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| 1 | MicroRNAs and Their Cross-Talks in Plant Development显示文摘Plant development is a complex process influenced by exogenous and endogenous elements.A series of postembryonic developmental events is involved to form the final architecture and contend with the changing environment.MicroRNA(miRNA) is one of endogenous non-coding RNAs,which plays an important role in plant developmental regulation.In this review,we summarized 34 miRNA families that are closely associated with plant development.Among these families,nine are expressed only in specific organs,whereas 20 families are expressed in at least two different organs.It is known that some miRNAs are expressed across most processes of plant growth,while some appear only at particular developmental stages or under special environmental conditions such as drought,waterlogging and short-day time.These miRNAs execute their diverse functions by regulating developmental gene expression levels,interacting with phytohormone signaling response,participating in the biogenesis of ta-siRNAs and affecting the production of miRNAs. | Danfeng Jin Yue Wang Yuhua Zhao Ming Chen | 2013 | Journal of Genetics and Genomics2013，40，4： | 9 |
| 2 | Normal Structure and Function of Endothecium Chloroplasts Maintained by ZmMs33-Mediated Lipid Biosynthesis in Tapetal Cells Are Critical for Anther Development in Maize显示文摘Genic male sterility(GMS)is critical for heterosis utilization and hybrid seed production.Although GMS mutants and genes have been studied extensively in plants,it has remained unclear whether chloroplast-associated photosynthetic and metabolic activities are involved in the regulation of anther development.In this study,we characterized the function of ZmMs33/ZmGPAT6,which encodes a member of the glycerol-3-phosphate acyltransferase(GPAT)family that catalyzes the first step of the glycerolipid synthetic pathway.We found that normal structure and function of endothecium(En)chloroplasts maintained by ZmMs33-mediated lipid biosynthesis in tapetal cells are crucial for maize anther development.ZmMs33 is expressed mainly in the tapetum at early anther developmental stages and critical for cell proliferation and expansion at late stages.Chloroplasts in En cells of wild-type anthers function as starch storage sites before stage 10 but as photosynthetic factories since stage 10 to enable starch metabolism and carbohydrate supply.Loss of ZmMs33 function inhibits the biosynthesis of glycolipids and phospholipids,which are major components of En chloroplast membranes,and disrupts the development and function of En chloroplasts,resulting in the formation of abnormal En chloroplasts containing numerous starch granules.Further analyses reveal that starch synthesis during the day and starch degradation at night are greatly suppressed in the mutant anthers,leading to carbon starvation and low energy status,as evidenced by low trehalose-6-phosphate content and a reduced ATP/AMP ratio.The energy sensor and inducer of autophagy,SnRK1,was activated to induce early and excessive autophagy,premature PCD,and metabolic reprogramming in tapetal cells,finally arresting the elongation and development of mutant anthers.Taken together,our results not only show that ZmMs33 is required for normal structure and function of En chloroplasts but also reveal that starch metabolism and photosynthetic activities of En chloroplasts at different developmental stages are essential for normal anther development.These findings provide novel insights for understanding how lipid biosynthesis in the tapetum,the structure and function of En chloroplasts,and energy and substance metabolism are coordinated to maintain maize anther development. | Taotao Zhu Ziwen Li Xueli An Yan Long Xiaofeng Xue Ke Xie Biao Ma Danfeng Zhang Yijian Guan Canfang Niu Zhenying Dong Quancan Hou Lina Zhao Suowei Wu Jinping Li Weiwei Jin Xiangyuan Wan | 2020 | Molecular Plant2020，13，11： | 9 |
| 3 | High-Resolution Genome-wide Association Study Identifies Genomic Regions and Candidate Genes for Important Agronomic Traits in Wheat显示文摘Wheat(Triticum aestivum)is a major staple food crop worldwide.Genetic dissection of important agronomic traits is essential for continuous improvement of wheat yield to meet the demand of the world's growing population.We conducted a large-scale genome-wide association study(GWAS)using a panel of 768 wheat cultivars that were genotyped with 327609 single-nucleotide polymorphisms generated by genotyping-by-sequencing and detected 395 quantitative trait loci(QTLs)for 12 traits under 7 environments.Among them,273 QTLs were delimited to≤1.0-Mb intervals and 7 of them are either known genes(Rht-D,Vrn-B1,and Vrn-D1)that have been cloned or known QTLs(TaGA2ox8,APO1,TaSus1-7B,and Rht12)that were previously mapped.Eight putative candidate genes were identified for three QTLs that enhance spike seed setting and grain size using gene expression data and were validated in three bi-parental populations.Protein sequence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTLs affecting similar traits.Large r^2 values for additive effects observed among the QTLs for most traits indicated that the phenotypes of these identified QTLs were highly predictable.Results from this study demonstrated that significantly increasing GWAS population size and marker density greatly improves detection and identification of candidate genes underlying a QTL,solidifying the foundation for large-scale QTL fine mapping,candidate gene validation,and developing functional markers for genomics-based breeding in wheat. | Yunlong Pang Chunxia Liu Danfeng Wang Paul St.Amand Amy Bernardo Wenhui Li Fang He Linzhi Li Liming Wang Xiufang Yuan Lei Dong Yu Su Huirui Zhang Meng Zhao Yunlong Liangi Hongze Jia Xitong Shen Yue Lu Hongming Jiang Yuye Wu Anfei Li Honggang Wang Lingrang Kong Guihua Bai Shubing Liu | 2020 | Molecular Plant2020，13，9： | 8 |
| 4 | Zinc finger protein 278, a potential oncogene in human colorectal cancer显示文摘(ZNF278 ) 锌手指蛋白质 278 是在人的纸巾是无所不在地分布式的新奇 Krueppel Cys2-His2-type 锌手指蛋白质。ZNF278 是否与 colorectal 癌症的发展有关,仍然是不清楚的。ZNF278 的 tran-scriptional 水平被即时聚合酶链反应在 colorectal 癌症学习。结果证明那 ZNF278 表情与相应非癌的纸巾相比在 53% colorectal 癌症纸巾被增加。ZNF278 的 Thetranscriptional 下面规定被检测在仅仅三(6%) 与相应非癌症纸巾相比的人的 colorectal 癌症纸巾。没有重要差别在 19 被检测(41%) 一些样品。然而,我们没能发现在抄写和年龄,性别,渗入的度,或肿瘤 colorectal 癌症缩放的 ZNF278 的起来规定之间的一个重要协会。在 colorectal carcinogenesis 学习 ZNF278 的函数,结肠癌房间线 SW1116 是稳定地有到构造的野类型的 ZNF278 plasmid 的 transfected 一个 overexpression 系统,并且短暂地有到构造的 ZNF278 的小介入 RNA 的 transfected 一个 ZNF278 击倒的系统。房间增长与 3- 被估计[4, 5-dimethylthiazol-2-yl ]-2,5-diphenyltetrazolium 溴化物染料和一个房间柜台。结果证明 ZNF278 支持房间生长,并且它的击倒压制房间增长。ZNF278 能是在 colorectal 癌症的潜在的 proto-oncogene。 | Xiaoqing Tian Danfeng Sun Yanjie Zhang Shuliang Zhao Hua Xiong Jingyuan Fang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，4： | 4 |
| 5 | Mitochondrial malic enzyme 2 promotes breast cancer metastasis via stabilizing HIF-1α under hypoxia显示文摘Objective: α-ketoglutarate(α-KG) is the substrate to hydroxylate collagen and hypoxia-inducible factor-1α(HIF-1α), which are important for cancer metastasis. Previous studies have shown that the upregulation of collagen prolyl 4-hydroxylase in breast cancer cells stabilizes the expression of HIF-1α by depleting α-KG levels. We hypothesized that mitochondrial malic enzyme 2(ME2) might also affect HIF-1α expression via modulating α-KG levels in breast cancer cells.Methods: We evaluated ME2 protein expression in 100 breast cancer patients using immunohistochemistry and correlated with clinicopathological indicators. The effect of ME2 knockout on cancer metastasis was evaluated using an orthotopic breast cancer model. The effect of ME2 knockout or knockdown on the levels of α-KG and HIF-1α proteins in breast cancer cell lines was determined both in vitro and in vivo.Results: ME2 was found to be upregulated in the human breast cancerous tissues compared with the matched precancerous tissues(P<0.001). The elevated expression of ME2 was associated with a poor prognosis(P=0.019).ME2 upregulation was also related to lymph node metastasis(P=0.016), pathological staging(P=0.033), and vascular cancer embolus(P=0.014). Also, ME2 knockout significantly inhibited lung metastasis in vivo. In the tumors formed by ME2 knockout cells, the levels of α-KG were significantly increased and collagen hydroxylation level did not change significantly but HIF-1α protein expression was significantly decreased, compared to the control samples. In cell culture, cells with ME2 knockout or knockdown demonstrated significantly higher α-KG levels but significantly lower HIF-1α protein expression than control cells under hypoxia. Exogenous malate and α-KG exerted similar effect on HIF-1α in breast cancer cells to ME2 knockout or knockdown. Additionally,treatment with malate significantly decreased 4 T1 breast cancer lung metastasis. ME2 expression was associated with HIF-1α levels in human breast cancer samples(P=0.008).Conclusions: Our results provide evidence that upregulation of ME2 is associated with a poor prognosis of breast cancer patients and propose a mechanistic understanding of a link between ME2 and breast cancer metastasis. | Duo You Danfeng Du Xueke Zhao Xinmin Li Minfeng Ying Xun Hu | 2021 | Chinese Journal of Cancer Research2021，33，3： | 3 |
| 6 | Plant buffering against the high-light stress- induced accumulation of CsGA2ox8 transcripts via alter native splici ng to fi n ely tune gibberelli n levels and maintain hypocotyl elongation显示文摘In plants,alternative splicing(AS)is markedly induced in response to environmental stresses,but it is unclear why plants generate multiple transcripts under stress conditions.In this study,RNA-seq was performed to identify AS events in cucumber seedlings grown under different light intensities.We identi fi ed a novel transcript of the gibberellin(GA)-deactivating enzyme Gibberellin 2-beta-dioxygenase 8(CsGA2ox8).Compared with canonical CsGA2ox8.1,the CsGA2ox8.2 isoform presented intron retention between the second and third exons.Functional analysis proved that the transcript of CsGA2ox8.1 but not CsGA2ox8.2 played a role in the deactivation of bioactive GAs.Moreover,expression analysis demonstrated that both transcripts were upregulated by increased light intensity,but the expression level of CsGA2ox8.1 increased slowly when the light intensity was>400μmol-m-2-s-1 PPFD(photosynthetic photon fl ux density),while the CsGA2ox8.2 transcript levels increased rapidly when the light intensity was>200 pmol-m-2-s-1 PPFD.Our fi ndings provide evidence that plants might fi nely tune their GA levels by buffering against the normal transcripts of CsGA2ox8 through AS. | Bin Liu Shuo Zhao Pengli Li Yilu Yin Qingliang Niu Jinqiang Yan Danfeng Huang | 2021 | Horticulture Research2021，8，1： | 2 |
| 7 | Cytoplasmic and nuclear genome variations of rice hybrids and their parents inform the trajectory and strategy of hybrid rice breeding显示文摘The male sterility(MS)line is a prerequisite for efficient production of hybrid seeds in rice,a self-pollinating species.MS line breeding is pivotal for hybrid rice improvement.Understanding the historical breeding tra-jectory will help to improve hybrid rice breeding strategies.Maternally inherited cytoplasm is an appro-priate tool for phylogenetic reconstruction and pedigree tracing in rice hybrids.In this study,we analyzed the cytoplasmic genomes of 1495 elite hybrid rice varieties and identified five major types of cytoplasm,which correspond to different hybrid production systems.As the cytoplasm donors for hybrids,461 MS lines were also divided into five major types based on cytoplasmic and nuclear genomic architecture.Spe-cific core accessions cooperating with different fertility-associated genes drove the sequence divergence of MS lines.Dozens to hundreds of convergent and divergent selective sweeps spanning several agro-nomic trait-associated genes were identified among different types of MS lines.We further analyzed the cross patterns between different types of MS lines and their corresponding restorers.This study system-atically analyzed the cytoplasmic genomes of rice hybrids revealed their relationships with nuclear ge-nomes of MS lines,and illustrated the trajectory of hybrid rice breeding and the strategies for breeding different types of MS lines providing new insights for future improvement of hybrid rice. | Zhoulin Gu Zhou Zhu Zhen Li Qilin Zhan Qi Feng Congcong Zhou Qiang Zhao Yan Zhao Xiaojian Peng Bingxin Dai Rongrong Sun Yan Li Hengyun Lu Lei Zhang Tao Huang Junyi Gong Danfeng Lv Xuehui Huang Bin Han | 2021 | Molecular Plant2021，14，12： | 2 |
| 8 | Possible link between new coronavirus variants and atmospheric lightning and seawater intrusion显示文摘自新型冠状病毒肺炎暴发一年多以来,已经对全球产生深远影响.新型冠状病毒肺炎变异毒株的出现使当前疫情发展充满了不确定性.从这方面出发,我们讨论病毒变异与大气因素之间的联系.根据固氮过程和硝酸盐在人体中的转化过程,我们提出了新型冠状病毒肺炎变异毒株的出现或许和闪电以及海水入侵有联系.我们的研究对新型冠状病毒肺炎变异毒株可能的产生原因提供新的观点. | Jianping Huang Yingjie Zhao Danfeng Wang | 2022 | Atmospheric and Oceanic Science Letters2022，15，1： | 2 |
| 9 | In situ growth of mesoporous NiO nanoplates on a graphene matrix as cathode catalysts for rechargeable lithium air batteries显示文摘 | Qiu Danfeng Bu Gang Zhao Bin | 2015 | Materials Letters2015，141，2： | 1 |
| 10 | GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependentmanner显示文摘 | Juan Ren Hui Guo Huili Wu Tao Tian Danfeng Dong Yuelang Zhang Yanxia Sui Yong Zhang Dongli Zhao Shufeng Wang Zongfang Li Xiaozhi Zhang Rui Liu Jianshneg Qian Hongxia Wei Wenjun Jiang Ya Liu Yi Li | 2015 | Oncology Reports2015，，： | 1 |
| 11 | ALGORITHMS AND ARCHITECTURE IMPLEMENTATIONS OF MIMO OFDM BASEBAND RECEIVER BASED ON THE SIMD DSP CORE显示文摘This letter presents a programmable single-chip architecture for Multi-Input and Multi-Output (MIMO) OFDM baseband receiver. The architecture comprises a Single Instruction Multiple Data (SIMD) DSP core and three coprocessors that are used for synchronization, FFT and channel decoder. In this MIMO OFDM system, the Zero Correlation Zone (ZCZ) code is used as the synchronization word preamble of packet in the physical layer in order to avoid the interference from other transmitting antennas. Furthermore, a simple channel estimation algorithm is proposed which is appropriate for the SIMD DSP computation. | Hao Xuefei Chen Jie Zhao Danfeng Zhou Chaoxian | 2006 | Journal of Electronics(China)2006，23，5： | 1 |
| 12 | A joint synchronization and channel estimation algorithm for MIMO-OFDM Sys- tem 显示文摘 | Gao Jingpeng Zhao Danfeng Wu Chaoqun | 2013 | Telkomnika2013，12，11： | 1 |
| 13 | Graphene anchored with mesoporous NiO nanoplates as anode material for lithium-ion batteries显示文摘 | Danfeng Qiu Zijing Xu Mingbo Zheng Bin Zhao Lijia Pan Lin Pu Yi Shi | 2012 | Journal of Solid State Electrochemistry2012，，5： | 1 |
| 14 | Improved iterative convergence method in Q-ary LDPC coded high order PR-CPM显示文摘The Q-ary low-density parity-check(LDPC) coded high order partial response continuous phase modulation(PR-CPM) with double iterative loops is investigated. This scheme shows significant improvements in power and bandwidth efficiency, but at the expense of long iterative decoding delay and computational complexity induced by the improper match between the demodulator and the decoder. To address this issue, the convergence behavior of Q-ary LDPC coded CPM is investigated for the Q=2 and Q>2 cases, and an optimized design method based on the extrinsic information transfer chart is proposed to improve the systematic iterative efficiency. Simulation results demonstrate that the proposed method can achieve a perfect tradeoff between iterative decoding delay and bit error rate performance to satisfy real-time applications. | Danfeng Zhao Yanbo Sun Rui Xue | 2016 | Journal of Systems Engineering and Electronics2016，27，3： | 0 |
| 15 | The regulatory roles of DDIT4 in TDCIPP-induced autophagy and apoptosis in PC12 cells显示文摘Tris(1,3-dichloro-2-propyl) phosphate(TDCIPP) is a commonly used organophosphatebased flame retardant and can bio-accumulate in human tissues and organs. As its structure is similar to that of neurotoxic organophosphate pesticides, the neurotoxicity of TDCIPP has raised widespread concerns. TDCIPP can increase neuronal apoptosis and induce autophagy.However, its regulatory mechanism remains unclear. In this study, we found that the expression upregulation of the DNA Damage-Inducible Transcript 4(DDIT4) protein, which might play essential roles in TDCIPP-induced neuronal autophagy and apoptosis, was observed in TDCIPP-treated differentiated rat PC12 cells. Furthermore, we determined the protective effect of the DDIT4 suppression on the autophagy and apoptosis induced by TDCIPP using Western blot(WB) and Flow cytometry(FACS) analysis. We observed that TDCIPP treatment increased the DDIT4, the autophagy marker Beclin-1, and the microtubule-associated protein light chain 3-II(LC_(3)II) expressions and decreased the mTOR phosphorylation levels. Conversely, the suppression of DDIT4 expression increased the p-mTOR expression and decreased cell autophagy and apoptosis. Collectively, our results revealed the function of DDIT4 in cell death mechanisms triggered by TDCIPP through the m TOR signaling axis in differentiated PC12 cells. Thus, this study provided vital evidence necessary to explain the mechanism of TDCIPP-induced neurotoxicity in differentiated PC12 cells. | Li Li Lingyi Xi JinWu Zunquan Zhao Youliang Chen Weili Liu Zhihui Pan Mingzhu Liu Danfeng Yang Zhaoli Chen Yanjun Fang | 2023 | Journal of Environmental Sciences2023，，3： | 0 |
| 16 | O-glycan profiling of serum glycan for potential renal cancer biomarkers显示文摘Serum was obtained from 25 male renal cell carcinoma(RCC) patients and 21 healthy males.O-glycans were released by a-elimination reaction and purified by graphitized carbon cartridge solid phase extraction,then profiled by matrix-assisted laser desorption/ionisation-time of flight mass spectrometry.After noise removal and peak alignment,1372 peaks were extracted from 200000 data points.Feature peaks were analyzed by calculation of differential sensitivity and specificity.The combination of two feature peaks was chosen as a biomarker and could clearly differentiate RCC and normal samples in our study group. | GAO Yi MA Fei ZHANG Wei ZHONG Fan TANG HaiLin XU DanFeng ZHAO Liang | 2013 | Science China(Life Sciences)2013，56，8： | 0 |
| 17 | ZmMS1/ZmLBD30-orchestrated transcriptional regulatory networks precisely control pollen exine development显示文摘Because of its significance for plant male fertility and,hence,direct impact on crop yield,pollen exine development has inspired decades of scientific inquiry.However,the molecularmechanismunderlying exine formation and thickness remains elusive.In this study,we identified that a previously unrecognized repressor,ZmMS1/ZmLBD30,controls proper pollen exine development in maize.Using an ms1 mutant with aberrantly thickened exine,we cloned a male-sterility gene,ZmMs1,which encodes a tapetum-specific lateral organ boundary domain transcription factor,ZmLBD30.Weshowed thatZmMs1/ZmLBD30 is initially turned on by a transcriptional activation cascade of ZmbHLH51-ZmMYB84-ZmMS7,and then it serves as a repressor to shut down this cascade via feedback repression to ensure timely tapetal degeneration and proper level of exine.This activation-feedback repression loop regulating male fertility is conserved in maize and sorghum,and similar regulatory mechanism may also exist in other flowering plants such as rice and Arabidopsis.Collectively,these findings reveal a novel regulatory mechanism of pollen exine development by which a long-sought master repressor of upstream activators prevents excessive exine formation. | Quancan Hou Xueli An Biao Ma Suowei Wu Xun Wei Tingwei Yan Yan Zhou Taotao Zhu Ke Xie Danfeng Zhang Ziwen Li Lina Zhao Canfang Niu Yan Long Chang Liu WeiZhao FeiNi Jinping Li Daolin Fu Zhong-NanYang Xiangyuan Wan | 2023 | Molecular Plant2023，16，8： | 0 |
| 18 | Optimized Content-Aware Image Resizing with Merging and Improved Importance Diffusion显示文摘A simple and effective content-aware image resizing method is proposed based on the row / column merging and improved importance diffusion,which preserves the important regions in an image as well as the global visual effect. By repeatedly merging two rows / columns into one row / column or inserting a new row /column between two rows / columns, this method realizes image-resolution reduction and expansion. The importance of the merged row / column is promoted and diffused to four rows / columns around the merged one,which is to avoid the unwanted image distortions resulted from excessively merging of un-important regions. In addition,the proposed method introduces the direction of gradient vector in the low-pass filter to reduce the interference caused by complex texture background and protect important content better. Furthermore,according to human mechanics principles,different weights are given to the row and column direction components of gradient vectors which can obtain better global visual effect. Experimented results show that the proposed method satisfied in not only visual effect but also objective evaluation. | Danfeng Zhao Bo Wang | 2015 | Journal of Harbin Institute of Technology(New Series)2015，22，2： | 0 |
| 19 | Design of Raptor Design of Raptor-Like Rate Compatible SC Like Rate Compatible SC-LDPC Codes显示文摘This paper proposes a family of raptor-like rate-compatible spatially coupled low-density parity-check(RL-RC-SC-LDPC)codes from RL-RC-LDPC block codes.There are two important keys.One is the performance of the base matrix.RL-LDPC codes have been adopted in the technical specification of 5G new radio(5G-NR).We use the 5G NR LDPC code as the base matrix.The other is the edge coupling design.In this regard,we have designed a rate-compatible coupling algorithm,which can improve performance under multiple code rates.The constructed RL-RC-SC-LDPC code property requires a large coupling length L and thus we improved the reciprocal channel approximation(RCA)algorithm and proposed a sliding window RCA algorithm.It can provide lower com-plexity and latency than RCA algorithm.The code family shows improved thresholds close to the Shannon limit and finite-length performance compared with 5G NR LDPC codes for the additive white Gaussian noise(AWGN)channel. | SHI Xiangyi HAN Tongzhou TIAN Hai ZHAO Danfeng | 2022 | ZTE Communications2022，20，S01： | 0 |
| 20 | APPLICATION OF TURBO CODES IN HIGH-SPEED REAL-TIME CHANNEL显示文摘The time delay of Turbo codes due to its iterative decoding is the main bottleneck of its application in real-time channel. However, the time delay can be greatly shortened through the adoption of parallel decod-ing algorithm, dividing the received bits into several sub-blocks and processing in parallel. This letter mainly discusses the applicability of turbo codes in high-speed real-time channel through the study of a parallel turbo decoding algorithm based on 3GPP-proposed turbo encoder and interleaver in various channel. Simulation re-sult shows that, by choosing an appropriate sub-block length, the time delay can be obviously shortened with-out degrading the performance and increasing hardware complexity, and furthermore indicates the applicability of Turbo codes in high-speed real-time channel. | Zhao Danfeng Yue Li Yang Jianhua | 2006 | Journal of Electronics(China)2006，23，4： | 0 |
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