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5篇 您的检索式:作者名="Mulaa"
    题名 作者 年代 出处 被引量
1Biodegradability of Poly ( lactic acid), Preparationand Characterization of PLA/ Gum Arabic Blends 显示文摘John M Onyari Francis Mulaa Joshua Muia Paul Shiundu 2008Journal of Polymers and the Environment2008,16,:1
2Enzymatic oil extraction and positional analysis of ω-3 fatty acids in Nile perch and salmon heads显示文摘Betty Mbatia Dietlind Adlercreutz Patrick Adlercreutz Ally Mahadhy Francis Mulaa Bo Mattiasson 2010Process Biochemistry2010,,5:1
3Enzymatic enrichment of omega-3 polyunsaturated fatty acids in Nile perch(Latesniloticus)viscera oil显示文摘Mbatia B Adlercreutz P Mulaa F 2010European Journal of Lipid Science and Technology2010,112,9:1
4Strategies for the enzymatic enrichment of PUFA from fish oil显示文摘Mbatia B Mattiasson B Mulaa F 2011European Journal of Lipid Science and Technology2011,113,6:1
5Structure of the 40S ribosomal subunit of Plasmodium falciparum by homology and de novo modeling显示文摘Generation of three dimensional structures of macromolecules using in silico structural modeling technologies such as homology and de novo modeling has improved dramatically and increased the speed by which tertiary structures of organisms can be generated. This is especially the case if a homologous crystal structure is already available. High-resolution structures can be rapidly created using only their sequence information as input, a process that has the potential to increase the speed of scientific discovery. In this study, homology modeling and structure prediction tools such as RNA123 and SWISS–MODEL were used to generate the 40 S ribosomal subunit from Plasmodium falciparum. This structure was modeled using the published crystal structure from Tetrahymena thermophila, a homologous eukaryote. In the absence of the Plasmodium falciparum 40 S ribosomal crystal structure, the model accurately depicts a global topology, secondary and tertiary connections, and gives an overall root mean square deviation(RMSD) value of 3.9 ? relative to the template's crystal structure. Deviations are somewhat larger in areas with no homology between the templates. These results demonstrate that this approach has the power to identify motifs of interest in RNA and identify potential drug targets for macromolecules whose crystal structures are unknown. The results also show the utility of RNA homology modeling software for structure determination and lay the groundwork for applying thisapproach to larger and more complex eukaryotic ribosomes and other RNA-protein complexes. Structures generated from this study can be used in in silico screening experiments and lead to the determination of structures for targets/hit complexes.Harrison Ndung'u Mwangi Peter Wagacha Peterson Mathenge Fredrick Sijenyi Francis Mulaa 2017Acta Pharmaceutica Sinica B2017,7,1:0
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