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| 1 | A de novo Genome of a Chinese Radish Cultivar显示文摘Here, we report a high-quality draft genome of a Chinese radish(Raphanus sativus) cultivar. This draft contains 387.73 Mb of assembled scaffolds, 83.93% of the scaffolds were anchored onto nine pseudochromosomes and 95.09% of 43 240 protein-coding genes were functionally annotated. 184.75 Mb(47.65%) of repeat sequences was identified in the assembled genome. By comparative analyses of the radish genome against 10 other plant genomes, 2 275 genes in 780 gene families were found unique to R. sativus. This genome is a good reference for genomic study and of great value for genetic improvement of radish. | ZHANG Xiaohui YUE Zhen MEI Shiyong QIU Yang YANG Xinhua CHEN Xiaohua CHENG Feng WU Zhangyan SUN Yuyan JING Yi LIU Bo SHEN Di WANG Haiping CUI Na DUAN Yundan WU Jian WANG Jinglei GAN Caixia WANG Jun WANG Xiaowu LI Xixiang | 2015 | Horticultural Plant Journal2015，1，3： | 10 |
| 2 | SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells显示文摘Intercellular adhesion molecule-1 (ICAM-1) plays an important role in the recruitment of leukocytes to the endothelium, which causes inflammation and initiation of atherosclerosis. We have previously shown that endothelium-specific over-expression of class III deacetylase SIRT1 decreases atherosclerosis. We therefore addressed the hypothesis that SIRT1 suppresses ICAM-1 expression in the endothelial cells. Here, we found that expression of SIRT1 and ICAM-1 was significantly induced by PMA and ionomycin (PMA/Io) in human umbilical vein endothelial cells (HUVECs). Adenovirus-mediated over-expression of SIRT1 significantly inhibited PMA/Io-induced ICAM-1 expression in HUVECs. Knockdown of SIRT1 by RNA interference (RNAi) resulted in increased expression of ICAM-1 in HUVECs. Luciferase report assay showed that over-expression of SIRT1 suppressed ICAM-1 promoter activity both in basic and in PMA/Io-induced conditions. We further found that SIRT1 was involved in transcription complex binding on the ICAM-1 promoter by chromatin immunoprecipitation (ChIP) assays. Furthermore, SIRT1 RNAi increased NF-κB p65 binding ability to the ICAM-1 promoter by ChIP assays. Overall, these data suggests that SIRT1 inhibits ICAM-1 expression in endothelial cells, which may contribute to its anti-atherosclerosis effect. | JIA YuYan GAO Peng CHEN HouZao WAN YanZhen ZHANG Ran ZHANG ZhuQin YANG RuiFeng WANG Xu XU Jing LIU DePei | 2013 | Science China(Life Sciences)2013，56，1： | 9 |
| 3 | Research of optical rainfall sensor based on CCD linear array显示文摘Rainfall monitoring is one of the most important meteorological observation elements for the disaster weather. The maintenance of current tipping bucket rain gauge and weighing type rain gauge is a critical issue. The optical rainfall sensor based on CCD linear array is mainly studied in this paper. Because of the maintenance-free time and good adaptability,it can be widely used in the automatic rainfall monitoring in severe environment and have a good perspective in using. | YANG Bifeng LIU Yuyan LU Ying WU Shangqian | 2015 | Instrumentation2015，2，3： | 9 |
| 4 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 5 | Differences of Hydrocarbon Enrichment between the Upper and the Lower Structural Layers in the Tazhong Paleouplift显示文摘Tazhong paleouplift 被划分成上面并且更低的结构的层,在奥陶纪碳酸盐岩石的顶由不顺从表面跳了。在从不同部分的二层的水库在数字变化,类型和储备,而是机制以前很少被研究。因此,机制的解释将在 Tazhong paleouplift 支持石油探索。在学习进化和 Tazhong paleouplift 的水库分发以后,在晚古苏格兰的、迟了的 Hercynian 和喜玛拉雅的时期的进化导致了,这被结束上面并且更低的结构的层。这也被定义在上面的结构的层,结构并且, stratigraphic 重叠水库为更低的结构的层在顶和 paleouplift 的上面的部分被开发,它被油水库统治, lithological 水库在 paleouplift 的更低的部分被开发,它被煤气的水库,和更多统治储备在更低的结构的层被发现比上面。通过累积条件的比较分析上面并且更低的结构的层,丰富差别的机制清楚地被解释。更低的结构的层的水库和封口条件比上面的层的那些好,它是更多的水库在前者被发现了的原因。在搬运人系统类型,陷井类型和收费时期在之间的差别上面并且更低的结构的层在水库类型和分布导致差别。一个累积模型为 Tazhong paleouplift 被建立。为上面的结构的层,,结构的水库和 stratigraphic 重叠水库为更低的结构的层在 paleouplift 的上面的部分被形成,捱过的外壳水库在顶被形成,礁石公寓水库在侧面的边缘上被形成,石灰岩地区常见的地形和里面水库在 paleouplift 的更低的部分被形成。 | JIANG Zhenxue YANG Haijun LI Zhuo PANG Xiongqi HAN Jianfa LI Dongxu HUANG Yuyan | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 7 |
| 6 | Discussion on Validity of Rana maoershanensis Based on Partial Sequence of 16S rRNA Gene显示文摘Rana maoershanensis found in Mt.Maoershan in Guangxi,China was reported as a new species in 2007,but there was no molecular data for this frog.The partial sequences(543 bp) of 16S rRNA gene from 12 specimens of 3 brown frog species(Rana hanluica,R.maoershanensis and R.chensinensis) were analyzed with 17 specimens of 9 species from GenBank.The nucleotide sequence divergence between R.maoershanensis and the other brown frog species were 4.5%-6.5%,with 22-30 nucleotide substitutions at this locus.The phylogenetic relationships based on MP,ML,and Bayesian inference indicate that the brown frogs from Southern China were diverged into three groups(Clades A,B and C).R.maoershanensis was clustered together a well-supported subclade(B-1).It is suggested that R.maoershanensis is a valid species. | YANG Baotian LU Yuyan LI Pipeng | 2010 | Asian Herpetological Research2010，1，2： | 5 |
| 7 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 8 | Completing China's Interest Rate Liberalization显示文摘 | Yuyan Tan Yang Ji Yiping Huang | 2016 | China & World Economy2016，24，2： | 4 |
| 9 | Survival difference between EGFR Del19 and L858R mutant advanced non-small cell lung cancer patients receiving gefitinib:a propensity score matching analysis显示文摘Objective: Although superior clinical benefits of epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors(TKIs) in the treatment of advanced non-small-cell lung cancer(NSCLC) had been reported,the survival difference between exon 19 deletion(Del19) and exon 21 Leu858 Arg substitution(L858 R) remains controversial.The purpose of this study is to investigate the differences in progression-free survival(PFS) and overall survival(OS) between different EGFR mutant subtypes among advanced NSCLC patients receiving gefitinib.Methods: There were 204 advanced NSCLC patients with EGFR mutations treated with gefitinib were enrolled in this retrospective cohort study.Patients were divided into the EGFR Del19 group and the L858 R mutated group according to their mutant subtype.Propensity score matching(PSM) was conducted by using a nearest-neighbor algorithm(1:1) to adjust for demographical and clinical covariates.Survival curves were constructed with the Kaplan-Meier method and compared by using the log-rank test.Results: The PFS in Del19 group was similar to that in the L858 R group [before PSM 8.6 vs.7.2 months,P=0.072; after PSM 7.3 vs.7.2 months,P=0.155].No differences were detected in OS between the L858 R and the Del19 group(before PSM 17.8 vs.13.1 months,P=0.253; after PSM 16.9 vs.13.1 months,P=0.339).The Del19 group was significantly younger compared with the L858 R mutation group in age(P=0.015).Conclusions: No significant difference was found in the PFS or OS between the Del19 and L858 R mutant NSCLC patients receiving gefitinib.The age gap might contribute to the survival differences between Del19 and L858 R groups.PSM is of important value to the elimination of potential bias. | Minglei Zhuo Qiwen Zheng Jun Zhao Meina Wu Tongtong An Yuyan Wang Jianjie Li Shuhang Wang Jia Zhong Xue Yang Hanxiao Chen Bo Jia Zhi Dong Emei Gao JingjingWang Ziping Wang | 2017 | Chinese Journal of Cancer Research2017，29，6： | 4 |
| 10 | Pan-genome of Raphanus highlights genetic variation and introgression among domesticated,wild,and weedy radishes显示文摘Post-polyploid diploidization associated with descending dysploidy and interspecific introgression drives plant genome evolution by unclear mechanisms.Raphanus is an economically and ecologically important Brassiceae genus and model system for studying post-polyploidization genome evolution and introgres-sion.Here,we report the de novo sequence assemblies for 11 genomes covering most of the typical sub-species and varieties of domesticated,wild and weedy radishes from East Asia,South Asia,Europe,and America.Divergence among the species,sub-species,and South/East Asian types coincided with Quaternary glaciations.A genus-level pan-genome was constructed with family-based,locus-based,and graph-based methods,and whole-genome comparisons revealed genetic variations ranging from single-nucleotide polymorphisms(SNPs)to inversions and translocations of whole ancestral karyotype(AK)blocks.Extensive gene flow occurred between wild,weedy,and domesticated radishes.High fre-quencies of genome reshuffling,biased retention,and large-fragment translocation have shaped the genomic diversity.Most variety-specific gene-rich blocks showed large structural variations.Extensive translocation and tandem duplication of dispensable genes were revealed in two large rearrangement-rich islands.Disease resistance genes mostly resided on specific and dispensable loci.Variations causing the loss of function of enzymes modulating gibberellin deactivation were identified and could play an important role in phenotype divergence and adaptive evolution.This study provides new insights into the genomic evolution underlying post-polyploid diploidization and lays the foundation for genetic improve-ment of radish crops,biological control of weeds,and protection of wild species'germplasms. | Xiaohui Zhang Tongjin Liu Jinglei Wang Peng Wang Yang Qiu Wei Zhao Shuai Pang Xiaoman Li Haiping Wang Jiangping Song Wenlin Zhang Wenlong Yang Yuyan Sun Xixiang Li | 2021 | Molecular Plant2021，14，12： | 3 |
| 11 | Intra-abdominal aortic balloon occlusion in the management of placenta percreta显示文摘Background:Massive bleeding is the main concern for the management of placenta percreta(PP).Intra-abdominal aortic balloon occlusion(IABO)is one method for pelvic devascularization,but the efficacy of IABO is uncertain.This study aims to investigate the outcomes of IABO in PP patients.Methods:We retrospectively reviewed the clinical data of PP cases from six tertiary centers in China between January 2011 and December 2015.PP cases with/without the use of IABO were analyzed.Propensity score matching analysis was performed to reduce the effect of selection bias.Postpartum hemorrhage(PPH)and the rate of hysterectomy,as well as neonatal outcomes,were analyzed.Results:One hundred and thirty-two matched pairs of patients were included in the final analysis.Compared with the control group,maternal outcomes,including PPH(68.9%vs.87.9%,χ^(2)=13.984,P<0.001),hysterectomy(8.3%vs.65.2%,χ^(2)=91.672,P<0.001),and repeated surgery(1.5%vs.12.1%,χ^(2)=11.686,P=0.001)were significantly reduced in the IABO group.For neonatal outcomes,Apgar scores at 1 minute(8.67±1.79vs.8.53±1.68,t=-0.638,P=0.947)and 5 minutes(9.43±1.55vs.9.53±1.26,t=0.566,P=0.293)were not significantly different between the two groups.Conclusions:IABO can significantly reduce blood loss,hysterectomies,and repeated surgeries.This procedure has not shown harmful effects on neonatal outcomes. | Weiran Zheng Ruochong Dou Jie Yan Xinrui Yang Xianlan Zhao Dunjin Chen Yuyan Ma Weishe Zhang Yiling Ding Ling Fan Huixia Yang | 2022 | Chinese Medical Journal2022，，4： | 2 |
| 12 | Phosphorylation of a wheat aquaporin at two sites enhances both plant growth and defense显示文摘Eukaryotic aquaporins share the characteristic of functional multiplicity in transporting distinct substrates and regulating various processes,but the underlying molecular basis for this is largely unknown.Here,we report that the wheat(Triticum aestivum)aquaporin TaPIP2;10 undergoes phosphorylation to promote photosynthesis and productivity and to confer innate immunity against pathogens and a generalist aphid pest.In response to elevated atmospheric CO_(2)concentrations,TaPIP2;10 is phosphorylated at the serine residue S280 and thereafter transports CO_(2)into wheat cells,resulting in enhanced photosynthesis and increased grain yield.In response to apoplastic H_(2)O_(2) induced by pathogen or insect attacks,TaPIP2;10 is phosphorylated at S121 and this phosphorylated form transports H_(2)O_(2) into the cytoplasm,where H_(2)O_(2)intensifies host defenses,restricting further attacks.Wheat resistance and grain yield could be simultaneously increased by TaPIP2;10 overexpression or by expressing a TaPIP2;10 phosphomimic with aspartic acid substitutions at S121 and S280,thereby improving both crop productivity and immunity. | Kai Lu Xiaochen Chen Xiaohui Yao Yuyan An Xuan Wang Lina Qin Xiaoxu Li Zuodong Wang Shuo Liu Zhimao Sun Liyuan Zhang Lei Chen Baoyan Li Baoyou Liu Weiyang Wang Xinhua Ding Yonghua Yang Meixiang Zhang Shenshen Zou Hansong Dong | 2022 | Molecular Plant2022，15，11： | 2 |
| 13 | Microstructure and magnetic fabric in the Shuanghe pluton:A synkinematic granite in Eastern Dabie Mountains,China显示文摘Strain analyses for the Shuanghe pluton show that the main strain planes suffered distinct deformation. The main strain value (XZ) is up to 1.59—2.18, and the value of Flinn index (K) ranges from 0.11 to 0.82. Anisotropy of magnetic susceptibility (AMS) measurements reveal that the orientations of the magnetic foliation and lineation gently dip SE, consistent with the macroscopic foliation of the pluton. The value of anisotropy degree (P) ranges from 1.109 to 1.639, and the shape parameter (T) from 0.079 to 0.534. These studies prove that the pluton was deformed under strong compression. Quartz c-axis textures, defined by monoclinic or triclinic asymmetry, usually developed the high maxima paralleling the b-axis, which is defined by the prismatic slip (1010)der the high temperature. These fabrics are quite different from those developed in the high-ultrahigh pressure rocks (UHP) which were captured in the pluton or country rocks. It is concluded that the Shuanghe pluton emplaced under regional compression slightly after the formation of UHP, and it is characterized by synkinematic granitic deformation. | YANG Kunguang LIU Qiang LIU Yuyan MA Changqian XU Yajun YANG Kuifeng | 2004 | Science China Earth Sciences2004，47，10： | 2 |
| 14 | Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes显示文摘Dear Editor,Obesity is caused by an imbalance between energy intake and expenditure,and has become a global epidemic with over 650 million adults affected.Adipose tissues in mammals are composed of white adipose tissue(WAT)and classical brown adipose tissue(BAT),and their balance is highly related to the occurrence of obesity.The browning of white adipocytes results in“beige”or“brite”adipocytes,which appear functionally similar to classical brown adipocytes,and can be detected in WAT deposits of animals that have been exposed to cold or other inducers(Fu et al.,2015). | Zhaomeng Cui Yang Liu Wei Wan Yuyan Xu Yehui Hu Meng Ding Xin Dou Ruina Wang Hailing Li Yongmei Meng Wei Li Wei Jiang Zengxia Li Yiming Li Minjia Tan Dengke KMa Yu Ding Jun OLiu Cheng Luo Biao Yu Qiqun Tang Yongjun Dang | 2021 | Protein & Cell2021，12，6： | 1 |
| 15 | Constructions of Balanced Quaternary Sequences显示文摘Binary and quaternary sequences have received a lot of attention since they are easy to be implemented as multiple-access sequence in practical communication systems,radar,and cryptography.In this paper,the two complete binary sequence of period N are analyzed.For odd prime N,new balanced quaternaruy sequences of even period 2 N are constructed using Gary mapping.Furthermore,we computer the complete autocorrelation distributions of this sequence. | WANG Jingjing ZHAO Min YANG Zhiyao GUO Yuyan ZHUO Zepeng | 2020 | Chinese Journal of Electronics2020，29，3： | 1 |
| 16 | Dielectric strength of laminated paper and polymer materials under aging and tensile stress at 77K显示文摘 | Yang Xin Li Weiguo Guo Yuyan | 2013 | IEEE Transaction on Applied Superconductivity2013，23，1： | 1 |
| 17 | PIK3CA mutation in Chinese patients with lung squamous cell carcinoma显示文摘Objective: To investigate PIK3CA mutation in Chinese patients with lung squamous cell carcinoma (LSCC) and explore their relationship with clinicopathological profiles. Methods: Tumor samples from 123 cases of LSCC were included in this study. PIK3CA mutations in exon 9 and 20 were screened by pyrosequencing and confirmed by clone sequencing or amplification refractory mutation system (ARMS). Denaturing performance liquid chromatography (DHPLC) was employed for evaluation of EGFR mutation in exon 19, 21 and KRAS mutation. Results: PIK3CA mutations were found in 3 (2.4%) patients. The mutation type included E545K, E452Q and H1047R. Of these three patients, one coupled with EGFR mutation, and the other two coupled with PIK3CA amplification. All the three patients shared the same clinicopathologic characteristics: male, less than 60 years old, had smoke history, stage III and carried wild-type KRAS. Conclusions: The frequency of PIK3CA mutation is low in Chinese patients with LSCC. The mutational status of PIK3CA is not mutually exclusive to EGFR mutation. | Jinglin Yu Hua Bai Zhijie Wang Zhigang Wei Xiaosheng Ding Jianchun Duan Lu Yang Meina Wu Yuyan Wang Jie Wang | 2013 | Chinese Journal of Cancer Research2013，25，4： | 1 |
| 18 | Colitis-accelerated colorectal cancer and metabolic dysregulation in a mouse model显示文摘 | Yuyan Gao Xin Li Ming Yang Qi Zhao Xiaolong Liu Guangyu Wang Xiaolin Lu Qi Wu Jin Wu Yanmei Yang Yue Yang Yanqiao Zhang | 2013 | Carcinogenesis2013，，8： | 1 |
| 19 | Plasma vaspin concentrations are decreased in acute coronary syndrome, but unchanged in patients without coronary lesions显示文摘 | Baowei Zhang Wenhui Peng Hailing Li Yuyan Lu Jianhui Zhuang Ke Wang Yang Su Yawei Xu | 2013 | Clinical Biochemistry2013，，： | 1 |
| 20 | Synergistic protective effect of astragaloside IV – tetramethylpyrazine against cerebral ischemic-reperfusion injury induced by transient focal ischemia显示文摘 | Jiehong Yang Jinhui Li Jing Lu Yuyan Zhang Zhenhong Zhu Haitong Wan | 2011 | Journal of Ethnopharmacology2011，，1： | 1 |
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