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| 1 | Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy显示文摘Treatment strategies,whether as follow-up or'total incisional biopsy'for gastric noninvasive intraepithelial neoplasia diagnosed by examination of an endoscopic forceps biopsy specimen,are controversial due to problems associated with the diagnostic accuracy of endoscopic forceps biopsy and questions about the safety and efficacy of endoscopic treatment.Based on the histological findings of the biopsy specimen,it is difficult to differentiate between reactive or regenerative changes,inflammation and neoplastic changes,intraepithelial and invasive tumors.Therefore,gastric neoplasia diagnosed as noninvasive intraepithelial often develop into invasive carcinoma during follow-up.Recent advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and highfrequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection(ESD),a therapeutic option for gastric intraepithelial neoplasia,including low-grade neoplasms.Future studies are required to evaluate whether ESD is a valid strategy for gastric intraepithelial neoplasm with regard to safety and cost effectiveness. | Tsutomu Nishida Shusaku Tsutsui Motohiko Kato Takuya Inoue Shunsuke Yamamoto Yoshito Hayashi Tomofumi Akasaka Takuya Yamada Shinichiro Shinzaki Hideki Iijima Masahiko Tsujii Tetsuo Takehara | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 18 |
| 2 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，15： | 13 |
| 3 | Choroidal and cutaneous metastasis from gastric adenocarcinoma显示文摘Choroidal or cutaneous metastasis of gastric cancer is rare. Gastrointestinal cancer was found in only 4% in patients with uveal metastasis. Choroidal metastasis from gastric cancer was reported in two cases in earlier literature. The frequency of gastric cancer as a primary lesion was 6% in cutaneous metastasis of men, and cutaneous metastasis occurs in 0.8% of all gastric cancers. We report a patient with gastric adenocarcinoma who presented with visual disorder in his left eye and skin pain on his head as his initial symptoms. These symptoms were diagnosed to be caused by choroidal and cutaneous metastasis of gastric adenocarcinoma. Two cycles of chemotherapy consisted of oral S-1 and intravenous cisplatin (SPIRITS regimen); this was markedly effective to reduce the primary gastric lesion and almost all the metastatic lesions. | Shoichiro Kawai Tsutomu Nishida Yoshito Hayashi Hisao Ezaki Takuya Yamada Shinichiro Shinzaki Masanori Miyazaki Kei Nakai Takayuki Yakushijin Kenji Watabe Hideki Iijima Masahiko Tsujii Kohji Nishida Tetsuo Takehara | 2013 | World Journal of Gastroenterology2013，19，9： | 6 |
| 4 | Endoscopic surveillance strategy after endoscopic resection for early gastric cancer显示文摘Early detection of early gastric cancer(EGC)is important to improve the prognosis of patients with gastric cancer.Recent advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and high-frequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection,a therapeutic option for gastric intraepithelial neoplasia.Consequently,short-term outcomes of endoscopic resection(ER)for EGC have improved.Therefore,surveillance with endoscopy after ER for EGC is becoming more important,but how to perform endoscopic surveillance after ER has not been established,even though the follow-up strategy for more advanced gastric cancer has been outlined.Therefore,a surveillance strategy for patients with EGC after ER is needed. | Tsutomu Nishida Masahiko Tsujii Motohiko Kato Yoshito Hayashi Tomofumi Akasaka Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，2： | 4 |
| 5 | Y chromosome microdeletion screening using a new molecular diagnostic method in 1030 Japanese males with infertility显示文摘The azoospermia factor(AZF)region is important for spermatogenesis,and deletions within these regions are a common cause of oligozoospermia and azoospermia.Although several studies have reported this cause,the present research,to the best of our knowledge,is the first large-scale study assessing this factor in Japan.In this study,1030 male patients with infertility who were examined for Y chromosome microdeletion using the polymerase chain reaction-reverse sequence-specific oligonucleotide(PCR-rSSO)method,a newly developed method for Y chromosome microdeletion screening,were included.The study enrolled 250 patients with severe oligospermia and 717 patients with azoospermia.Among the 1030 patients,4,4,10,and 52 had AZFa,AZFb,AZFb+c,and AZFc deletions,respectively.The sperm recovery rate(SRR)of microdissection testicular sperm extraction in patients with AZFc deletions was significantly higher than that in those without AZF deletions(60.0%vs 28.7%,P=0.04).In patients with gr/gr deletion,SRR was 18.7%,which was lower than that in those without gr/gr deletion,but was not statistically significant.In conclusion,our study showed that the frequency of Y chromosome microdeletion in male patients in Japan was similar to that reported in patients from other countries,and SRR was higher in patients with AZFc deletion. | Masashi Iijima Kazuyoshi Shigehara Hideki Igarashi Koichi Kyono Yasuo Suzuki Yuji Tsuji Yoshitomo Kobori Hideyuki Kobayashi Atsushi Mizokami | 2020 | Asian Journal of Andrology2020，22，4： | 4 |
| 6 | Immune checkpoint inhibitor-induced diarrhea/colitis: Endoscopic and pathologic findings显示文摘The indications of immune checkpoint inhibitors(ICPIs)for cancer treatment have rapidly expanded,and their use is increasing in clinical settings worldwide.Despite the considerable clinical benefits of ICPIs,frequent immune-related adverse events(ir AEs)have become nonnegligible concerns.Among ir AEs,ICPIinduced colitis/diarrhea is frequent and recognized not only by oncologists but also by gastroenterologists or endoscopists.The endoscopic findings show similarity to those of inflammatory bowel disease to a certain extent,particularly ulcerative colitis,but do not seem to be identical.The pathological findings of ICPI-induced colitis may vary among drug classes.They show acute or chronic inflammation,but it may depend on the time of colitis suggested by colonoscopy,including biopsy or treatment intervention.In the case of chronic inflammation determined by biopsy,the endoscopy findings may overlap with those of inflammatory bowel disease.Here,we provide a comprehensive review of ICPIinduced colitis based on clinical,endoscopic and pathologic findings. | Tsutomu Nishida Hideki Iijima Shiro Adachi | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，2： | 3 |
| 7 | Clinical problems with antithrombotic therapy for endoscopic submucosal dissection for gastric neoplasms显示文摘Endoscopic submucosal dissection(ESD) is minimally invasive and thus has become a widely accepted treatment for gastric neoplasms,particularly for patients with comorbidities.Antithrombotic agents are used to prevent thrombotic events in patients with comorbidities such as cardio-cerebrovascular diseases and atrial fibrillation.With appropriate cessation,antithrombotic therapy does not increase delayed bleeding in low thrombosis-risk patients.However,high thrombosisrisk patients are often treated with combination therapy with antithrombotic agents and occasionally require the continuation of antithrombotic agents or heparin bridge therapy(HBT) in the perioperative period.Dual antiplatelet therapy(DAPT),a representative combination therapy,is frequently used after placement of drug-eluting stents and has a high risk of delayed bleeding.In patients receiving DAPT,gastric ESD may be postponed until DAPT is no longer required.HBT is often required for patients treated with anticoagulants and has an extremely high bleeding risk.The continuous use of warfarin or direct oral anticoagulants may be possible alternatives.Here,we show that some antithrombotic therapies in high thrombosis-risk patients increase delayed bleeding after gastric ESD,whereas most antithrombotic therapies do not.The management of high thrombosis-risk patients is crucial for improved outcomes. | Toshiyuki Yoshio Tsutomu Nishida Yoshito Hayashi Hideki Iijima Masahiko Tsujii Junko Fujisaki Tetsuo Takehara | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 8 | CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylori-related carcinogenesis显示文摘 | Yoshito Hayashi Masahiko Tsujii Jun Wang Jumpei Kondo Tomofumi Akasaka Ying Jin Wei Li Toru Nakamura Tsutomu Nishida Hideki Iijima Shingo Tsuji Sunao Kawano Norio Hayashi Tetsuo Takehara | 2013 | Gut2013，，11： | 2 |
| 9 | Mucosal immune network in the gut for the control of infectious diseases 显示文摘 | Hideki Iijima Ichiro Takahashi Hiroshi Kiyono | 2001 | Reviews in Medical Virology2001，，11： | 1 |
| 10 | Efficiency of bone marrow-derived cells in regeneration of the stomach after induction of ethanol-induced ulcers in rats显示文摘 | Masato Komori Shingo Tsuji Masahiko Tsujii Hiroaki Murata Hideki Iijima Masakazu Yasumaru Tsutomu Nishida Takanobu Irie Sunao Kawano Masatsugu Hori | 2005 | Journal of Gastroenterology2005，，6： | 1 |
| 11 | Efficiency of bone marrow-derived cells in regeneration of the stomach after induction of ethanol-induced ulcers in rats显示文摘 | Masato Komori Shingo Tsuji Masahiko Tsujii Hiroaki Murata Hideki Iijima Masakazu Yasumaru Tsutomu Nishida Takanobu Irie Sunao Kawano Masatsugu Hori | 2005 | Journal of Gastroenterology2005，，6： | 1 |
| 12 | Evaluation of Endoscopic Ultrasound Image Quality Is Necessary in Endosonographic Assessment of Early Gastric Cancer Invasion Depth显示文摘 | Shunsuke Yamamoto Tsutomu Nishida Motohiko Kato Takuya Inoue Yoshito Hayashi Jumpei Kondo Tomofumi Akasaka Takuya Yamada Shinichiro Shinzaki Hideki Iijima Masahiko Tsujii Tetsuo Takehara Salem Omar | 2012 | <journal-title>Gastroenterology Research and Practice2012，，： | 1 |
| 13 | Effects of long-term androgen replacement therapy on the physical and mental statuses of aging males with late-onset hypogonadism: a multicenter, randomized controlled trial in Japan (EARTH Study)显示文摘迟了发作的性腺机能减退(LOH ) 上的雄激素代替治疗(艺术) 功效广泛地在西方的国家被调查了;然而,艺术是否能改进健康并且延长活跃生活方式,仍然保持争论。我们有希望地在在日本与 LOH 使人变老的物理、心理的地位上估计了长期的艺术效果。主要端点是问询表估计的生活的健康相关的质量。第二等的端点包括了 glycemic 控制,类脂化合物参数,血压,腰圆周,身体作文,肌肉发达的力量,国际前列腺症状分数(IPSS ) ,可勃起的 Function-5 (IIEF-5 ) 分数的国际索引,和前列腺特定的抗原铺平的浆液。1637 个合格志愿者, 334 个病人 > 有 LOH 的 40 年随机被分到 ART 也(n = 169 ) 或控制组(n = 165 ) 。在起始的治疗以后的 52 个星期,艺术显著地影响了角色短 form-36 健康调查(SF-36 ) 的物理子域规模(P = 0.0318 ) 。艺术也在腰情形与重要减少被联系( P = 0.002 )并且浆液 triglyceride ( TG )( P = 0.013 )并且随的重要增加整个身体并且腿肌肉团体积( P = 0.071 和 0.0108 ,分别地),浆液血红素( P < 0.001 ), IPSS voiding subscore ( P = 0.0418 ),并且 IIEF-5 上的第二个问题( P = 0.0049 )。以严重不利事件这些组之间没有重要差别。在结论,在有 LOH 的病人,长期的艺术在 SF-36 规模,浆液 TG,腰情形,肌肉团体积, IPSS 的 voiding subscore,和 IIEF-5 的第二个问题的角色物理子域上施加了有益的效果。我们希望我们的学习将贡献这个区域的未来发展。 | Hiroyuki Konaka Kazuhiro Sugimoto Hideki Orikasa Teruaki Iwamoto Toshinari Takamura Yoshiyu Takeda Kazuyoshi Shigehara Masashi Iijima Eitetsu Koh Mikio Namiki | 2016 | Asian Journal of Andrology2016，18，1： | 1 |
| 14 | Evaluation of Endoscopic Ultrasound Image Quality Is Necessary in Endosonographic Assessment of Early Gastric Cancer Invasion Depth显示文摘 | Shunsuke Yamamoto Tsutomu Nishida Motohiko Kato Takuya Inoue Yoshito Hayashi Jumpei Kondo Tomofumi Akasaka Takuya Yamada Shinichiro Shinzaki Hideki Iijima Masahiko Tsujii Tetsuo Takehara Salem Omar | 2012 | <journal-title>Gastroenterology Research and Practice2012，，： | 1 |
| 15 | An NMR study of O-glycosylation induced structural changes in the α-helix of calcitonin显示文摘 | Mizuka Tagashira Hideki Iijima Kazunori Toma | 2002 | Glycoconjugate Journal2002，，1： | 1 |
| 16 | Prolonged hepatic warm ischemia in non-heart-beating donors: Protective effects of FK506 and a platelet activating factor antagonist in porcine liver transplantation显示文摘 | Yasutsugu Takada Hideki Taniguchi Kiyoshi Fukunaga Kenji Yuzawa Masaaki Otsuka Takeshi Todoroki Tatsuo Iijima Katashi Fukao | 1998 | Surgery1998，，6： | 1 |
| 17 | Evaluation of the PyloriTek test for detection of Helicobacter pylori infection in cases with and without eradication therapy显示文摘 | Hiroaki Murata Sunao Kawano Shingo Tsuji Masahiko Tsujii Hitoshi Sawaoka Hideki Iijima Naoki Kawai Masatsugu Hori | 1998 | The American Journal of Gastroenterology1998，，11： | 1 |
| 18 | RHEOLOGICAL BEHAVIOR OF ERWINIA GUM IN AQUEOUS SOLUTION显示文摘Erwinia (E) gum, an extracellular polysaccharide, is composed of fucose, galatose, glucose andglucuronic acid. Its viscosity behavior was investigated by a low-shear-rate multiball viscometer and arotational viscometer. Its weight-average molecular weight M_w and intrinsic viscosity [η] in 0.2 mol/L NaClaqueous solution were measured by light scattering method at 35℃and viscometry at 25℃and found to be1.06×10~6 g/mol and 1050 mL/g, respectively, and its aggregates in aqueous solution were proved by gelpermeation chromatography (GPC). These results indicated that E gum in water has exceedingly highviscosity and exhibits Binham fluid behavior, owing to its aggregation. The viscosity of E gum decreasedwith increasing temperature, and the turning point appeared at 38℃for dilute solution and 80℃forconcentrated solution suggesting that the aggregates of E gum in water started to disaggregate under thesetemperatures. In addition, the aggregates can be disrupted by adding either acid or base. The experimentalresults indicated that the E gum is a good thickening agent, and its fluid behavior is similar to xanthan. | 张俐娜 Hideki Iijima Hiromichi Tsuchiya | 1999 | Chinese Journal of Polymer Science1999，17，6： | 0 |
| 19 | Detection of fucosylated haptoglobin using the 10-7G antibody as a biomarker for evaluating endoscopic remission in ulcerative colitis显示文摘BACKGROUND Inflammatory bowel disease(IBD)is a chronic,relapsing inflammation of the digestive tract.Although fecal and serum biomarkers have been extremely important and supportive for monitoring of IBD,their low sensitivity and high variability characteristics limit clinical efficacy.Thus,the establishment of better biomarkers is expected.Fucosylation is one of the most important glycosylation modifications of proteins.Fucosylated haptoglobin(Fuc-Hpt)is used as a biomarker for several cancers and inflammation-related diseases.We recently established a novel glycan monoclonal antibody(mAb),designated 10-7G,which recognizes Fuc-Hpt.We developed an enzyme-linked immunosorbent assay(ELISA)to measure serum levels of Fuc-Hpt(10-7G values).AIM To investigate the usefulness of the serum 10-7G values as a potential biomarker for monitoring disease activity in IBD.METHODS This was a case control study.Intestinal tissues of IBD patients(n=10)were examined immunohistochemically using the 10-7G mAb.We determined 10-7G values using serum from patients with ulcerative colitis(UC,n=110),Crohn’s disease(n=45),acute enteritis(AE,n=11),and healthy volunteers(HVs)who exhibited normal(n=20)or high(n=79)C-reactive protein(CRP)levels at medical check-up.We investigated the correlation between the 10-7G value and various clinical parameters of IBD patients by correlation analysis.Receiver operating characteristic(ROC)curve analysis was performed to evaluate the usefulness of the 10-7G values as a biomarker for clinical and endoscopic remission of UC compared to conventional serum biomarkers.RESULTS In the immunohistochemical analysis,positive 10-7G mAb staining was observed in lymphocytes infiltrating into inflammatory sites of the mucosal layer and lymphoid follicles.The 10-7G values were significantly higher in patients with IBD(P<0.001)and AE(P<0.05)compared with HVs.In addition,10-7G values were correlated with clinical examination parameters related to inflammation in patients with UC,particularly the CRP level(rs=0.525,P=0.003)and clinical activity index score(rs=0.435,P=0.038).However,there was no correlation between 10-7G values and CRP in HVs with high CRP levels,suggesting that the 10-7G values is not the same as a general inflammation biomarker.ROC curve analysis showed that area under the curve(AUC)value of 10-7G values for the diagnosis of endoscopic remission was higher than other biomarkers(AUC value=0.699).CONCLUSION The serum 10-7G value is a novel biomarker for evaluating intestinal inflammation and endoscopic mucosal healing in UC. | Kei Motooka Koichi Morishita Nami Ito Shinichiro Shinzaki Taku Tashiro Satoshi Nojima Kayoko Shimizu Mutsuhiro Date Natsumi Sakata Momoko Yamada Shinji Takamatsu Yoshihiro Kamada Hideki Iijima Tsunekazu Mizushima Eiichi Morii Tetsuo Takehara Eiji Miyoshi | 2021 | World Journal of Gastroenterology2021，27，2： | 0 |
| 20 | Molecular Weight and Aggregation of Erwinia Gum in Aqueous Solutions显示文摘Erwinia(E) gum is composed of glucose, fucose, galactose and glucuronic acid. The weightaverage molecular weights M w, numberaverage molecular weights M n and intrinsic viscosities[η] of the four fractions and the unfractionated E gum in aqueous solutions at desired temperatures were studied by light scattering, membrane osmometry, size exclusion chromatography(SEC) and viscometry. The experimental results prove that E gum formed aggregates in the aqueous solution at 25 ℃ and the aggregates were broken gradually with increasing temperature. The dissociation of the aggregates of E gum in the aqueous solution started at 36 ℃, and was completed at around 90 ℃. The [η] values of E gum and its fractions are much higher than those of the conventional polymers with the similar molecular weights, and decrease with increasing NaCl concentration. | ZHANG Lina XU Xiaojuan ZHU RongPing Iijima Hideki | 2000 | Chemical Research in Chinese Universities2000，16，2： | 0 |
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