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| 1 | Identification of immunoreactive proteins of Brucella melitensis by immunoproteomics显示文摘Infection with Brucella causes brucellosis, a chronic disease in humans, which induces abortion and sterility in livestock. Among the different Brucella species, Brucella melitensis is considered the most virulent and is the predominant species associated with outbreaks in China. To date, no safe human vaccine is available against Brucella infection. The currently used live vaccines against Brucella in livestock induce antibodies that interfere with the diagnosis of field infection in vaccinated animals, which is harmful to eradication programs. However, there is as yet no complete profile of immunogenic proteins of B. melitensis. Towards the development of a safer, equally efficacious, and field infection-distinguishable vaccine, we used immunoproteomics to identify novel candidate immunogenic proteins from B. melitensis M5. Eighty-eight immunoreactive protein spots from B. melitensis M5 were identified by Western blotting and were assigned to sixty-one proteins by mass spectrometry, including many new immunoreactive proteins such as elongation factor G, F0F1 ATP synthase subunit beta, and OMP1. These provide many candidate immunoreactive proteins for vaccine development. | ZHAO ZhongPeng YAN Fang JI WenHui LUO DeYan LIU Xin XING Li DUAN YueQiang YANG PengHui SHI XiuMin LI Zhong WANG XiLiang | 2011 | Science China(Life Sciences)2011，54，9： | 12 |
| 2 | Efficacy of tanshinone ⅡA and mesenchymal stem cell treatment of learning and memory impairment in a rat model of vascular dementia显示文摘OBJECTIVE: To investigate the efficacy of administration of tanshinone Ⅱ A(TSA) combined with mesenchymal stem cells(MSCs) for the treatment of learning and memory impairment caused by vascular dementia(Va D) and to determine the underlying mechanism.METHODS: Modified four-vessel occlusion was used to establish a Va D model in rats, and their spatial learning and memory capacity was assessed by the Morris water maze. The rats were randomized into MSCs, TSA, MSCs combined with TSA, vehicle and sham groups. Histological changes were determined by hematoxylin and eosin staining, and the hippocampal neuron apoptosis ratio was assessed by flow cytometry. Western blotting was performed to detect Bcl-2 and Bax expression. The reactive oxidative species(ROS) levels and the activity of total superoxide dismutase(T-SOD), an antioxidant enzyme in the rat hippocampus, were determined.RESULTS: TSA combined with MSCs treatment administered by intravenous injection in the tail significantly attenuated cognitive deficits in the Va D model compared with the vehicle group(P < 0.01),and its protective effect on cognitive function was greater than that obtained by treatment with MSCs or TSA alone. Furthermore, TSA combined with MSCs treatment achieved synergistic effects in suppressing neuronal apoptosis in the rat hippocampus caused by global brain ischemia via up-regulating the expression of Bcl-2, an anti-apoptosis protein, and decreasing the expression of Bax, a pro-apoptotic protein. In addition, TSA combined with MSCs treatment attenuated ROS production and enhanced T-SOD activity in the rat hippocampus, and the antioxidant effect was greater than that of treatment with MSCs or TSA alone.CONCLUSION: TSA combined with MSCs treatment improved the spatial learning and memory capacity in a Va D model via suppressing neuronal apoptosis and antioxidant activity in the hippocampus, and this improvement was greater with combined treatment than with treatment with MSCs or TSA alone. | KONG Deyan LUO Jiefeng SHI Shengliang HUANG Zhenhua | 2021 | Journal of Traditional Chinese Medicine2021，41，1： | 9 |
| 3 | Effect of rGO Coating on Interconnected Co_3O_4 Nanosheets and Improved Supercapacitive Behavior of Co_3O_4/rGO/NF Architecture显示文摘In this study, the effect of reduced graphene oxide(rGO) on interconnected Co_3O_4 nanosheets and the improved supercapacitive behaviors is reported. By optimizing the experimental parameters, we achieved a specific capacitance of ~1016.4 F g^(-1) for the Co_3O_4/rGO/NF(nickel foam) system at a current density of 1 A g^(-1). However, the Co_3O_4/NF structure without rGO only delivers a specific capacitance of ~520.0 F g^(-1)at the same current density. The stability test demonstrates that Co_3O_4/rGO/NF retains ~95.5% of the initial capacitance value even after 3000 charge–discharge cycles at a high current density of 7 A g^(-1). Further investigation reveals that capacitance improvement for the Co_3O_4/rGO/NF structure is mainly because of a higher specific surface area(~87.8 m^2g^(-1))and a more optimal mesoporous size(4–15 nm) compared to the corresponding values of 67.1 m^2g^(-1) and 6–25 nm,respectively, for the Co_3O_4/NF structure. rGO and the thinner Co_3O_4 nanosheets benefit from the strain relaxation during the charge and discharge processes, improving the cycling stability of Co_3O_4/rGO/NF. | Tinghui Yao Xin Guo Shengchun Qin Fangyuan Xia Qun Li Yali Li Qiang Chen Junshuai Li Deyan He | 2017 | Nano-Micro Letters2017，9，4： | 8 |
| 4 | Ultraviolet Photoconductance of a Single Hexagonal WO_(3) Nanowire显示文摘The ultraviolet (UV) photoconductance properties of a single hexagonal WO_(3) nanowire have been studied systematically. The conductance of WO_(3) nanowires is very sensitive to ultraviolet B light and a field-effect transistor (FET) nanodevice incorporating a single WO_(3) nanowire exhibits excellent sensitivity, reversibility, and wavelength selectivity. A high photoconductivity gain suggests that WO_(3) nanowires can be used as the sensing element for UV photodetectors. Measurements under UV light in vacuum show that the adsorption and desorption of oxygen molecules on the surface of the WO_(3) nanowire can significantly influence its photoelectrical properties. The WO_(3) nanowires have potential applications in biological sensors, optoelectronic devices, optical memory, and other areas. | Kai Huang Qing Zhang Feng Yang Deyan He | 2010 | Nano Research2010，3，4： | 7 |
| 5 | Division of Matrix- and Fracture-Type Shale Oils in the Jiyang Depression and Their Differences显示文摘This study discussed the division of matrix- and fracture-type shale oils in the Jiyang Depression, and proposed the concept of fracture development coefficient. The fracture development coefficient is defined as the ratio of fault throw to the distance between a shale oil well and the nearest fault. Based on CO_2 content, state of water, oil production and logging response of shale oil formations, the classification of shale oils was established, i.e., a fracture-type shale oil well has a fracture development coefficient greater than 0.2, while a matrix-type one has a fracture development coefficient less than 0.2. Furthermore, the key control factors of matrix- and fracture-type shale oil enrichment were analyzed using typical anatomical and statistical methods. For matrix-type shale oil enrichment, these factors are lithofacies, total organic carbon(TOC), shale porosity and abnormal pressure; for fracture-type shale oil enrichment, they are lithofacies, extent of fracture development, and abnormal pressure. This study also first described the differences between matrix- and fracture-type shale oils. The results provide reference for the exploration of terrestrial faulted basins in eastern China. | NING Fangxing WANG Xuejun HAO Xuefeng ZHU Deyan ZHU Deshun | 2015 | Acta Geologica Sinica(English Edition)2015，89，6： | 7 |
| 6 | Dynamics of dissolved organic carbon in the mires in the Sanjiang Plain,Northeast China显示文摘Mires in boreal area had proved to be an important dissolved organic carbon (DOC) reserve for the sensitivity to climate change and human interfering. The study was focused on the temporal and spatial dynamics and controlling factors of DOC in a seasonally-waterlogged mire (SLM) and perennially-waterlogged mire (PLM) in the Sanjiang Plain, Northest China. In the two mires, DOC concentrations in both surface water and upper soil strata experienced pronounced seasonal variation. DOC concentrations in the surface waters were the greatest and averagely was 47.82 in SLM and 34.84 mg/L and PLM, whereas that in soil water at 0.3-m depth had little difference (20.25 mg/L in SLM and 26.51 mg/L in PLM). Results revealed that DOC concentrations declined 5-8 times vertically from the surface down to groundwater. DOC in the groundwater only was in a very small part with the average concentration of 5.18 mg/L. In relation to the surface water, DOC concentrations varied positively with temperature just before 8 August, and only in early spring and later autumn DOC concentrations exhibited identifiable spatial trends along with standing water depths in PLM. It was supposed that the influences from standing water depth took effect only in conditions of low temperature, and temperature should be the most powerful factor controlling DOC dynamics in the mires. Redox potential (Red) showed negative relationship with DOC values while total nitrogen (TN) and the majority of free ions in the soil solution exhibited no relationship. High soil TOC/TN ratio and low redox potentials also led to DOC accumulation in the mires in the Sanjiang Plain. | Yuedong Guo Zhongmei Wan Deyan Liu | 2010 | Journal of Environmental Sciences2010，22，1： | 5 |
| 7 | A novel inhibitor of N^(6)-methyladenosine demethylase FTO induces m RNA methylation and shows anti-cancer activities显示文摘N^(6)-methyladenosine(m^(6)A)modification is critical for m RNA splicing,nuclear export,stability and translation.Fat mass and obesity-associated protein(FTO),the first identified m^(6)A demethylase,is critical for cancer progression.Herein,we developed small-molecule inhibitors of FTO by virtual screening,structural optimization,and bioassay.As a result,two FTO inhibitors namely 18077 and 18097 were identified,which can selectively inhibit demethylase activity of FTO.Specifically,18097 bound to the active site of FTO and then inhibited cell cycle process and migration of cancer cells.In addition,18097 reprogrammed the epi-transcriptome of breast cancer cells,particularly for genes related to P53 pathway.18097 increased the abundance of m^(6)A modification of suppressor of cytokine signaling1(SOCS1)m RNA,which recruited IGF2 BP1 to increase m RNA stability of SOCS1 and subsequently activated the P53 signaling pathway.Further,18097 suppressed cellular lipogenesis via downregulation of peroxisome proliferator-activated receptor gamma(PPARγ),CCAAT/enhancer-binding protein alpha(C/EBPa),and C/EBPβ.Animal studies confirmed that 18097 can significantly suppress in vivo growth and lung colonization of breast cancer cells.Collectively,we identified that FTO can work as a potential drug target and the small-molecule inhibitor 18097 can serve as a potential agent against breast cancer. | Guoyou Xie Xu-Nian Wu Yuyi Ling Yalan Rui Deyan Wu Jiawang Zhou Jiexin Li Shuibin Lin Qin Peng Zigang Li Hongsheng Wang Hai-Bin Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 8 | Field electron emission of diamond films on nanocrystalline diamond coating by CVD method显示文摘The preparation process, structure feature and field electron emission characteristic of diamond films on nanocyrstalline diamond coating by the CVD method were studied. The field electron emission measurements on the samples showed that the diamond films have lower turn-on voltage and higher field emission current density. A further detailed theory explanation to the results was given. | CAI Rangqi CHEN Guanghua SONG Xuemei XING Guangjian FENG Zhenjian HE Deyan | 2003 | Chinese Science Bulletin2003，48，18： | 3 |
| 9 | Responses of soil microbial communities and functions associated with organic carbon mineralization to nitrogen addition in a Tibetan grassland显示文摘Alpine grasslands with a high soil organic carbon(SOC)storage on the Tibetan Plateau are experiencing rapid climate warming and anthropogenic nitrogen(N)deposition;this is expected to substantially increase the soil N availability,which may impact carbon(C)cycling.However,little is known regarding how N enrichment influences soil microbial communities and functions relative to C cycling in this region.We conducted a 4-year field experiment on an alpine grassland to evaluate the effects of four different rates of N addition(0,25,50,and 100 kg N ha^-1 year^-1)on the abundance and community structure(phospholipid fatty acids,PLFAs)of microbes,enzyme activities,and community level physiological profiles(CLPP)in soil.We found that N addition increased the microbial biomass C(MBC)and N(MBN),along with an increased abundance of bacterial PLFAs,especially Gram-negative bacterial PLFAs,with a decreasing ratio of Gram-positive to Gram-negative bacteria.The N addition also stimulated the growth of fungi,especially arbuscular mycorrhizal fungi,reducing the ratio of fungi to bacteria.Microbial functional diversity and activity of enzymes involved in C cycling(β-1,4-glucosidase and phenol oxidase)and N cycling(β-1,4-N-acetyl-glucosaminidase and leucine aminopeptidase)increased after N addition,resulting in a loss of SOC.A meta-analysis showed that the soil C/N ratio was a key factor in the response of oxidase activity to N amendment,suggesting that the responses of soil microbial functions,which are linked to C turnover relative to N input,primarily depended upon the soil C/N ratio.Overall,our findings highlight that N addition has a positive influence on microbial communities and their associated functions,which may reduce soil C storage in alpine grasslands under global change scenarios. | Ruyi LUO Jiafa LUO Jianling FAN Deyan LIU Jin-Sheng HE Nazia PERVEEN Weixin DING | 2020 | Pedosphere2020，30，2： | 3 |
| 10 | Sol-Gel Preparation of Zn2 SiO4 :Mn Phosphor Layers on Silica Spheres and Their Luminescent Properties显示文摘The synthesis and luminescence properties of Zn2 SiO4: Mn phosphor layers on spherical silica spheres, i.e.,a kind of core-shell complex phosphor, Zn2SiO4: Mn@ SiO2 were described.Firstly, monodisperse silica spheres were obtained via the Stober method by the hydrolysis of tetraethoxysilane(TEOS) Si ( OC2H5 ) 4 under base condition ( using NH4 OH as the catalyst).Secondly, the silica spheres were coated with a Zn2 SiO4: Mn phosphor layer by a Pechini solgel process.X-ray diffraction ( XRD), scanning electron microscope ( SEM), energy-dispersive X-ray spectrum ( EDS )and photoluminescence (PL) were employed to characterize the resulting complex phosphor.The results confirm that1000 ℃ annealed sample consists of crystalline Zn2SiO4: Mn shells and amorphous SiO2 cores.The phosphor show the green emission of Mn2+ at 521 nm corresponding 4T1 (4G) - 6 A1 (6S) transition, and the possible luminescence mechanism is proposed. | Kong Deyan Yu Min Lin Cuikun Lin Jun | 2004 | Journal of Rare Earths2004，22，z1： | 3 |
| 11 | Early Cretaceous Paleoclimate Characteristics of China:Clues from Continental Climate-indicative Sediments显示文摘The Cretaceous was one of the most remarkable ‘greenhouse' climate periods in geological history. Most of the reported studies of the Cretaceous paleoclimate are based upon marine sedimentary records. Large spatial scale paleoclimatic reconstruction, which has a higher time resolution based upon continental sediments in China, is rarely found. This study presents paleoclimate reconstruction for the six time periods of the Early Cretaceous in China by employing continental climate-indicative sediments, including calcareous deposits, coal, oil shale, gypsum, halite, desert sedimentary systems, ferruginous deposits and laterite, copper-bearing deposits, limestone and dolomite. Based on the distribution of the association of climate-indicative sediments and the influences of paleotopography and orogenic belts(or important structural belts) on climate, seven climatic zones have been identified: 1) a warm and humid zone; 2) a warm and humid-warm and arid zone; 3) a warm and arid zone; 4) an arid and hot zone; 5) the Tibet hot and humid zone; 6) a hot and arid-semiarid zone; and 7) a hot and humid-hot and arid one. It is found that the Early Cretaceous climatic zones of China were nearly latitudinally distributed from northwest to southeast. The aridhot climatic zone expanded in the Aptian, suggesting that a hotter and drier climate prevailed in later period of the Early Cretaceous. Conversely, the humid climatic zone expanded in the Albian, indicating that a wetter climate appeared at the end of the Early Cretaceous. The overall distribution pattern of the seven climatic zones indicates that a hot-warm and arid climate was predominant in China; this coincides with a global ‘greenhouse climate' background. However, palaeogeographic features and specific geologic events, such as the existence and disappearance of the eastern high plateau, and the uplift and denudation of Yinshan, Yanshan, Tianshan, Qinling and Dabie Mountains, led to distinctive regional climatic features of the Cretaceous in China. | XIANG Fang ZHANG Deyan CHEN Kang FENG Qin | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 3 |
| 12 | Preparation and electrochemical performance of MWCNTs@MnO_2 nanocomposite for lithium ion batteries显示文摘Tubular nanocomposite with interconnected MnO2 nanoflakes coated on MWCNTs(MWCNTs@MnO2)was fabricated by an aqueous solution method at 80°C.Scanning electron microscopy,X-ray diffraction and galvanostatic charge-discharge tests were used to characterize the structures and electrochemical performances of the as-prepared nanocomposite.The capacity reaches 1233.6 mA h g-1 at a current density of 100 mA g-1 for the first discharge,and it can still maintain a capacity of 633.1mA h g-1 after 100 charge-discharge cycles.The results show that MWCNTs with good electrical conductivity as anchors of MnO2 can provide fast electron transport channels for MnO2 in the electrochemical reactions,and the as-prepared MWCNTs@MnO2 nanocomposite is a potential anode material for lithium ion batteries. | LIU YingQi LI XiuWan WEI ZhiWei ZHANG LiPing WEI XiuCheng HE DeYan | 2014 | Science China(Technological Sciences)2014，57，6： | 2 |
| 13 | Yield-scaled nitrous oxide emissions from nitrogen-fertilized croplands in China: A meta-analysis of contrasting mitigation scenarios显示文摘Nitrogen(N) losses in cropland resulting from the application of synthetic fertilizers decrease crop productivity and exacerbate environmental pollution.Mitigation measures, such as reduction in N fertilizer application rates, can have unintentional adverse effects on crop yield. We conducted a meta-analysis of soil N_(2)O emissions from agricultural fields across China under contrasting mitigation scenarios as a novel approach to identify the most effective strategy for the mitigation of emissions of N_(2)O derived from N fertilizer use in China. Current standard agricultural practice was used as a baseline scenario(BS), and 12 potential mitigation scenarios(S1–S12) were derived from the available literature and comprised single and combinations of management scenarios that accounted for crop yield. Mitigation scenarios S6(nitrification inhibitor 3,4-dimethylpyrazole phosphate) and S11(20% reduction in N application rate plus nitrification inhibitor dicyandiamide) in maize, rice, and wheat crops led to an average 56.0% reduction in N_(2)O emissions at the national level, whereas scenario S4(nitrification inhibitor dicyandiamide) led to yield optimization, with a 14.0% increase for maize and 8.0% increase for rice as compared to the BS. Implementation of these most effective mitigation scenarios(S4, S6, and S11) might help China, as a signatory to the 2015 United Nations Framework Convention on Climate Change(Paris Agreement), to achieve a 30% reduction in N_(2)O emissions by 2030. | Garba ALIYU Jiafa LUO Hong J.DI Deyan LIU Junji YUAN Zengming CHEN Tiehu HE Weixin DING | 2021 | Pedosphere2021，31，2： | 2 |
| 14 | Experimental study on the phase change behavior of phase change material confined in pores显示文摘 | Dong Zhang Shengli Tian Deyan Xiao | 2006 | Solar Energy2006，，5： | 2 |
| 15 | MXenes for Solar Cells显示文摘Application of two-dimensional MXene materials in photovoltaics has attracted increasing attention since the first report in 2018 due to their metallic electrical conductivity,high carrier mobility,excellent transparency,tunable work function and superior mechanical property.In this review,all developments and applications of the Ti3C2Tx MXene(here,it is noteworthy that there are still no reports on other MXenes’application in photovoltaics by far)as additive,electrode and hole/electron transport layer in solar cells are detailedly summarized,and meanwhile,the problems existing in the related studies are also discussed.In view of these problems,some suggestions are given for pushing exploration of the MXenes’application in solar cells.It is believed that this review can provide a comprehensive and deep understanding into the research status and,moreover,helps widen a new situation for the study of MXenes in photovoltaics. | Lujie Yin Yingtao Li Xincheng Yao Yanzhou Wang Lin Jia Qiming Liu Junshuai Li Yali Li Deyan He | 2021 | Nano-Micro Letters2021，13，5： | 2 |
| 16 | A novel sparse representation method based on virtual samples for face recognition 显示文摘 | Tang Deyan Zhu Ningbo Yu Fu | 2014 | Neural Computing and Applications2014，24，34： | 1 |
| 17 | Trace determination of clenbuterol with an MWCNT - Nafion nanocomposite modified electrode显示文摘 | GUO Renxia XU Qin WANG Deyan | 2008 | Microchim Acta2008，161，： | 1 |
| 18 | Kinetic Monte Carlo simulation of film morphologies at the initial stages显示文摘The morphologies at the initial stages of thin film growth were studied by using Kinetic Monte Carlo techniques.A more efficient model was used to calculate the activity energy.The model involves incident atom attachment,diffusion,detachment from the surface,detached atom returning,and dimer diffusion.We edited a set of software of the model and simulated the surface morphologies by the principle of computer graphics.It is shown that the nucleuses formed at the initial stages and the surface morphologies at high temperatures are very different from those at low temperatures.The later surface growth depends on the nucleuses at the initial stages.The mechanism results from the atom thermal movement,the temperature determines the diffusion ability,and the deposition rate determines the diffusion time. | ZHENG XiaoPing ZHANG PeiFeng HE DeYan LI Lian | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，1： | 1 |
| 19 | Fabrication of Si nanodot arrays by plasma enhanced CVD using porous alumina templates显示文摘 | HU Hailong HE Deyan | 2006 | Materials Letters2006，60，： | 1 |
| 20 | Six steps for building a technological knowledge base for future taxonomic work显示文摘Species are the principal category we use to study,understand,and conserve the natural world,so how we define species has a cascading impact across fields,well beyond biology[1].Despite such importance,debate on species concepts continues to this day([2]2020),with consequences for what organisms we recognize,study and protect.Given the wealth of life forms on our planet. | Michael C.Orr Anderson Feijó Douglas Chesters Alfried P.Vogler Silas Bossert Rafael R.Ferrari Mark John Costello Alice C.Hughes Lars Krogmann John S.Ascher Xin Zhou De-Zhu Li Ming Bai Jun Chen Deyan Ge Arong Luo Gexia Qiao Paul H.Williams Ai-bing Zhang Keping Ma Feng Zhang Chao-Dong Zhu | 2022 | National Science Review2022，9，12： | 1 |
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