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| 1 | 3-year Treatment of Tenofovir Alafenamide vs.Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China显示文摘Background and Aims:Tenofovir alafenamide(TAF)has similar efficacy to tenofovir disoproxil fumarate(TDF)but with improved renal and bone safety in chronic hepatitis B patients studied outside of China.We report 3-year results from two phase 3 studies with TAF in China(Clinicaltrials.gov:NCT02836249 and NCT02836236).Methods:Chinese hepatitis B e antigen(HBeAg)-positive and-negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks(3 years).Efficacy responses were assessed by individual study while safety was assessed by a pooled analysis.Results:Of the 334 patients(180 HBeAg-positive and 154 HBeAg-negative)randomized and treated,baseline characteristics were similar between groups.The overall mean age was 38 years and 73%were male.The mean HBV DNA was 6.4 log10 IU/mL.The median alanine aminotransferase was 88 U/L,and 37%had a history of antiviral use.At week 144,the proportion with HBV DNA<29 IU/mL was similar among the two groups,with TAF at 83%vs.TDF at 79%,and TAF at 93%vs.TDF at 92%for the HBeAg-positive and-negative patients,respectively.In each study,higher proportions of TAF than TDF patients showed normalized alanine aminotransferase(via the American Association for the Study of Liver Diseases and the China criteria)and showed loss of HBsAg;meanwhile,the HBeAg seroconversion rates were similar.Treatment was well-tolerated among the TAF patients,who showed a smaller median decline in creatinine clearance(−0.4 vs.−3.2 mL/min;p=0.014)and less percentage change in bone mineral density vs.TDF at hip(−0.95%vs.−1.93%)and spine(+0.35%vs.−1.40%).Conclusions:In chronic hepatitis B patients from China,TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years. | Jinlin Hou Qin Ning Zhongping Duan You Chen Qing Xie Fu-Sheng Wang Lunli Zhang Shanming Wu Hong Tang Jun Li Feng Lin Yongfeng Yang Guozhong Gong John FFlaherty Anuj Gaggar Shuyuan Mo Cong Cheng Gregory Camus Chengwei Chen Yan Huang Jidong Jia Mingxiang Zhang GS-US-320-0110 and GS-US-320-0108 China Investigators | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 7 |
| 2 | Detecting visually salient scene areas and deriving their relative spatial relations from continuous street-view panoramas显示文摘A salient scene is an area within an image that contains visual elements that stand out from surrounding areas.They are important for distinguishing landmarks in first-person-view(FPV)applications and determining spatial relations in images.The relative spatial relation between salient scenes acts as a visual guide that is easily accepted and understood by users in FPV applications.However,current digitally navigable maps and location-based services fall short of providing information on visual spatial relations for users.This shortcoming has a critical influence on the popularity and innovation of FPV applications.This paper addresses the issue by proposing a method for detecting visually salient scene areas(SSAs)and deriving their relative spatial relationships from continuous panoramas.This method includes three critical steps.First,an SSA detection approach is introduced by fusing region-based saliency derived from super-pixel segmentation and the frequency-tuned saliency model.The method focuses on a segmented landmark area in a panorama.Secondly,a street-view-oriented SSA generation method is introduced by matching and merging the visual SSAs from continuous panoramas.Thirdly,a continuous geotagged panorama-based referencing approach is introduced to derive the relative spatial relationships of SSAs from continuous panoramas.This information includes the relative azimuth,elevation angle,and the relative distance.Experiment results show that the error for the SSA relative azimuth angle is approximately±6°(with an average error of 2.67°),and the SSA relative elevation angle is approximately±4°(with an average error of 1.32°)when using Baidu street-view panoramas.These results demonstrate the feasibility of the proposed approach.The method proposed in this study can facilitate the development of FPV applications such as augmented reality(AR)and pedestrian navigation using proper spatial relation. | Fangli Guan Zhixiang Fang Tao Yu Mingxiang Feng Fan Yang | 2020 | International Journal of Digital Earth2020，13，12： | 2 |
| 3 | The twoscale asymptotic error analysis for piezoelectric problems in the quasi-periodic structure显示文摘Applications for piezoelectric efect have grown rapidly,and piezoelectric materials play important roles in countless areas of modern life.By means of twoscale method and coupled boundary layer,some new kinds of twoscale asymptotic expansions for solutions to the electrical potential and the displacement in quasi-periodic structure under coupled piezoelectric efect are derived,and the homogenization constants of piezoelectric materials are presented.The coupled twoscale relation between the electrical potential and the displacement is set up,and some improved asymptotic error estimates are analyzed. | FENG YongPing DENG MingXiang GUAN XiaoFei | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，10： | 1 |
| 4 | Thoracoscopic Esophagectomy in Prone Versus Decubitus Position: Ergonomic Evaluation From a Randomized and Controlled Study显示文摘 | Yaxing Shen Mingxiang Feng Lijie Tan Hao Wang Jingpei Li Yong Xi Qun Wang | 2014 | The Annals of Thoracic Surgery2014，，： | 1 |
| 5 | Integrative Analysis of Genome,3D Genome,and Transcriptome Alterations of Clinical Lung Cancer Samples显示文摘Genomic studies of cancer cell alterations,such as mutations,copy number variations(CNVs),and translocations,greatly promote our understanding of the genesis and development of cancers.However,the 3D genome architecture of cancers remains less studied due to the complexity of cancer genomes and technical difficulties.To explore the 3D genome structure in clinical lung cancer,we performed Hi-C experiments using paired normal and tumor cells harvested from patients with lung cancer,combining with RNA sequenceing analysis.We demonstrated the feasibility of studying 3D genome of clinical lung cancer samples with a small number of cells(1×10^(4)),compared the genome architecture between clinical samples and cell lines of lung cancer,and identified conserved and changed spatial chromatin structures between normal and cancer samples.We also showed that Hi-C data can be used to infer CNVs and point mutations in cancer.By integrating those different types of cancer alterations,we showed significant associations between CNVs,3D genome,and gene expression.We propose that 3D genome mediates the effects of cancer genomic alterations on gene expression through altering regulatory chromatin structures.Our study highlights the importance of analyzing 3D genomes of clinical cancer samples in addition to cancer cell lines and provides an integrative genomic analysis pipeline for future larger-scale studies in lung cancer and other cancers. | Tingting Li Ruifeng Li Xuan Dong Lin Shi Miao Lin Ting Peng Pengze Wu Yuting Liu Xiaoting Li Xuheng He Xu Han Bin Kang Yinan Wang Zhiheng Liu Qing Chen Yue Shen Mingxiang Feng Xiangdong Wang Duojiao Wu Jian Wang Cheng Li | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 1 |
| 6 | Thoracolaparoscopic Esophagectomy: Is the Prone Position a Safe Alternative to the Decubitus Position?显示文摘 | Mingxiang Feng Yaxing Shen Hao Wang Lijie Tan Yi Zhang Muhammad Asim Khan Qun Wang | 2012 | Journal of the American College of Surgeons2012，，： | 1 |
| 7 | Enhancing maize's nitrogen-fixing potential through ZmSBT3, a gene suppressing mucilage secretion∞显示文摘Maize(Zea mays)requires substantial amounts of nitrogen,posing a challenge for its cultivation.Recent work discovered that some ancient Mexican maize landraces harbored diazotrophic bacteria in mucilage secreted by their aerial roots.To see if this trait is retained in modern maize,we conducted a field study of aerial root mucilage(ARM)in 258 inbred lines.We observed that ARM secretion is common in modern maize,but the amount significantly varies,and only a few lines have retained the nitrogen‐fixing traits found in ancient landraces.The mucilage of the high‐ARM inbred line HN5‐724 had high nitrogen‐fixing enzyme activity and abundant diazotrophic bacteria.Our genome‐wide association study identified 17 candidate genes associated with ARM across three environments.Knockouts of one candidate gene,the subtilase family gene ZmSBT3,confirmed that it negatively regulates ARM secretion.Notably,the ZmSBT3 knockout lines had increased biomass and total nitrogen accumulation under nitrogen‐free culture conditions.High ARM was associated with three ZmSBT3 haplotypes that were gradually lost during maize domestication,being retained in only a few modern inbred lines such as HN5‐724.In summary,our results identify ZmSBT3 as a potential tool for enhancing ARM,and thus nitrogen fixation,in maize. | Jingyang Gao Peijiang Feng Jingli Zhang Chaopei Dong Zhao Wang Mingxiang Chen Zhongliang Yu Bowen Zhao Xin Hou Huijuan Wang Zhaokun Wu Razia Sultana Jemim Haidong Yu Doudou Sun Pei Jing Jiafa Chen Weibin Song Xuecai Zhang Zijian Zhou Jianyu Wu | 2023 | Journal of Integrative Plant Biology2023，65，12： | 0 |
| 8 | Ground glass nodules with scattered or eccentric island-shaped consolidations may have poor outcomes显示文摘Background:To explore the effect of scattered or eccentric shaped types of ground glass opacity(GGO)on outcomes of patients with solid-dominant peripheral lung adenocarcinoma.Methods:We evaluated patients with solid-dominant peripheral lung adenocarcinoma,who underwent radical surgery at Zhongshan Hospital,Fudan University,between January 2013 and December 2015.Morphologically heterogeneous solid-dominant lung adenocarcinoma in imaging findings was based on the last preoperative computed tomography(CT)scans.Endpoints were recurrence-free survival(RFS)and overall survival(OS).Kaplan-Meier analysis and the log-rank test were used to estimate survival differences.Impact factors were assessed by univariable logistic regression analysis.Results:We retrospectively collected data from 200 patients,including 170 patients with central island-shaped CT imaging,18 patients with scattered shaped CT imaging,and 12 patients with eccentric shaped CT imaging.Eleven patients experienced recurrence or metastases.Kaplan-Meier survival curves showed significant survival differences between the central island-shaped type and scattered shaped or eccentric shaped type for OS(c-stage IA:5-year OS:100%vs.92.1%;HR=0.019,p=0.0025;p-stage IA:100%vs.95.2%;HR=0.146,p=0.1139)and RFS(c-stage IA:5-year RFS:100%vs.59.7%;HR=0.001,p<0.0001;p-stage IA:100%vs.64.5%;HR<0.001,p<0.0001).Univariable logistic regression analysis showed that scattered and eccentric shaped types were related to poor outcomes(p<0.012,odds ratio=18.8)。Conclusions:Relative spatial position of GGO and solid components may affect patient outcomes.Patients with scattered or eccentric shaped GGO may have a poor prognosis. | Ming Li Junjie Xi Huan Zhang Xing Jin Zhuoyang Fan Cheng Zhan Mingxiang Feng Lijie Tan Qun Wang | 2023 | Cancer Innovation2023，2，2： | 0 |
| 9 | Microstructural Characterization for Ge Clusters Embedded in a-SiNy Matrix Prepared by PECVD Method显示文摘We report the successful synthesis of Ge clusters embedded in a-SiNy:H matrix prepared by the plasma enhanced chemical vapor deposition(PECVD)method.Chemical and microstructural characteristics of this granular thin film were analyzed using the infrared absorption,x-ray diffraction,Raman scattering,and transmission electron microscopy.Finally we discuss briefly the synthesis mechanism of this new material. | QU Xuexuan CHEN Kunji WANG Mingxiang LI Zhifeng XIA Hua FENG Duan | 1994 | Chinese Physics Letters1994，11，4： | 0 |
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