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您的检索式：作者名="Marcel Geyer"
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| 1 | Improving the bioavailability of pharmacologically active substances in pharmaceutical and cosmetic formulations显示文摘One and the same active ingredient can be used in different pharmaceutical applications to treat and cure diseases.Furthermore,the active ingredient can be used also in cosmetic formulations to care or aid the healing process.When applied topically via creams or lotions,they are referred as cosmeceuticals.In general,one aims to improve the bioavailability through tailored formulations and careful selection of components.An example is the use of latanoprost in ophthalmology for lowering the intraocular pressure in glaucoma patients with side effects including stimulated growth of eyelashes.Does this open up the possibility of using latanoprost for the local treatment for hair loss? | Joachim Storsberg Marcel W.Laughton Martin Geyer Mont Kumpugdee-Vollrath Christian Schmidt | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 0 |
| 2 | Impact of transplant nephrectomy on peak PRA levels and outcome after kidney re-transplantation显示文摘AIM: To determine the impact of transplant nephrectomy on peak panel reactive antibody(PRA) levels, patient and graft survival in kidney re-transplants. METHODS: From 1969 to 2006, a total of 609 kidney re-transplantations were performed at the University of Freiburg and the Campus Benjamin Franklin of the University of Berlin. Patients with PRA levels above(5%) before first kidney transplantation were excluded from further analysis(n = 304). Patients with graft nephrectomy(n = 245, NE+) were retrospectively compared to 60 kidney re-transplants without prior graft nephrectomy(NE-).RESULTS: Peak PRA levels between the first and the second transplantation were higher in patients undergoing graft nephrectomy(P = 0.098), whereas the last PRA levels before the second kidney transplantation did not differ between the groups. Age adjusted survival for the second kidney graft, censored for death with functioning graft, were comparable in both groups. Waiting time between first and second transplantation did not influence the graft survival significantly in the group that underwent nephrectomy. In contrast, patients without nephrectomy experienced better graft survival rates when re-transplantation was performed within one year after graft loss(P = 0.033). Age adjusted patient survival rates at 1 and 5 years were 94.1% and 86.3% vs 83.1% and 75.4% group NE+ and NE-, respectively(P < 0.01). CONCLUSION: Transplant nephrectomy leads to a temporary increase in PRA levels that normalize before kidney re-transplantation. In patients without nephrectomy of a non-viable kidney graft timing of re-transplantation significantly influences graft survival after a second transplantation. Most importantly, transplant nephrectomy is associated with a significantly longer patient survival. | Dietlind Tittelbach-Helmrich Przemyslaw Pisarski Gerd Offermann Marcel Geyer Oliver Thomusch Ulrich Theodor Hopt Oliver Drognitz | 2014 | World Journal of Transplantation2014，4，2： | 0 |
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