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| 1 | BCLC策略:预后预测和治疗推荐2022版更新显示文摘2018版BCLC预后和治疗推荐策略发布后,肝细胞癌(简称HCC)的研究又取得了重大进展。本次更新基于肝癌各领域的研究进展结果。重点关注影响策略的重要研究进展。虽然近年的研究结果成绩斐然,但将其引入为临床医生和研究者提供行动依据的循证模型指南来说证据效力依然不够确切。本文对该问题进行分析,阐述了为HCC患者制定个体化治疗临床决策所需的批判性思维和专业知识。 | Reig M Forner A Rimola J Ferrer-Fabrega J Burrel M Garcia-Criado A Kelley RK Galle PR Mazzaferro V Salem R Sangro B Singal AG Vogel A Fuster J Ayuso C Bruix J 刘永凡(摘译) 崔笑(摘译) 耿小平(审校) | 2022 | 肝胆外科杂志2022，30，5： | 80 |
| 2 | Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome显示文摘Polycystic ovary syndrome(PCOS) is the most common endocrine disorder in reproductive-aged women. Women with PCOS frequently have metabolic complications including insulin resistance(IR), early diabetes, hypertension and dyslipidemia. Recent studies have demonstrated an association between PCOS and another metabolic complication: nonalcoholic fatty liver disease(NAFLD). NAFLD occurs as a result of abnormal lipid handling by the liver, which sensitizes the liver to injury and inflammation. It can progress to nonalcoholic steatohepatitis(NASH), which is characterized by hepatocyte injury and apoptosis. With time and further inflammation, NASH can progress to cirrhosis. Thus, given the young age at which NAFLD may occur in PCOS, these women may be at significant risk for progressive hepatic injury over the course of their lives. Many potential links between PCOS and NAFLD have been proposed, most notably IR and hyperandrogenemia. Further studies are needed to clarify the association between PCOS and NAFLD. In the interim, clinicians should be aware of this connection and consider screening for NAFLD in PCOS patients who have other metabolic risk factors. The optimal method of screening is unknown. However, measuring alanine aminotransferase and/or obtaining ultrasound on high-risk patients can be considered. First line treatment consists of lifestyle interventions and weight loss, with possible pharmacologic interventions in some cases. | Carly E Kelley Ann J Brown Anna Mae Diehl Tracy L Setji | 2014 | World Journal of Gastroenterology2014，20，39： | 11 |
| 3 | Role of the NLRP3 inflammasome in neurodegenerative diseases and therapeutic implications显示文摘Neurodegenerative diseases are a group of neuronal disorders caused by progressive neuronal cell death in different regions of the human brain.Alzheimer's disease(AD)and Parkinson's disease(PD)are the most common types of neurodegenerative diseases that affect millions of people worldwide.There is no cure available for either disease.One of the pathological hallmarks of neurodegenerative diseases is the abnormal protein aggregation in the central nervous system. | Yanhui Duan Nathan Kelley Yuan He | 2020 | Neural Regeneration Research2020，15，7： | 10 |
| 4 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 5 | Juvenile hominoid cranium from the terminal Miocene of Yunnan,China显示文摘Fossil apes are known from several late Miocene localities in Yunnan Province,southwestern China,principally from Shihuiba(Lufeng)and the Yuanmou Basin,and represent three species of Lufengpithecus.They mostly comprise large samples of isolated teeth,but there are also several partial or complete adult crania from Shihuiba and a single juvenile cranium from Yuanmou.Here we describe a new,relatively complete and largely undistorted juvenile cranium from the terminal Miocene locality of Shuitangba,also in Yunnan.It is only the second ape juvenile cranium recovered from the Miocene of Eurasia and it is provisionally assigned to the species present at Shihuiba,Lufengpithecus lufengensis.Lufengpithecus has most often been linked to the extant orangutan,Pongo pygmaeus,but recent studies of the crania from Shihuiba and Yuanmou have demonstrated that this is unlikely.The new cranium reinforces the view that Lufengpithecus represents a distinct,late surviving lineage of large apes in the late Miocene of East Asia that does not appear to be closely affiliated with any extant ape lineage.It substantially increases knowledge of cranial morphology in Lufengpithecus and demonstrates that species of this genus represent a morphologically diverse radiation of apes,which is consistent with the dynamic tectonic and biotic milieu of southwestern China in the late Miocene. | JI XuePing JABLONSKI Nina G SU Denise F DENG ChengLong FLYNN Lawrence J YOU YouShan KELLEY Jay | 2013 | Chinese Science Bulletin2013，58，31： | 8 |
| 6 | Application of Avaatech X-ray fluorescence core-scanning in Sr/Ca analysis of speleothems显示文摘Application of X-ray fluorescence core-scanning(XRF-CS) on both marine and lake sediments has achieved remarkable results. However, its application has not been widely extended to the research on speleothems. In this study, we measure the Sr abundance and the Sr/Ca ratios of three stalagmites(two aragonite stalagmites, one calcite stalagmite) using the state-of-the-art fourth-generation Avaatech high-resolution XRF core scanner. Through comparisons among different scan paths and among different scan resolutions, as well as comparisons with inductively coupled plasma optical emission spectrometer(ICP-OES), Itrax XRF, and Artax XRF results, we confirm that the Avaatech XRF core scanner could precisely, quickly, and nondestructively analyze the high-resolution Sr abundance of speleothems. Furthermore, we combine the stalagmite δ^(18)O records to explore the paleoclimatic significance of the measured stalagmite Sr/Ca. | Dong LI Liangcheng TAN Fei GUO Yanjun CAI Youbin SUN Gang XUE Xing CHENG Hong YAN Hai CHENG R.Lawrence EDWARDS Yongli GAO Jessica KELLEY | 2019 | Science China Earth Sciences2019，62，6： | 7 |
| 7 | Increased dietary intake of tyrosine upregulates melanin deposition in the hair of adult black-coated dogs显示文摘The principle determinant of melanin derived hair colour and patterning in mammals is genetic, but environmental factors are now thought to play a role. It has been shown that the concentration of melanins in cat hair is influenced by the amino acid composition of their diets. Also, puppies were found to require tyrosine(Tyr) intake significantly greater than that recommended for normal growth and development in order to optimize melanin expression in their coats. Much of the work to date has been conducted in growing animals. Less is known about the relationship between nutrition and hair melanin deposition in healthy adult animals. In this study, we fed 2 groups of adult black Labrador retrievers(12 dogs/group) different concentrations of Phe + Tyr(5.6 vs. 3.5 g/Mcal) for 24 weeks and used spectrophotometric measurements every 8 weeks to detect any associated changes in the dogs' hair colour.The higher intake dogs showed reduced dilution of their black coat pigment compared with the lower intake dogs. Specifically, following 16 weeks at the higher intake, the dogs showed less yellow pigmentation to their coats(P = 0.0032), and after 24 weeks at the higher intake, the dogs showed less red(P < 0.0001) and yellow(P< 0.0001), as well as greater overall dark pigmentation(P < 0.0001). In conclusion, we have demonstrated for the first time that colour expression in the hair-coat of adult dogs is dependent on dietary intake of Tyr, and that the requirement appears to be in excess of the minimum level recommended to maintain health. | Adrian Watson Jamie Wayman Russell Kelley AlexANDre Feugier Vincent Biourge | 2018 | Animal Nutrition2018，，4： | 7 |
| 8 | Sphingosine-1-phosphate signaling in vasculogenesis and angiogenesis显示文摘Blood vessels either form de novo through the process of vasculogenesis or through angiogenesis that involves the sprouting and proliferation of endothelial cells in pre-existing blood vessels. A complex interactive network of signaling cascades downstream from at least three of the nine known G-protein-coupled sphingosine-1-phosphate (S1P) receptors act as a prime effector of neovascularization that occurs in embryonic development and in association with various pathologies. This review focuses on the current knowledge of the roles of S1P signaling in vasculogenesis and angiogenesis, with particular emphasis on vascular cell adhesion and motility responses. | Kelley M Argraves Brent A Wilkerson W Scott Argraves | 2010 | World Journal of Biological Chemistry2010，1，10： | 6 |
| 9 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 10 | Avaatech XRF岩芯扫描分析方法在石笋Sr/Ca测试中的应用显示文摘XRF岩芯扫描分析方法在海洋和湖泊沉积环境变化方面的应用研究,已取得了显著的成果.然而,目前其应用还没有广泛拓展到洞穴石笋的研究中.在本文中,我们利用最先进的第四代Avaatech高分辨率XRF岩芯扫描仪测试了3根石笋(2根文石石笋, 1根方解石石笋)的Sr元素以及Sr/Ca比值.通过不同扫描路径之间和不同扫描分辨率之间的对比,以及与ICP-OES、Itrax XRF和Artax XRF结果的对比,证实了Avaatech XRF岩芯扫描仪可以准确、快速、无损地进行石笋高分辨率Sr元素的测试.此外,我们还结合石笋氧同位素记录,尝试解释了所测石笋Sr/Ca的古气候意义. | 李东 谭亮成 郭飞 蔡演军 孙有斌 薛刚 成星 晏宏 程海 R.Lawrence EDWARDS 高永利 Jessica KELLEY | 2019 | 中国科学:地球科学2019，49，6： | 6 |
| 11 | 骨肉瘤DNA损伤修复相关基因表达与预后的关系显示文摘目的研究DNA损伤修复基因MPG、APE1、XRCC1和MGMT在人体骨肉瘤中的表达特点及其与患者预后的关系,为判估骨肉瘤对化疗的反应性及其预后提供有价值的指标。方法应用免疫组化方法检测60例骨肉瘤组织和3株骨肉瘤细胞中MPG、APE1、XRCC1和MGMT的表达,按染色强度将其分为低表达组和高表达组。统计分析它们与临床病理及患者预后的关系。结果3株骨肉瘤细胞中APE1和XRCC1呈强阳性,MPG和MGMT呈弱阳性。60例骨肉瘤中MPG、APE1、XRCC1和MGMT高表达分别为40例(65%)、43例(72%)、23例(38%)和32例(53%)。APE1表达和患者年龄,Price’s分级和WHO分型有显著性差异(P<0·05),MPG表达和WHO分型有显著性差异(P<0·05)。Spearman秩相关检验显示上述4项指标之间密切相关。单因素相关分析显示APE1和MPG表达与患者预后有显著性差异(P<0·05),COX比例风险模型显示MPG表达与患者预后有关(P<0·01)。结论DNA损伤修复基因MPG、APE1、XRCC1和MGMT的共同表达是骨肉瘤的特点,APE1和MPG表达对于判估骨肉瘤患者的预后可能更有意义。 | 王东 张沁宏 仲召阳 李增鹏 Mark R Kelley | 2005 | 第三军医大学学报2005，27，13： | 5 |
| 12 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 13 | Gastric cancer epidemiology and risk factors显示文摘 | Jon R. Kelley John M. Duggan | 2003 | Journal of Clinical Epidemiology2003，，1： | 4 |
| 14 | Antecedents to customer expectations for service recovery显示文摘 | Scott W. Kelley Mark A. Davis | 1994 | Journal of the Academy of Marketing Science1994，，1： | 2 |
| 15 | Gastric cancer epidemiology and risk factors 显示文摘 | Kelley JR Duggan JM | 2003 | J Clin Epidemiol2003，56，1： | 2 |
| 16 | Saving, dependency and development显示文摘 | Allen C. Kelley Robert M. Schmidt | 1996 | Journal of Population Economics1996，，4： | 2 |
| 17 | Study of immunological dysfunction in periparturient Holstein cattle selected for high and average milk production显示文摘 | J.C. Detilleux M.E. Kehrli J.R. Stabel A.E. Freeman D.H. Kelley | 1995 | Veterinary Immunology and Immunopathology1995，，3： | 2 |
| 18 | Intermittent gastric outlet obstruction caused by a prolapsing antral gastric polyp显示文摘Most gastric polyps have an asymptomatic presentation and are an incidental finding on upper endoscopy. Symptomatic presentations can range from an ulcerated polyp leading to anemia and occult bleed to complete gastric outlet obstruction. We report a case of an 89-year-old woman who presented with postprandial nausea and early satiety. Her upper endoscopy revealed a 2 cm pedunculated hyperplastic polyp arising from the antrum of the stomach which was seen prolapsing into the pylorus causing intermittent gastric outlet obstruction. In the present report, we statistically analyzed 39 prolapsing gastric polyps previously reported in the English literature and demonstrate the current utility of monopolar snare polypectomy in establishing a histological diagnosis while offering simultaneous treatment. Additionally, we review the literature for the management of all hyperplastic gastric polyps in relation to advancements in digestive endoscopy. | Mehul Parikh Brian Kelley Gabriel Rendon Bincy Abraham | 2010 | World Journal of Gastrointestinal Oncology2010，2，5： | 2 |
| 19 | 双功能基因APE1敲低后人体骨肉瘤细胞基因表达谱变化的研究显示文摘目的探索APE1敲低后骨肉瘤细胞恶性表型受抑的可能机制,以及APE1相互作用的可能分子。方法应用免疫印迹和AP核酸内切酶活性检测确证合成APE1 siRNA对人体骨肉瘤细胞HOS APE1基因的敲低作用;应用GEAr-rayTMQ系列cDNA微阵列研究HOS细胞APE1敲低后基因表达谱的改变。结果APE1 siRNA对HOS细胞APE1基因具有特异性“敲低”作用,其抑制效率为91.5%。APE1抑制对cDNA微阵列六族途径均有影响,其中对细胞周期族基因影响较少;96个基因中有42个基因有明显变化(43.8%),其中CDK4、FGFR2、KAI1和NCAM1表达上升,其余38个基因表达均呈下降。结论APE1的敲低对骨肉瘤细胞的细胞周期及DNA损伤、细胞凋亡、信号转导、细胞黏附、血管生成、肿瘤转移途径基因均有影响。 | 王东 仲召阳 李增鹏 杨镇洲 Mark R Kelley | 2007 | 第三军医大学学报2007，29，1： | 2 |
| 20 | Spatial Autoregression Techniques for Real Estate Data显示文摘 | Robin Dubin R. Kelley Pace Thomas G. Thibodeau | 1999 | Journal of Real Estate Literature1999，，1： | 2 |
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