongsheng Gao Changgui | 2010 | Chemical Geology2010，269，34： | 1 |
| 8 | In situ analysis of major andtrace elements of anhydrous minerals by LA-ICP-MS withoutapplying an internal standard 显示文摘 | Liu Yongsheng Hu Zhaochu Gao Shan Günther D Xu Juan Gao Changgui Chen Haihong | 2008 | Chem Geol2008，257，12： | 1 |
| 9 | Continental and oceanic crustrecycling-induced melt-peridotite interactions in theTrans-North China Orogen: U-Pb dating, Hf isotopes andtrace elements in zircons of mantle xenoliths 显示文摘 | Liu Yongsheng Gao Shan Hu Zhaochu Gao Changgui ZongKeqing Wang Dongbing | 2010 | J Petrol2010，51，53： | 1 |
| 10 | In situ analysis of major and trace elements of anhydrous minerals by LA-ICP-MS without applying an internal standard 显示文摘 | Liu Yongsheng Hu Zhaochu Gao Shan Gfintherc D Xu Juan Gao Changgui Chen Haihong | 2008 | Chem Geol2008，257，12： | 1 |
| 11 | 显示文摘 | Gao Xiaorui Lei Lixu Lv Changgui | 2008 | Journal of Solid State Chemistry2008，181，8： | 1 |
| 12 | Preparation and Photoluminescence Property of a Loose Powder Ca3 Al2 O6 :Eu^3+ by Calcination of a Layered Double Hydroxide Precursor显示文摘 | Gao Xiaorui Lei Lixu Lv Changgui | 2008 | Journal of Solid State Chemistry2008，181，： | 1 |
| 13 | In situ analysis of major and trace elements of anhydrous minerals by LA-ICP-MS without applying an internal standard显示文摘 | Yongsheng Liu Zhaochu Hu Shan Gao Detlef Günther Juan Xu Changgui Gao Haihong Chen | 2008 | Chemical Geology2008，，1： | 1 |
| 14 | ln-situ analysis of major and trace elements of anhydrous minerals by LA-ICP-MS without applying an internal standard 显示文摘 | Liu Yongsheng Hu Zhaochu Gao Shah Gtinther D Xu Juan Gao Changgui Chen Haihong | 2008 | Chemical Geology2008，257，12： | 1 |
| 15 | Melting-induced fluid flow during exhumation of gneisses of the Sulu ultrahigh-pressure terrane显示文摘 | Keqing Zong Yongsheng Liu Zhaochu Hu Timothy Kusky Dongbin Wang Changgui Gao Shan Gao Jianqi Wang | 2010 | LITHOS2010，，3： | 1 |
| 16 | Discovery and inspiration of large-and medium-sized glutenite-rich oil and gas fields in the eastern South China Sea:An example from Paleogene Enping Formation in Huizhou 26 subsag,Pearl River Mouth Basin显示文摘Based on the practice of oil and gas exploration in the Huizhou Sag of the Pearl River Mouth Basin,the geochemical indexes of source rocks were measured,the reservoir development morphology was restored,the rocks and minerals were characterized microscopically,the measured trap sealing indexes were compared,the biomarker compounds of crude oil were extracted,the genesis of condensate gas was identified,and the reservoir-forming conditions were examined.On this basis,the Paleogene Enping Formation in the Huizhou 26 subsag was systematically analyzed for the potential of oil and gas resources,the development characteristics of large-scale high-quality conglomerate reservoirs,the trapping effectiveness of faults,the hydrocarbon migration and accumulation model,and the formation conditions and exploration targets of large-and medium-sized glutenite-rich oil and gas fields.The research results were obtained in four aspects.First,the Paleogene Wenchang Formation in the Huizhou 26 subsag develops extensive and thick high-quality source rocks of semi-deep to deep lacustrine subfacies,which have typical hydrocarbon expulsion characteristics of'great oil generation in the early stage and huge gas expulsion in the late stage',providing a sufficient material basis for hydrocarbon accumulation in the Enping Formation.Second,under the joint control of the steep slope zone and transition zone of the fault within the sag,the large-scale near-source glutenite reservoirs are highly heterogeneous,with the development scale dominated hierarchically by three factors(favorable facies zone,particle component,and microfracture).The(subaqueous)distributary channels near the fault system,with equal grains,a low mud content(<5%),and a high content of feldspar composition,are conducive to the development of sweet spot reservoirs.Third,the strike-slip pressurization trap covered by stable lake flooding mudstone is a necessary condition for oil and gas preservation,and the NE and nearly EW faults obliquely to the principal stress have the best control on traps.Fourth,the spatiotemporal configuration of high-quality source rocks,fault transport/sealing,and glutenite reservoirs controls the degree of hydrocarbon enrichment.From top to bottom,three hydrocarbon accumulation units,i.e.low-fill zone,transition zone,and high-fill zone,are recognized.The main area of the channel in the nearly pressurized source-connecting fault zone is favorable for large-scale hydrocarbon enrichment.The research results suggest a new direction for the exploration of large-scale glutenite-rich reservoirs in the Enping Formation of the Pearl River Mouth Basin,and present a major breakthrough in oil and gas exploration. | XU Changgui GAO Yangdong LIU Jun PENG Guangrong LIU Pei XIONG Wanlin SONG Penglin | 2024 | Petroleum Exploration and Development2024，51，1： | 0 |
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