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| 1 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
| 2 | Rapid inactivation of multidrug-resistant bacteria and enhancement of osteoinduction via titania nanotubes grafted with polyguanidines显示文摘The rapid in situ inhibition of bacterial contamination and subsequent infection without inducing drug resistance is highly vital for the successful implantation and long-term service of titanium(Ti)-based orthopedic implants.However,the instability and potential cytotoxicity of current coatings have deterred their clinical practice.In this study,anodic oxidized titania nanotubes(TNT)were modified with antibacterial polyhexamethylene guanidine(PG)with the assistance of 3,4-dihydroxyphenylacetic acid.Interestingly,the prepared TNT-PG coating exhibited superior in vitro antibacterial activity than flat Ti-PG coating and effectively killed typical pathogens such as Escherichia coli and superbug methicillinresistant Staphylococcus aureus with above 4-log reduction(>99.99%killed)in only 5 min.TNT-PG coating also exerted excellent hemocompatibility with red blood cells and nontoxicity toward mouse pre-osteoblasts(MC3 T3-E1)in 1 week of coculture.In addition,the efficient in vivo anti-infective property of this coating was observed in a rat subcutaneous infection model.More importantly,TNT-PG coating improved the expression of alkaline phosphatase and enhanced the extracellular matrix mineralization of pre-osteoblasts,denoting its osteoinductive capacity.This versatile TNT-PG coating with excellent antibacterial activity and biocompatibility could be a promising candidate for advanced orthopedic implant applications. | Wei Feng Nian Liu Lingling Gao Qian Zhou Luofeng Yu Xiaoting Ye Jingjing Huo Xiao Huang Peng Li Wei Huang | 2021 | Journal of Materials Science & Technology2021，，10： | 2 |
| 3 | Robust Semi-nonnegative Matrix Factorization with Adaptive Graph Regularization for Gene Representation显示文摘Various data representation algorithms have been proposed for gene expression.There are some shor tcomings in tradi tio nal gene expression met hods,such as learning the ideal affinity matrix to effectively cap ture the geometric st rue ture of gene tic data space,and reducing noises and outliers influences of data input.We propose a novel matrix factorization algorithm called Robust semi-nonnegative matrix factorization(RSNMF)with adaptive graph regularization,which simultaneously performs matrix robust fhetorization with learning affinity matrix in a unified optimization framework.RSNMF also uses a loss function based on€2,i_norm to improve the robus tn ess of the model agains t noises and outliers.A novel Augmented Lagrange multiplier(ALM)is designed to obtain the optimal solution of RSNMF.The results of extensive experiments that were performed on gene expression datasets demonstrate that RSNMF out performs the ot her algori thms,which valida tes the effectiveness and robustness of RSNMF. | JIANG Wei MA Tingting FENG Xiaoting ZHAI Yun TANG Kewei ZHANG Jie | 2020 | Chinese Journal of Electronics2020，29，1： | 2 |
| 4 | Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2显示文摘Dear Editor To date,tens of millions of people have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing the outbreak of the respiratory disease named the coronavirus disease 2019(COVID-19).As a newly emerged member of the coronavirus family,SARS-CoV-2 is an enveloped positive-strand RNA virus,which has probably the largest genome(approximately 30 kb)among all RNA viruses.The nucleocapsid(N)protein of SARS-CoV-2 is mainly responsible for recognizing and wrapping viral RNA into helically symmetric structures(Malik,2020). | Dan Zhao Weifan Xu Xiaofan Zhang Xiaoting Wang Yiyue Ge Enming Yuan Yuanpeng Xiong Shenyang Wu Shuya Li Nian Wu Tingzhong Tian Xiaolong Feng Hantao Shu Peng Lang Jingxin Li Fengcai Zhu Xiaokun Shen Haitao Li Pilong Li Jianyang Zeng | 2021 | Protein & Cell2021，12，9： | 1 |
| 5 | Selection of reference genes for gene expression studies in porcine skeletal muscle using SYBR green qPCR显示文摘 | Xiaoting Feng Yuanzhu Xiong Hui Qian Minggang Lei Dequan Xu Zhuqing Ren | 2010 | Journal of Biotechnology2010，，3： | 1 |
| 6 | New Algorithm Rules Out Acute-on-chronic Liver Failure Development within 28 Days from Acute Decompensation of Cirrhosis显示文摘Background and Aims:Approximately 10%of patients with acute decompensated(AD)cirrhosis develop acute-on-chronic liver failure(ACLF)within 28 days.Such cases have high mortality and are difficult to predict.Therefore,we aimed to establish and validate an algorithm to identify these patients on hospitalization.Methods:Hospitalized patients with AD who developed ACLF within 28 days were considered pre-ACLF.Organ dysfunction was defined accord-ing to the chronic liver failure-sequential organ failure as-sessment(CLIF-SOFA)criteria,and proven bacterial infec-tion was taken to indicate immune system dysfunction.A retrospective multicenter cohort and prospective one were used to derive and to validate the potential algorithm,re-spectively.A miss rate of<5%was acceptable for the calcu-lating algorithm to rule out pre-ACLF.Results:In the deri-vation cohort(n=673),46 patients developed ACLF within 28 days.Serum total bilirubin,creatinine,international normalized ratio,and present proven bacterial infection at admission were associated with the development of ACLF.AD patients with≥2 organ dysfunctions had a higher risk for pre-ACLF patients[odds ratio=16.58195%confidence interval:(4.271-64.363),p<0.001].In the derivation co-hort,67.5%of patients(454/673)had≤1 organ dysfunction and two patients(0.4%)were pre-ACLF,with a miss rate of 4.3%(missed/total,2/46).In the validation cohort,65.9%of patients(914/1388)had≤1 organ dysfunction,and four(0.3%)of them were pre-ACLF,with a miss rate of 3.4%(missed/total,4/117).Conclusions:AD patients with≤1 organ dysfunction had a significantly lower risk of developing ACLF within 28 days of admission and could be safely ruled out with a pre-ACLF miss rate of<5%. | Xiaoting Tang Hai Li Guohong Deng Xin Zheng Xianbo Wang Yan Huang Yanhang Gao Zhongji Meng Zhiping Qian Feng Liu Xiaobo Lu Yu Shi Beiling Li Wenyi Gu Xiaomei Xiang Yan Xiong Yixin Hou Jun Chen Na Gao Sen Luo Liujuan Ji Jing Li Rongjiong Zheng Haotang Ren Jinjun Chen | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 1 |
| 7 | Differential proteome and transcriptome analysis of porcine skeletal muscle during development显示文摘 | Yongjie Xu Hui Qian Xiaoting Feng Yuanzhu Xiong Minggang Lei Zhuqing Ren Bo Zuo Dequan Xu Yun Ma Hongyu Yuan | 2012 | Journal of Proteomics2012，，7： | 1 |
| 8 | Integrative Analysis of Genome,3D Genome,and Transcriptome Alterations of Clinical Lung Cancer Samples显示文摘Genomic studies of cancer cell alterations,such as mutations,copy number variations(CNVs),and translocations,greatly promote our understanding of the genesis and development of cancers.However,the 3D genome architecture of cancers remains less studied due to the complexity of cancer genomes and technical difficulties.To explore the 3D genome structure in clinical lung cancer,we performed Hi-C experiments using paired normal and tumor cells harvested from patients with lung cancer,combining with RNA sequenceing analysis.We demonstrated the feasibility of studying 3D genome of clinical lung cancer samples with a small number of cells(1×10^(4)),compared the genome architecture between clinical samples and cell lines of lung cancer,and identified conserved and changed spatial chromatin structures between normal and cancer samples.We also showed that Hi-C data can be used to infer CNVs and point mutations in cancer.By integrating those different types of cancer alterations,we showed significant associations between CNVs,3D genome,and gene expression.We propose that 3D genome mediates the effects of cancer genomic alterations on gene expression through altering regulatory chromatin structures.Our study highlights the importance of analyzing 3D genomes of clinical cancer samples in addition to cancer cell lines and provides an integrative genomic analysis pipeline for future larger-scale studies in lung cancer and other cancers. | Tingting Li Ruifeng Li Xuan Dong Lin Shi Miao Lin Ting Peng Pengze Wu Yuting Liu Xiaoting Li Xuheng He Xu Han Bin Kang Yinan Wang Zhiheng Liu Qing Chen Yue Shen Mingxiang Feng Xiangdong Wang Duojiao Wu Jian Wang Cheng Li | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 1 |
| 9 | Patterns and ecological determinants of woody plant height in eastern Eurasia and its relation to primary productivity显示文摘Aims Plant height is a key functional trait related to aboveground bio-mass,leaf photosynthesis and plant fitness.However,large-scale geographical patterns in community-average plant height(cAPH)of woody species and drivers of these patterns across different life forms remain hotly debated.Moreover,whether cAPH could be used as a predictor of ecosystem primary productivity is unknown.Methods We compiled mature height and distributions of 11422 woody spe-cies in eastern Eurasia,and estimated geographic patterns in cAPH for different taxonomic groups and life forms.then we evaluated the effects of environmental(including current climate and historical climate change since the Last Glacial Maximum(LGM))and evolutionary factors on cAPH.Lastly,we compared the predictive power of cAPH on primary productivity with that of LiDAR-derived canopy-height data from a global survey.Important Findings Geographic patterns of cAPH and their drivers differed among taxonomic groups and life forms.the strongest predictor for cAPH of all woody species combined,angiosperms,all dicots and deciduous dicots was actual evapotranspiration,while temperature was the strongest pre-dictor for cAPH of monocots and tree,shrub and evergreen dicots,and water availability for gymnosperms.Historical climate change since the LGM had only weak effects on cAPH.No phylogenetic signal was detected in family-wise average height,which was also unrelated to the tested environmental factors.Finally,we found a strong correlation between cAPH and ecosystem primary productivity.Primary productivity showed a weaker relationship with cAPH of the tallest species within a grid cell and no relationship with LiDAR-derived canopy height reported in the global survey.Our findings suggest that current climate rather than historical climate change and evolutionary history determine the geographical patterns in cAPH.However,the relative effects of climatic factors representing environmental energy and water availability on spatial variations of cAPH vary among plant life forms.Moreover,our results also suggest that cAPH can be used as a good predictor of ecosystem primary productivity. | Zhiheng Wang Yaoqi Li Xiangyan Su Shengli Tao Xiao Feng Qinggang Wang Xiaoting Xu Yunpeng Liu Sean T.Michaletz Nawal Shrestha Markku Larjavaara Brian J.Enquist | 2019 | Journal of Plant Ecology2019，12，5： | 0 |
| 10 | Recent advances in the catalytic production of bio-based diol 2,5-bis(hydroxymethyl)furan显示文摘Biomass-derived 2,5-bis(hydroxymethyl)furan(BHMF)has received great attention and interest due to its broad application prospects in polyesters and medicine.Over the past decades,the catalytic systems including thermocatalytic,biocatalytic,electrocatalytic,and photocatalytic hydrogenation of 5-hydroxymethylfurfural(HMF)into BHMF have been developed to a great extent.To understand the present status and challenges of BHMF production,this review systematically evaluates recent findings and developments of HMF hydrogenation through various reaction systems,with an emphasis on catalyst screening,synthesis processes,and reaction mechanism.Furthermore,a few potential research trends are also proposed,in order to provide innovative ideas for further exploration of BHMF synthesis in a simpler,efficient,and economical way. | Wenguang Zhao Feng Wang Kangyu Zhao Xianxiang Liu Xiaoting Zhu Le Yan Yuan Yin Qiong Xu Dulin Yin | 2023 | Carbon Resources Conversion2023，6，2： | 0 |
| 11 | Novel magnetic field computation model in pattern classification显示文摘Field computation, an emerging computation technique,has inspired passion of intelligence science research. A novel field computation model based on the magnetic field theory is constructed. The proposed magnetic field computation(MFC) model consists of a field simulator, a non-derivative optimization algorithm and an auxiliary data processing unit. The mathematical model is deduced and proved that the MFC model is equivalent to a quadratic discriminant function. Furthermore, the finite element prototype is derived, and the simulator is developed, combining with particle swarm optimizer for the field configuration. Two benchmark classification experiments are studied in the numerical experiment, and one notable advantage is demonstrated that less training samples are required and a better generalization can be achieved. | Feng Pan Xiaoting Li Ting Long Xiaohui Hu Tingting Ren Junping Du | 2013 | Journal of Systems Engineering and Electronics2013，24，5： | 0 |
| 12 | Role of daily anal stimulation for intractable functional constipation in infants显示文摘Objective Functional constipation is one of the most common problems in pediatric gastroenterology.The aim of the present study was to evaluate the effectiveness of daily anal stimulation in infants with intractable functional constipation(IFC).Our evaluation was based on clinical improvement and on changes in manometric parameters through time.Methods Infants with IFC treated between January 2018 and December 2019 were included in this retrospective study.Treatment processing included daily anal stimulation for infants and psychological counseling for parents.All cases underwent a complete intervention program and were evaluated for improvement in symptoms and for changes in anorectal manometry within 1 year of follow-up.results A total of 161 patients were included in this study.Positive response was achieved in all patients.Frequency of defecation,change in stool form and decrease in the defecatory pain were significantly relieved in all infants after intervention.On anorectal manometry,no significant difference was found in the peristaltic frequency of distal rectum before and after treatment.There was a significant increase in the mean amplitude of peristalsis and improvement in the rhythm after intervention.In the 1 year of follow-up,three patients had recurrence of constipation requiring colectomy.Conclusion In terms of the high clinical efficacy and limited side effects,daily anal stimulation may be included in the initial part of an intervention program for IFC in infants. | Tianqi Zhu Xiaoyi Sun Dan Zhu Qian You Xiaoting Wan Xinyao Meng Jiexiong Feng | 2020 | World Journal of Pediatric Surgery2020，3，2： | 0 |
| 13 | Research on variance of subnets in network sampling显示文摘In the recent research of network sampling, some sampling concepts are misunderstood, and the variance of subnets is not taken into account. We propose the correct definition of the sample and sampling rate in network sampling, as well as the formula for calculating the variance of subnets. Then, three commonly used sampling strategies are applied to databases of the connecting nearest-neighbor(CNN) model, random network and small-world network to explore the variance in network sampling. As proved by the results, snowball sampling obtains the most variance of subnets, but does well in capturing the network structure. The variance of networks sampled by the hub and random strategy are much smaller. The hub strategy performs well in reflecting the property of the whole network, while random sampling obtains more accurate results in evaluating clustering coefficient. | Qi Gao Xiaoting Li Feng Pan | 2014 | Journal of Systems Engineering and Electronics2014，25，6： | 0 |
| 14 | An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19显示文摘The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2.Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat COVID-19.Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect.In addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection. | Yiyue Ge Tingzhong Tian Suling Huang Fangping Wan Jingxin Li Shuya Li Xiaoting Wang Hui Yang Lixiang Hong Nian Wu Enming Yuan Yunan Luo Lili Cheng Chengliang Hu Yipin Lei Hantao Shu Xiaolong Feng Ziyuan Jiang Yunfu Wu Ying Chi Xiling Guo Lunbiao Cui Liang Xiao Zeng Li Chunhao Yang Zehong Miao Ligong Chen Haitao Li Hainian Zeng Dan Zhao Fengcai Zhu Xiaokun Shen Jianyang Zeng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 15 | Variability of urban fractional vegetation cover and its driving factors in 328 cities in China显示文摘Urban green space promotes the health of urban residents,enhances urban ecosystem biodiversity,mitigates environmental pollution,and attenuates urban heat island effect.However,urban vegetation cover is highly heterogeneous and difficult to quantify.In this study,the variation of urban fractional vegetation cover(FVC)in 328 cities in China from 1990 to2022 was quantified based on Landsat satellite data at a 30-m resolution.It was found that from 1990 to 2005,due to increases in building density and impervious surfaces in cities,the national mean urban vegetation cover decreased from 0.38 to 0.35.After2005,urban vegetation cover began to reverse,reaching 0.45 in 2022.This increasing trend was most pronounced in newly built urban districts.The decrease in average urban vegetation cover before 2005 was mainly due to the expansion of low vegetation cover areas,while the increase in urban vegetation cover after 2005 manifested as the expansion of high vegetation cover areas.The reversal in the trend of urban vegetation cover change after 2004 is related to the gradual implementation of national policies requiring increased urban green space coverage.The urban gross domestic product(GDP)showed the highest correlation with changes in urban vegetation cover.For large and medium-sized cities,the top three factors influencing vegetation cover were GDP,urban population,and temperature.However,for cities in arid/semi-arid regions,changes in vegetation cover were more sensitive to climatic factors(such as precipitation).Although the urban vegetation cover in China has substantially increased in recent years,the urban green space in small-sized cities and in the old urban districts of large-sized cities still have room to improve. | Fei FENG Xin YANG Baoquan JIA Xiaoting LI Xianwen LI Chengyang XU Kaicun WANG | 2024 | Science China Earth Sciences2024，67，2： | 0 |
| 16 | New considerations on the phylogeny of Sessilida(Protista:Ciliophora:Peritrichia)based on multiple-gene information,with emphasis on colonial taxa显示文摘The subclass Peritrichia,containing two orders Sessilida and Mobilida,is a major group of ciliates with worldwide distribution and high species diversity.Several studies have investigated the phylogeny of peritrichs;however,the evolutionary relationships and classification of some families and genera within the Sessilida remain unclear.In the present study,we isolated and identified 22 peritrich populations representing four families and six genera and obtained 64 rDNA sequences to perform phylogenetic analyses and assess their systematic relationships.Ancestral character reconstruction was also carried out to infer evolutionary routes within the Sessilida.The results indicate:(1)family Vaginicolidae is monophyletic and acquisition of the typical peritrich lorica represents a single evolutionary divergence;(2)core epistylidids evolved from a Zoothamnium-like ancestor and experienced spasmoneme loss during evolution;(3)Campanella clusters with species in the basal clade and shows stable morphological differences with other epistylidids,supporting its assignment to a separate family;(4)the structure of the peristomial lip may be a genus-level character rather than a diagnostic character for discriminating Epistylididae and Operculariidae,thus a redefinition of Operculariidae should be carried out when more species have been investigated;(5)some characters,such as lifestyle(solitary or colonial),spasmoneme and living habit(sessile or free-swimming),evolved repeatedly among sessilids indicating that species with non-contractile stalks or that are free-swimming have multiple evolutionary routes and might derive from any sessilid lineage without a lorica.The close phylogenetic relationships of some morphologically distinct sessilids imply that the diagnoses of some genera and families should be improved. | Zhe Wang Xiaoting Feng Lifang Li Khaled A.S.Al-Rasheid Alan Warren Chundi Wang Zemao Gu | 2022 | Marine Life Science & Technology2022，4，4： | 0 |
| 17 | O-alg-THAM/gel hydrogels functionalized with engineered microspheres based on mesenchymal stem cell secretion recruit endogenous stem cells for cartilage repair显示文摘Lacking self-repair abilities,injuries to articular cartilage can lead to cartilage degeneration and ultimately result in osteoarthritis.Tissue engineering based on functional bioactive scaffolds are emerging as promising approaches for articular cartilage regeneration and repair.Although the use of cell-laden scaffolds prior to implantation can regenerate and repair cartilage lesions to some extent,these approaches are still restricted by limited cell sources,excessive costs,risks of disease transmission and complex manufacturing practices.Acellular approaches through the recruitment of endogenous cells offer great promise for in situ articular cartilage regeneration.In this study,we propose an endogenous stem cell recruitment strategy for cartilage repair.Based on an injectable,adhesive and self-healable o-alg-THAM/gel hydrogel system as scaffolds and a biophysio-enhanced bioactive microspheres engineered based on hBMSCs secretion during chondrogenic differentiation as bioactive supplement,the as proposed functional material effectively and specifically recruit endogenous stem cells for cartilage repair,providing new insights into in situ articular cartilage regeneration. | Yucong Li Linlong Li Ming Wang Boguang Yang Baozhen Huang Shanshan Bai Xiaoting Zhang Nan Hou Haixing Wang Zhengmeng Yang Chong Tang Ye Li Wayne Yuk-Wai Lee Lu Feng Micky D.Tortorella Gang Li | 2023 | Bioactive Materials2023，，10： | 0 |
| 18 | Enlarged interlayer of separator coating enabling high-performance lithiumsulfur batteries显示文摘Lithiumsulfur batteries have been intensively studied due to their high theoretical energy density and abundant sulfur resources. However, their commercial application is hindered by the low redox kinetics and high sulfur losses. In principle, in the design of cathodes and separators, the adsorption toward lithium-polysulfides should be enhanced and the conversion of soluble high-order lithium-polysulfides should be catalyzed. Herein, a KV_(3)O_(8)·0.75H_(2)O separator is designed as an effective lithium-polysulfides mediator in lithiumsulfur batteries. The intercalated K+ would enlarge the interlayer spacing of vanadium oxides, preventing the collapse of the layer structure and improving the electrical/ion conductivity of the interface. Moreover, the KV_(3)O_(8)·0.75H_(2)O modified separator possess a prior adsorption and high redox kinetics toward lithium-polysulfides due to the enhanced diffusion kinetics, which guarantees the high-rate capability and efficient utilization of sulfur. As a result, lithiumsulfur batteries exhibit a high capacity of 1362 mAh·g^(-1) and a long lifespan with a low capacity loss of 0.073% per cycle. This work may provide an alternative way to establish a functional separator to balance the adsorption and conversion of polysulfides during the redox back and forth. | Yanqi Feng Hui Liu Xiaoting Liu Qiongqiong Lu | 2024 | Frontiers of Chemical Science and Engineering2024，18，2： | 0 |
| 19 | A chromosome-scale reference genome of Lobularia maritima,an ornamental plant with high stress tolerance显示文摘Lobularia maritima(L.)Desv.is an ornamental plant cultivated across the world.It belongs to the family Brassicaceae and can tolerate dry,poor and contaminated habitats.Here,we present a chromosome-scale,high-quality genome assembly of L.maritima based on integrated approaches combining Illumina short reads and Hi–C chromosome conformation data.The genome was assembled into 12 pseudochromosomes with a 197.70 Mb length,and it includes 25,813 protein-coding genes.Approximately 41.94%of the genome consists of repetitive sequences,with abundant long terminal repeat transposable elements.Comparative genomic analysis confirmed that L.maritima underwent a species-specific whole-genome duplication(WGD)event~22.99 million years ago.We identified~1900 species-specific genes,25 expanded gene families,and 50 positively selected genes in L.maritima.Functional annotations of these genes indicated that they are mainly related to stress tolerance.These results provide new insights into the stress tolerance of L.maritima,and this genomic resource will be valuable for further genetic improvement of this important ornamental plant. | Li Huang Yazhen Ma Jiebei Jiang Ting Li Wenjie Yang Lei Zhang Lei Wu Landi Feng Zhenxiang Xi Xiaoting Xu Jianquan Liu Quanjun Hu | 2020 | Horticulture Research2020，7，1： | 0 |
| 20 | Causal Effect of Genetically Determined Blood Copper Concentrations on Multiple Diseases: A Mendelian Randomization and Phenome-Wide Association Study显示文摘Exposures to copper have become a health concern.We aim to explore the broad clinical effects of blood copper concentrations.A total of 376,346 Caucasian subjects were enrolled.We performed a Mendelian randomization and phenome-wide association study(MR-PheWAS)to evaluate the causal association between copper and a wide range of outcomes in UK Biobank,and we constructed a protein-protein interaction network.We found association between blood copper concentrations and five diseases in the overall population and nine diseases in male.MR analysis implicated a causal role of blood copper in five diseases(overall population),including prostate cancer(OR=0.87,95%CI 0.77-0.98),malignant and unknown neoplasms of the brain and nervous system(OR=0.58,95%CI 0.38-0.89),and hypertension(OR=0.94,95%CI 0.90-0.98),essential hypertension(OR=0.94,95%CI 0.90-0.98)and cancer of brain and nervous system(OR=0.63,95%CI 0.41-0.98).For male,except for dysphagia being newly associated with blood copper(OR=1.39,95%CI 1.18-1.63),other MR results were consistent with the overall population.In addition,the PPI network showed possible relationship between blood copper and four outcomes,namely brain cancer,prostate cancer,hypertension,and dysphagia.Blood copper may have causal association with prostate cancer,malignant and unknown neoplasms of the brain and nervous system,hypertension,and dysphagia.Considering that copper is modifiable,exploring whether regulation of copper levels can be used to optimize health outcomes might have public health importance. | Xiuming Feng Wenjun Yang Lulu Huang Hong Cheng Xiaoting Ge Gaohui Zan Yanli Tan Lili Xiao Chaoqun Liu Xing Chen Zengnan Mo Longman Li Xiaobo Yang | 2022 | Phenomics2022，2，4： | 0 |
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