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| 1 | Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, ameliorates hepatic fibrosis in rats with type 2 diabetes显示文摘 | Zhou Hong Fang Caixia Zhang Lihui Deng Yonggui Wang Mian Meng Fengling | 2014 | Chinese Medical Journal2014，，2： | 20 |
| 2 | Chaiqinchengqi decoction regulates necrosis-apoptosis via regulating the release of mitochondrial cytochrome c and caspase-3 in rats with acute necrotizing pancreatitis显示文摘OBJECTIVE: To explore the effect and the mechanism of Chaiqinchengqi decoction(CQCQD) on the apoptosis-necrosis switch of pancreatic acinar cells in acute necrotizing pancreatitis(ANP) in rats.METHODS: Sixty Sprague-Dawley rats were randomized into the control group, the ANP group and the CQCQD group. The acute pancreatitis(AP)model was induced by intraperitoneal injections of4 g/kg 8% L-Arginine(PH 7.0) twice with a 1 h interval. Rats in the CQCQD group were intragastrically administered CQCQD(20 mL/kg every 2 h, 3 times,then 20 mL/kg every 6 h, 3 times). Rats were killed at the 6 and 24 h after the induction of AP.The pancreatic tissues were collected for pathology and to isolate pancreatic acinar cells and mitochondria.RESULTS: CQCQD significantly ameliorated the severity of ANP by reducing the pancreatic histopathology score, indicated by lactate dehydrogenase levels at the 6 and 24 h. The CQCQD group promoted the apoptosis of pancreatic acinar cells by raising the apoptosis index compared with the ANP group and the control group. Mitochondrial cytochrome c at the 6 and 24 h in the ANP group were lower than that in the control group or the CQCQD group(0.67±0.13 vs 1.54±0.03 vs 0.81±0.09; 0.71±0.08 vs 1.55±0.09 vs 0.89±0.16, P<0.01). The cytochrome c levels in the cytoplasm at the 6 and 2 h in the CQCQD group were higher than in the control group(1.36±0.15 vs 0.67±0.04, 1.46±0.08 vs 0.59±0.09, P<0.01), or the ANP group(0.96±0.13, P>0.05;0.97±0.09, P<0.05). CQCQD increased caspase-3 activity over the ANP group at the 6 h.CONCLUSION: CQCQD can induce apoptosis and relieve the necrosis of pancreatic acinar cells via promoting the release of mitochondrial cytochrome c and increasing pancreatic caspase-3 activity in ANP rats. | Ziqi Lin Jia Guo Ping Xue Lei Huang Lihui Deng Xiaonan Yang Qing Xia | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 10 |
| 3 | Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients显示文摘Dear Editor,In 2019,a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was identified as the causative agent of Coronavirus Disease 2019(COVID-19).As of 8 June 2020,the World Health Organization(WHO)has reported 6,912,751 globally confirmed cases with 400,469 deaths.Although generally causes mild disease,SARS-CoV-2 infection can result in serious outcomes,including acute lung injury(ALI)and acute respiratory distress syndrome(ARDS),the leading cause of mortality in patients with comorbidities.Recent autopsy studies of COVID-19 patients revealed mononuclear infiltration and excessive production of mucus in the infected lung,especially in the damaged small airways and alveoli(Bian and Team,2020;Liu et al.,2020). | Jiangping He Shuijiang Cai Huijian Feng Baomei Cai Lihui Lin Yuanbang Mai Yinqiang Fan Airu Zhu Huang Huang Junjie Shi Dingxin Li' Yuanjie Wei Yueping Li Yingying Zhao’ Yuejun Pan He Liu Xiaoneng Mo Xi He Shangtao Cao FengYu Hu Jincun Zhao Jie Wang Nanshan Zhong Xinwen Chen Xilong Deng Jiekai Chen | 2020 | Protein & Cell2020，11，9： | 7 |
| 4 | Microstructures and Mechanical Properties of Nb-Ti Bearing Hot-rolled TRIP Steels显示文摘有高粘性和保留的奥氏体的适当体积百分比的 Nb-Ti 热转动的帮助旅行的钢在实验基于好铁酸盐谷物被开发了。测试,结果证明铌趋于与更少的 降水,和铌钛在矩阵处于答案状态存在能被猛抛处于良好的竟技状态( Nb , Ti ) C 或( Nb , Ti )( C , N ),它在增加收益力量起一个重要作用(从 495 MPa 到 610 MPa )。而且,保留的奥氏体在在张力的变丑期间由转变改进粘性进马氏体上有积极效果。 | Yu CHEN Guoyi TANG Haoyang TIAN Feipeng LI Yu ZHANG Lihui WANG Zhaojun DENG Dexing LUO | 2006 | Journal of Materials Science & Technology2006，22，6： | 2 |
| 5 | Career adaptability, job search self-efficacy and outcomes: A three-wave investigation among Chinese university graduates显示文摘 | Yanjun Guan Hong Deng Jiaqing Sun Yanan Wang Zijun Cai Lihui Ye Ruchunyi Fu Yang Wang Shu Zhang Yuhui Li | 2013 | Journal of Vocational Behavior2013，，3： | 1 |
| 6 | Influence of cryogenic treatment on microstructure and evaluation by internal friction of a tool steel显示文摘 | Li Shaohong Deng Lihui Wu Xiaochun | 2010 | Cryogenics2010，50，12： | 1 |
| 7 | Influence of deep cryogenic treatment on microstructure and evaluation by internal friction of a tool steel显示文摘 | Shaohong Li Lihui Deng Xiaochun Wu Yong’an Min Hongbin Wang | 2010 | Cryogenics2010，，11： | 1 |
| 8 | The mechanism investigation of deep cryogenic treatment on high alloy martensitic steel by low frequency internal friction 显示文摘 | Shaohong Li Lihui Deng XiaochunWu | 2010 | Cryogenics2010，50，8： | 1 |
| 9 | Influence of deep cryogenic treatment on mierostructure and evaluation by internal friction behavior of a tool steel显示文摘 | Shaohong Li Lihui Deng Xiaochun Wu | 2010 | Cryogenics2010，50，1112： | 1 |
| 10 | Synthesis and luminescence properties of glass ceramics containing MSiO 3 :Eu 2+ (M=Ca, Sr, Ba) phosphors for white LED显示文摘 | Zhiguang Cui Guohua Jia Degang Deng Youjie Hua Shilong Zhao Lihui Huang Huanping Wang Hongping Ma Shiqing Xu | 2011 | Journal of Luminescence2011，，1： | 1 |
| 11 | Luminescence properties and energy transfer of Eu/Tb ions codoped aluminoborosilicate glasses显示文摘 | Shilong Zhao Fengxia Xin Shiqing Xu Degang Deng Lihui Huang Huanping Wang Youjie Hua | 2010 | Journal of Non-Crystalline Solids2010，，11： | 1 |
| 12 | Structure and luminescence properties of Eu/Tb codoped oxyfluoride glass ceramics containing Sr 2 GdF 7 nanocrystals显示文摘 | Fengxia Xin Shilong Zhao Shiqing Xu Lihui Huang Guohua Jia Degang Deng Huanping Wang | 2011 | Optical Materials2011，，1： | 1 |
| 13 | Overexpression of estrogen receptor beta alleviates the toxic effects of beta-amyloid protein on PC12 cells via non-hormonal ligands显示文摘After binding to the estrogen receptor, estrogen can alleviate the toxic effects of beta-amyloid protein, and thereby exert a therapeutic effect on Alzheimer's disease patients. Estrogen can increase the incidence of breast carcinoma and endometrial cancer in post-menopausal women, so it is not suitable for clinical treatment of Alzheimer's disease. There is recent evidence that the estrogen receptor can exert its neuroprotective effects without estrogen dependence. Real-time quantitative PCR and flow cytometry results showed that, compared with non-transfected PC12 cells, adenovirus-mediated estrogen receptor β gene-transfected PC12 cells exhibited lower expression of tumor necrosis factor α and interleukin 1β under stimulation with beta-amyloid protein and stronger protection from apoptosis. The Akt-specific inhibitor Abi-2 decreased the anti-inflammatory and anti-apoptotic effects of estrogen receptor β gene-transfection. These findings suggest that overexpression of estrogen receptor β can alleviate the toxic effect of beta-amyloid protein on PC12 cells, without estrogen dependence. The Akt pathway is one of the potential means for the anti-inflammatory and anti-apoptotic effects of the estrogen receptor. | Hui Wang Lihui Si Xiaoxi Li Weiguo Deng Haimiao Yang Yuyan Yang Yan Fu | 2012 | Neural Regeneration Research2012，7，14： | 1 |
| 14 | Energy transfer and 2 μm emission in Tm^(3+)/Ho^(3+) co-doped(Y_(0.87)La_(0.1)Zr_(0.03))_2O_3 nanopowders显示文摘(Y_(0.87)La_(0.1)Zr_(0.03))_2O_3 nanopowders doped with various concentrations of Tm^(3+) and Ho^(3+) were prepared by the citrate method. The standard cubic Y_2O_3 phase can be matched in the Tm^(3+)/Ho^(3+) co-doped(Y_(0.87)La_(0.1)Zr_(0.03))_2 O_3 nanopowders. The nanopowders exhibit average particle sizes of 40,60, 80 and 100 nm after calcinated at 900,1000,1100 and 1200℃,respectively. The energy transfer from Tm^(3+) to Ho^(3+) and the optimum fluorescence emission around 2 μm were investigated. Results indicate that the emission bands at around 1.86 and 1.95 μm correspond to ~3 F_4→~3 H_6 transition of Tm^(3+) and ~5 I_7→~5 I_8 transition of Ho^(3+), respectively.Better spectral properties were achieved in Tm^(3+)/Ho^(3+) co-doped(Y_(0.87)La_(0.1)Zr_(0.03))_2O_3 nanopowders with the average size of 100 nm obtained at the conditions of the treatment of precursors calcinated at 1200 ℃ for 2 h doped with 1.5 mol% Tm^(3+) and 1 mol% Ho^(3+). | Yaqian Chen Huanping Wang Xiaoting Zhang Zhen Xiao Qinghua Yang Ruoshan Lei Degang Deng Lihui Huang Shiqing Xu | 2018 | Journal of Rare Earths2018，36，5： | 1 |
| 15 | Water flooding flowing area identification for oil reservoirs based on the method of streamline clustering artificial intelligence显示文摘For the case of carbonate reservoir water flooding development, the flow field identification method based on streamline modeling result was proposed. The Ocean for Petrel platform was used to build the plug-in that exported the streamline data, and the subsequent data was processed and clustered through Python programming, to display the flow field with different water flooding efficiencies at different time in the reservoir. We used density peak clustering as primary streamline cluster algorithm, and Silhouette algorithm as the cluster validation algorithm to select reasonable cluster number, and the results of different clustering algorithms were compared. The results showed that the density peak clustering algorithm could provide better identified capacity and higher Silhouette coefficient than K-means, hierachical clustering and spectral clustering algorithms when clustering coefficients are the same. Based on the results of streamline clustering method, the reservoir engineers can easily identify the flow area with quantification treatment, the inefficient water injection channels and area with developing potential in reservoirs can be identified. Meanwhile, streamlines between the same injector and producer can be subdivided to describe driving capacity distribution in water phase, providing useful information for the decision making of water flooding optimization, well pattern adjustment and deep profile modification. | JIA Hu DENG Lihui | 2018 | Petroleum Exploration and Development2018，45，2： | 0 |
| 16 | Side-chain fluorination on the pyrido[3,4-b]pyrazine unit towards efficient photovoltaic polymers显示文摘A series of new polymer donors (PT-PP, PT-2fPP and PT-4fPP) were synthesized based on alkylthiophene substituted benzodithiophene (BDT-T) and pyrido[3,4-b]pyrazine (PP) building blocks and the effects of fluorination on the polymer properties were explored. Photophysical properties, charge mobilities and morphologies of the three polymers have been intensively investigated. The results indicated that the introduction of the fluorine atom at meta-positions of phenyl substituted PP unit hardly affected their highest occupied molecular orbital (HOMO) level. More importantly, controlling the degree of side-chain fluorination in the polymers is crucial for optimizing the blend morphology. Three polymers showed different photovoltaic properties. The polymer solar cell (PSC) based on the single layer device structure of ITO/PEDOT:PSS/PT-4fPP:PC71BM (1:1, w:w)/ZrAcac/Al demonstrates a high power conversion efficiency (PCE) of 7.61% under the illumination of AM 1.5G,100 mW cm-2, which is the highest value for PP-based PSCs. | Tao Wang Liuliu Feng Jun Yuan Lihui Jiang Wei Deng Zhi-Guo Zhang Yongfang Li Yingping Zou | 2018 | Science China Chemistry2018，61，2： | 0 |
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