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| 1 | 妇女乳腺癌及其早期筛查知识、态度、行为的相关性研究显示文摘[目的]了解上海市妇女乳腺癌及其早期筛查知识、态度和行为现状以及三者的关系。[方法]采用乳腺癌及其早期筛查知识问卷、乳腺自我检查态度问卷和早期筛查行为调查问卷对上海市739名妇女进行调查。[结果]妇女对于乳腺癌的临床表现和早期筛查方法的知晓率较高,但对于乳腺癌的高危因素不了解;对自我检查的态度评分为3.13分±0.50分,态度较积极;有70.1%的人曾做过乳腺自我检查,但每月做1次的只有3.9%,分别有51.2%和6.5%的人曾做过乳腺临床检查和乳腺X线摄片,但只有11.0%和5.5%的人是1年做1次。乳腺癌及其早期筛查的知识与乳腺自我检查的态度及早期筛查的3种行为之间呈正相关(r分别为0.262、0.072、0.090、0.120),对于乳腺自我检查的态度也与早期筛查的3种行为呈正相关(r分别为0.272、0.169、0.188)。[结论]护理人员要重视提高妇女对于乳腺癌的认知,帮助她们树立积极的态度,从而改善早期筛查率低的现状。 | 陈瑜 夏海鸥 Deborah Oakley 贾宏丽 邓薇 | 2007 | 护理研究(上旬版)2007，21，10： | 41 |
| 2 | 上海市妇女对乳腺癌及其早期筛查认知情况的调查显示文摘目的了解上海市妇女对于乳腺癌及早期筛查的认知情况和获取相关信息的来源。方法采用乳腺癌及其早期筛查的知识问卷和有关信息来源的问卷对739名妇女进行调查。结果92%的妇女知道乳房肿块是乳腺癌的早期症状,有98.1%和95.7%的妇女认为乳腺自我检测和乳腺临床检查可以早期发现乳腺癌,只有26.7%和24.6%的妇女知道肥胖和年龄是乳腺癌的高危因素。居住在市区、文化程度高的妇女,乳腺癌的认知情况较好(P<0.01)。目前妇女了解乳腺癌早期筛查知识的渠道主要是通过报纸或杂志(43.3%),55.2%的人最想从医师或护士处得到相关信息,同时也有45.3%的人认为从医师或护士处得到的信息最有助于她们做出早期筛查的决定。结论妇女对于乳腺癌及早期筛查知识的掌握程度分布不均,传媒要加强对乳腺癌早期筛查的宣传,护理人员要加强有关的健康教育,针对不同人群实施有效的健康指导,以提高妇女的认知水平。 | 陈瑜 夏海鸥 Deborah Oakley 贾宏丽 邓薇 | 2007 | 上海护理2007，7，3： | 36 |
| 3 | 护理干预对促进上海市妇女乳腺癌早期筛查信念及行为的效果研究显示文摘目的评价护理干预对促进妇女乳腺癌早期筛查信念及行为的效果。方法方便选取上海市4个社区,完全随机将其分为干预组和对照组,每组再次方便选取180名研究对象,共选取739名。干预组接受以健康信念模式为指导的为期一年的护理干预,对照组只接受一般防癌宣教。结果干预后妇女感知的易感性、感知的益处增加(B=0.210,P<0.01;B=0.105,P<0.01),感知障碍减少(B=-0.086,P<0.05);每月1次乳腺自我检查的人数增多,进行乳腺临床检查和乳腺X线摄片的人数增多(OR分别为3.094、2.746)。结论以健康信念模式为指导的护理干预帮助妇女树立了健康信念,提高了早期筛查的参与率,对广泛开展乳腺癌的早期筛查工作具有重要意义。 | 陈瑜 夏海鸥 Deborah Oakley 贾宏丽 邓薇 | 2010 | 中华护理杂志2010，45，5： | 21 |
| 4 | Vascular endothelial growth factor and tryptase changes after chemoembolization in hepatocarcinoma patients显示文摘AIM: To evaluate vascular endothelial growth factor(VEGF) and tryptase in hepatocellular cancer(HCC)before and after trans-arterial chemoembolization(TACE).METHODS: VEGF and tryptase serum concentrations were assessed from 71 unresectable HCC patients before and after hepatic TACE performed by binding DC-Beads?to doxorubicin. VEGF levels were examined for each serum sample using the Quantikine Human VEGF-enzyme-linked immuno-absorbent assay(ELISA),whereas tryptase serum concentrations were assessed for each serum sample by means of fluoro-enzyme immunoassay(FEIA) using the Uni-CAP100 tool.Differences between serum VEGF and tryptase values before and after TACE were evaluated using Student t test. Person's correlation was used to assess the degree of association between the two variables.RESULTS: VEGF levels and serum tryptase in HCCpatients before TACE had a mean value and standard deviation(SD) of 114.31 ± 79.58 pg/mL and 8.13± 3.61 μg/L, respectively. The mean levels and SD of VEGF levels and serum tryptase in HCC patients after TACE were 238.14 ± 109.41 pg/mL and 4.02 ±3.03 μg/L. The changes between the mean values of concentration of VEGF and tryptase before treatment and after treatment was statistically significant(P <0.000231 and P < 0.00124, by Wilcoxon-Mann-Whitney respectively). A significant correlation between VEGF levels before and after TACE and between tryptase levels before and after TACE was demonstrated(r =0.68, P = 0.003; r = 0.84, P = 0.000 respectively).CONCLUSION: Our pilot results suggest that the higher serum VEGF levels and the lower tryptase levels following TACE may be potential biomarkers changing in response to therapy. | Girolamo Ranieri Michele Ammendola Ilaria Marech Annamaria Laterza Ines Abbate Caroline Oakley Angelo Vacca Rosario Sacco Cosmo Damiano Gadaleta | 2015 | World Journal of Gastroenterology2015，21，19： | 13 |
| 5 | 护理干预对妇女乳癌认知及乳腺自检行为的影响显示文摘目的探讨护理干预对妇女乳癌认知和乳腺自检行为的影响。方法将上海市4个社区的739名妇女随机分为观察组(360名)和对照组(379名)。对照组仅进行一般防癌宣教;观察组实施为期1年的护理干预,包括乳癌相关知识的健康教育讲座,乳腺自我检查的技能辅导,第3、6、9个月的电话随访,以及第6个月的宣传资料邮寄等。结果干预后观察组乳癌相关知识水平显著高于对照组(P<0.01),乳腺自我检查行为显著优于对照组(P<0.01)。结论对社区健康妇女实施恰当的护理干预,能有效提高妇女的乳癌相关知识水平和参与乳腺自我检查的积极性,对广泛开展乳癌的早期筛查工作具有重要价值。 | 陈瑜 夏海鸥 Deborah Oakley 贾宏丽 邓薇 | 2009 | 护理学杂志(外科版)2009，24，4： | 9 |
| 6 | Targeting mast cells in gastric cancer with special reference to bone metastases显示文摘Bone metastases from gastric cancer(GC) are considered a relatively uncommon finding; however, they are related to poorer prognosis. Both primary GC and its metastatic progression rely on angiogenesis. Several lines of evidence from GC patients strongly support the involvement of mast cells(MCs) positive to tryptase(MCPT) in primary gastric tumor angiogenesis. Recently,we analyzed infiltrating MCs and neovascularization in bone tissue metastases from primary GC patients, and observed a significant correlation between infiltrating MCPT and angiogenesis. Such a finding suggested the involvement of peritumoral MCPT by infiltrating surrounding tumor cells, and in bone metastasis angiogenesis from primary GC. Thus, an MCPT-stimulated angiogenic process could support the development of metastases in bone tissue. From this perspective, we aim to review the hypothetical involvement of tumorinfiltrating,peritumoral MCPT in angiogenesis-mediated GC cell growth in the bone microenvironment and in tumor-induced osteoclastic bone resorption. We also focus on the potential use of MCPT targeting agents,such as MCs tryptase inhibitors(gabexate mesylate,nafamostat mesylate) or c-KitR tyrosine kinase inhibitors(imatinib, masitinib), as possible new anti-angiogenic and anti-resorptive strategies for the treatment of GC patientsaffected by bone metastases. | Christian Leporini Michele Ammendola Ilaria Marech Giuseppe Sammarco Rosario Sacco Cosmo Damiano Gadaleta Caroline Oakley Emilio Russo Giovambattista De Sarro Girolamo Ranieri | 2015 | World Journal of Gastroenterology2015，21，37： | 5 |
| 7 | OPG对TNF诱导的成骨细胞凋亡的抑制作用显示文摘目的 探讨TNF α能否诱导成骨类细胞凋亡及OPG能否抑制其凋亡 ,开辟一条防治骨质疏松的新路。方法 将人间充质干细胞在分化培养液中培养 2 1天使之成为成骨细胞 ,与MG6 3一起用于凋亡实验。鼠WEHI 16 4细胞系用于阳性对照。AnnexinV和TUNEL分析方法检测成骨类细胞凋亡。结果 和FasL诱导细胞凋亡一样 ,TNF α能引起MG6 3骨肉瘤细胞、间充质干细胞和成骨细胞的凋亡 ,并表现为明显的浓度依赖和时间依赖。低浓度TNF α(170~ 5 0 0 pmol/L)作用于细胞 2~ 4h就显示了较明显的凋亡 ,而 0 4 5~1 5nmol/LOPG几乎完全抑制了 5 0 0 pmol/LTNF α诱导的凋亡。结论 OPG能够抑制TNF α诱导的成骨类细胞凋亡。 | 步荣发 李亚男 Jennifer I Oakley Harry C Blair | 2004 | 解放军医学杂志2004，29，4： | 4 |
| 8 | Possible biological and translational significance of mast cells density in colorectal cancer显示文摘Mast cells(MCs), located ubiquitously near blood vessels, are descended from CD34+ hematopoietic stem cells. Initially, although their role has been well defined in hypersensitivity reactions, the discovery of their sharing in both innate and adaptive immunity has allowed to redefine their crucial interplay on the regulatory function between inflammatory and tumor cells through the release of mediators granule-associated(mainly tryptase and vascular endothelial growth factor). In particular, in several animal and human malignancies it has been well demonstrated that activated c-Kit receptor(c-KitR) and tryptase(an agonist of the proteinase-activated receptor-2) take pivotal part in tumor angiogenesis after the MCs activation, contributing to tumor cells invasion and metastasis. In this review, we focused on crucial MCs density(MCD) role in colorectal cancer(CRC) development and progression angiogenesis-mediated; then, we will analyze the principal studies that have focused on MCD as possible prognostic factor. Finally, we will consider a possible role of MCD as novel therapeutic target mainly by c-KitR tyrosine kinase inhibitors(imatinib, masitinib) and tryptase inhibitors(gabexate and nafamostat mesylate) with the aim to prevent CRC progression. | Ilaria Marech Michele Ammendola Claudia Gadaleta Nicola Zizzo Caroline Oakley Cosmo Damiano Gadaleta Girolamo Ranieri | 2014 | World Journal of Gastroenterology2014，20，27： | 3 |
| 9 | Myosin binding protein C:Structural abnormalities in familial hypertrophic cardiomyopathy显示文摘The muscle protein myosin binding protein C (MyBPC) is a large multi-domain protein whose role in the sarcomere is complex and not yet fully understood. Mutations in MyBPC are strongly associated with the heart disease familial hypertrophic cardiomyopathy (FHC) and these experiments of nature have provided some insight into the intricate workings of this protein in the heart. While some regions of the MyBPC molecule have been assigned a function in the regulation of muscle contraction, the interaction of other regions with various parts of the myosin molecule and the sarcomeric proteins, actin and titin, remain obscure. In additic n, several intra-domain interactions between adjacent MyBPC molecules have been identified. Although the basic structure of the molecule (a series of immunoglobulin and fibronectin domains) has been elucidated, the assembly of MyBPC in the sarcomere is a topic for debate. By analysing the MyBPC sequence with respect to FHC-causing mutations it is possible to identify individual residues or regions of each domain that may be important either for binding or regulation. This review looks at the current literature, in concert with alignments and the structural models of MyBPC, in an attempt to understand how FHC mutations may lead to the disease state. | Cecily E OAKLEY Brett D HAMBLY Paul MG CURMI Louise J BROWN | 2004 | Cell Research2004，14，2： | 2 |
| 10 | The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis显示文摘 | A. M. Elsharkawy F. Oakley D. A. Mann | 2005 | Apoptosis2005，，5： | 2 |
| 11 | Mierotubule nucleation 显示文摘 | Job D Valiron O Oakley B | 2003 | Curr Opin Cell Biol2003，15，1： | 1 |
| 12 | Probabilistic sensitivity analysis of complex model: a Bayesian approach显示文摘 | Oakley J O'Hagan A | 2004 | Journal of the Royal Statistical Society B2004，66，3： | 1 |
| 13 | The accuracy of image analysis methods in spur gear metrology 显示文摘 | Robinson M J Oakley J P Cunningham M J | 1995 | Measurement Science and Technology1995，6，7： | 1 |
| 14 | Anticoagulants in pregnancy显示文摘 | Oakley C M | 1995 | Br Heart J1995，74，2： | 1 |
| 15 | Practical dihydroxylation and C-C cleavage of unsaturated fatty acids显示文摘 | Oakley M A Woodward S Coupland K | 1999 | J Mol Catal A:Chem1999，150，： | 1 |
| 16 | Probabilistic Sensitivity Analysis of Complex Models: a Bayesian Approach 显示文摘 | Oakley J E O' Hagan A | 2004 | Royal Statistical Society2004，66，3： | 1 |
| 17 | Modem management of patellar instability显示文摘 | Rhee SJ Pavlou G Oakley J | 2012 | Int Orthop2012，，12： | 1 |
| 18 | Proinflammatory cytokines regulate human glncocorticoid receptor gene expression and lead to the accumulation of the dominant negative 显示文摘 | Webster JC Oakley RH Jewell CM | 2001 | Proc Natl Acad Sci USA2001，98，12： | 1 |
| 19 | The use of accelerated ageing procedures to predict the long term strength of GRC composites显示文摘 | LITHERLAND K L OAKLEY D R PROCTORB A | 1981 | Cement and Concrete Re- search1981，11，3： | 1 |
| 20 | The distribution and origin of Keratin 20 containing taste buds in rat and buman显示文摘 | Zhang C Oakley B | 1996 | Differentiation1996，61，： | 1 |
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