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| 1 | Effects of transdermal magnesium chloride on quality of life for patients with fibromyalgia: a feasibility study显示文摘BACKGROUND: Fibromyalgia is a syndrome characterized by chronic pain, fatigue, depression, and sleep disturbances. Its primary cause is unclear. Several studies have reported decreased intracellular magnesium levels in patients with fibromyalgia and have found negative correlation between magnesium levels and fibromyalgia symptoms.OBJECTIVE: To gather preliminary data on whether transdermal magnesium can improve quality of life for women who have fibromyalgia.DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: This is a patient questionnaires and survey in a fibromyalgia clinic at a tertiary medical center. Forty female patients with the diagnosis of fibromyalgia were enrolled. Each participant was provided a spray bottle containing a transdermal magnesium chloride solution and asked to apply 4 sprays per limb twice daily for 4 weeks. Participants were asked to complete the Revised Fibromyalgia Impact Questionnaire, SF-36v2 Health Survey, and a quality-of-life analog scale at baseline, week 2, and week 4.MAIN OUTCOME MEASURE: Questionnaire and survey scores, evaluated through intent-to-treat and per-protocol analyses.RESULTS: Twenty-four patients completed the study(mean [SD] age, 57.2 [7.6] years; white, 95%; mean body mass index, 31.3 kg/m2). With intention-to-treat analysis, Revised Fibromyalgia Impact Questionnaire subscale and total scores were significantly improved at week 2 and week 4(total score, P = 0.001). Per-protocol analysis results were similar: all subscales of the Revised Fibromyalgia Impact Questionnaire were significantly improved at week 2 and week 4(total score, P = 0.001). CONCLUSION: This pilot study suggests that transdermal magnesium chloride applied on upper and lower limbs may be beneficial to patients with fibromyalgia.TRIAL REGISTRATION: Clinical Trials.gov.ldentifier NCT01968772. | Deborah J.Engen Samantha J.Mc Allister Mary O.Whipple Stephen S.Cha Liza J.Dion Ann Vincent Brent A.Bauer Dietlind L.Wahner-Roedler | 2015 | Journal of Integrative Medicine2015，13，5： | 2 |
| 2 | Tumor antigen specific iTreg accumulate in the tumor microenvironment and suppress therapeutic vaccination显示文摘 | Taylor H. Schreiber Dietlinde Wolf Maria Bodero Eckhard Podack | 2012 | OncoImmunology2012，，： | 1 |
| 3 | Enzymatic oil extraction and positional analysis of co-3 fatty acids in Nile perch and salmon heads 显示文摘 | Betty M Dietlind A Patrick A | 2010 | Process Biochemistry2010，45，5： | 1 |
| 4 | Enzymatic oil extraction and positional analysis of n-3 fatty acids in Nile perch and salmon heads显示文摘 | Betty Mbatia Dietlind Adlercreutz Patrick Adlercreutz | 2010 | Process Biochemistry2010，45，5： | 1 |
| 5 | Rapamycin effects transcriptional programs in smooth muscle cells controlling proliferative and inflammatory properties显示文摘 | Dietlind Z Thomas G Franz-Josef N | 2004 | Molecular Pharmacology2004，65，7： | 1 |
| 6 | Role of Bone Marrow–Derived Cells in the Genetic Control of Restenosis显示文摘 | Nicolas Langwieser Johannes B.K. Schwarz Christoph Reichenb?cher Bastian Stemmer Steffen Massberg Nicole N. Langwieser Dietlind Zohlnh?fer | 2009 | Arteriosclerosis Thrombosis and Vascular Biology2009，，10： | 1 |
| 7 | Chemo-enzymatic epoxidation of oleic acid and methyl oleate in solvent-free medium 显示文摘 | Cecilia O Ulrika T Dietlind A C | 2005 | Biocatalysis and Biotransformation2005，23，6： | 1 |
| 8 | Rapamycin effects transcriptional programs in smooth muscle cells controlling proliferative and inflammatory properties显示文摘 | Dietlind Z Thomas G Franz-Josef N | 2004 | Molecular Pharmacology2004，65，4： | 1 |
| 9 | Enzymatic oil extraction and positional analysis of ω-3 fatty acids in Nile perch and salmon heads显示文摘 | Betty Mbatia Dietlind Adlercreutz Patrick Adlercreutz Ally Mahadhy Francis Mulaa Bo Mattiasson | 2010 | Process Biochemistry2010，，5： | 1 |
| 10 | HIV Nef Enhances Tat-Mediated Viral Transcription through a hnRNP-K-Nucleated Signaling Complex显示文摘 | Dietlinde Wolf Vanessa Witte Pat Clark Katja Blume Mathias G. Lichtenheld Andreas S. Baur | 2008 | Cell Host & Microbe2008，，4： | 1 |
| 11 | Enzymatic oil extraction and positional analysis of co- 3 fatty acids in Nile perch and salmon heads显示文摘 | Betty M Dietlind A Pantrick A | 2010 | Process Biochemistry2010，45，5： | 1 |
| 12 | The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons显示文摘 | Leffler Andreas Fischer Michael J Rehner Dietlinde Kienel Stephanie Kistner Katrin Sauer Susanne K Gavva Narender R Reeh Peter W Nau Carla | 2008 | Journal of Clinical Investigation2008，，： | 1 |
| 13 | Pulmonary abnormalities in inflammatory bowel disease显示文摘 | Dietlind Schleiermacher J?rg C. Hoffmann | 2007 | Journal of Crohn’s and Colitis2007，，2： | 1 |
| 14 | Enzymatic oil extraction and positional analysis ofω-3fatty acids in Nile perch and salmon heads显示文摘 | BETTY MBATIAA DIETLIND ADLERCREUTZA PATRICK ADLER-CREUTZA | 2010 | Process Biochemistry2010，45，5： | 1 |
| 15 | Early Mortality and Long-Term Survival after Abdominal Surgery in Patients with Liver Cirrhosis显示文摘 | Hannes P. Neeff Geraldine C. Streule Oliver Drognitz Dietlind Tittelbach-Helmrich Hans-Christian Spangenberg Ulrich T. Hopt Frank Makowiec | 2013 | Surgery2013，，： | 1 |
| 16 | The hits and misses of Namibia’s attempt to implement the Ecosystem Approach to Fisheries(EAF)Management显示文摘Ecosystem Approach to Fisheries(EAF)management is a concept aimed at the conservation and sustainable use of the entire ecosystem.While EAF is a noble approach,its implementation has been challenging.Although Namibia has committed to the implementation of EAF,only limited assessment has been done of Namibian fisheries management processes and instruments concerning EAF.A qualitative assesment was done to ascertain if the Namibian fisheries management processes and instruments conform to the EAF principles.Namibian fisheries management processes and instruments largely conform to the EAF principles,although there are notable areas needing improvements.The conformities were pronounced in the total allowable catch setting,rebuilding depleted stocks,minimizing bycatch,and fishing impact minimization.The polluter pays,and user pays principles were also applied.Areas that were found lacking in this study included setting the indicators for EAF and ecosystem integrity.The assessment also noted the absence of guidelines for the precautionary approach principle and a transparent policy for quota and right allocation processes.The strategies for managing transboundary fish species are also not formulated.Overall,this assessment showed the complexities and challenges that Namibia and other countries need to overcome to implement EAF successfully. | Johannes A.Iitembu Victoria N.Erasmus Uatjavi Uanivi Dietlinde Nakwaya Richard R.Horaeb Ester Nangolo Festus P.Nashima Theopolina K.Iita Osmund Mwandemele | 2021 | Ecosystem Health and Sustainability2021，7，1： | 0 |
| 17 | Impact of transplant nephrectomy on peak PRA levels and outcome after kidney re-transplantation显示文摘AIM: To determine the impact of transplant nephrectomy on peak panel reactive antibody(PRA) levels, patient and graft survival in kidney re-transplants. METHODS: From 1969 to 2006, a total of 609 kidney re-transplantations were performed at the University of Freiburg and the Campus Benjamin Franklin of the University of Berlin. Patients with PRA levels above(5%) before first kidney transplantation were excluded from further analysis(n = 304). Patients with graft nephrectomy(n = 245, NE+) were retrospectively compared to 60 kidney re-transplants without prior graft nephrectomy(NE-).RESULTS: Peak PRA levels between the first and the second transplantation were higher in patients undergoing graft nephrectomy(P = 0.098), whereas the last PRA levels before the second kidney transplantation did not differ between the groups. Age adjusted survival for the second kidney graft, censored for death with functioning graft, were comparable in both groups. Waiting time between first and second transplantation did not influence the graft survival significantly in the group that underwent nephrectomy. In contrast, patients without nephrectomy experienced better graft survival rates when re-transplantation was performed within one year after graft loss(P = 0.033). Age adjusted patient survival rates at 1 and 5 years were 94.1% and 86.3% vs 83.1% and 75.4% group NE+ and NE-, respectively(P < 0.01). CONCLUSION: Transplant nephrectomy leads to a temporary increase in PRA levels that normalize before kidney re-transplantation. In patients without nephrectomy of a non-viable kidney graft timing of re-transplantation significantly influences graft survival after a second transplantation. Most importantly, transplant nephrectomy is associated with a significantly longer patient survival. | Dietlind Tittelbach-Helmrich Przemyslaw Pisarski Gerd Offermann Marcel Geyer Oliver Thomusch Ulrich Theodor Hopt Oliver Drognitz | 2014 | World Journal of Transplantation2014，4，2： | 0 |
| 18 | Incorporation of integrative medicine education into undergraduate medical education:a longitudinal study显示文摘OBJECTIVE: Integrative medicine(IM) combines complementary medical approaches into conventional medicine and considers the whole person. We implemented a longitudinal IM short-course curriculum into our medical school education. This study aimed to evaluate the feasibility and effectiveness of the curriculum via knowledge and attitude surveys regarding IM among students. METHODS: A mandatory short IM curriculum across all years of medical school was created and taught by IM professionals and physician faculty members with expertise in integrative therapies. Graduating classes of 2015 and 2016 completed the same survey in their first and third years of medical school. Paired data analysis was done, and only students who completed surveys at both time points were included in final analyses. RESULTS: Of 52 students in each class, 17(33%) in the class of 2015 and 22(42%) in the class of 2016 completed both surveys. After the IM curriculum, students' knowledge of and comfort with several IM therapies—biofeedback, mindfulness, and the use of St. John's wort—improved significantly. Students' personal health practices also improved, including better sleep, exercise, and stress management for the class of 2015. Students graduating in 2016 reported decreased alcohol use in their third year compared with their first year.CONCLUSION: It is feasible to incorporate IM education into undergraduate medical education, and this is associated with improvement in students' knowledge of IM and personal health practices. | saswati mahapatra anjali bhagra bisrat fekadu zhuo li brent a.bauer dietlind l.wahner-roedler | 2017 | Journal of Integrative Medicine2017，15，6： | 0 |
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