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| 1 | 高纯度茶氨酸的合成与特性(英文)显示文摘报道了一种改进的茶氨酸(γ-谷酰基乙胺)的合成方法,包括L-谷氨酸的去氢成为吡咯烷酮羟酸(PCA),然后再加纯的乙胺(99%,气-液)反应,得率92.6%,再在84%乙醇溶液中重结晶后,高纯度茶氨酸(A型) 的得率37.4%。其结晶在透视和扫描电镜下呈长方形棱柱,具丝光状。A型茶氨酸的融点为224℃。B型茶氨酸从L-PCA合成,为甘蓝叶状,边缘呈波浪型,融点217—218℃。用HPLC分析证明,A和B型茶氨酸是混合异构体,A型含47.9%的L-茶氨酸,B型含90.9%的L-茶氨酸,100%的L-茶氨酸的旋光度(á)为+8.57 。 | YAN Shou He Jean-Pierre DUFOUR Marc MEURENS | 2003 | 茶叶科学2003，23，2： | 13 |
| 2 | Tumor suppressor and hepatocellular carcinoma显示文摘A few signaling pathways are driving the growth of hepatocellular carcinoma.Each of these pathways possesses negative regulators.These enzymes,which normally suppress unchecked cell proliferation,are circumvented in the oncogenic process,either the overactivity of oncogenes is sufficient to annihilate the activity of tumor suppressors or tumor suppressors have been rendered ineffective.The loss of several key tumor suppressors has been described in hepatocellular carcinoma.Here,we systematically review the evidence implicating tumor suppressors in the development of hepatocellular carcinoma. | Juliette Martin Jean-Franois Dufour | 2008 | World Journal of Gastroenterology2008，14，11： | 10 |
| 3 | Heterogeneity of Patients with Intermediate (BCLC B) Hepatocellular Carcinoma: Proposal for a Subclassification to Facilitate Treatment Decisions显示文摘 | Luigi Bolondi Andrew Burroughs Jean-Fran?ois Dufour Peter Galle Vincenzo Mazzaferro Fabio Piscaglia Jean Raoul Bruno Sangro | 2012 | Semin Liver Dis2012，，04： | 7 |
| 4 | Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma显示文摘 | Y.-L. Liu G.L. Patman J.B.S. Leathart A.-C. Piguet A.D. Burt J.-F. Dufour C.P. Day A.K. Daly H.L. Reeves Q.M. Anstee | 2014 | Journal of Hepatology2014，，： | 5 |
| 5 | 乳腺癌辅助内分泌治疗显示文摘 | Thierry Petit 任国胜 Patrick Dufour 甘露 | 2007 | 中国普外基础与临床杂志2007，14，3： | 4 |
| 6 | Medical management of metabolic and cardiovascular complications after liver transplantation显示文摘Liver transplantation represents the only curative option for patients with endstage liver disease,fulminant hepatitis and advanced hepatocellular carcinoma.Even though major advances in transplantation in the last decades have achieved excellent survival rates in the early post-transplantation period,long-term survival is hampered by the lack of improvement in survival in the late post transplantation period(over 5 years after transplantation).The main etiologies for late mortality are malignancies and cardiovascular complications.The latter are increasingly prevalent in liver transplant recipients due to the development or worsening of metabolic syndrome and all its components(arterial hypertension,dyslipidemia,obesity,renal injury,etc.).These comorbidities result from a combination of pre-liver transplant features,immunosuppressive agent side-effects,changes in metabolism and hemodynamics after liver transplantation and the adoption of a sedentary lifestyle.In this review we describe the most prevalent metabolic and cardiovascular complications present after liver transplantation,as well as proposing management strategies. | Chiara Becchetti Melisa Dirchwolf Vanessa Banz Jean-Francois Dufour | 2020 | World Journal of Gastroenterology2020，26，18： | 4 |
| 7 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 8 | Early diverting colostomy for perianal sepsis in children with acute leukemia显示文摘 | Alessio Pini Prato Elio Castagnola Concetta Micalizzi Carlo Dufour Stefano Avanzini Luca Pio Edoardo Guida Girolamo Mattioli Vincenzo Jasonni Nicola Disma Leila Mameli Giovanni Montobbio Piero Buffa | 2012 | Journal of Pediatric Surgery2012，，10： | 2 |
| 9 | Total tumor volume and alpha‐fetoprotein for selection of transplant candidates with hepatocellular carcinoma: A prospective validation显示文摘 | Christian Toso Glenda Meeberg Roberto Hernandez‐Alejandro Jean‐Fran?ois Dufour Paul Marotta Pietro Majno Norman M. Kneteman | 2015 | Hepatology2015，，1： | 2 |
| 10 | Effect of thrombocytopenia on treatment tolerability and outcome in patients with chronic HCV infection and advanced hepatic fibrosis显示文摘 | Raoel Maan Adriaan J. van der Meer Bettina E. Hansen Jordan J. Feld Heiner Wedemeyer Jean-Fran?ois Dufour Hooman F. Zangneh Frank Lammert Michael P. Manns Stefan Zeuzem Harry L.A. Janssen Robert J. de Knegt Bart J. Veldt | 2014 | Journal of Hepatology2014，，： | 2 |
| 11 | 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult – 2009 recommendations显示文摘 | Jacques Genest Ruth McPherson Jiri Frohlich Todd Anderson Norm Campbell André Carpentier Patrick Couture Robert Dufour George Fodor Gordon A. Francis Steven Grover Milan Gupta Robert A. Hegele David C. Lau Lawrence Leiter Gary F. Lewis Eva Lonn G.B. John | 2009 | Canadian Journal of Cardiology2009，，10： | 2 |
| 12 | Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study显示文摘 | Andri Rauch Zoltán Kutalik Patrick Descombes Tao Cai Julia Di Iulio Tobias Mueller Murielle Bochud Manuel Battegay Enos Bernasconi Jan Borovicka Sara Colombo Andreas Cerny Jean–Fran?ois Dufour Hansjakob Furrer Huldrych F. Günthard Markus Heim Bernard Hirs | 2010 | Gastroenterology2010，，4： | 2 |
| 13 | Hepatocellular carcinoma in a non-cirrhotic patient with Wilson's disease显示文摘We report the exceptional case of hepatocellular carcinoma in a non-cirrhotic patient, whose Wilson's disease was diagnosed at the unusual age of 58 years. The liver histology revealed macrovesicular steatosis with fibrosis, but no cirrhosis. The disease was treated with D-penicillamine for 3 years until acute discomfort in the right upper quadrant led to detection of multifocal hepatocellular carcinoma, which was successfully resected. The histological examination confirmed the malignant nature of the 4 lesions, which were classified according to Edmondson and Steiner as poorly differentiated hepatocellular carcinoma grade 3. The non-tumoral parenchyma showed 80% steatosis with ballooned cells, lobular inflammation, septal fibrosis but no cirrhosis. Hepatocellular carcinoma is rare in Wilson's disease, especially in the absence of cirrhosis. The literature's 28 published cases are reviewed and the contributory role of copper in the hepatocarcinogenic process is discussed. | Raphael Thattil Jean-Franois Dufour | 2013 | World Journal of Gastroenterology2013，19，13： | 2 |
| 14 | The impact of the COVID-19 pandemic on the mental health of young people:A comparison between China and the United Kingdom显示文摘Purpose:As COVID-19 spreads globally and affects people's health,there are concerns that the pandemic and control policies may have psychological effects on young people(age from 17 to 35 years).This psychological impact might vary in different countries,and thus we compared the prevalence of self-reported psychological distress,loneliness and posttraumatic stress symptoms(PTSS)among young people in the United Kingdom(UK)and China at the beginning of the COVID-19 pandemic.Methods:Data of this study came from two sources.One source was the first wave of COVID-19 study in Understanding Society,a special wave of the UK household longitudinal study,which provided the high-quality,national-wide representative panel data.The sample comprised 1054 young people.The other source was an online survey on the mental health of 1003 young people from Shanghai,a highly developed area in China.The questionnaire included questions on the prevalence of common mental disorders(cut-off score≥4),loneliness and potential PTSS(cut-off≥33).Univariable analyses were conducted to test the differences in the self-reported prevalence of psychological distress and loneliness between the two groups.Multivariable logistic regression analyses were run to explore the predictors of psychological distress and loneliness among all the young people from England and Shanghai.Results:Among the samples with self-reported psychological distress,the UK sample accounted for 34.4%(n=1054)and the Chinese sample accounted for 14.1%(n=1003).The difference between the two groups was statistically significant(p<0.001).Additionally,57.1%of people in the UK and 46.7%in China reported that they sometimes or often felt lonely,of which the difference is statistically significant(p<0.001).Regression analysis of the entire samples showed that nationality,gender,psychotherapy and loneliness were significant predictors of 12-item General Health Questionnaire scores,while the variables of age and living alone were not.Significant predictors of self-reported loneliness were the nationality,gender,age,living alone and psychotherapy.In China,123(12.3%)young people,49 men(11.3%)and 74 women(13.0%),met the criteria of PTSS symptoms(cut-off scores≥33).These scores were only collected in China.Conclusion:This evidence suggests that mental health and loneliness reported by young people were lower in China than that in the UK during the studied period.More research is needed to understand these differences.If the differential negative psychological impacts are confirmed,country-specific measures of prevention and intervention should be adopted to improve the mental health of young people under the ongoing impact of the pandemic. | Ming-Bo Liu Geraldine Dufour Zhuo-Er Sun Julieta Galante Chen-Qi Xing Jing-Ye Zhan Li-Li Wu | 2021 | Chinese Journal of Traumatology2021，24，4： | 2 |
| 15 | Hemolytic activity of new linear surfactin aanalogs in relation to their physico-chemical properties显示文摘 | Dufour S Deleu M Nott K | 2005 | Biochim Biophys Acta2005，，： | 1 |
| 16 | Improving yield of adventitious shoots in apple显示文摘 | | 1990 | Acta Horticulturae1990，280，： | 1 |
| 17 | Antiphospholipid syndrome and recurrent miscarriages显示文摘 | Dufour P Cosson M | 2001 | Eur J Obstet Gynecol Reprod Biol2001，96，1： | 1 |
| 18 | Homozygosis for (12) CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population显示文摘 | Dufour C Capasso M Svahn J | 2004 | Br J Haematol2004，126，5： | 1 |
| 19 | Intraoperative autologous blood transfusion in i ntracranla] surgery显示文摘 | Cataldi S Bruder N Dufour | 1997 | Neurosurgery1997，40，4： | 1 |
| 20 | Antiphospholipid syndromeand recurrent miscarriages显示文摘 | Vinatier D Dufour P Cosson M | 2001 | Eur J Obstet Gynecol Reprod Biol2001，96，1： | 1 |
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