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| 1 | Discovery of Paleogene marine stratum along the southern side of Yarlung-Zangbo suture zone and its implications in tectonics显示文摘The Jiachala Formatiom is a new lithostratigraphic unit set up in this paper. This is the first report on the Paleogene marine sequences and microfaunas in Gyangze to the southern side of the Yarlung-Zangbo suture zone. On the basis of fossil abundance, species diversity, dominant species and first and last occurrences of key species, three dinoflagellate assemblages and three polynological assemblages were recognized in the Jiachala Formatiom. They are in ascending order as follows: Apectodinium quinquelatum-Apectodinium hyperacanthum, Cannin- gia chinensis-Palaeoperidinium pyrophorum and Cymatiosphaera reticulosa-Samlandia chla- mydophora dinoflagellate assemblages, and Arliaceoipollenites baculatus-Anacolosidites sub- trudens, Aglaoreidia cyclops-Pinuspollenites microinsigis, and Elaeangnacites asper-Ilexpol- lenites iliacus polynological Assemblages. According to the assemblages, the age of the Jiachala Formation is referred to Paleocene-early Eocene. The preliminary study on the Jiachala Forma- tion shows that this group of Paleogene deposits accumulated in an underfilled peripheral fore- land basin which was in response to the load of the crust thickening resulted from the Asia-India collision. The stratigraphic evidences provided by the evolution of foreland basin indicate that the India-Asia initional collision should occure near the Cretaceous/Paleogene boundary. The de- velopment and evolution of the southern Tibet foreland basin was under the control of the stress field from the subduct-collision between India and Asia and the structure pattern of the basement. The withering of Tethys Sea might occur after early Eocene in the Gyangze basin and should be after Priabonian of late Eocene in southern Tibet. | LI Guobiao 1 , WAN Xiaoqiao 1 , LIU Wencan 1 , LIANG Dingyi 1 & Hyesu Yun 2 1. China University of Geosciences, Beijing 100083, China 2. Chungnam National University, Daejon, 305-350, Korea | 2005 | Science China Earth Sciences2005，48，5： | 21 |
| 2 | Effectiveness and safety of heat-sensitive moxibustion on bronchial asthma:a Meta-analysis of randomized control trials显示文摘OBJECTIVE: To systematically evaluate the effectiveness and safety of heat-sensitive moxibustion(HSM)onasthma.METHODS: Large databases in China and overseas were searched by electronic and manual means to collect information on randomized controlled trials(RCTs).Two evaluators independently extracted data and evaluated the quality of RCTs according to Cochrane Review Handbook v5.0. RevMan v5.0.20 was used for statisticalanalyses.RESULTS: Fourteen RCTs involving 637 patients were collected.Thirteen RCTs compared the effects of HSM and Western Medicine. After 3-month treatment and after 6-month follow-up, there was no significant difference in effective rate [relative risk(RR)=1.01, 95% CI(0.92, 1.12), and 1.12,(0.93, 1.36),respectively], in the asthma control test score of asthma symptoms [weighted mean difference(WMD)=﹣1.54, 95% CI(﹣3.54, 0.47), and 1.41,(﹣0.48, 3.29), respectively] and in the forced expiratory volumein 1 second(FEV1)and peak expiratory flow(PEF). One RCT compared the effect of HSM with warm-suspended moxibustion. After 6-month follow-up, there was a significant difference in FEV1 and PEF [WMD=0.51, 95% CI(0.10, 0.92), and 1.78,(1.06, 2.50), respectively]. After 3-month treatment,there was no significant difference between the two groups. One RCT compared the effect of HSM with acupoint application. After 3-month treatment, there was no significant difference in the effectiverate[RR=0.68,95%CI(0.42,1.12)].CONCLUSION: HSM did not show superiority to conventional Western Medicine and acupoint application in terms of curative effects, and may be superior to warm-suspended moxibustion with regard to long-term curative effects. Because of low quality of the included RCTs, this conclusion must be bolstered with higher-quality RCTs. | Jun Xiong Zhongyong Liu Rixin Chen Dingyi Xie Zhenhai Chi Bo Zhang | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 11 |
| 3 | Identification and fine mapping of quantitative trait loci for the number of vascular bundle in maize stem显示文摘Studies that investigated the genetic basis of source and sink related traits have been widely conducted.However, the vascular system that links source and sink received much less attention. When maize was domesticated from its wild ancestor, teosinte, the external morphology has changed dramatically; however, less is known for the internal anatomy changes. In this study, using a large maize-teosinte experimental population, we performed a high-resolution quantitative trait locus(QTL) mapping for the number of vascular bundle in the uppermost internode of maize stem.The results showed that vascular bundle number is dominated by a large number of small-effect QTLs, in which a total of 16 QTLs that jointly accounts for 52.2% of phenotypic variation were detected, with no single QTL explaining more than 6% of variation. Different from QTLs for typical domestication traits, QTLs for vascular bundle number might not be under directional selection following domestication.Using Near Isogenic Lines(NILs) developed from heterogeneous inbred family(HIF), we further validated the effect of one QTL qVb9-2 on chromosome 9 and fine mapped the QTL to a 1.8-Mb physical region. This study provides important insights for the genetic architecture of vascular bundle number in maize stem and sets basis for cloning of qVb9-2. | Cheng Huang Qiuyue Chen Guanghui Xu Dingyi Xu Jinge Tian Feng Tian | 2016 | Journal of Integrative Plant Biology2016，58，1： | 8 |
| 4 | Genome-wide Analysis of Transcriptional Variability in a Large Maize-Teosinte Population显示文摘基因表示规定在控制植物显型和改编起一个重要作用。这里,我们报导对通过 transcriptome 的基因表示变化的一个全面评价大 maize-teosinte 分析试验性的人口。染色体宽的印射识别了 25 ? 660 表示为 17 的量的特点 loci (eQTL )? 311 基因,捕获表示变化的一个崭新的范围。我们发现本地 eQTL 更经常被印射到邻近的基因,显示表示 piggybacking 的一个模式,它因而创造了共同调整的基因簇。在共同调整的基因簇以内的基因趋于有相关功能和分享的染色质修正。远 eQTL 与他们显著地在特定的功能的范畴充实的目标形成了 125 个重要远 eQTL 热点。由集成信息的不同来源,我们为许多新陈代谢的小径识别了通常认为的 trans- 管理者。我们证明 bHLH 抄写因素 R1 和 hexokinase HEX9 可能分别地为 flavonoid 生合成和 glycolysis 充当关键管理者。而且,我们证明驯服或改进显著地影响了全球基因表示,与选择指向的许多基因。特别兴趣,为生合成可能经历了的 benzoxazinoid 的 Bx 基因协调了在玉米和 teosinte 之间的 cis 规章的分叉,并且当玉米与一个不同草食动物社区传播了进适度的环境,使 Bx12 失去活性的 transposon 插入在强壮的选择下面。 | Xufeng Wang Qiuyue Chen Yaoyao Wu Zachary H. Lemmon Guanghui Xu Cheng Huang Yameng Liang Dingyi Xu Dan Li John F. Doebley Feng Tian | 2018 | Molecular Plant2018，11，3： | 7 |
| 5 | Construction of Boolean functions with maximum algebraic immunity and count of their annihilators at lowest degree显示文摘Boolean functions used in stream ciphers against algebraic attacks are required to have a necessary cryptographic property-high algebraic immunity (AI). In this paper, Boolean functions of even variables with the maximum AI are investigated. The number of independent annihilators at the lowest degree of Boolean functions of even variables with the maximum AI is determined. It is shown that when n is even, one can get an (n + 1)-variable Boolean function with the maximum AI from two n-variable Boolean functions with the maximum AI only if the Hamming weights of the two functions satisfy the given conditions. The nonlinearity of the Boolean functions obtained in this way is computed. Similarly, one can get an (n + 2)-variable Boolean function with the maximum AI from four n-variable Boolean functions with the maximum AI. The nonlinearity of a class of Boolean functions with the maximum AI is determined such that their Hamming weights are either the maximum or the minimum. | DU YuSong PEI DingYi | 2010 | Science China(Information Sciences)2010，53，4： | 6 |
| 6 | Overburden failure and the prevention of water and sand inrush during coal mining under thin bedrock显示文摘Coal mining under thin bedrock or thick unconsolidated soil layers brings mining problems related to these special geological conditions. The meaning of the term ''thin bedrock'' is defined through the thick- ness statistics of the coal seam and the bedrock layer. The coal-bearing strata having thick, unconsoli- dated aquifers and thin bedrock located at the Taiping Coal Mine in Shandong province were taken as a geological prototype for subsequent study. The geological, hydro-geological and engineering character- istics of the thin bedrock were analyzed. An engineering geological model was than established. Overbur- den failure and the development of ''Three Zones'' were studied by physical model tests. The rupture pattern and rock failure were analyzed for mining conditions under thin bedrock. The height of the caving zone and the freely flowing water fractured zone of different mining thicknesses were separately calcu- lated. The results show that a mining thickness greater than 3.5 m causes the height of the freely flowing water fractured zone to be sufficient to touch the weathered zone and the bottom of the Quaternary sys- tem aquifer, to various degrees. This, then, would lead to water and sand inrush into the working face. Measures to prevent water and sand flow inrush disasters by eliminating the power source are put fore- word. A field dewatering scheme was designed and observational data were obtained. The dewatering project had an obvious effect and the water level at working face number 8309 dropped to a safe level. The average draw down of the groundwater was observed to be 7.86 m. This showed that the dewatering project played a role in decreasing the hydraulic pressure and ensuring safety mining. | Yang Weifeng Xia Xiaohong Zhao Guorong Ji Yubin Shen Dingyi | 2011 | Mining Science and Technology2011，21，5： | 6 |
| 7 | Phase-transfer synthesis of α-Co(OH)_2 and its conversion to CoO for efficient electrocatalytic water oxidation显示文摘Water splitting is an attractive way to produce recyclable hydrogen energy resource. The oxygen evolution reaction(OER) is the rate-determine step of water electrolysis. The exploring of low-cost, highly efficient and durable electrocatalysts for OER is thus extremely important. In this work, we developed a facile two-phase protocol to fabricate an α-Co(OH)_2 using sodium oleate as the phase-transfer surfactant.The crystallinity and structure of the α-Co(OH)_2 was regulated by heat treatments toward enhanced electrocatalytic OER activity. With the calcination of the as-prepared α-Co(OH)_2 at 200 °C, a networked and well-dispersed CoO nanoparticles were formed. The CoO sample afforded an OER current density of 10 mA cm^(-2) under a low overpotential of 312 mV in a 1 mol L^(-1) KOH aqueous solution. The high activity of the CoO material is believed to be associated with its ultra-small particle size and plentiful open spaces in the material, both of which can provide abundant surface catalytic sites. | Dingyi Guo Fangfang Chen Wei Zhang Rui Cao | 2017 | Science Bulletin2017，62，9： | 6 |
| 8 | A novel key pre-distribution scheme for wireless distributed sensor networks显示文摘A novel key pre-distribution scheme for sensor networks is proposed, which enables sensor nodes to communicate securely with each other using cryptographic techniques. The approach uses the rational normal curves in the projective space with the dimension n over the finite field F q . Both secure connectivity and resilience of the resulting sensor networks are analyzed. By choosing the parameters q and n properly, this key pre-distribution scheme has some advantages over the previous known schemes. In addition, if the number of the rational normal curves in the scheme becomes too large for an application, the size may be reduced by choosing a part of the curves randomly. This reduction has, shown by our experiments, only minimal impact on secure connectivity and resilience of the resulting sensor network. | PEI DingYi DONG JunWu RONG ChunMing | 2010 | Science China(Information Sciences)2010，53，2： | 6 |
| 9 | Neuronal apoptosis and inflammatory reaction in rat models of focal cerebral ischemia following 40-minute suspended moxibustion显示文摘The treatment duration of heat-sensitive moxibustion(approximately 40 minutes on average) is longer than that of traditional suspended moxibustion.The present study investigated expression changes of three inflammatory and apoptosis-associated proteins(inducible nitric oxide synthase,cyclooxygenase-2 and caspase-3) in transient middle cerebral artery occlusion model rats following suspended moxibustion for 40 minutes,to explore the mechanisms underlying neuroprotective action of suspended moxibustion.The results indicated that suspended moxibustion at acupoint Dazhui(DU 14) for 40 minutes reduced the cortical expression of caspase-3,cyclooxygenase-2 and inducible nitric oxide synthase proteins of transient middle cerebral artery occlusion model rats,as well as decreasing infarct volume and ameliorating the neurological deficit score.Outcomes with 40 minutes of moxibustion were superior to the outcomes after suspended moxibustion for 15 minutes. | Rixin Chen Zhimai Lv Mingren Chen Xin An Dingyi Xie Jing Yi | 2011 | Neural Regeneration Research2011，6，15： | 6 |
| 10 | Identification and construction of Boolean functions with maximum algebraic immunity显示文摘Boolean functions with maximum algebraic immunity have been considered as one class of cryptographically significant functions. It is known that Boolean functions on odd variables have maximum algebraic immunity if and only if a correlative matrix has column full rank, and Boolean functions on even variables have maximum algebraic immunity if and only if two correlative matrices have column full rank. Recently, a smaller matrix was used in the odd case. We find that one or two smaller matrices can be used in the even case and consequently present several sufficient and necessary conditions for Boolean functions with maximum algebraic immunity. This result advances the ability to identify whether Boolean functions on even variables achieve maximum algebraic immunity. We also present a construction algorithm for n-variable Boolean functions with maximum algebraic immunity, specially with the Hamming weights of ∑2 n i=0 -1 . It is easily realized for not too large n and helps construct balanced Boolean functions with maximum algebraic immunity on even variables. Furthermore, we present a sufficient and necessary condition for balanced Boolean functions to achieve maximum algebraic immunity and optimum algebraic degree, and modify the construction algorithm to con- struct Boolean functions on odd variables with maximum algebraic immunity, optimum algebraic degree and high nonlinearity. | LIU MeiCheng, PEI DingYi & DU YuSong College of Mathematics and Information Sciences, Guangzhou University, Guangzhou 510006, China | 2010 | Science China(Information Sciences)2010，53，7： | 6 |
| 11 | Delegateable signatures based on non-interactive witness indistinguishable and non-interactive witness hiding proofs显示文摘A delegateable signature scheme(DSS)which was first introduced by Barak is mainly based on the non-interactive zero-knowledge proof(NIZK)for preventing the signing verifier from telling which witness(i.e.,restricted subset)is being used. However,the scheme is not significantly efficient due to the difficulty of constructing NIZK.We first show that a non-interactive witness indistinguishable(NIWI)proof sys- tem and a non-interactive witness hiding(NIWH)proof system are easier and more efficient proof models than NIZK in some cases.Furthermore,the witnesses em- ployed in these two protocols(NIWI and NIWT)cannot also be distinguished by the verifiers.Combined with theΣ-protocol,we then construct NIWI and NIWH proofs for any NP statement under the existence of one-way functions and show that each proof is different from those under the existence of trapdoor permutations.Finally,based on our NIWI and NIWH proofs,we construct delegateable signature schemes under the existence of one-way functions,which are more efficient than Barak's scheme under the existence of trapdoor permutations. | TANG ChunMing PEI DingYi WANG XiaoFeng LIU ZhuoJun | 2008 | Science in China(Series F)2008，51，2： | 5 |
| 12 | 全球尺度上氮添加影响植物生物量分配但不影响不同器官间的异速生长关系显示文摘生物量在不同器官间的分配是植物对环境变化响应的一个关键生态生理学过程。然而,在全球尺度上有关不同陆地生态系统植物生物量分配对氮沉降响应的认识还比较欠缺。本文通过整合分析333篇己发表文章的5474个观测值,基于“最优分配假说”和“异速分配假说”,评估了全球尺度上氮添加对植物生物量及其在不同器官间分配的影响。结果表明:(1)氮添加显著增加了整株植物或不同器官的生物量,降低了根冠比和根质量分数,但对叶质量分数和茎质量分数无显著影响;(2)氮添加对不同器官质量分数的影响受实验条件、植物功能性状、纬度、氮添加率等因子单独或交互作用的调控;(3)氮添加对生物量在不同器官间的异速分配率无显著影响,表明氮添加导致的根冠比和根质量分数减少是在异速分配模式下由整株植物生物量增加而致。虽然氮添加改变了地上和地下部分的质量分数,但不同器官生物量间异速分配模式的稳定性表明“异速分配假说”能更好地描述植物生物量分配对氮添加的响应规律。该研究结果将有助于深入认识氮沉降环境下植物生物量的分配规律,同时表明将生物量分配纳入有关氮沉降对陆地生态系统影响的预测模型中的重要性。 | Kai Yue Dario A.Fomara Wang Li Xiangyin Ni Yan Peng Shu Liao Siyi Tan Dingyi Wang Fuzhong Wu Yusheng Yang | 2021 | Journal of Plant Ecology2021，14，3： | 5 |
| 13 | Additive manufacturing alumina components with lattice structures by digital light processing technique显示文摘Digital light processing technique was applied to manufacture alumina ceramic parts with two types of lattice structure units, i.e. vertex interconnect structure and edge structure. The internal porosity of the unit is 40%. The printed parts were sintered and the grain size is about 1.1 μm. The bending strength of the vertex interconnect structure is much larger than that of the edge structure. Materials genome initiative(MGI) aims to digital design and intelligent manufacture for advanced components. This research shows us an example to achieve this goal. | Qjngfeng Zeng Changhao Yang Dingyi Tang Jiayao Li Zhiqiang Feng Jiantao Liu Kang Guan | 2019 | Journal of Materials Science & Technology2019，35，12： | 5 |
| 14 | 3D Printed Integrated Gradient-Conductive MXene/CNT/Polyimide Aerogel Frames for Electromagnetic Interference Shielding with Ultra-Low Reflection显示文摘Construction of advanced electromagnetic interference(EMI)shielding materials with miniaturized,programmable structure and low reflection are promising but challenging.Herein,an integrated transition-metal carbides/carbon nanotube/polyimide(gradient-conductive MXene/CNT/PI,GCMCP)aerogel frame with hierarchical porous structure and gradient-conductivity has been constructed to achieve EMI shielding with ultra-low reflection.The gradient-conductive structures are obtained by continuous 3D printing of MXene/CNT/poly(amic acid)inks with different CNT contents,where the slightly conductive top layer serves as EM absorption layer and the highly conductive bottom layer as reflection layer.In addition,the hierarchical porous structure could extend the EM dissipation path and dissipate EM by multiple reflections.Consequently,the GCMCP aerogel frames exhibit an excellent average EMI shielding efficiency(68.2 dB)and low reflection(R=0.23).Furthermore,the GCMCP aerogel frames with miniaturized and programmable structures can be used as EMI shielding gaskets and effectively block wireless power transmission,which shows a prosperous application prospect in defense industry and aerospace. | Tiantian Xue Yi Yang Dingyi Yu Qamar Wali Zhenyu Wang Xuesong Cao Wei Fan Tianxi Liu | 2023 | Nano-Micro Letters2023，15，3： | 5 |
| 15 | Controllable synthesis of highly crystallized mesoporous TiO2/WO3 heterojunctions for acetone gas sensing显示文摘Mesoporous semiconducting metal oxides(SMOs)heterojunctions are appealing sensors for gas detecting.However,due to the different hydrolysis and condensation mechanism of every metal precursor and the contradiction between high crystallinity and high surface area,the synthesis of mesoporous SMOs heterojunctions with highly o rdered mesostructures,highly crystallized frameworks,and high surface area remains a huge challenge.In this work,we develop a novel'acid-base pair'adjusted solvent evaporation induced self-assembly(EISA)strategy to prepare highly crystallized ordered mesoporous TiO2/WO3(OM-TiO2/WO3)heterojunctions.The WCl6 and titanium isopropoxide(TIPO)are used as the precursors,respectively,which function as the'acid-base pair',enabling the coassembly with the structure directing agent(PEO-b-PS)into highly ordered meso structures.In addition,PEO-b-PS can be converted to rigid carbon which can protect the meso structures from collapse during the crystallization process.The resultant OM-TiO2/WO3 heterojunctions possess primitive cubic mesostructures,large pore size(~21.1 nm),highly crystalline frameworks and surface area(~98 m2/g).As a sensor for acetone,the obtained OM-TiO2/WO3 show excellent re sponse/recovery perfo rmance(3 s/5 s),good linear dependence,repeatability,selectivity,and long-term stability(35 days). | Changyao Wang Yuhui Li Pengpeng Qiu Linlin Duan Wei Bi Yan Chen Dingyi Guo Yupu Liu Wei Luo Yonghui Deng | 2020 | Chinese Chemical Letters2020，31，5： | 4 |
| 16 | Theoretical analysis of reactive solid-liquid interfacial energies显示文摘The characterization of reactive solid-liquid interfacial energies and solid surface energies is a pressing problem in materials science and surface science. Based on the concept that unbalanced forces doing work, a mathematical formulation between surface energies and interfacial energies for reactive wetting is presented. The resulting formalism has significant generality in which the equilibrium Young's equation for solid-liquid interfacial energies is just a special case. It is shown that a solid-liquid interfacial energy at non-equilibrium is always higher than that at equilibrium, and that the transformation of reactive interfaces to equilib-rium interfaces is an inevitable, spontaneous process. The numerical range of solid-liquid interfacial energies γsl for a limited, solid-liquid interfacial wetting system was calculated to be 0 ≤γsl ≤γsg. The calculation methods for reactive solid-liquid interfacial energies and solid surface energies are presented. They are significant for composite materials and weld, powder sinter, package of electronic devices, and other surface and interfacial issues in metallurgy. | ZHU DingYi LIAO XuanMao DAI PinQiang | 2012 | Chinese Science Bulletin2012，57，34： | 4 |
| 17 | Aggregate modeling and analysis of air conditioning load using coupled Fokker–Planck equations显示文摘Demand response has gained significant attention recently with the increasing penetration of renewable energy sources in power systems. Air conditioning loads are typical thermostatically controlled loads which can play an active role in ancillary services by regulating their aggregated power consumption. The aggregation of air conditioners is essential to the control of air conditioning loads. In this paper, linear state equations are proposed to aggregate air conditioning loads by solving coupled Fokker–Planck equations(CFPEs) using the finite difference method. By analyzing the numerical stability and convergence of the difference scheme, the grid spacings, including temperature step and time step, are properly determined according to the maximal principle. Stationary solutions of the CFPEs are obtained by analytical and numerical methods. Furthermore, a classification method using dimension reduction is proposed to deal with the problem of heterogeneous parameters and interval estimation is applied to describe the stochastic behavior of air conditioning loads. The simulation results verify the effectiveness of the proposed methods. | Dingyi CHENG Wen ZHANG Yutian LIU | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，6： | 4 |
| 18 | Synthesis, characterization and tribological evaluation of novel1,4-diazabicyclo[2.2.2]octane based dicationic ionic liquids as efficient antiwear lubricant additives显示文摘Ionic liquids have developed and been applied in lubricant field since 2001. Nevertheless, it is little known about novel dicationic ionic liquids for tribology applications in the past several years. In this paper, a sequence of novel dicationic ionic liquids based on 1,4-diazabicyclo[2.2.2]octane cations(DABCO) and different anions have been designed and identified. The structures of ILs were confirmed by Fourier transform infrared(FTIR) spectra, multinuclear(~1H,^(13)C,^(11)B,^(31)P and ^(19)F) magnetic resonance and mass spectrometry. The effects of anion type on thermal properties, wettability, kinematic viscosity and tribological properties were studied. It is found that all of these dicationic ionic liquids as additives exhibit excellent anti-wear and friction-reducing properties in PEG synthetic base oil under boundary lubrication conditions for steel-to-steel contact, which offers great potential for the highly efficient lubricant additives. Simultaneously, novel 1,4-diazabicyclo[2.2.2]octane cation offers an exceptional chance for the research and development of dicationic ionic liquids in various applications. | ZHAO LiNa CAI Tao ZHANG YunXiao YE MengTing SHANG WangJi LIU Dan TONG DingYi LIU ShengGao | 2019 | Science China(Technological Sciences)2019，62，2： | 3 |
| 19 | Glossy15 Plays an Important Role in the Divergence of the Vegetative Transition between Maize and Its Progenitor, Teosinte显示文摘 | Dingyi Xu Xufeng Wang Cheng Huang Guanghui Xu Yameng Liang Qiuyue Chen Chenglong Wang Dan Li Jinge Tian Lishuan Wu Yaoyao Wu Li Guo Xuehan Wang Weihao Wu Weiqiang Zhang Xiaohong Yang Feng Tian | 2017 | Molecular Plant2017，10，12： | 3 |
| 20 | Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson's disease显示文摘Parkinson's disease(PD) is the second most common neurodegenerative disease in the world;however,it lacks effective and safe treatments. Ginkgo biloba dropping pill(GBDP), a unique Chinese G. biloba leaf extract preparation, exhibits antioxidant and neuroprotective effects and has a potential as an alternative therapy for PD. Thus, the aims of this study were to evaluate the effects of GBDP in in vitro and in vivo PD models and to compare the chemical constituents and pharmacological activities of GBDP and the G. biloba extract EGb 761. Using liquid chromatography tandem-mass spectrometry, 46 GBDP constituents were identified. Principal component analysis identified differences in the chemical profiles of GBDP and EGb 761. A quantitative analysis of 12 constituents showed that GBDP had higher levels of several flavonoids and terpene trilactones than EGb 761, whereas EGb 761 had higher levels of organic acids.Moreover, we found that GBDP prevented 6-hydroxydopamine-induced dopaminergic neuron loss in zebrafish and improved cognitive impairment and neuronal damage in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mice. Although similar effects were observed after EGb 761 treatment,the neuroprotective effects were greater after GBDP treatment on several endpoints. In addition, in vitro results suggested that the Akt/GSK3β pathway may be involved in the neuroprotective effects of GBDP.These findings demonstrated that GBDP have potential neuroprotective effects in the treatment of PD. | Dingyi Yu Pengli Zhang Junying Li Ting Liu Yaodan Zhang Qingqing Wang Jianbing Zhang Xiaoyan Lu Xiaohui Fan | 2021 | Journal of Pharmaceutical Analysis2021，11，2： | 3 |
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