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| 1 | Transcranial Doppler ultrasonography: From methodology to major clinical applications显示文摘Non-invasive Doppler ultrasonographic study of cerebral arteries [transcranial Doppler(TCD)] has been extensively applied on both outpatient and inpatient settings. It is performed placing a low-frequency(≤ 2 MHz) transducer on the scalp of the patient over specific acoustic windows, in order to visualize the intracranial arterial vessels and to evaluate the cerebral blood flow velocity and its alteration in many different conditions. Nowadays the most widespread indication for TCD in outpatient setting is the research of right to left shunting, responsable of so called 'paradoxical embolism', most often due to patency of foramen ovale which is responsable of the majority of cryptogenic strokes occuring in patients younger than 55 years old. TCD also allows to classify the grade of severity of such shunts using the so called 'microembolic signal grading score'. In addition TCD has found many useful applications in neurocritical care practice. It is useful on both adults and children for day-to-day bedside assessment of critical conditions including vasospasm in subarachnoidal haemorrhage(caused by aneurysm rupture or traumatic injury), traumatic brain injury, brain stem death. It is used also to evaluate cerebral hemodynamic changes after stroke. It also allows to investigate cerebral pressure autoregulation and for the clinical evaluation of cerebral autoregulatory reserve. | Antonello D'Andrea Marianna Conte Massimo Cavallaro Raffaella Scarafile Lucia Riegler Rosangela Cocchia Enrica Pezzullo Andreina Carbone Francesco Natale Giuseppe Santoro Pio Caso Maria Giovanna Russo Eduardo Bossone Raffaele Calabrò | 2016 | World Journal of Cardiology2016，8，7： | 10 |
| 2 | Prevalence of bile reflux in gastroesophageal reflux disease patients not responsive to proton pump inhibitors显示文摘AIM:To determine the prevalence and characteristics of bile reflux in gastroesophageal reflux disease(GERD) patients with persistent symptoms who are non-responsive to medical therapy.METHODS:Sixty-five patients(40 male,25 female;mean age,50 ± 7.8 years) who continued to report symptoms after 8 wk of high-dose proton pump inhibitor(PPI) therapy,as well as 18 patients with Barrett's esophagus,were studied.All patients filled out symptom questionnaires and underwent endoscopy,manometry and combined pH-metry and bilimetry.RESULTS:There were 4 groups of patients:22(26.5%) without esophagitis,24(28.9%) grade A-B esophagitis,19(22.8%) grade C-D and 18(21.6%) Barrett's esophagus.Heartburn was present in 71 patients(85.5%) and regurgitation in 55(66.2%),with 44(53%) reporting simultaneous heartburn and regurgitation.The prevalence of pathologic acid reflux in the groups without esophagitis and with grades A-B and C-D esophagitis was 45.4%,66.6% and 73.6%,respectively.The prevalence of pathologic bilirubin exposure in these 3 groups was 53.3%,75% and 78.9%,respectively.The overall prevalence of bile reflux in non-responsive patients was 68.7%.Pathologic acid and bile reflux was observed in 22.7% and 58.1% of non-esophagitic patients and esophagitic patients,respectively.CONCLUSION:The high percentage of patients poorly responsive to PPI therapy may result from poor control of duodenogastroesophageal reflux.Many patients without esophagitis have simultaneous acid and bile reflux,which increases with increasing esophagitis grade. | Luigi Monaco Antonio Brillantino Francesco Torelli Michele Schettino Giuseppe Izzo Angelo Cosenza Natale Di Martino | 2009 | World Journal of Gastroenterology2009，15，3： | 8 |
| 3 | Adipose tissue and vascular inflammation in coronary artery disease显示文摘Obesity has become an important public health issue in Western and developing countries,with well known metabolic and cardiovascular complications.In the last decades,evidence have been growing about the active role of adipose tissue as an endocrine organ in determining these pathological consequences.As a consequence of the expansion of fat depots,in obese subjects,adipose tissue cells develope a phenotypic modification,which turns into a change of the secretory output.Adipocytokines produced by both adipocytes and adipose stromal cells are involved in the modulation of glucose and lipid handling,vascular biology and,moreover,participate to the systemic inflammatory response,which characterizes obesity and metabolic syndrome.This might represent an important pathophysiological link with atherosclerotic complications and cardiovascular events.A great number of adipocytokines have been described recently,linking inflammatory mileu and vascular pathology.The understanding of these pathways is crucial not only from a pathophysiological point of view,but also to a better cardiovascular disease risk stratification and to the identification of possible therapeutic targets.The aim of this paper is to review the role of Adipocytokines as a possible link between obesity and vascular disease. | Enrica Golia Giuseppe Limongelli Francesco Natale Fabio Fimiani Valeria Maddaloni Pina Elvira Russo Lucia Riegler Renatomaria Bianchi Mario Crisci Gaetano Di Palma Paolo Golino Maria Giovanna Russo Raffaele Calabrò Paolo Calabrò | 2014 | World Journal of Cardiology2014，6，7： | 8 |
| 4 | Adenocarcinoma of gastric cardia in the elderly: Surgical problems and prognostic factors显示文摘AIM: To analyze retrospectively, our results about patients who underwent surgical treatment for adenocarcinoma of the cardia in relation to age, in order to evaluate surgical problems and prognostic factors.METHODS: From January 1987 to March 2003, 140 patients with adenocarcinoma of the cardia underwent resection in the authors' institution. They were divided into three groups with regard to age. Patients <70 and >60 year old (31) were excluded; we also excluded 18 out of 109 patients with poor general status or systemic metastases. So, we compared 51 elderly (≥ 70 year old)and 58 younger patients (≤ 60 year old). The treatment was esophagectomy for type Ⅰ tumors, and extended gastrectomy and distal esophagectomy for type Ⅱ and Ⅲ lesions.RESULTS: Laparotomy was carried out in 91 patients (83.4%), 38 in the elderly (74.5%) and 53 in younger patients (91.3%, P<0.05). Primary resection was performed in 811 cases (89%) without significant differences between the two groups. Postoperative death was higher in the elderly (12.1%) than the other group (4.1%, P<0.05), while morbidity was similar in both groups. A curative resection (R0) was performed in 59 patients (72.8%), 69.6% in the elderly and 75% in the younger group (P>0.05). The overall 3- and 5-year survival rates were 26.7% and 117.8% respectively for the elderly and 40.7% and 35.1% respectively for younger patients (P = 0.1544). Survival rates were significantly associated with R0 resection,pathological node-positive category and tumor differentiation in both groups.CONCLUSION: As the age of the general population increases, more elderly patients with gastric cardia cancer will be candidates for surgical resection. Age alone should not preclude surgical treatment in elderly patients with gastric cardia cancer and a tumor resection can be carried out safely. Certainly, we should take care in defining the surgical treatment in elderly patients, particularly as regarding the surgical approach; although the surgical approach does not influence the survival rate, the transhiatal way still remains the best one due, to the lower incidence of respiratory morbidity and thoracic pain. | Natale Di Martino Giuseppe Izzo Angelo Cosenza Guido Cerullo Francesco Torelli Antonio Brillantino Alberto del Genio | 2005 | World Journal of Gastroenterology2005，11，33： | 5 |
| 5 | Neoadjuvant strategies for pancreatic cancer显示文摘Pancreatic cancer(PC)is the fourth cause of cancer death in Western countries,the only chance for long term survival is an R0 surgical resection that is feasible in about 10%-20%of all cases.Five years cumulative survival is less than 5%and rises to 25%for radically resected patients.About 40%has locally advanced in PC either borderline resectable(BRPC)or unresectable locally advanced(LAPC).Since LAPC and BRPC have been recognized as a particular form of PC neoadjuvant therapy(NT)has increasingly became a valid treatment option.The aim of NT is to reach local control of disease but,also,it is recognized to convert about40%of LAPC patients to R0 resectability,thus providing a significant improvement of prognosis for responding patients.Once R0 resection is achieved,survival is comparable to that of early stage PCs treated by upfront surgery.Thus it is crucial to look for a proper patient selection.Neoadjuvant strategies are multiples and include neoadjuvant chemotherapy(nCT),and the association of nCT with radiotherapy(nCRT)given as either a combination of a radio sensitizing drug as gemcitabine or capecitabine or and concomitant irradiation or as upfront nCT followed by nRT associated to a radio sensitizing drug.This latter seem to be most promising as it may select patients who do not go on disease progression during initial treatment and seem to have a better prognosis.The clinical relevance of nCRT may be enhanced by the application of higher active protocols as FOLFIRINOX. | Francesco Polistina Giuseppe Di Natale Giorgio Bonciarelli Giovanni Ambrosino Mauro Frego | 2014 | World Journal of Gastroenterology2014，20，28： | 3 |
| 6 | Antioxidant and Antiproliferative Activity of Diospyros lotus L. Extract and Isolated Compounds显示文摘 | Monica Rosa Loizzo Ataa Said Rosa Tundis Usama W. Hawas Khaled Rashed Federica Menichini Natale Giuseppe Frega Francesco Menichini | 2009 | Plant Foods for Human Nutrition2009，，4： | 1 |
| 7 | Relation of Myocardial Blush Grade to Microvascular Perfusion and Myocardial Infarct Size After Primary or Rescue Percutaneous Coronary Intervention显示文摘 | Italo Porto Francesco Burzotta Marta Brancati Carlo Trani Antonella Lombardo Enrico Romagnoli Giampaolo Niccoli Luigi Natale Lorenzo Bonomo Filippo Crea | 2007 | The American Journal of Cardiology2007，，12： | 1 |
| 8 | Schedule-based transit assignment: A new dynamic equilibrium model with vehicle capacity constraints显示文摘 | Natale Papola Francesco Filippi Guido Gentile | 2009 | Operations Research2009，46，10： | 1 |
| 9 | CT colonography after incomplete colonoscopy in subjects with positive faecal occult blood test显示文摘AIM: To report our experience with computed tomog- raphy colonography (CTC) systematically performed in subjects with positive faecal occult blood test (FOBT) and an incomplete colonoscopy in the setting of a population-based screening for colorectal cancer (CRC). METHODS: From April 2006 to April 2007, 43 290 indi- viduals (age range 50-70) who adhered to the regional screening program for the prevention of CRC under-went immunochemical FOBT. FOBT was positive in 1882 subjects (4.3%). 1463 (77.7%) of these subjects underwent colonoscopy, 903 performed in a single center. Of 903 colonoscopies 65 (7.2%) were incom- plete. Forty-two of these subjects underwent CTC. CTC was performed with a 16-MDCT scanner after standard bowel prep (polyethyleneglycole) in both supine and prone position. Subjects whose CTC showed polyps or masses were referred to the endoscopist for repeat colonoscopy under sedation or underwent surgery. Per-lesion and per-segment positive predictive values (PPV) were calculated. RESULTS: Twenty-one (50%) of 42 CTCs showed pol-yps or masses. Fifty-five of these subjects underwent a repeat colonoscopy, whereas 2 subjects underwentsurgery for colonic masses of indeterminate nature. Four subjects refused further examinations. CTC cor- rectly identified 2 colonic masses and 20 polyps. PPV for masses or polyps greater than 9 mm was of 87.5%. Per-lesion and per-segment PPV were, respectively, 83.3% and 83.3% for polyps greater or equal to 10 mm, and 77.8% and 85.7% for polyps of 6-9 mm. CONCLUSION: In the context of a screening program for CRC based on FOBT, CTC shows high per-segment and per-lesion PPV for colonic masses and polyps greater than 9 mm. Therefore, CTC has the potential to become a useful technique for evaluation of the non visualized part of the colon after incomplete colonos-copy. | Lapo Sali Massimo Falchini Andrea Giovanni Bonanomi Guido Castiglione Stefano Ciatto Paola Mantellini Francesco Mungai Ilario Menchi Natale Villari Mario Mascalchi | 2008 | World Journal of Gastroenterology2008，14，28： | 1 |
| 10 | A spatio-temporal concealment technique using boundary matching algorithm and mesh -based warping (BMA -MBW) 显示文摘 | Atzori Luigi De Natale Francesco G B | | IEEE TRANSACTIONS ON MULTIMEDIA0，3，3： | 1 |
| 11 | New technologies for marine diesel engine emission control显示文摘 | di Natale Francesco Carotenuto Claudia Addio Luca D | 2013 | Chemical Engineering Transactions2013，32，： | 1 |
| 12 | Chemical analysis, antioxidant, antiinflammatory and anticholinesterase activities of Origanum ehrenbergii Boiss and Origanum syriacum L. essential oils显示文摘 | Monica R. Loizzo Federica Menichini Filomena Conforti Rosa Tundis Marco Bonesi Antoine M. Saab Giancarlo A. Statti Bruno de Cindio Peter J Houghton Francesco Menichini Natale Giuseppe Frega | 2009 | Food Chemistry2009，，1： | 1 |
| 13 | Clinical, Manometric, and Ultrasonographic Results of Pneumatic Balloon Dilatation vs. Lateral Internal Sphincterotomy for Chronic Anal Fissure: A Prospective, Randomized, Controlled Trial显示文摘 | Adolfo Renzi M.D. Ph.D. Domenico Izzo M.D. Giandomenico Sarno M.D. Pasquale Talento M.D. Francesco Torelli M.D. Ph.D. Giuseppe Izzo M.D. Natale Martino M.D | 2008 | Diseases of the Colon & Rectum2008，，1： | 1 |
| 14 | Quantitative Blush Evaluator accurately quantifies microvascular dysfunction in patients with ST-elevation myocardial infarction: Comparison with cardiovascular magnetic resonance显示文摘 | Italo Porto Christian Hamilton-Craig Giovanni Luigi De Maria Rocco Vergallo Giorgio Cautilli Leonarda Galiuto Francesco Burzotta Antonio Maria Leone Giampaolo Niccoli Luigi Natale Lorenzo Bonomo Filippo Crea | 2011 | American Heart Journal2011，，2： | 1 |
| 15 | Combined Laparoscopic-Endoscopic 'Rendez-vous' Procedure for Minimally Invasive Resection of Gastrointestinal Stromal Tumors of the Stomach显示文摘 | Marano Luigi Torelli Francesco Schettino Michele Porfidia Raffaele Reda Gianmarco Grassia Michele Braccio Bartolomeo Petrillo Marianna Di Martino Natale | 2011 | The American Surgeon2011，，8： | 1 |
| 16 | 减少海洋航运环境排放的新方法显示文摘Maritime shipping is a strategic sector with a strong international vocation and management.The need to define regulations valid for many different countries without generating disparities of treatment slowed down the formulation of environmental regulations,especially for atmospheric emissions.In particular,regulations pertaining to the reduction of sulphur compounds allowed two distinct approaches:the use of low-sulphur fuels or exhaust gas cleaning systems,the so-called Scrubbers.The actual implementation of these solutions presents specific concerns either related to the toxicity of atmospheric by-products and to the fuel cost or to the generation of polluting washwaters that may need treatment before discharge.In this paper we analyzed the potential environmental benefit deriving from the use of a distillate fuel,not compliant with current IMO Sulphur Regulations,together with a Scrubber.The pilot-scale experimental results indicated that a limited amount of water and/or scrubber volume is needed to reduce sulphur emissions below regulations on maritime shipping,especially with the addition of NaOH reaching a water-saving between 25%-33%compared to the use of pure seawater.Experiments indicated that scrubber washwater PAHs emissions are within the available water quality standards indicated by EU and USA guidelines.A bottom-up analysis on heavy metals concentration shed light on the prominent role of metal-parts corrosion on the washwater emissions.Taking into account for corrosion phenomena,the actual heavy metals concentration in the washwater deriving from scrubbing was normally below the water quality standards. | Domenico Flagiello Martina Esposito Francesco Di Natale Kent Salo | 2021 | Journal of Marine Science and Application2021，20，2： | 1 |
| 17 | Tako-Tsubo cardiomyopathy following an allergic asthma attack after cephalosporin administration显示文摘 | Francesco Santoro Michele Correale Riccardo Ieva Maria Filomena Caiaffa Ilaria Pappalardo Matteo Di Biase Natale Daniele Brunetti | 2011 | International Journal of Cardiology2011，，1： | 1 |
| 18 | Inflammation and Cardiovascular Disease: From Pathogenesis to Therapeutic Target显示文摘 | Enrica Golia Giuseppe Limongelli Francesco Natale Fabio Fimiani Valeria Maddaloni Ivana Pariggiano Renatomaria Bianchi Mario Crisci Ludovica D’Acierno Roberto Giordano Gaetano Palma Marianna Conte Paolo Golino Maria Giovanna Russo Raffaele Calabrò Paolo C | 2014 | Current Atherosclerosis Reports2014，，9： | 1 |
| 19 | Clinical and procedural outcome of patients implanted with a quadripolar left ventricular lead: Early results of a prospective multicenter study显示文摘 | Giovanni B. Forleo Massimo Mantica Luigi Di Biase Germana Panattoni Domenico G. Della Rocca Lida P. Papavasileiou Matteo Santamaria Pasquale Santangeli Andrea Avella Domenico Sergi Luca Santini Claudio Tondo Andrea Natale Francesco Romeo | 2012 | Heart Rhythm2012，，11： | 1 |
| 20 | Clinical and procedural outcome of patients implanted with a quadripolar left ventricular lead: Early results of a prospective multicenter study显示文摘 | Giovanni B. Forleo Massimo Mantica Luigi Di Biase Germana Panattoni Domenico G. Della Rocca Lida P. Papavasileiou Matteo Santamaria Pasquale Santangeli Andrea Avella Domenico Sergi Luca Santini Claudio Tondo Andrea Natale Francesco Romeo | 2012 | Heart Rhythm2012，，11： | 1 |
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