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| 1 | Role of live microbial feed supplements with reference to anaerobic fungi in ruminant productivity: A review显示文摘To keep the concept of a safe food supply to the consumers, animal feed industries world over are showing an increasing interest in the direct-fed microbials(DFM) for improved animal performance in terms of growth or productivity. This becomes all the more essential in a situation, where a number of the residues of antibiotics and/or other growth stimulants reach in milk and meat with a number of associated potential risks for the consumers. Hence, in the absence of growth stimulants, a positive manipulation of the rumen microbial ecosystem to enhance the feedstuff utilization for improved production efficiency by ruminants has become of much interest to the researchers and entrepreneurs. A few genera of live microbes(i.e., bacteria, fungi and yeasts in different types of formulations from paste to powder) are infrequently used as DFM for the domestic ruminants. These DFM products are live microbial feed supplements containing naturally occurring microbes in the rumen. Among different DFM possibilities, anaerobic rumen fungi(ARF) based additives have been found to improve ruminant productivity consistently during feeding trials. Administration of ARF during the few trials conducted, led to the increased weight gain, milk production, and total tract digestibility of feed components in ruminants. Anaerobic fungi in the rumen display very strong cell-wall degrading cellulolytic and xylanolytic activities through rhizoid development, resulting in the physical disruption of feed structure paving the way for bacterial action. Significant improvements in the fiber digestibility were found to coincide with increases in ARF in the rumen indicating their role. Most of the researches based on DFM have indicated a positive response in nutrient digestion and methane reducing potential during in vivo and/or in vitro supplementation of ARF as DFM. Therefore, DFM especially ARF will gain popularity but it is necessary that all the strains are thoroughly studied for their beneficial properties to have a confirmed ‘generally regarded as safe' status for ruminants. | Anil K Puniya Abdelfattah Z M Salem Sanjay Kumar Sumit S Dagar Gareth W Griffith Monica Puniya Sreenivas R Ravella Nikhil Kumar Tejpal Dhewa Ravinder Kumar | 2015 | Journal of Integrative Agriculture2015，14，3： | 17 |
| 2 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 5 |
| 3 | Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial显示文摘 | Somnath Mukherjee Christopher N Hurt John Bridgewater Stephen Falk Sebastian Cummins Harpreet Wasan Tom Crosby Catherine Jephcott Rajarshi Roy Ganesh Radhakrishna Alec McDonald Ruby Ray George Joseph John Staffurth Ross A Abrams Gareth Griffiths Tim Maugh | 2013 | Lancet Oncology2013，，4： | 4 |
| 4 | Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype显示文摘AIM To identify whether Cp G island methylator phenotype(CIMP) is predictive of response to neoadjuvant chemoradiotherapy(NACRT) and outcomes in rectal cancer.METHODS Patients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status(high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined uponhistological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed.RESULTS There were 160 patients analysed with a median followup time of 46.4 mo. Twenty-one(13%) patients demonstrated high levels of CIMP methylation(CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion(EMVI) compared with CIMP-L [8/21(38%) vs 15/99(15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival(P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation(P = 0.01). There were 14(9%) patients with a pathological complete response(pC R) compared to 116(73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pC R had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant(P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced 'T' stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurrence.CONCLUSION We report a novel association of pre-treatment characterisation of CIMP-H with EMVI status which has prognostic implications and is not readily detectable on pre-treatment histological examination. | Jeremy Stuart Williamson Huw Geraint Jones Namor Williams Anthony Paul Griffiths Gareth Jenkins John Beynon Dean Anthony Harris | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 4 |
| 5 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 3 |
| 6 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet . 2009 (9666)2009，，9666： | 3 |
| 7 | New aspects and strategies for methane mitigation from ruminants显示文摘 | Sanjay Kumar Prasanta Kumar Choudhury Maria Dolores Carro Gareth Wyn Griffith Sumit Singh Dagar Monica Puniya Serena Calabro Sreenivas Rao Ravella Tejpal Dhewa Ramesh Chandra Upadhyay Sunil Kumar Sirohi Shivlal Singh Kundu Metha Wanapat Anil Kumar Puniya | 2014 | Applied Microbiology and Biotechnology2014，，： | 1 |
| 8 | Ultrahigh Efficiency Fluorescent Single and Bi‐Layer Organic Light Emitting Diodes: The Key Role of Triplet Fusion显示文摘 | Chien‐Jung Chiang Alpay Kimyonok Marc K. Etherington Gareth C. Griffiths Vygintas Jankus Figen Turksoy Andy P. Monkman | 2012 | Adv Funct Mater2012，，6： | 1 |
| 9 | A modi- fied pressure-sinkage model for small rigid wheels on deformable terrains显示文摘 | Gareth Meirion Griffith Matthew Spenko | 2011 | Journal of Terramechanics2011，48，2： | 1 |
| 10 | A pres- sure-sinkage model for small-diameter wheels on compactive,deformable terrain显示文摘 | Gareth Meirion Griffith Matthew Spenko | 2013 | Journal of Terra- mechanics2013，50，1： | 1 |
| 11 | Effects of antibiotics on intracellular symbiotes in the pea aphid, Acyrthosiphon pisum显示文摘 | Gareth W. Griffiths Stanley D. Beck | 1974 | Cell and Tissue Research1974，，3： | 1 |
| 12 | Curcumin abrogates bile-induced NF-κB activity and DNA damage in vitro and suppresses NF-κB activity whilst promoting apoptosis in vivo, suggesting chemopreventative potential in Barrett’s oesophagus显示文摘 | Nihit Rawat Ali Alhamdani Elizabeth McAdam James Cronin Zak Eltahir Paul Lewis Paul Griffiths John N. Baxter Gareth J. S. Jenkins | 2012 | Clinical and Translational Oncology2012，，4： | 1 |
| 13 | A modified pressure - sinkage model for small, rigid wheels on deformable terrains 显示文摘 | Gareth Meirion -Griffith Matthew Spenko | 2011 | Journal of Terramechanics2011，48，2： | 1 |
| 14 | Postcolonial Studies Reader显示文摘 | Bill Ashcroft Gareth Griffiths and Helen Tiffin | 2000 | Routledge2000，，： | 1 |
| 15 | Postcolonial Studies Reader显示文摘 | Bill Ashcroft Gareth Griffiths and Helen Tiffin | 2000 | Roudedge2000，，： | 1 |
| 16 | Applications of an efficient method for comparing immunogold labelling patterns in the same sets of compartments in different groups of cells显示文摘 | Terry M. Mayhew Gareth Griffiths John M. Lucocq | 2004 | Histochemistry and Cell Biology2004，，2： | 1 |
| 17 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 1 |
| 18 | Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial显示文摘 | Paul D Griffiths Anna Stanton Erin McCarrell Colette Smith Mohamed Osman Mark Harber Andrew Davenport Gareth Jones David C Wheeler James O’Beirne Douglas Thorburn David Patch Claire E Atkinson Sylvie Pichon Paul Sweny Marisa Lanzman Elizabeth Woodford Emi | 2011 | The Lancet2011，，9773： | 1 |
| 19 | Empire Writes Back:The Theory and Practice in Colonial Literature显示文摘 | Ashcroft Bill Gareth Griffiths and Helen Tiffin eds | 2002 | London and New York:Routledge2002，，： | 1 |
| 20 | Factors affecting rumen methanogens and methane mitigation strategies显示文摘 | Sanjay Kumar Anil Kumar Puniya Monica Puniya Sumit Singh Dagar Sunil Kumar Sirohi Kishan Singh Gareth Wyn Griffith | 2009 | World Journal of Microbiology and Biotechnology2009，，： | 1 |
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