|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cross-kingdom inhibition of breast cancer growth by plant miR159显示文摘MicroRNAs (miRNAs ) 是基因表示的批评管理者,并且在优核质的开发,生理学,和疾病施加广泛的影响。并行的高度在植物和动物在 miRNA 生物的续生说和行动的分子的基础被发现。最近的研究有趣地建议导出植物的 miRNAs 的一个潜在的跨王国的行动,通过饮食的吸入,在调整哺乳动物的基因表示。尽管在哺乳动物的标本检测的植物 miRNAs 的来源和范围仍然保持争论,这些起始的研究鼓舞了我们决定植物 miRNAs 是否能在西方的人的 sera 被检测并且这些植物 miRNAs 是否能影响与象癌症那样的人的疾病有关的基因表示和细胞的过程。这里,我们发现西方的施主 sera 包含了植物 miRNA miR159,其在浆液的丰富相反地在病人与乳癌发生和前进被相关。在人的 sera, miR159 主要在细胞外的泡被检测,并且对在 3 ′ 上建议发源植物的 2'-O-methylation 的钠 periodate 氧化抵抗;终端核糖。在乳癌房间然而并非非癌的乳房的上皮的房间,一合成 miR159 模仿能够由指向编码表明抄写因素的 Wnt 的 TCF7 禁止增长,在 MYC 蛋白质层次导致减少。miR159 的口头的管理显著地模仿在老鼠压制了异种皮移植胸肿瘤的生长。这些结果第一次证明植物 miRNA 能在哺乳动物禁止癌症生长。 | Andrew R Chin Miranda Y Fong George Somlo Jun Wu Piotr Swiderski Xiwei Wu Shizhen Emily Wang | 2016 | Cell Research2016，26，2： | 35 |
| 2 | EMT and Dissemination Precede Pancreatic Tumor Formation显示文摘 | Andrew D. Rhim Emily T. Mirek Nicole M. Aiello Anirban Maitra Jennifer M. Bailey Florencia McAllister Maximilian Reichert Gregory L. Beatty Anil K. Rustgi Robert H. Vonderheide Steven D. Leach Ben Z. Stanger | 2012 | Cell2012，，1： | 13 |
| 3 | Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma显示文摘 | Andrew D. Rhim Paul E. Oberstein Dafydd H. Thomas Emily T. Mirek Carmine F. Palermo Stephen A. Sastra Erin N. Dekleva Tyler Saunders Claudia P. Becerra Ian W. Tattersall C. Benedikt Westphalen Jan Kitajewski Maite G. Fernandez-Barrena Martin E. Fernandez- | 2014 | Cancer Cell2014，，： | 5 |
| 4 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 5 | Nanoparticles with Surface Antibody Against CD98 and Carrying CD98 Small Interfering RNA Reduce Colitis in Mice显示文摘 | Bo Xiao Hamed Laroui Emilie Viennois Saravanan Ayyadurai Moiz A. Charania Yuchen Zhang Zhan Zhang Mark T. Baker Benyue Zhang Andrew T. Gewirtz Didier Merlin | 2014 | Gastroenterology2014，，： | 2 |
| 6 | Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair显示文摘Macrophage plasticity is critical for normal tissue repair following injury.In pathologic states such as diabetes,macrophage plasticity is impaired,and macrophages remain in a persistent proinflammatory state;however,the reasons for this are unknown.Here,using single-cell RNA sequencing of human diabetic wounds,we identified increased JMJD3 in diabetic wound macrophages,resulting in increased inflammatory gene expression.Mechanistically,we report that in wound healing,JMJD3 directs early macrophage-mediated inflammation via JAK1,3/STAT3 signaling.However,in the diabetic state,we found that IL-6,a cytokine increased in diabetic wound tissue at later time points post-injury,regulates JMJD3 expression in diabetic wound macrophages via the JAK1,3/STAT3 pathway and that this late increase in JMJD3 induces NFκB-mediated inflammatory gene transcription in wound macrophages via an H3K27me3 mechanism.Interestingly,RNA sequencing of wound macrophages isolated from mice with JMJD3-deficient myeloid cells(Jmjd3f/fLyz2Cre+)identified that the STING gene(Tmem173)is regulated by JMJD3 in wound macrophages.STING limits inflammatory cytokine production by wound macrophages during healing.However,in diabetic mice,its role changes to limit wound repair and enhance inflammation.This finding is important since STING is associated with chronic inflammation,and we found STING to be elevated in human and murine diabetic wound macrophages at late time points.Finally,we demonstrate that macrophage-specific,nanoparticle inhibition of JMJD3 in diabetic wounds significantly improves diabetic wound repair by decreasing inflammatory cytokines and STING.Taken together,this work highlights the central role of JMJD3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic wounds. | Christopher O.Audu William J.Melvin Amrita D.Joshi Sonya J.Wolf Jadie Y.Moon Frank M.Davis Emily C.Barrett Kevin D.Mangum Hongping Deng Xianying Xing Rachel Wasikowski Lam C.Tsoi Sriganesh B.Sharma Tyler M.Bauer James Shadiow Matthew A.Corriere Andrea TObi Steven LKunkel Benjamin Levi Bethany BMoore Johann EGudjonsson Andrew MSmith Katherine A.Gallagher | 2022 | Cellular & Molecular Immunology2022，19，11： | 2 |
| 7 | Impact of deforestation on habitat connectivity thresholds for large carnivores in tropical forests显示文摘Introduction:Deforestation significantly impacts large carnivores that depend on large tracts of interconnected forest habitat and that are sensitive to human activities.Understanding the relationship between habitat use and spatial distribution of such species across human modified landscapes is critical when planning effective conservation strategies.This study assessed the presence of potential landscape connectivity thresholds resulting from habitat fragmentation associated with different deforestation patterns using a scale-based approach that links species-specific home ranges with the extent of anthropogenic activities.The objectives were(1)to quantify the spatial and temporal distribution of natural vegetation for five common deforestation patterns and(2)to evaluate the connectivity associated with these patterns and the existence of potential thresholds affecting jaguar dispersal.The Bolivian lowlands,located within jaguar conservation units,were analysed with landscape metrics to capture the spatial and temporal changes within deforested areas and to determine potential impact on jaguar connectivity and connectivity thresholds for dispersal.Results:Over the period of 1976–2005,the amount of natural vegetation has decreased by more than 40%in all locations with the biggest changes occurring between 1991 and 2000.Landscape spatial structure around jaguar locations showed that jaguars used areas with mean proportion of natural areas=83.14%(SE=3.72%),mean patch density=1.16 patches/100 ha(SE=0.28 patches/100 ha),mean patch area=616.95 ha(SE=172.89 ha)and mean edge density=705.27 m/ha(SE=182.19 m/ha).We observed strong fragmentation processes in all study locations,which has resulted in the connectivity of jaguar habitat decreasing to<20%by 2005.A connectivity threshold zone was observed when the proportion of natural vegetation was less than 58.4%(SE=1.3).Conclusions:Assessing fragmentation and connectivity for carnivores within the extent of human-modified landscapes proved to be an effective way to understand the changes caused by deforestation and their potential effects on large carnivore habitats.Our study highlights the importance of scale-based approaches for assessing current conservation challenges to protect large carnivores. | Miriam A.Zemanova Humberto L.Perotto-Baldivieso Emily L.Dickins Andrew B.Gill John P.Leonard David B.Wester | 2017 | Ecological Processes2017，6，1： | 2 |
| 8 | Association Between Colorectal Cancer Susceptibility Loci and Survival Time After Diagnosis With Colorectal Cancer显示文摘 | Amanda I. Phipps Polly A. Newcomb Xabier Garcia–Albeniz Carolyn M. Hutter Emily White Charles S. Fuchs Aditi Hazra Shuji Ogino Hongmei Nan Jing Ma Peter T. Campbell Jane C. Figueiredo Ulrike Peters Andrew T. Chan | 2012 | Gastroenterology2012，，1： | 1 |
| 9 | Microbes Central to Human Reproduction显示文摘 | Gregor Reid Patrizia Brigidi Jeremy P. Burton Nikhat Contractor Sylvia Duncan Emilie Fargier Colin Hill Sarah Lebeer Rocio Martín Andrew J. McBain Gil Mor Catherine O’Neill Juan Miguel Rodríguez Jonathan Swann Saskia Hemert Juliett Ansell | 2015 | Am J Reprod Immunol2015，，1： | 1 |
| 10 | Positive interpretation training:Effects of mental imagery versus verbal training on positive mood显示文摘 | Emily A Holmes Andrew Mathews Tim Dalgleish Bundy Mackintosh | | 0，，03： | 1 |
| 11 | 显示文摘 | Jolan M. Terner Andrew C. Barrett Emily Grossell Mitchell J. Picker | 2002 | Psychopharmacology2002，，2： | 1 |
| 12 | Differential impact of retrotransposon populations on the genome of allotetraploid tobacco (Nicotiana tabacum)显示文摘 | Maud Petit K. Yoong Lim Emilie Julio Charles Poncet Fran?ois Dorlhac de Borne Ales Kovarik Andrew R. Leitch Marie-Angèle Grandbastien Corinne Mhiri | 2007 | Molecular Genetics and Genomics2007，，1： | 1 |
| 13 | X-ray imaging of 30 year old wine grape wood reveals cumulative impacts of rootstocks on scion secondary growth and Ravaz index显示文摘Annual rings from 30 year old vines in a California rootstock trial were measured to determine the effects of 15 different rootstocks on Chardonnay and Cabernet Sauvignon scions.Viticultural traits measuring vegetative growth,yield,berry quality,and nutrient uptake were collected at the beginning(1995 to 1999)and end(2017 to 2020)of the lifetime of a vineyard initially planted in 1991 and removed in 2021.X-ray Computed Tomography(CT)was used to measure ring widths in 103 vines.Ring width was modeled as a function of ring number using a negative exponential model.Early and late wood ring widths,cambium width,and scion trunk radius were correlated with 27 traits.Modeling of annual ring width shows that scions alter the width of the first rings but that rootstocks alter the decay of later rings,consistently shortening ring width throughout the lifetime of the vine.Ravaz index,juice pH,photosynthetic assimilation and transpiration rates,and instantaneous water use efficiency are correlated with scion trunk radius.Ultimately,our research indicates that rootstocks modulate secondary growth over years,altering physiology and agronomic traits.Rootstocks act in similar but distinct ways from climate to modulate ring width,which borrowing techniques from dendrochronology,can be used to monitor both genetic and environmental effects in woody perennial crop species. | ZoëMigicovsky Michelle Y.Quigley Joey Mullins Tahira Ali Joel F.Swift Anita Rose Agasaveeran Joseph D.Dougherty Brendan Michael Grant Ilayda Korkmaz Maneesh Reddy Malpeddi Emily L.McNichol Andrew W.Sharp Jackie L.Harris Danielle R.Hopkins Lindsay M.Jordan Misha T.Kwasniewski R.Keith Striegler Asia L.Dowtin Stephanie Stotts Peter Cousins Daniel H.Chitwood | 2023 | Horticulture Research2023，10，1： | 1 |
| 14 | Wind resource estimates with an analog ensemble approach显示文摘 | Vanvyve Emilie Delle Monache Luca Monaghan Andrew J | 2015 | Renewable Energy2015，74，： | 1 |
| 15 | A comparison of parathyroid hormone‐related protein (1‐36) and parathyroid hormone (1‐34) on markers of bone turnover and bone density in postmenopausal women: The PrOP study显示文摘 | Mara J Horwitz Marilyn Augustine Leila Kahn Emily Martin Christine C Oakley Raquel M Carneiro Mary Beth Tedesco Angela Laslavic Susan M Sereika Alessandro Bisello Adolfo Garcia‐Oca?a Caren M Gundberg Jane A Cauley Andrew F Stewart | 2013 | J Bone Miner Res2013，，11： | 1 |
| 16 | A phase II study of bevacizumab plus erlotinib for gemcitabine-refractory metastatic pancreatic cancer显示文摘 | Andrew H. Ko Alan P. Venook Emily K. Bergsland R. Kate Kelley W. Michael Korn Elizabeth Dito Brian Schillinger Janet Scott Jimmy Hwang Margaret A. Tempero | 2010 | Cancer Chemotherapy and Pharmacology2010，，6： | 1 |
| 17 | Early detection of nasopharyngeal carcinoma by plasma Epstein‐Barr virus DNA analysis in a surveillance program显示文摘 | K. C. Allen Chan Emily C. W. Hung John K. S. Woo Paul K. S. Chan Sing‐Fai Leung Franco P. T. Lai Anita S. M. Cheng Sze Wan Yeung Yin Wah Chan Teresa K. C. Tsui Jeffrey S. S. Kwok Ann D. King Anthony T. C. Chan Andrew C. van Hasselt Y. M. Dennis Lo | 2013 | Cancer2013，，10： | 1 |
| 18 | A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma显示文摘 | Andrew H. Ko Noelle LoConte Margaret A. Tempero Evan J. Walker R. Kate Kelley Stephanie Lewis Wei-Chou Chang Emily Kantoff Michael W. Vannier Daniel V. Catenacci Alan P. Venook Hedy L. Kindler | 2016 | Pancreas2016，，3： | 1 |
| 19 | Jejunal Diverticulosis and Gastrointestinal Bleeding显示文摘 | Heron E. Rodriguez M. Firdos Ziauddin Emily D. Quiros Andrew M. Brown Francis J. Podbielski | 2001 | Journal of Clinical Gastroenterology2001，，5： | 1 |
| 20 | Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer: Evidence supporting a mesothelial-to-epithelial transition显示文摘 | Ausra Bendoraite Emily C. Knouf Kavita S. Garg Rachael K. Parkin Evan M. Kroh Kathy C. O’Briant Aviva P. Ventura Andrew K. Godwin Beth Y. Karlan Charles W. Drescher Nicole Urban Beatrice S. Knudsen Muneesh Tewari | 2009 | Gynecologic Oncology2009，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员