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| 1 | Reappraisement and refinement of zircon U-Pb isotope and trace element analyses by LA-ICP-MS显示文摘A protocol was established for simultaneous measurements of zircon U-Pb ages and trace elements by LA-ICP-MS at spot sizes of 16 32 μm.This was accomplished by introducing N 2 into ICP to increase the sensitivity.The obtained U-Pb ages for zircon standards GJ-1,TEMORA and SK10-2 are consistent with the preferred values within about 1% uncertainty (2σ) by simple external calibration against zircon standard 91500.Different data reduction softwares could yield different uncertainties for calculation of U-Pb ages.The commercially available program GLITTER4.4 could apply an improper uncertainty calculation strategy,but it may yield artificial high precisions for single analyses.Our trace element analyses indicate that Si is not an ideal internal standard for zircon when calibrated against the NIST glasses.Calibration against the NIST glasses using Si as an internal standard,a systematic deviation of 10% 30% was found for most trace elements including Zr.However,the trace element compositions of zircon can be accurately measured by calibration against multiple reference materials with natural compositions (e.g.,BCR-2G,BHVO-2G and BIR-1G),or calibration against NIST SRM 610 and using Zr as an internal standard.Analyses of two pieces of GJ-1 demonstrate that it is relatively homogenous for most trace elements (except for Ti). | LIU YongSheng HU ZhaoChu ZONG KeQing GAO ChangGui GAO Shan XU Juan CHEN HaiHong | 2010 | Chinese Science Bulletin2010，55，15： | 1011 |
| 2 | Prevalence and drug resistance characteristics of carbapenem-resistant Enterobacteriaceae in Hangzhou, China显示文摘与在开发国家的抗菌剂代理人的滥用,增加 carbapenem 抵抗的 Enterobacteriaceae (CRE ) 的数字吸引了可观的公共担心。回顾的研究在东南中国在 Hangzhou,调查流行的中国和 CRE 的药抵抗特征从一所第三级的医院基于 242 CRE 紧张被进行。细菌的种类被识别。抗菌剂危险性被肉汤 microdilution 方法或 epsilometer 测试检验。抵抗 -lactamase 基因被聚合酶链反应识别并且定序。遗传型被种系发生的分析调查。Klebsiella pneumoniae 和 Escherichia coli 分别地是种类的最流行的类型,与在 71.9% 紧张和 21.9% 的出现。所有紧张展出了高抵抗(>70%) 对酮抗菌素, ciprofloxacin, trimethoprimsulfamethoxazole,和 nitrofurantoin 但是对 tigecycline (0.8%) 和 minocycline (8.3%) 的展出低抵抗。多于二种 -lactamase 基因怀有的 123 紧张的一个总数。 bla KPC-2 , bla SHV-11 , bla TEM-1 ,和 bla CTX-M-14 是占优势的遗传型与60.3%,61.6%,43.4%,和16.5%的察觉率,分别地,并且与在不同国家的参考序列是高度相同的,显示潜在的水平传播。IMP-4 是在这研究的最经常的班 B metallo-lactamases。在结论,连续监视和有效预防应该被强调减少 CRE 的传播。 | Yan Yang Jian Chen Di Lin Xujian Xu Jun Cheng Changgui Sun | 2018 | Frontiers of Medicine2018，12，2： | 8 |
| 3 | Development characteristics of the fault system and its control on basin structure, Bodong Sag, East China显示文摘The Bodong Sag,located in the Bohai Sea,offshore China,is one of the most petroliferous basins in China.Based on three dimensional seismic reflection data and time slice data,we analyze the fault system of the Bodong area in detail,establish the fault structure pattern of different types and summarize the distribution of the fault system.It is concluded that the development characteristics of the Cenozoic fault system are in accordance with the dextral stress field of the Tanlu Fault,which displayed a brush structure with NNE strike-slip faults as its principal faults,NE-trending extensional faults as secondary faults and EW-trending faults as minor faults.Faults can be divided into (1) strike-slip type,(2) extensional type,(3) strike-slip extensional type and (4) extensional strike-slip type.The spatial structures of different faults have obvious differences because of the fault properties and activity intensity.The fault system at different stages shows tremendous differences because of the transition of the Tanlu Fault from sinistral strike-slip to dextral strike-slip,the transition between extension and strike-slip,and the transition from mantle upwelling to thermal subsidence.According to the controlling effect of faults on basin structure,the Cenozoic basin experienced four evolutionary stages,(a) transition stage from sinistral strike-slip to dextral strike-slip,(b) strike-slip extensional faulted stage,(c) extensional strike-slip faulted stage and (d) strike-slip depression stage.The identification of temporal and spatial differences of faults could be used as a significant guideline for oil and gas exploration in the Bodong area. | Wu Zhiping Cheng Yanjun Yan Shiyong Su Wen Wang Xin Xu Changgui Zhou Xinhuai | 2013 | Petroleum Science2013，10，4： | 4 |
| 4 | In situ analysis of major and trace elements of anhydrous minerals by LA-ICP-MS without applying an internal standard显示文摘 | Yongsheng Liu Zhaochu Hu Shan Gao Detlef Günther Juan Xu Changgui Gao Haihong Chen | 2008 | Chemical Geology2008，，1： | 3 |
| 5 | Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates显示文摘Emerging SARS-CoV-2 variants and the gradually decreasing neutralizing antibodies over time post vaccination have led to an increase in incidents of breakthrough infection across the world.To investigate the potential protective effect of the recombinant protein subunit COVID-19 vaccine targeting receptor-binding domain(RBD)(PS-RBD)and whole inactivated virus particle vaccine(IV)against the variant strains,in this study,rhesus macaques were immunized with PS-RBD or IV vaccine,followed by a Beta variant(B.1.351)challenge.Although neutralizing activity against the Beta variant was reduced compared with that against the prototype,the decreased viral load in both upper and lower respiratory tracts,milder pathological changes,and downregulated inflammatory cytokine levels in lung tissues after challenge demonstrated that PS-RBD and IV still provided effective protection against the Beta variant in the macaque model.Furthermore,PS-RBD-induced macaque sera possessed general binding and neutralizing activity to Alpha,Beta,Delta,and Omicron variants in our study,though the neutralizing antibody(NAb)titers declined by varying degrees,demonstrating potential protection of PS-RBD against current circulating variants of concern(VOCs).Interestingly,although the IV vaccine-induced extremely low neutralizing antibody titers against the Beta variant,it still showed reduction for viral load and significantly alleviated pathological change.Other correlates of vaccine-induced protection(CoP)like antibody-dependent cellular cytotoxicity(ADCC)and immune memory were both confirmed to be existing in IV vaccinated group and possibly be involved in the protective mechanism. | Qian He Qunying Mao Xiaozhong Peng Zhanlong He Shuaiyao Lu Jialu Zhang Fan Gao Lianlian Bian Chaoqiang An Wenhai Yu Fengmei Yang Yanan Zhou Yun Yang Yanyan Li Yadi Yuan Xujia Yan Jinghuan Yang Xing Wu Weijin Huang Changgui Li Junzhi Wang Zhenglun Liang Miao Xu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 6 | In situ analysis of major and trace elements of anhydrous minerals by LA-ICP-MS without applying an internal standard显示文摘 | Liu Yongsheng Hu Zhaochu Gao Shan Ganther D Xu Juan Gao Changgui Chen Haibong | | 0，，： | 1 |
| 7 | Hydraulic lift in drought-tolerant and-susceptible maize hybrids显示文摘 | WAN Changgui XU Wenwei SOSEBEE R E | 2000 | Plant and soil2000，219，12： | 1 |
| 8 | Hydraulic lift in drought tolerance and susceptible maize hybrids 显示文摘 | Changgui Wan Wenwei Xu Ronad E | 2000 | Plant and Soil2000，，219： | 1 |
| 9 | Effects of Remifentanil Combined with Gastrodin Injection on Cerebral Oxygen Metabolism and Early Postoperative Cognitive Function in Patients Undergoing Laparoscopic Surgery for Cervical Cancer显示文摘Objective Effects of Remifentanil combined with Gastrodin injection on cerebral oxygen metabolism and early postoperative cognitive function in patients undergoing laparoscopic surgery for cervical cancer.Methods 107 cases of laparoscopic cervical carcinoma were randomly divided into observation group(54 cases)and control group(53 cases),the control group received anesthesia induction therapy based on Remifentanil,the observation group was given intravenous Gastrodin injection to 120h after operation on the basis of control group.the brain oxygen metabolism and brain injury related indexes 6h,12h,72h and 120h after operation were observed,and the preoperative cognitive function and postoperative cognitive function of two groups after 6h,1d,3d and 5d were evaluated by using Mini-Mental State Examination(MMSE)test method.Results Compared to the preoperative data,the oxygen saturation of the internal jugular vein(SjvO22)and cerebral oxygen saturation(rSO2)of two groups after 6h of operation was significantly decreased(p<0.05),and the indexes all back to normal after 120h,and observation group’s indexes were higher than that in control group(P<0.05);and the Cerebral arterial-venous oxygen content difference(Da-jvO2)and Cerebral Oxygen extraction rate(CERO2)of two groups after 6h of operation was significantly increased(P<0.05),and the indexes all back to normal after 120h and observation group’s indexes were lower than that in control group(P<0.05);serum neuron specific enolase(NSE)and S100B protein level of two groups after 6h of operation was significantly increased and back to normal after 120h,and observation group’s indexes were lower than that in control group(P<0.05);The MMSE score of 6h,12h,72h and 120h were higher in the observation group than in the control group,and the incidence of postoperative cognitive dysfunction(POCD)was lower than that in the control group(P-<0.05).Conclusion In the anesthesia induction program based on Remifentanil,the use of Gastrodin injection can reduce the incidence of cognitive dysfunction after laparoscopic surgery for cervical cancer,and its mechanism may be related to the improvement of brain metabolism and the reduction of hypoxia injury in neurons of cranial nerves. | Xu Changgui | 2018 | Proceedings of Anticancer Research2018，2，1： | 1 |
| 10 | COVID-19 vaccines: progress and understanding on quality control and evaluation显示文摘The outbreak of COVID-19 has posed a huge threat to global health and economy.Countermeasures have revolutionized norms for working,socializing,learning,and travel.Importantly,vaccines have been considered as most effective tools to combat with COVID-19.As of the beginning of 2021,>200 COVID-19 vaccine candidates,covering nearly all existing technologies and platforms,are being research and development(R&D)by multiple manufacturers worldwide.This has posed a huge obstacle to the quality control and evaluation of those candidate vaccines,especially in China,where five vaccine platforms are deployed in parallel.To accelerate the R&D progress of COVID-19 vaccines,the guidances on R&D of COVID-19 vaccine have been issued by National Regulatory Authorities or organizations worldwide.The Center for Drug Evaluation and national quality control laboratory in China have played a leading role in launching the research on quality control and evaluation in collaboration with relevant laboratories involved in the vaccine R&D,which greatly supported the progression of vaccines R&D,and accelerated the approval for emergency use and conditional marketing of currently vaccine candidates.In this paper,the progress and experience gained in quality control and evaluation of COVID-19 vaccines developed in China are summarized,which might provide references for the R&D of current and next generation of COVID-19 vaccines worldwide. | Qunying Mao Miao Xu Qian He Changgui Li Shufang Meng Yiping Wang Bopei Cui Zhenglun Liang Junzhi Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 1 |
| 11 | Sedative and hypnotic activities of the ethanol fraction from Fructus Schisandrae in mice and rats显示文摘 | Fang Huang Yating Xiong Lihua Xu Shiping Ma Changgui Dou | 2006 | Journal of Ethnopharmacology2006，，3： | 1 |
| 12 | In situ analysis of major andtrace elements of anhydrous minerals by LA-ICP-MS withoutapplying an internal standard 显示文摘 | Liu Yongsheng Hu Zhaochu Gao Shan Günther D Xu Juan Gao Changgui Chen Haihong | 2008 | Chem Geol2008，257，12： | 1 |
| 13 | Laser-annealing-made amplified spontaneous emission of 'giant' CdSe/CdS core/shell nanocrystals transferred from bulk-like shell to quantum-confined core显示文摘'Giant' Cd Se/Cd S core/shell nanocrystals(NCs) were synthesized with thick Cd S shell(15 monolayers), and the x-ray diffraction(XRD) measurement indicates there is a zinc blende phase in the thick Cd S shell, whereas it transformed into wurtzite phase under 5 min radiation with a 400 nm, 594 μJ∕cm2femtosecond(fs) laser beam.The evolution of the NCs’ spontaneous emission under the fs laser radiation was recorded with a Hamamatsu streak camera. The as-synthesized NCs exhibit an amplified spontaneous emission(ASE) at 530 nm, which comes from a bulk-like Cd S shell due to the interfacial potential barrier, which could slow down the relaxation of holes from the shell to the core. After being annealed by an fs laser, the ASE of the g-NCs is transferred from a bulk-like Cd S shell to a quantum-confined Cd Se core because the phase transformation determined with the XRD measurement could remove the interfacial barrier. Besides the ASE at 643 nm, two shorter-wavelength ASE peaks at 589 and 541 nm, corresponding to optical transitions of the second(1P) and third(1D) electron quantization shells of the Cd Se core, also appear, thus indicating that Auger recombination is effectively suppressed. | Chen Liao Kai Fan Ruilin Xu Huichao Zhang Changgui Lu Yiping Cui Jiayu Zhang | 2015 | Photonics Research2015，3，5： | 1 |
| 14 | In situ analysis of major and trace elements of anhydrous minerals by LA-ICP-MS without applying an internal standard 显示文摘 | Liu Yongsheng Hu Zhaochu Gao Shan Gfintherc D Xu Juan Gao Changgui Chen Haihong | 2008 | Chem Geol2008，257，12： | 1 |
| 15 | Genetic mechanism of the granite buried-hill reservoir of the Penglai 9-1 oilfield in Bohai Sea显示文摘The Penglai 9-1 oilfield is the largest granite buried-hill oilfield in China presently,genesis and evolution of the granite buried-hill reservoir is complex.Based on geochemical,geophysical,experimental simulation and other methods,and combined with field geological observation,genetic mechanism of the granite buried-hill reservoir of the Penglai 9-1 oilfield and its hydrocarbon accumulation mode were well investigated.Results showed that the granite was formed by magmatic intrusion along deep faults under intraplate breakup of North China Plate,it was the product of magmatic activities of Yanshan tectonic episode of Circum-Pacific Tectonic Region,and the intrusion time was 160e170 Ma of the Jurassic.Formation of the granite buried-hill reservoir was mainly controlled by the epigenic karstification and tectonic reconstruction,the Yanshanian weathering and denudation controlled macroscopic development characteristics of the granite buried-hill reservoir,and faults and joints formed by Cenozoic tectonic movement promoted modification of the granite buried-hill reservoir.Laterally,thickness of the granite buried-hill reservoir had a positive correlation with fracture density.Vertically,the granite rocks could be divided into five zones:soil zone,sandy zone,broken zone,fracture zone and base rock zone.The upper-middle part(sandy zone,broken zone,fracture zone)of the granite buried hill was the highquality favorable reservoir zone and the main oil-bearing interval. | Zhiwei Hu Changgui Xu Bo Yang Zhi Huang Wen Su | 2017 | Petroleum Research2017，2，4： | 1 |
| 16 | In situ analysis of major and trace elements of anhydrous minerals by LA-ICP-MS without applying an internal standard 显示文摘 | Liu Yongsheng Hu Zhaochu Gac Shan Gtinther D Xu Juan Gan Changgui Chen Haihong | 2008 | Chem Geol2008，257，12： | 1 |
| 17 | In situ analysis of major and trace elements of anhydrous minerals by LA-ICP-MS without applying an internal standard显示文摘 | Yongsheng Liu Zhaochu Hu Shan Gao Detlef Günther Juan Xu Changgui Gao Haihong Chen | 2008 | Chemical Geology2008，，1： | 1 |
| 18 | ln-situ analysis of major and trace elements of anhydrous minerals by LA-ICP-MS without applying an internal standard 显示文摘 | Liu Yongsheng Hu Zhaochu Gao Shah Gtinther D Xu Juan Gao Changgui Chen Haihong | 2008 | Chemical Geology2008，257，12： | 1 |
| 19 | Hydraulic lift in drought-tolerant and -susceptible maize hybrids显示文摘 | Changgui Wan Wenwei Xu Ronald E. Sosebee Stephen Machado Tom Archer | 2000 | Plant and Soil (-)2000，，1： | 1 |
| 20 | Formation conditions and accumulation characteristics of Bozhong 19-6 large condensate gas field in offshore Bohai Bay Basin显示文摘Based on the study of natural gas resource, low buried hill trap formation mechanism, high quality reservoir control factors and natural gas preservation conditions, the formation conditions and reservoir accumulation characteristics of Bozhong 19-6 large condensate gas field were summarized. Large gas generation potential of multiple sets of thick humic-sapropelic source rocks in high maturity stage in Bozhong depression was the basis of large gas field formation. The multi-stage tectonic evolution since Indosinian period formed large-scale buried hill traps. The Tanlu fault activity formed multi-type reservoirs, and buried hill metamorphic rock of Archean and sand-conglomerate of Kongdian Formation were high-quality reservoirs. Thick overpressure lacustrine mudstone and weak neotectonic movement provided good preservation conditions. Bozhong 19-6 gas reservoir was a condensate gas reservoir with very high condensate oil content, and the gas origin was humic-sapropelic and kerogen-cracking gas, and the gas field had large gas thickness, high gas column characteristics and the accumulation process was first oil and then gas. The buried hill reservoir was a massive reservoir and the Kongdian reservoir was a stratified reservoir. The gas field had multi-channel hydrocarbon intense charge from overpressure source rocks, atmospheric-weak overpressure reservoir favorable for accumulation, thick overpressure mudstone caprock favorable for preservation, and natural gas ultra-late rapid accumulation model. | XU Changgui YU Haibo WANG Jun LIU Xiaojian | 2019 | Petroleum Exploration and Development2019，46，1： | 1 |
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