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| 1 | A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer显示文摘The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety of cancers, the efficacy of immune checkpoint inhibitors is still low in colorectal cancer(CRC). This is mainly due to the immunosuppressive feature of the tumor microenvironment(TME). Emerging evidence reveals that certain chemotherapeutic drugs induce immunogenic cell death(ICD), demonstrating great potential for remodeling the immunosuppressive TME. In this study, the potential of ginsenoside Rg3(Rg3) as an ICD inducer against CRC cells was confirmed using in vitro and in vivo experimental approaches. The ICD efficacy of Rg3 could be significantly enhanced by quercetin(QTN) that elicited reactive oxygen species(ROS). To amelioratein vivo delivery barriers associated with chemotherapeutic drugs, a folate(FA)-targeted polyethylene glycol(PEG)-modified amphiphilic cyclodextrin nanoparticle(NP) was developed for co-encapsulation of Rg3 and QTN. The resultant nanoformulation(CD-PEG-FA.Rg3.QTN) significantly prolonged blood circulation and enhanced tumor targeting in an orthotopic CRC mouse model, resulting in the conversion of immunosuppressive TME. Furthermore, the CD-PEG-FA.Rg3.QTN achieved significantly longer survival of animals in combination with Anti-PD-L1. The study provides a promising strategy for the treatment of CRC. | Dandan Sun Yifang Zou Liu Song Shulan Han Hao Yang Di Chu Yun Dai Jie Ma Caitriona M.O’Driscoll Zhuo Yu Jianfeng Guo | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 2 | Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblasti显示文摘B-cell precursor acute lymphoblastic leukemia(BCP-ALL)is characterized by genetic alterations with high heterogeneity.Precise subtypes with distinct genomic and/or gene expression patterns have been recently revealed using high-throughput sequencing technology.Most of these profiles are associated with recurrent non-overlapping rearrangements or hotspot point mutations that are analogous to the established subtypes,such as DUX4 rearrangements,MEF2D rearrangements,ZNF384/ZNF362 rearrangements,NUTM1 rearrangements,BCL2/MYC and/or BCL6 rearrangements,ETV6-RUNX1-like gene expression,PAX5alt(diverse PAX5 alterations,including rearrangements,intragenic amplifications,or mutations),and hotspot mutations PAX5(p.Pro80Arg)with biallelic PAX5 alterations,IKZF1(p.Asn159Tyr),and ZEB2(p.His1038Arg).These molecular subtypes could be classified by gene expression patterns with RNA-seq technology.Refined molecular classification greatly improved the treatment strategy.Multiagent therapy regimens,including target inhibitors(e.g.,imatinib),immunomodulators,monoclonal antibodies,and chimeric antigen receptor T-cell(CAR-T)therapy,are transforming the clinical practice from chemotherapy drugs to personalized medicine in the field of risk-directed disease management.We provide an update on our knowledge of emerging molecular subtypes and therapeutic targets in BCP-ALL. | Jianfeng Li Yuting Dai Liang Wu Ming Zhang Wen Ouyang Jinyan Huang Saijuan Chen | 2021 | Frontiers of Medicine2021，15，3： | 6 |
| 3 | 溃疡性结肠炎内镜下严重度指数(UCEIS评分)与Mayo内镜评分(MES)用于预测急性重症结肠炎患者行肠切除术的比较研究显示文摘背景溃疡性结肠炎内镜下严重度指数(UCEIS)和Mayo内镜评分(MES)都是溃疡性结肠炎(UC)内镜下严重程度的客观评估方法,然而,对于这两种评分方法能否用于筛选出需要行结肠切除术的急性重症结肠炎患者,目前仍不明了。方法:对2012年1月至2016年5月间连续收治的ASC患者进行回顾性分析。提取并分析入组患者的人口统计资料、既往治疗史、疾病特征资料、实验室指标、药物治疗及内镜评估等资料。主要结局指标是住院和随访期间需行结肠切除术的患者比例。结果:92例患者纳入研究,其中37例(40.2%)需行结肠切除术。多因素分析显示,UCEIS评分是需行结肠切除术的独立预测因素(OR=3.25,95%CI:1.77~5.97;P<0.001)。UCEIS评分的ROC曲线下面积为0.85;以7分作为最佳阈值,其预测需行结肠切除术的敏感度为60.3%,特异度为85.5%。UCEIS评分对于需要行结肠切除术的预测价值优于MES评分,后者曲线下面积仅为0.65。当UCEIS评分≥7分时,有80%的ASC患者最终需行结肠切除术。结论:预测ASC患者的肠切除风险,UCEIS评分优于MES评分。对于USEIS≥7分的患者,由于其药物治疗失败风险较高,因此,可考虑早期行结肠切除术。 | Tingbin Xie Tenghui Zhang Chao Ding Xujie Dai Yi Li Zhen Guo Yao Wei Jianfeng Gong Weiming Zhu Jieshou Li | 2018 | Gastroenterology Report2018，6，1： | 6 |
| 4 | Design of a C-band polarization rotator-splitter based on a mode-evolution structure and an asymmetric directional coupler显示文摘A C-band polarization rotator-splitter based on a mode-evolution structure and an asymmetric directional coupler is proposed. The mode-evolution structure is designed in a bi-level taper through which the TM_0 mode can evolve into the TE_1 mode. Then the TE_1 mode is coupled to the TE_0 mode at the cross port using the asymmetric directional coupler. The input TE_0 mode propagates along the waveguide without mode conversion and output at the through port. From the experimental results, the extinction ratio is lower than 30 dB and the excess loss is less than 1 dB for input TE_0 mode at the whole C-band. For input TM_0 mode, the ER and the EL are, respectively,lower than-10 and 1.5 dB. | Chen Yuan Jincheng Dai Hao Jia Jianfeng Ding Lei Zhang Xin Fu Lin Yang | 2018 | Journal of Semiconductors2018，39，12： | 4 |
| 5 | Preparation and particle size characterization of Cu nanoparticles prepared by anodic arc plasma显示文摘Copper nanoparticles were successfully prepared in large scale by means of anodic arc discharging plasma method in inert atmosphere. The particle size, specific surface area, crystal structure, and morphology of the samples were characterized by X-ray diffraction (XRD), BET equation, transmission electron microscopy (TEM), and the corresponding selected area electron diffraction (SAED). The experimental results indicate that the crystal structure of the samples is fcc structure the same as that of the bulk materials. The specific surface area is 11 m2/g, the particle size distribution is 30 to 90 nm, and the average particle size is about 67 nm obtained from TEM and confirmed from XRD and BET results. The nanoparticles with uniform size, high purity, narrow size distribution and spherical shape can be prepared by this convenient and effective method. | WEI Zhiqiang XIA Tiandong FENG Wangjun DAI Jianfeng WANG Qing LI Weixue YAN Pengxun | 2006 | Rare Metals2006，25，2： | 4 |
| 6 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 7 | Retinoschisis and intravitreal ranibizumab treatment for myopic choroidal neovascularization显示文摘 | Huang Jianfeng Chen Tong Lu Yingyi Long Li Dai Hong | 2014 | Chinese Medical Journal2014，，11： | 3 |
| 8 | Network Virtualization Based Seamless Networking Scheme for Fiber-Wireless (FiWi) Networks显示文摘In order to reduce cost and complexity,fiber-wireless(FiWi) networks emerge,combining the huge amount of available bandwidth of fiber networks and the flexibility,mobility of wireless networks.However,there is still a long way to go before taking fiber and wireless systems as fully integrated networks.In this paper,we propose a network visualization based seamless networking scheme for FiWi networks,including hierarchical model,service model,service implementation and dynamic bandwidth assignment(DBA).Then,we evaluate the performance changes after network virtualization is introduced.Throughput for nodes,bandwidth for links and overheads leaded by network virtualization are analyzed.The performance of our proposed networking scheme is evaluated by simulation and real implementations,respectively.The results show that,compared to traditional networking scheme,our scheme has a better performance. | DAI Qinglong ZOU Jianfeng SHOU Guochu HU Yihong GUO Zhigang | 2014 | China Communications2014，11，5： | 3 |
| 9 | T cells expressing CD5/CD7 bispecific chimeric antigen receptors with fully human heavy-chain-only domains mitigate tumor antigen escape显示文摘Bispecific chimeric antigen receptor T-cell(CAR-T)therapies have shown promising results in clinical trials for advanced B-cell malignancies.However,it is challenging to broaden the success of bispecific CAR-T therapies to treat refractory/relapse(r/r)T-cell leukemia/lymphoma because targeting multiple T-cell-expressing antigens leads to exacerbated CAR-T cell fratricide and potential safety concerns.Fully human heavy chain variable(FHVH)antibodies that specifically target CD5 or CD7 were screened and constructed to CD5/CD7 bispecific CARs.A truncated Epidermal growth factor receptor were integrated into CAR constructs to address safety concerns.To tackle the fratricidal issue of CAR-T cells targeting T-cell-pan marker(s),CRISPR/Cas9-based CD5 and CD7 genes knockout were performed before lentiviral transduction of bispecific CARs.Functional comparison between different bispecific CAR structures:tandem CARs and dual CAR were performed in vitro and in vivo to determine the optimal construct suitable for addressing T-cell malignancy antigen escape in clinical setting.Knockout of CD5 and CD7 prevents fratricide of CD5/CD7 bispecific CAR-T cells,and FHVH-derived CD5/CD7 bispecific CAR-T cells demonstrate potent antitumor activity in vitro and in vivo.The fratricide-resistant FHVH-derived CD5/CD7 bispecific CAR-T cells have potent antitumor activity against T-cell malignancies,and tandem CARs are more effective than dual CAR in preventing tumor escape in heterogeneous leukemic cells.The meaningful clinical efficacy and safety of tandem CD5/CD7 CAR-T cells deserve to be explored urgently. | Zhenyu Dai Wei Mu Ya Zhao Jiali Cheng Haolong Lin Kedong Ouyang Xiangyin Jia Jianwei Liu Qiaoe Wei Meng Wang Chaohong Liu Taochao Tan Jianfeng Zhou | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 3 |
| 10 | Prevalence and Presentation of Lactose Intolerance and Effects on Dairy Product Intake in Healthy Subjects and Patients With Irritable Bowel Syndrome显示文摘 | Jianfeng Yang Yanyong Deng Hua Chu Yanqun Cong Jianmin Zhao Daniel Pohl Benjamin Misselwitz Michael Fried Ning Dai Mark Fox | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 11 | Effects of Different Dietary Energy and Protein Levels on Meat Performance and Meat Quality of Jinghai Yellow Chickens显示文摘To investigate the effect of different dietary energy and protein levels on meat performance and meat quality of Jinghai yellow chickens,480 43-day old Jinghai yellow chickens with similar weight were randomly divided into four experimental groups: experimental group 1( protein 15%,metabolic energy 9. 95 MJ /kg),experimental group 2( protein 16%,metabolic energy 10. 95 MJ /kg),experimental group 3( protein 17%,metabolic energy 12. 65 MJ /kg) and experimental group 4( protein 18%,metabolic energy 13. 95 MJ /kg),respectively. All chickens were slaughtered at 112-day old. The breast and leg muscles of Jinghai yellow chickens were collected,to determine the slaughter performance,conventional meat quality and muscle chemical indicators. The results indicated that dressing-out percentage and eviscerated yield percentage in four experimental groups were above 87. 27% and 67. 00%,respectively; other slaughter performance indicators exhibited no significant differences among various groups( P > 0. 05); breast muscle color of hens in experimental group 4 varied significantly from that in other three groups( P < 0. 05); leg muscle color of hens in experimental group 2 varied extremely significantly from that in other three groups( P < 0. 01); water-holding capacity of breast muscles of hens in experimental group 3 was significantly higher than that in experimental group 4( P < 0. 05); thiamine content of breast muscles of cocks in experimental group 3 was significantly higher than that in experimental group 2( P < 0. 05); however,other properties exhibited no significant differences among various groups( P > 0. 05). | Jianfeng WANG Lulu CUI Kaizhou XIE Yingying SUN Lirui SUN Jianyu LIU Genxi ZHANG Guojun DAI Jinyu WANG | 2014 | Agricultural Biotechnology2014，3，4： | 2 |
| 12 | A DNA Aptamer Based Method for Detection of SARS-CoV-2 Nucleocapsid Protein显示文摘Dear Editor,Since December 2019, the outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) induced human disease, the coronavirus disease 2019(COVID-19),has been reported in more than 200 countries and areas around the world(Wu et al. 2020). | Zhiqiang Chen Qihan Wu Jing Chen Xiaohua Ni Jianfeng Dai | 2020 | Virologica Sinica2020，35，3： | 2 |
| 13 | The general structural character and the MS substructures of C60 and C70显示文摘 | DAI Jianfeng | 2003 | Microelectronic engineering2003，66，： | 1 |
| 14 | Efficient preparation of La@C60,C60Br24 and the electrical conductivity of sulfur-doped C60 films 显示文摘 | Jianfeng Dai Guangji Xu Yutian Ding | 2003 | Microelectronic Engineering2003，，66： | 1 |
| 15 | Scientific objectives and payloads of Chang' E-1 lunar satellite 显示文摘 | Sun Huixian Dai Shuwu Yang Jianfeng | 2005 | Journal of Earth System Science2005，114，6： | 1 |
| 16 | Properties of Well Aligned SWNT Modified Poly (methyl methacrylate ) Nanocomposites 显示文摘 | Dai Jianfeng Wang Qing Li Weixue | 2007 | Materials Letters2007，1，： | 1 |
| 17 | Predictive Symptoms and Signs of Severe Dengue Disease for Patients with Dengue Fever: A Meta-Analysis显示文摘 | H. Zhang Y. P. Zhou H. J. Peng X. H. Zhang F. Y. Zhou Z. H. Liu X. G. Chen Jianfeng Dai | 2014 | BioMed Research International2014，，： | 1 |
| 18 | Modelling the effects of soil water potential on growth and quality of cut chrysanthemum ( Chrysanthemum morifolium )显示文摘 | Lu Lin Wenwen Li Jingqing Shao Weihong Luo Jianfeng Dai Xinyou Yin Yanbao Zhou Chunjiang Zhao | 2011 | Scientia Horticulturae2011，，1： | 1 |
| 19 | Quantifying the effects of nitrogen on fruit growth and yield of cucumber crop in greenhouses显示文摘 | Jianfeng Dai Shanshan Liu Wanru Zhang Rui Xu Weihong Luo Shengfei Zhang Xinyou Yin Li Han Weiping Chen | 2011 | Scientia Horticulturae2011，，3： | 1 |
| 20 | The edge techniques as used in Brillouin lidar for remote sensing of the ocean显示文摘 | Dai Rui Gong Wenping Xu Jianfeng | 2004 | Appl Phys B2004，79，： | 1 |
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