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| 1 | A transcription factor with a bHLH domain regulates root hair development in rice显示文摘 | Wona Ding Zhiming Yu Yanli Tong Wei Huang Hanmin Chen Ping Wu | 2009 | Cell Research2009，19，11： | 18 |
| 2 | Changes in visibility with PM_(2.5) composition and relative humidity at a background site in the Pearl River Delta region显示文摘In fall–winter, 2007–2013, visibility and light scattering coefficients(b sp) were measured along with PM_(2.5)mass concentrations and chemical compositions at a background site in the Pearl River Delta(PRD) region. The daily average visibility increased significantly(p < 0.01) at a rate of 1.1 km/year, yet its median stabilized at ~13 km. No haze days occurred when the 24-hr mean PM_(2.5)mass concentration was below 75 μg/m^3. By multiple linear regression on the chemical budget of particle scattering coefficient(b sp), we obtained site-specific mass scattering efficiency(MSE) values of 6.5 ± 0.2, 2.6 ± 0.3, 2.4 ± 0.7 and 7.3 ± 1.2 m2/g,respectively, for organic matter(OM), ammonium sulfate(AS), ammonium nitrate(AN) and sea salt(SS). The reconstructed light extinction coefficient(b ext) based on the Interagency Monitoring of Protected Visual Environments(IMPROVE) algorithm with our site-specific MSE revealed that OM, AS, AN, SS and light-absorbing carbon(LAC) on average contributed 45.9% ± 1.6%,25.6% ± 1.2%, 12.0% ± 0.7%, 11.2% ± 0.9% and 5.4% ± 0.3% to light extinction, respectively.Averaged b ext displayed a significant reduction rate of 14.1/Mm·year(p < 0.05); this rate would be 82% higher if it were not counteracted by increasing relative humidity(RH) and hygroscopic growth factor(f(RH)) at rates of 2.5% and 0.16/year-1(p < 0.01), respectively, during the fall–winter, 2007–2013. This growth of RH and f(RH) partly offsets the positive effects of lowered AS in improving visibility, and aggravated the negative effects of increasing AN to impair visibility. | Xiaoxin Fu Xinming Wang Qihou Hu Guanghui Li Xiang Ding Yanli Zhang Quanfu He Tengyu Liu Zhou Zhang Qingqing Yu Ruqing Shen Xinhui Bi | 2016 | Journal of Environmental Sciences2016，28，2： | 18 |
| 3 | Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses显示文摘Hematopoietic stem cells(HSCs)in adults are believed to be born from hemogenic endothelial cells(HECs)in mid-gestational embryos.Due to the rare and transient nature,the HSC-competent HECs have never been stringently identified and accurately captured,let alone their genuine vascular precursors.Here,we first used high-precision single-cell transcriptomics to unbiasedly examine the relevant EC populations at continuous developmental stages with intervals of 0.5 days from embryonic day(E)9.5 to E11.0.As a consequence,we transcriptomically identified two molecularly different arterial EC populations and putative HSCprimed HECs,whose number peaked at El 0.0 and sharply decreased thereafter,in the dorsal aorta of the aorta-gonadmesonephros(AGM)region.Combining computational prediction and in vivo functional validation,we precisely captured HSCcompetent HECs by the newly constructed Neurl3-EGFP reporter mouse model,and realized the enrichment further by a combination of surface markers(Procr+Kit+CD44+,PK44).Surprisingly,the endothelial-hematopoietic dual potential was rarely but reliably witnessed in the cultures of single HECs.Noteworthy,primitive vascular ECs from E8.0 experienced two-step fate choices to become HSC-primed HECs,namely an Initial arterial fate choice followed by a hemogenic fate conversion.This finding resolves several previously observed contradictions.Taken together,comprehensive understanding of endothelial evolutions and molecular programs underlying HSC-primed HEC specification in vivo will facilitate future investigations directing HSC production in vitro. | Siyuan Hou Zongcheng Li Xiaona Zheng Yun Gao Ji Dong Yanli Ni Xiaobo Wang Yunqiao Li Xiaochen Ding Zhilin Chang Shuaili Li Yuqiong Hu Xiaoying Fan Yu Hou Lu Wen Bing Liu Fuchou Tang Yu Lan | 2020 | Cell Research2020，30，5： | 8 |
| 4 | Role of ammonia in forming secondary aerosols from gasoline vehicle exhaust显示文摘Ammonia(NH3) plays vital roles in new particle formation and atmospheric chemistry. Although previous studies have revealed that it also influences the formation of secondary organic aerosols(SOA) from ozonolysis of biogenic and anthropogenic volatile organic compounds(VOCs), the influence of NH3 on particle formation from complex mixtures such as vehicle exhausts is still poorly understood. Here we directly introduced gasoline vehicles exhausts(GVE) into a smog chamber with NH3 absorbed by denuders to examine the role of NH3 in particle formation from GVE. We found that removing NH3 from GVE would greatly suppress the formation and growth of particles. Adding NH3 into the reactor after 3 h photo-oxidation of GVE, the particle number concentration and mass concentrations jumped explosively to much higher levels, indicating that the numbers and mass of particles might be enhanced when aged vehicle exhausts are transported to rural areas and mixed with NH3-rich plumes. We also found that the presence of NH3 had no significant influence on SOA formation from GVE. Very similar oxygen to carbon(O:C) and hydrogen to carbon(H:C) ratios resolved by aerosol mass spectrometer with and without NH3 indicated that the presence of NH3 also had no impact on the average carbon oxidation state of SOA from GVE. | Tengyu Liu Xinming Wang Wei Deng Yanli Zhang Biwu Chu Xiang Ding Qihou Hu Hong He Jiming Hao | 2015 | Science China Chemistry2015，58，9： | 7 |
| 5 | A strategy for generating rice apomixis by gene editing显示文摘Apomixis is an asexual reproduction way of plants that can produce clonal offspring through seeds.In this study,we introduced apomixis into rice(Oryza sativa)by mutating OsSPO11-1,OsREC8,OsOSD1,and OsMATL through a CRISPR/Cas9 system.The quadruple mutant showed a transformation from meiosis to mitosis and produced clonal diploid gametes.With mutated Osmatl,which gives rise to haploid induction in plants,the quadruple mutant is expected to be able to be produced apomictic diploid offspring.We named this quadruple mutant as AOP(Apomictic Offspring Producer)for its ability to produce apomictic offspring. | En Xie Yafei Li Ding Tang Yanli Lv Yi Shen Zhukuan Cheng | 2019 | Journal of Integrative Plant Biology2019，61，8： | 6 |
| 6 | Compositions and sources of organic acids in fine particles(PM_(2.5)) over the Pearl River Delta region, south China显示文摘Organic acids as important constituents of organic aerosols not only influence the aerosols' hygroscopic property, but also enhance the formation of new particles and secondary organic aerosols. This study reported organic acids including C14–C32fatty acids, C4–C9dicarboxylic acids and aromatic acids in PM2.5collected during winter 2009 at six typical urban, suburban and rural sites in the Pearl River Delta region. Averaged concentrations of C14–C32fatty acids, aromatic acids and C4– C9 dicarboxylic acids were 157, 72.5 and 50.7 ng/m3, respectively. They totally accounted for 1.7% of measured organic carbon. C20–C32fatty acids mainly deriving from higher plant wax showed the highest concentration at the upwind rural site with more vegetation around, while C14–C18fatty acids were more abundant at urban and suburban sites, and dicarboxylic acids and aromatic acids except 1,4-phthalic acid peaked at the downwind rural site. Succinic and azelaic acid were the most abundant among C4–C9dicarboxylic acids, and 1,2-phthalic and 1,4-phthalic acid were dominant aromatic acids. Dicarboxylic acids and aromatic acids exhibited significant mutual correlations except for 1,4-phthalic acid, which was probably primarily emitted from combustion of solid wastes containing polyethylene terephthalate plastics. Spatial patterns and correlations with typical source tracers suggested that C14–C32fatty acids were mainly primary while dicarboxylic and aromatic acids were largely secondary. Principal component analysis resolved six sources including biomass burning, natural higher plant wax, two mixed anthropogenic and two secondary sources; further multiple linear regression revealed their contributions to individual organic acids. It turned out that more than 70% of C14–C18fatty acids were attributed to anthropogenic sources, about 50%–85% of the C20–C32fatty acids were attributed to natural sources, 80%–95% of dicarboxylic acids and 1,2-phthalic acid were secondary in contrast with that 81% of 1,4-phthalic acid was primary. | Xiuying Zhao Xinming Wang Xiang Ding Quanfu He Zhou Zhang Tengyu Liu Xiaoxin Fu Bo Gao Yunpeng Wang Yanli Zhang Xuejiao Deng Dui Wu | 2014 | Journal of Environmental Sciences2014，26，1： | 6 |
| 7 | New algorithms for verifiable outsourcing of bilinear pairings显示文摘Dear editor,Outsourcing of computation has received widespread attention with the development of cloud computing and the proliferation of mobile devices[1].Despite the huge benefits that it provides,it also encounters some security concerns and other challenges.First,the | Yanli REN Ning DING Tianyin WANG Haining LU Dawu GU | 2016 | Science China(Information Sciences)2016，59，9： | 3 |
| 8 | Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics显示文摘Objective:The high expression of cell division cycle 42 protein(CDC42)may be involved in the occurrence and progression of several tumors.However,the expression and function of CDC42 in cervical squamous cell carcinoma remains unclear.This study aimed to investigate the expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics.Methods:The expression of CDC42 in 162 cervical squamous cell carcinoma tissue samples and 33 normal cervical tissue samples was investigated by immunohistochemistry.The CDC42 mRNA expression was detected by reverse transcription-polymerase chain reaction(RT-PCR).Results:ThecervicalsquamouscellcarcinomagroupshowedasignificantlyhigherCDC42positiverate,compared to the normal cervical tissues(P<0.05).Furthermore,the tissues of stage II-IV carcinoma patients showed higher CDC42 expression levels compared to stage I patients(P=0.05).In addition,the expression of CDC42 was not correlated to age of patients,differentiation degree of cancer cells,or lymph node metastasis(P>0.05).Furthermore,compare with normal cervical tissues,the CDC42 mRNAexpressionincervicalcancerhadnosignificantdifference.Conclusions:CDC42 was up-regulated at protein level,but not mRNA level,in cervical squamous cell carcinoma.The high expression of CDC42 was correlated to the clinical stage of the patients,indicating that CDC42 might contribute to the progression of cervical squamous cell carcinoma. | Ding Ma Yuan Cheng Youyi Zhang Yanli Guo Zijian Li Geng Li | 2013 | Chinese Journal of Cancer Research2013，25，6： | 3 |
| 9 | Evaluation of Cold Dew Wind Monitoring Precision for Late Rice Based on CLDAS Data in Guangxi显示文摘The low temperature process of cold dew wind( from September 19 to 27 in 2011) for late rice production was dynamically monitored by using CLDAS temperature,combined with the background information of rice cultivation from multi-source satellite database together with an reference to the monitoring indexes of cold dew wind disaster to verify the precision of CLDAS data,so as to provide a reference for monitoring chilling damage caused by cold dew wind in late rice production in Guangxi. The results showed that the cold wind dew caused heavy damage to an area of 3 159. 76 km^2,moderate damage to an area of 559. 77 km^2 and light damage to an area of 2 452. 14 km^2. The correlation coefficients between CLDAS inversion temperature and actual temperature of 12 verification meteorological stations were all larger than 0. 93,and the difference in daily average temperature was 0. 3 ℃. The time difference between maximum and minimum temperature provided by CLDAS and corresponding actual temperature from 12 meteorological stations was less than 1 h. The temperature data provided by CLDAS was in accordance with actual temperature data. With an advantage of rapidly,minutely and accurately monitoring the grade distribution of local cold dew wind disaster for late rice,CLDAS can be used in monitoring cold dew wind in late rice production in Guangxi. | Yanli CHEN Yan HE Jianfei MO Yongming LUO Meihua DING | 2019 | Agricultural Biotechnology2019，8，1： | 2 |
| 10 | Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals显示文摘Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective circulation to compromised tissues in patients.Deciphering the origin and specification of arterial endothelial cells during embryonic development will shed light on the understanding of adult arteriogenesis.However,during early embryonic angiogenesis,the process of endothelial diversification and molecular events underlying arteriovenous fate settling remain largely unresolved in mammals.Here,we constructed the single-cell transcriptomic Iandscape of vascular endothelial cells(VECs)during the time window for the occurrenee of key vasculogenic and angiogenic events in both mouse and human embryos.We uncovered two distinct arterial VEC types,the major artery VECs and arterial plexus VECs,and un expectedly diverge nt arteriove nous characteristics among VECs that are located in morphologically undistinguishable vascular plexus intra-embryonically.Using computational prediction and further lineage tracing of venous-featured VECs with a newly developed Nr2f2^(CrexER) | Siyuan Hou Zongcheng Li Ji Dong Yun Gao Zhilin Chang Xiaochen Ding Shuaili Li Yunqiao Li Yang Zeng Qian Xin Baihan Wang Yanli Ni Xiaowei Ning Yuqiong Hu Xiaoying Fan Yu Hou Xianlong Li Lu Wen Bin Zhou Bing Liu Fuchou Tang Yu Lan | 2022 | Cell Research2022，32，4： | 2 |
| 11 | Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population显示文摘 | Yanli Li Shen-Chih Chang Binh Y. Goldstein William L. Scheider Lin Cai Nai-Chieh Y. You Heather P. Tarleton Baoguo Ding Jinkou Zhao Ming Wu Qingwu Jiang Shunzhang Yu Jianyu Rao Qing-Yi Lu Zuo-Feng Zhang Lina Mu | 2011 | Cancer Epidemiology2011，，4： | 2 |
| 12 | Expression of Pseudorabies Virus gE Core Epitopes in Escherichia coli Strain BL21 and Utilization of Indirect PRV gE-ELISA显示文摘Pseudorabies virus glycoprotein E( PRV gE) has been recognized as a suitable diagnostic antigen for pseudorabies. In order to produce gE antigen in large quantities and at low cost,a gene fragment encoding PRV gE core epitopes was expressed in E. coli BL21 expression system. SDS-PAGE and Western Blotting revealed that the expression product in culture supernatant of E. coli BL21 was a recombinant protein,approximately 51. 8 Kd. At 5 h post-induction,protein concentration assay showed that the expression product amounted to 1. 65 mg /ml,accounting for 24. 17% of total proteins in the culture supernatant. An indirect PRV gE-ELISA was established by using the recombinant expression product as a coating antigen. Cross-reactivity assay showed that this antigen was PRV specific. In addition,the assay was consistently reproducible. Comparison of detection results of 240 serum samples between PRV gE-ELISA and a commercially available PRV diagnostic kit showed that there was no significant difference between these two methods( P > 0. 05). | Guangjun GUO Sufang LU Guanggang QU Feng LI Lin DONG Yanli BI Jinliang WANG Feng WEI Na TANG Chunling ZHANG Zhuang DING Zhiqiang SHEN | 2014 | Agricultural Biotechnology2014，3，4： | 2 |
| 13 | Real-time contrast-enhanced ultrasonography of resected and immunohistochemically proven hepatic angiomyolipomas显示文摘 | Rui Li Xiaohang Zhang Xing Hua Ping Cai Hua Zhong Yanli Guo Shiyi Ding XiaoChu Yan | 2010 | Abdominal Imaging2010，，6： | 1 |
| 14 | Visualized and cascade-enhanced gene silencing by smart DNAzyme-graphene nanocomplex显示文摘BCL-2 gene as well as its products is recognized as a promising target for the molecular targeted therapy of tumors.However,due to certain defense measures of tumor cells,the therapeutic effect based on the gene silencing of BCL-2 is greatly reduced.Here we fabricate a smart response nucleic acid therapeutic that could silence the gene effectively through a dual-targeted and cascade-enhanced strategy.In brief,nano-graphene oxide(GO),working as a nano-carrier,is loaded with a well-designed DNAzyme,which can target and silence the BCL-2 mRNA.Furthermore,upon binding with the BCL-2 mRNA,the enzymatic activity of the DNAzyme can be initiated,cutting a substrate oligonucleotide to produce an anti-nucleolin aptamer AS1411.Nucleolin,a nucleolar phosphoprotein,is known as a stabilizer of BCL-2 mRNA.Via binding and inactivating the nucleolin,AS1411 can destabilize BCL-2 mRNA.By this means of simultaneously targeting mRNA and its stabilizer in an integrated system,effective silencing of the BCL-2 gene of tumor cells is achieved at both the cellular and in vivo levels.After being dosed with this nucleic acid therapeutic and without any chemotherapeutics,apoptosis of tumor cells at the cellular level and apparent shrinkage of tumors in vivo are observed.By labeling a molecular beacon on the substrate of DNAzyme,visualization of the enzymatic activity as well as the tumor in vivo can be also achieved.Our work presents a pure bio-therapeutic strategy that has positive implications for enhancing tumor treatment and avoiding side effects of chemotherapeutics. | Lingjie Ren Xiaoxia Chen Chang Feng Lei Ding Xiaomin Liu Tianshu Chen Fan Zhang Yanli Li Zhongliang Ma Bo Tian Xiaoli Zhu | 2020 | Nano Research2020，13，8： | 1 |
| 15 | Kinetics of esterification of acidified oil with different alcohols by a cation ion- exchange resinfpolyethersulfone hybrid catalytic membrane显示文摘 | Honglei Zhang Jincheng Ding Yanli Qiu | 2012 | Bioresource Technology2012，112，： | 1 |
| 16 | Effects of daidzein on antioxidant capacity in weaned pigs and IPEC-J2cells显示文摘Our previous study found that soybean isoflavones in soybean meal play an important role in improving growth performance and antioxidant capacity in pigs.However,it is still unknown whether long-term supplementation with daidzein,an active molecule deglycosylated from daidzin,in a corn-soybean meal diet can enhance growth performance in pigs.Thus,in the present study,an animal trial was carried out to investigate the effects of dietary supplementation with daidzein on the growth performance and antioxidant capacity of pigs.A total of 80 weaned piglets(40 barrows and 40 females)were assigned to 4treatments with 5 pens per treatment and 4 piglets per pen and fed a diet supplemented with 0,25,50 and 100 mg/kg daidzein for a 72-day trial.In addition,porcine intestinal epithelial cells(IPEC-J2)were used as an in vitro model to explore the underlying antioxidant mechanisms of daidzein.IPEC-J2 cells were treated with 0.6 mM hydrogen peroxide(H_(2)O_(2))in the presence or absence of 40μM daidzein.The results showed that adding 50 mg/kg of daidzein to the diet significantly improved body weight on day72,average daily gain(ADG)during days 0 to 72 and plasma superoxide dismutase(SOD)activity on day42,and decreased malondialdehyde(MDA)content on day 14(P<0.05).Treatment with 0.6 m M H_(2)O_(2)for 1 h significantly decreased cell viability and catalase(CAT)activity and increased intracellular reactive oxygen species(ROS)levels and MDA content(P<0.05),while pretreatment with 40μM daidzein prevented the decrease in cell viability and CAT activity and the increase in intracellular ROS levels and MDA content caused by H_(2)O_(2)(P<0.05).In addition,H_(2)O_(2)stimulation significantly suppressed the expression of nuclear factor erythroid-2-related factor 2(Nrf2),CAT,occludin and zonula occludens-1(ZO-1),while pretreatment with daidzein preserved the expression of Nrf2,CAT and occludin in H_(2)O_(2)-stimulated IPEC-J2 cells(P<0.05).In conclusion,our results suggested that long-term dietary supplementation with 50 mg/kg daidzein improved growth performance in pigs and was beneficial to the antioxidant capacity of pigs.Daidzein exerted protective effects against H_(2)O_(2)-induced oxidative stress in IPEC-J2 cells and the underlying mechanism may be related to the activation of the Nrf2 signaling pathway. | Yanpin Li Xianren Jiang Long Cai Yanli Zhang Hongbiao Ding Jingdong Yin Xilong Li | 2022 | Animal Nutrition2022，，4： | 1 |
| 17 | Two step pyrolysis process to synthesize highly dispersed Pt Ru/carbon nanotube catalysts for methanol electrooxidation 显示文摘 | Yao Yanli Ding Ya Ye Lesheng | 2006 | Carbon2006，44，1： | 1 |
| 18 | FGOALS-g3 Model Datasets for CMIP6 Flux-Anomaly-Forced Model Intercomparison Project显示文摘The Flux-Anomaly-Forced Model Intercomparison Project(FAFMIP)is an endorsed Model Intercomparison Project in phase 6 of the Coupled Model Intercomparison Project(CMIP6).The goal of FAFMIP is to investigate the spread in the atmosphere–ocean general circulation model projections of ocean climate change forced by increased CO2,including the uncertainties in the simulations of ocean heat uptake,global mean sea level rise due to ocean thermal expansion and dynamic sea level change due to ocean circulation and density changes.The FAFMIP experiments have already been conducted with the Flexible Global Ocean–Atmosphere–Land System Model,gridpoint version 3.0(FGOALS-g3).The model datasets have been submitted to the Earth System Grid Federation(ESGF)node.Here,the details of the experiments,the output variables and some baseline results are presented.Compared with the preliminary results of other models,the evolutions of global mean variables can be reproduced well by FGOALS-g3.The simulations of spatial patterns are also consistent with those of other models in most regions except the North Atlantic and the Southern Ocean,indicating large uncertainties in the regional sea level projections of these two regions. | Yaqi WANG Zipeng YU Pengfei LIN Hailong LIU Jiangbo JIN Lijuan LI Yanli TANG Li DONG Kangjun CHEN Yiwen LI Qian YANG Mengrong DING Yao MENG Bowen ZHAO Jilin WEI Jinfeng MA and Zhikuo SUN | 2020 | Advances in Atmospheric Sciences2020，37，10： | 1 |
| 19 | Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance显示文摘 | Liwu Fu Yongju Liang Liwen Deng Yan Ding Liming Chen Yanli Ye Xiaoping Yang Qichao Pan | 2004 | Cancer Chemotherapy and Pharmacology2004，，4： | 1 |
| 20 | Status and progressof dynamic electrocardiogram clinical application 显示文摘 | Li Hao Qian Chunli Ding Yanli | 2008 | Central Plains Medical Journal2008，35，6： | 1 |
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