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| 1 | Prevalence of bile reflux in gastroesophageal reflux disease patients not responsive to proton pump inhibitors显示文摘AIM:To determine the prevalence and characteristics of bile reflux in gastroesophageal reflux disease(GERD) patients with persistent symptoms who are non-responsive to medical therapy.METHODS:Sixty-five patients(40 male,25 female;mean age,50 ± 7.8 years) who continued to report symptoms after 8 wk of high-dose proton pump inhibitor(PPI) therapy,as well as 18 patients with Barrett's esophagus,were studied.All patients filled out symptom questionnaires and underwent endoscopy,manometry and combined pH-metry and bilimetry.RESULTS:There were 4 groups of patients:22(26.5%) without esophagitis,24(28.9%) grade A-B esophagitis,19(22.8%) grade C-D and 18(21.6%) Barrett's esophagus.Heartburn was present in 71 patients(85.5%) and regurgitation in 55(66.2%),with 44(53%) reporting simultaneous heartburn and regurgitation.The prevalence of pathologic acid reflux in the groups without esophagitis and with grades A-B and C-D esophagitis was 45.4%,66.6% and 73.6%,respectively.The prevalence of pathologic bilirubin exposure in these 3 groups was 53.3%,75% and 78.9%,respectively.The overall prevalence of bile reflux in non-responsive patients was 68.7%.Pathologic acid and bile reflux was observed in 22.7% and 58.1% of non-esophagitic patients and esophagitic patients,respectively.CONCLUSION:The high percentage of patients poorly responsive to PPI therapy may result from poor control of duodenogastroesophageal reflux.Many patients without esophagitis have simultaneous acid and bile reflux,which increases with increasing esophagitis grade. | Luigi Monaco Antonio Brillantino Francesco Torelli Michele Schettino Giuseppe Izzo Angelo Cosenza Natale Di Martino | 2009 | World Journal of Gastroenterology2009，15，3： | 8 |
| 2 | Long lasting response to second-line everolimus in kidney cancer显示文摘In the case presented here, everolimus was administered after first line therapy with sunitinib in a patient with metastatic renal cell carcinoma. The safety profile was excellent. The prolonged progression-free survival(PFS) obtained with everolimus in this case is of peculiar interest, as it is a multiple of the median PFS obtained in with everolimus in the regulatory trial. Such finding suggests that a subset of patients with renal cell carcinma may particularly benefit from everolimus. | Antonella Virtuoso Tania Policastro Michela Izzo Piera Federico Carlo Buonerba Pasquale Rescigno Giuseppe Di Lorenzo | 2013 | World Journal of Clinical Cases2013，1，5： | 6 |
| 3 | Adenocarcinoma of gastric cardia in the elderly: Surgical problems and prognostic factors显示文摘AIM: To analyze retrospectively, our results about patients who underwent surgical treatment for adenocarcinoma of the cardia in relation to age, in order to evaluate surgical problems and prognostic factors.METHODS: From January 1987 to March 2003, 140 patients with adenocarcinoma of the cardia underwent resection in the authors' institution. They were divided into three groups with regard to age. Patients <70 and >60 year old (31) were excluded; we also excluded 18 out of 109 patients with poor general status or systemic metastases. So, we compared 51 elderly (≥ 70 year old)and 58 younger patients (≤ 60 year old). The treatment was esophagectomy for type Ⅰ tumors, and extended gastrectomy and distal esophagectomy for type Ⅱ and Ⅲ lesions.RESULTS: Laparotomy was carried out in 91 patients (83.4%), 38 in the elderly (74.5%) and 53 in younger patients (91.3%, P<0.05). Primary resection was performed in 811 cases (89%) without significant differences between the two groups. Postoperative death was higher in the elderly (12.1%) than the other group (4.1%, P<0.05), while morbidity was similar in both groups. A curative resection (R0) was performed in 59 patients (72.8%), 69.6% in the elderly and 75% in the younger group (P>0.05). The overall 3- and 5-year survival rates were 26.7% and 117.8% respectively for the elderly and 40.7% and 35.1% respectively for younger patients (P = 0.1544). Survival rates were significantly associated with R0 resection,pathological node-positive category and tumor differentiation in both groups.CONCLUSION: As the age of the general population increases, more elderly patients with gastric cardia cancer will be candidates for surgical resection. Age alone should not preclude surgical treatment in elderly patients with gastric cardia cancer and a tumor resection can be carried out safely. Certainly, we should take care in defining the surgical treatment in elderly patients, particularly as regarding the surgical approach; although the surgical approach does not influence the survival rate, the transhiatal way still remains the best one due, to the lower incidence of respiratory morbidity and thoracic pain. | Natale Di Martino Giuseppe Izzo Angelo Cosenza Guido Cerullo Francesco Torelli Antonio Brillantino Alberto del Genio | 2005 | World Journal of Gastroenterology2005，11，33： | 5 |
| 4 | Laparoscopic calibrated total vs partial fundoplication following Heller myotomy for oesophageal achalasia显示文摘AIM:To compare the mid-term outcomes of laparoscopic calibrated Nissen-Rossetti fundoplication with Dor fundoplication performed after Heller myotomy for oesophageal achalasia.METHODS:Fifty-six patients(26 men,30 women;mean age 42.8±14.7 years)presenting for minimally invasive surgery for oesophageal achalasia,were enrolled.All patients underwent laparoscopic Heller myotomy followed by a 180°anterior partial fundoplication in 30 cases(group 1)and calibrated NissenRossetti fundoplication in 26(group 2).Intraoperative endoscopy and manometry were used to calibrate the myotomy and fundoplication.A 6-mo follow-up period with symptomatic evaluation and barium swallow was undertaken.One and two years after surgery,the patients underwent symptom questionnaires,endoscopy,oesophageal manometry and 24 h oesophago-gastric pH monitoring.RESULTS:At the 2-year follow-up,no significant difference in the median symptom score was observed between the 2 groups(P=0.66;Mann-WhitneyU-test).The median percentage time with oesophageal pH< 4 was significantly higher in the Dor group compared to the Nissen-Rossetti group(2;range 0.8-10 vs 0.35;range 0-2)(P<0.0001;Mann-WhitneyU-test).CONCLUSION:Laparoscopic Dor and calibrated Nissen-Rossetti fundoplication achieved similar results in the resolution of dysphagia.Nissen-Rossetti fundoplication seems to be more effective in suppressing oesophageal acid exposure. | Natale Di Martino Antonio Brillantino Luigi Monaco Luigi Marano Michele Schettino Raffaele Porfidia Giuseppe Izzo Angelo Cosenza | 2011 | World Journal of Gastroenterology2011，17，29： | 4 |
| 5 | Cabazitaxel in castration resistant prostate cancer with brain metastases: 3 case reports显示文摘Prostate cancer is the most common non-cutaneous malignancy for men. The skeleton is the most common metastatic site but, following an improvement in survival, metastases in uncommon sites are being found more frequently in clinical practice, especially brain metastases. Despite the new drugs now available for metastatic castration resistant prostate cancer, no clinical evidence exists about their effectiveness on brain metastases. We describe the clinical history of 3 patients treated with cabazitaxel plus whole brain radiotherapy. These case reports demonstrate that cabazitaxel is highly active and well tolerated in brain metastases. | Sabino De Placido Pasquale Rescigno Piera Federico Carlo Buonerba Davide Bosso Livio Puglia Michela Izzo Tania Policastro Giuseppe Di Lorenzo | 2014 | World Journal of Clinical Cases2014，2，6： | 2 |
| 6 | Clinical and Immunological Impact of Early Postoperative Enteral Immunonutrition After Total Gastrectomy in Gastric Cancer Patients: A Prospective Randomized Study显示文摘 | Luigi Marano Raffaele Porfidia Modestino Pezzella Michele Grassia Marianna Petrillo Giuseppe Esposito Bartolomeo Braccio PierLuigi Gallo Virginia Boccardi Angelo Cosenza Giuseppe Izzo Natale Di Martino | 2013 | Annals of Surgical Oncology2013，，12： | 1 |
| 7 | Evaluation of the appropriate perioperative antibiotic prophylaxis in Italy显示文摘 | Napolitano F Izzo MT Giuseppe GD | 2013 | Plo S One2013，8，79： | 1 |
| 8 | Clinical, Manometric, and Ultrasonographic Results of Pneumatic Balloon Dilatation vs. Lateral Internal Sphincterotomy for Chronic Anal Fissure: A Prospective, Randomized, Controlled Trial显示文摘 | Adolfo Renzi M.D. Ph.D. Domenico Izzo M.D. Giandomenico Sarno M.D. Pasquale Talento M.D. Francesco Torelli M.D. Ph.D. Giuseppe Izzo M.D. Natale Martino M.D | 2008 | Diseases of the Colon & Rectum2008，，1： | 1 |
| 9 | the Collaborative working group(2013)evaluation of the appropriate perioperative antibiotic prophylaxis in italy显示文摘 | Napolitano F Izzo MT Di Giuseppe G | 2013 | PLoS One2013，8，79： | 1 |
| 10 | HCV-related hepatocellular carcinoma: From chronic inflammation to cancer显示文摘 | Giuseppe Castello Stefania Scala Giuseppe Palmieri Steven A. Curley Francesco Izzo | 2009 | Clinical Immunology2009，，： | 1 |
| 11 | Unilateral post-chemotherapy robot-assisted retroperitoneal lymph node dissection in Stage II non-seminomatous germ cell tumor:A tertiary care experience显示文摘Objective Post-chemotherapy retroperitoneal lymph node dissection(PC-RPLND)represents an integral component of the management of patients with non-seminomatous germ cell tumor(NSGCT).Modified templates have been proposed to minimize the surgical morbidity of the procedure.Moreover,the implementation of robotic surgery in this setting has been explored.We report our experience with unilateral post-chemotherapy robot-assisted retroperitoneal lymph node dissection(PC-rRPLND)for clinical Stages IIA and IIB NSGCTs.Methods A retrospective single institution review was performed including 33 patients undergoing PC-rRPLND for Stages IIA and IIB NSGCTs between January 2015 and February 2019.Following orchiectomy,patients were scheduled for chemotherapy with three cycles of bleomycin-etoposide-cisplatin.Patients with a residual tumor of<5 cm and an ipsilateral metastatic disease on pre-and post-chemotherapy CT scans were eligible for a unilateral template in absence of rising tumor markers.Descriptive statistics were provided for demographics,clinical characteristics,intraoperative and postoperative parameters.Perioperative,oncological,and functional outcomes were recorded.Results Overall,7(21.2%)patients exhibited necrosis or fibrosis;14(42.4%)had mature teratoma;and 12(36.4%)had viable tumor at final histology.The median lymph node size at surgery was 25(interquartile range[IQR]21-36)mm.Median operative time was 180(IQR 165-215)min and no major postoperative complications were observed.Anterograde ejaculation was preserved in 75.8%of patients.Median follow-up was 26(IQR 19-30)months and a total of three recurrences were recorded.Conclusion PC-rRPLND is a reliable and technically reproducible procedure with safe oncological outcomes and acceptable postoperative ejaculatory function in well selected patients with NSGCTs. | Dario Franzese Antonio Tufano Alessandro Izzo Raffaele Muscariello Giovanni Grimaldi Giuseppe Quarto Luigi Castaldo Sabrina Rossetti Savio Domenico Pandolfo Sonia Desicato Paola Del Prete Matteo Ferro Sandro Pignata Sisto Perdonà | 2023 | Asian Journal of Urology2023，10，4： | 0 |
| 12 | Non-AIDS-related Kaposi’s sarcoma:A single-institution experience显示文摘AIM:To evaluate the outcomes and potential prognostic factors in patients with non-acquired immunodeficiency syndrome(AIDS)-related Kaposi’s sarcoma(KS).METHODS:Patients with histologically proven non-AIDS-related KS treated with systemic chemotherapy were included in this retrospective analysis.In some cases,the human herpes virus 8 status was assessed by immunohistochemistry.The patients were staged according to the Mediterranean KS staging system.A multivariable model was constructed using a forward stepwise selection procedure.A P value<0.05 was considered statistically significant,and all tests were two-sided.RESULTS:Thirty-two cases were included in this analysis.The average age at diagnosis was 70 years,with a male/female ratio of approximately 2:1.Eighty-four percent of the cases had classic KS.All patients received systemic chemotherapy containing one of the following agents:vinca alkaloid,taxane,and pegylated liposomal doxorubicin.Ten patients(31.5%)experienced a partial response,and a complete response was achieved in four patients(12.4%)and stable disease in sixteen cases(50%).Two patients(6.2%)were refractory to the systemic treatment.The median progression-free survival(PFS)was 11.7 mo,whereas the median overall survival was 28.5 mo.At multivariate analysis,the presence of nodular lesions(vs macular lesions only)was significantly related to a lower PFS(hazard ratio:3.09;95%CI:1.18-8.13,P=0.0133).CONCLUSION:Non-AIDS-related KS appears mostly limited to the skin and is well-responsive to systemic therapies.Our data show that nodular lesions may be associated with a shorter PFS in patients receiving chemotherapy. | Pasquale Rescigno Rossella Di Trolio Carlo Buonerba Gaia De Fata Piera Federico Davide Bosso Antonella Virtuoso Michela Izzo Tania Policastro Luca Vaccaro Gianfranco Cimmino Francesco Perri Elide Matano Mario Delfino Sabino De Placido Giovannella Palmieri Giuseppe Di Lorenzo | 2013 | World Journal of Clinical Oncology2013，4，2： | 0 |
| 13 | Large symptomatic gastric diverticula:Two case reports and a brief review of literature显示文摘Gastric diverticula are rare and uncommon conditions.Most gastric diverticula are asymptomatic.When symptoms arise,they are most commonly upper abdominal pain,nausea and emesis,while dyspepsia and vomiting are less common.Occasionally,patients with gastric diverticula can have dramatic presentations related to massive bleeding or perforation.The diagnosis may be difficult,as symptoms can be caused by more common gastrointestinal pathologies and only aggravated by diverticula.The appropriate management of diverticula depends mainly on the symptom pattern and as well as diverticulum size.There is no specific therapeutic strategy for an asymptomatic diverticulum.Although some authors support conservative therapy with antacids,this provides only temporary symptom relief since it is not able to resolve the underlying pathology.Surgical resection is the mainstay of treatment when the diverticulum is large,symptomatic or complicated by bleeding,perforation or malignancy,with over two-thirds of patients remaining symptom-free after surgery,while laparoscopic resection,combined with intraoperative endoscopy,is a safe and feasible approach with excellent outcomes.Here,we present two cases of uncommon large symptomatic gastric diverticula with a discussion of the cornerstones in management and report a minimally invasive solution,with a brief review of the literature. | Luigi Marano Gianmarco Reda Raffaele Porfidia Michele Grassia Marianna Petrillo Giuseppe Esposito Francesco Torelli Angelo Cosenza Giuseppe Izzo Natale Di Martino | 2013 | World Journal of Gastroenterology2013，19，36： | 0 |
| 14 | Preface to Focused Section on Efficient High-Order Time Discretization Methods for Partial Differential Equations显示文摘During May 8-10,2019,the International Workshop on Efficient High-Order Time Discretization Methods for Partial Differential Equations took place in Villa Orlandi,Anacapri,Italy,a Congress Center of the University of Naples Federico II.About 40 senior researchers,young scholars,and Ph.D.students attended this workshop.The purpose of this event was to explore recent trends and directions in the area of time discretization for the numerical solution of evolutionary partial differential equations with particular application to high-order methods for hyperbolic systems with source and advection-diffusion-reaction equations,and with special emphasis on efficient time-stepping methods such as implicit-explicit(IMEX),semi-implicit and strong stability preserving(SSP)time discretization.The present focused section entitled“Efficient High-Order Time Discretization Methods for Partial Differential Equations”in Communications on Applied Mathematics and Computation(CAMC)consists of five regularly reviewed manuscripts,which were selected from submissions of works presented during the workshop.We thank all the authors of these contributions,and hope that the readers are interested in the topics,techniques and methods,and results of these papers.We also want to thank the CAMC journal editorial staff as well as all the referees for their contributions during the review and publication processes of this focused section. | Sebastiano Boscarino Giuseppe Izzo Lorenzo Pareschi Giovanni Russo Chi-Wang Shu | 2021 | Communications on Applied Mathematics and Computation2021，3，4： | 0 |
| 15 | Strong Stability Preserving IMEX Methods for Partitioned Systems of Differential Equations显示文摘We investigate strong stability preserving(SSP)implicit-explicit(IMEX)methods for partitioned systems of differential equations with stiff and nonstiff subsystems.Conditions for order p and stage order q=p are derived,and characterization of SSP IMEX methods is provided following the recent work by Spijker.Stability properties of these methods with respect to the decoupled linear system with a complex parameter,and a coupled linear system with real parameters are also investigated.Examples of methods up to the order p=4 and stage order q—p are provided.Numerical examples on six partitioned test systems confirm that the derived methods achieve the expected order of convergence for large range of stepsizes of integration,and they are also suitable for preserving the accuracy in the stiff limit or preserving the positivity of the numerical solution for large stepsizes. | Giuseppe Izzo Zdzislaw Jackiewicz | 2021 | Communications on Applied Mathematics and Computation2021，3，4： | 0 |
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