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| 1 | Endoscopy and polyps-diagnostic and therapeutic advances in management显示文摘Despite multiple efforts aimed at early detection through screening, colon cancer remains the third leading cause of cancer-related deaths in the United States, with an estimated 51000 deaths during 2013 alone. The goal remains to identify and remove benign neoplastic polyps prior to becoming invasive cancers. Polypoid lesions of the colon vary widely from hyperplastic, hamartomatous and inflammatory to neoplastic adenomatous growths. Although these lesions are all benign, they are common, with up to one-quarter of patients over 60 years old will develop pre-malignant adenomatous polyps. Colonoscopy is the most effective screening tool to detect polyps and colon cancer, although several studies have demonstrated missed polyp rates from 6%-29%, largely due to variations in polyp size. This number can be as high as 40%, even with advanced (> 1 cm) adenomas. Other factors including sub-optimal bowel preparation, experience of the endoscopist, and patient anatomical variations all affect the detection rate. Additional challenges in decision-making exist when dealing with more advanced, and typically larger, polyps that have traditionally required formal resection. In this brief review, we will explore the recent advances in polyp detection and therapeutic options. | Scott R Steele Eric K Johnson Bradley Champagne Brad Davis Sang Lee David Rivadeneira Howard Ross Dana A Hayden Justin A Maykel | 2013 | World Journal of Gastroenterology2013，19，27： | 16 |
| 2 | Operative considerations for rectovaginal fistulas显示文摘To describe the etiology, anatomy and pathophysiology of rectovaginal fistulas(RVFs); and to describe a systematic surgical approach to help achieve optimal outcomes. A current review of the literature was performed to identify the most up-to-date techniques and outcomes for repair of RVFs. RVFs present a difficult problem that is frustrating for patients and surgeons alike. Multiple trips to the operating room are generally needed to resolve the fistula, and the recurrence rate approaches40% when considering all of the surgical options. At present, surgical options range from collagen plugs and endorectal advancement flaps to sphincter repairs or resection with colo-anal reconstruction. There are general principles that will allow the best chance for resolution of the fistula with the least morbidity to the patient. These principles include: resolving the sepsis, identifying the anatomy, starting with least invasive surgical options, and interposing healthy tissue for complex or recurrent fistulas. | Kevin R Kniery Eric K Johnson Scott R Steele | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 7 |
| 3 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 5 |
| 4 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 3 |
| 5 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet . 2009 (9666)2009，，9666： | 3 |
| 6 | Hantavirus Nucleocapsid Protein Coiled - Coil Domains 显示文摘 | Ayna Alfadhli Eric Steel Liam Finlay | 2002 | J Biol Chem2002，277，27： | 1 |
| 7 | Inherently superoleophobic nanocomposite coatings by spray atomization显示文摘 | Adam Steele Ilker Bayer Eric Loth | | 0，，01： | 1 |
| 8 | Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial显示文摘 | Phil Quirke Robert Steele John Monson Robert Grieve Subhash Khanna Jean Couture Chris O’Callaghan Arthur Sun Myint Eric Bessell Lindsay C Thompson Mahesh Parmar Richard J Stephens David Sebag-Montefiore | 2009 | The Lancet2009，，9666： | 1 |
| 9 | Inherently supero- leophobic nanocomposite coatings by spray atomization 显示文摘 | Steele Adam Bayer Ilker Loth Eric | 2009 | Nano Letters2009，9，1： | 1 |
| 10 | Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial显示文摘 | Phil Quirke Robert Steele John Monson Robert Grieve Subhash Khanna Jean Couture Chris O’Callaghan Arthur Sun Myint Eric Bessell Lindsay C Thompson Mahesh Parmar Richard J Stephens David Sebag-Montefiore | 2009 | The Lancet . 2009 (9666)2009，，9666： | 1 |
| 11 | Activation of the fusiform gyrus when individuals with autism spectrum disorder view faces显示文摘 | Nouchine Hadjikhani Robert M Joseph Josh Snyder Christopher F Chabris Jill Clark Shelly Steele Lauren McGrath Mark Vangel Itzhak Aharon Eric Feczko Gordon J Harris Helen Tager-Flusberg | 2004 | Neuroimage2004，，3： | 1 |
| 12 | Anal squamous cell carcinoma: An evolution in disease and management显示文摘Anal cancer represents less than 1% of all new cancers diagnosed annually in the United States. Yet, despite the relative paucity of cases, the incidence of anal cancer has seen a steady about 2% rise each year over the last decade. As such, all healthcare providers need to be cognizant of the evaluation and treatment of anal squamous cell carcinoma. While chemoradiation remains the mainstay of therapy for most patients with anal cancer, surgery may still be required in recurrent, recalcitrant and palliative disease. In this manuscript, we will explore the diagnosis and management of squamous cell carcinoma of the anus. | Marc C Osborne Justin Maykel Eric K Johnson Scott R Steele | 2014 | World Journal of Gastroenterology2014，20，36： | 1 |
| 13 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 1 |
| 14 | SJWK14081300000036显示文摘 | Vlad V. Simianu Amir L. Bastawrous Richard P. Billingham Ellen T. Farrokhi Alessandro Fichera Daniel O. Herzig Eric Johnson Scott R. Steele Richard C. Thirlby David R. Flum | 2014 | Annals of Surgery2014，，3： | 1 |
| 15 | Routine colonic endoscopic evaluation following resolution of acute diverticulitis:Is it necessary?显示文摘Diverticular disease incidence is increasing up to 65% by age 85 in industrialized nations,low fiber diets,and in younger and obese patients.Twenty-five percent of patients with diverticulosis will develop acute diverticulitis.This imposes a significant burden on healthcare systems,resulting in greater than 300000 admissions per year with an estimated annual cost of $3 billion USD.Abdominal computed tomography(CT) is the diagnostic study of choice,with a sensitivity and specificity greater than 95%.Unfortunately,similar CT findings can be present in colonic neoplasia,especially when perforated or inflamed.This prompted professional societies such as the American Society of Colon Rectal Surgeons to recommend patients undergo routine colonoscopy after an episode of acute diverticulitis to rule out malignancy.Yet,the data supporting routine colonoscopy after acute diverticulitis is sparse and based small cohort studies utilizing outdated technology.While any patient with an indication for a colonoscopy should undergo appropriate endoscopic evaluation,in the era of widespread use of high-resolution computed tomography,routine colonic endoscopic evaluation following resolution of acute uncomplicated diverticulitis poses additional costs,comes with inherent risks,and may require further study.In this manuscript,we review the current data related to this recommendation. | Amit K Agarwal Burzeen E Karanjawala Justin A Maykel Eric K Johnson Scott R Steele | 2014 | World Journal of Gastroenterology2014，20，35： | 0 |
| 16 | 直肠癌患者术前放疗与选择性术后放化疗比较(MRC CR07与NCIC—CTG C016):一项多中心、随机试验显示文摘背景术前或术后放疗可降低术后直肠癌患者局部复发的风险。然而,随着手术技术与组织病理学评估的进展,需要对放疗的效应进行重新评估。本研究中,作者比较了短期术前放疗与术后选择性放化疗的效应差异。方法在4个国家的80所医疗中心进行了该项随机试验。采用最小化随机分组方法将1350例可手术切除的直肠腺癌患者随机分配至短期术前放疗组(25Gy分5次,n=674)或选择性术后放化疗组(45Gy分25次+氟尿嘧啶,n=676),后者的术后化疗仅限于手术环周切缘阳性患者。主要结局指标为局部复发,采用意向治疗分析。本研究注册编码为ISRCTN 28785842。结果对所有参与者进行了分析,330例患者死亡(术前放疗组157例US选择性术后放化疗组173例),对存活患者的中位随访时间为4年。99例患者局部复发(术前放疗组27例VS选择性术后放化疗组72例。术前放疗组患者局部复发的相对风险下降了61%(HR0.39,95%C10.27~0.58,P〈0.0001),两组间3年时的绝对差异为6.2%(95%CI5-3%~7.1%)(术前放疗组4.4%US选择性术后放化疗组10.6%)。术前放疗组患者的无病存活率相对提高24%(HR0.76,95%C10.62~0.94,P=0.013),两组间3年时的绝对差异为6.O%(95%CI5.3%~6.8%)(术前放疗组77.5%us选择性术后放化疗组71.5%)。两组间总体存活率无显著性差异(HR0.91,95%C10.73~1.13,P=0.40)。结论结合其他随机试验结果,本研究提供了令人信服的一致性证据,即短期术前放疗对于可手术切除的直肠癌患者是一项有效的治疗手段。 | Mahesh Parmar Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson | 2009 | 世界临床医学2009，，7： | 0 |
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