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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Characteristics of the Chinese subjects entered the Hypertension in the Very Elderly Trial显示文摘在多民族的试用的病人的基线特征是的背景可能,与比较的心血管的 outcome.This 学习有关,病人的基线特征在中国招募了,那些在超过 80 年岁的 508 个中国高血压的男人和进入了高血压在的 728 个女人全部的另外的 countries.Methods A 招募了老试用( HYVET )与在 860 个男人和在另外的 countries.Results 进入了试用的 1 348 个女人的那些相比中国 | LIU Li-sheng WANG Ji-guang MA Shu-ping WANG Wen LU Fang-hong ZHANG Liang-qing Winston Banya Ruth Peters Nigel Beckett Astrid Fletcher Christopher J. Bulpitt | 2008 | Chinese Medical Journal2008，，16： | 5 |
| 3 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 4 | Selenium and Iodine Deficiencies and Selenoprotein Function显示文摘This paper reviews some recent findings on the interactions between selenium deficiency and iodine deficency. Both micronutrients can control the levels of selenoprotein mRNAs, particularly in the thyroid and brain. When selenium and iodine supplies are limiting the compensatory mechanisms work to minimise adverse effects on thyroid hormone metabolsm and thus neurological developtnent. The mechanisms for regulation of selenoproteins in selenium and iodine deficiency are however very tissue-specific. For example, unlike the brain and thyroid,brown adipose tissue is unable to retain selenoproteins in selenium and iodine deficiency and is therefore at greater risk from injurious effects of the deficiencies. | JOHN R. ARTHUR FERGUS NICOL JULIE H. MITCHELL AND GEOFFREY J. BECKETT(Division Of Biochemical Sciences, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK Cellular Endocrinology Unit,University Department of Clinical Biochemistry, The Royal In | 1997 | Biomedical and Environmental Sciences1997，10，2： | 2 |
| 5 | Urban woodlands: their role in reducing the effects of particulate pollution显示文摘 | K.P. Beckett P.H. Freer-Smith G. Taylor | 1998 | Environmental Pollution1998，，3： | 2 |
| 6 | Serum p24 antigen level as an intermediate end point in clinical trials of zidovudine in people infected with human immunodeficiency virus type 1显示文摘 | DeGruttola V Beckett LA Coombs RW | 1994 | J Infect Dis1994，169，4： | 2 |
| 7 | Deposition velocities to Sorbus aria , Acer campestre , Populus deltoides × trichocarpa ‘Beaupré’, Pinus nigra and × Cupressocyparis leylandii for coarse, fine and ultra-fine particles in the urban environment显示文摘 | P.H. Freer-Smith K.P. Beckett Gail Taylor | 2004 | Environmental Pollution2004，，1： | 2 |
| 8 | Treatment of hypertension in patients 80 years of age or older显示文摘 | BECKETT N S PETER R FLETCHER A E | 2008 | N Engl J Med2008，358，18： | 1 |
| 9 | Age-speci?cincidence of Alzheimer's disease in a community population显示文摘 | Hebert LE Scherr PA Beckett LA | 1995 | Jama1995，273，： | 1 |
| 10 | Blockade of the vas- cular endothelial growth factor stress response increases the antitumor effects of ionizing radiation显示文摘 | Gorski D H Beckett M A Jaskowiak N T | 1999 | Cancer Res1999，59，14： | 1 |
| 11 | The effect of seaweed concentrate on the growth and yield of potassium-stressed wheat显示文摘 | Beckett RP | 1989 | Plant Soil1989，116，1： | 1 |
| 12 | Pharmacotherapy and airway remodelling in asthma? 显示文摘 | Beckett PA Howarth PH | 2003 | Thorax2003，58，2： | 1 |
| 13 | Knowledge Management: Strategy or Software Management显示文摘 | Man J Beckett Charles E R Wainwright David Bance | | Decision0，38，： | 1 |
| 14 | Enhanced sonochemical decomposition of 1,4 -dioxane by ferrous iron显示文摘 | Michael A Beckett Inez Hua | 2003 | Water Research2003，，37： | 1 |
| 15 | Hypertension in the Very Elderly Trial (HYVET) : protocol for the main trial 显示文摘 | Bulpitt C Fletcher A Beckett N | 2001 | Drugs aging2001，18，： | 1 |
| 16 | Toward defining the preelinieal stages of Alzheimer' s disease: Recommendations from the National Institute Aging-Alzheimer' s Association workgroups diagnostic guidelines for Alzheimer' s disease显示文摘 | 8perlingRA AisenPS Beckett LA etal | 2011 | A/zheimers Dement2011，7，： | 1 |
| 17 | Constraints on diagenesis and reservoir quality in the fractured Hasdrubal Field,Offshore Tunisia 显示文摘 | Macaulay C I Beckett D Braithwaite K | 2001 | Journal of Petroleum Geology2001，24，1： | 1 |
| 18 | Results of the pilot studyfor the Hypertension in the Very Elderly Trial显示文摘 | Bulpitt C J Beckett N S Cooke J | 2003 | J Hypertens2003，21，12： | 1 |
| 19 | Urban woodlands:their role in reducing the effects of particulate pollution显示文摘 | BECKETT K P FREER - SMITH P H TAYLOR G | 1998 | Environmental Pollution1998，99，： | 1 |
| 20 | Barley yellow dwarf virus:Luteoviridae or Tombusviridae显示文摘 | Miller A W Liu S J Beckett R | 2002 | Molecular Plant Pathology2002，3，4： | 1 |
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