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| 1 | COL4A3 mutations cause focal segmenta glomerulosclerosis显示文摘 | Jingyuan Xie Xiaoxi Wu Hong Ren Weiming Wang Zhaohui Wang Xiaoxia Pan Xu Hao Jun Tong Jun Ma Zhibin Ye Guoyu Meng Yufei Zhu Krzysztof Kiryluk Xiangyin Kong Landian Hu Nan Chen | 2014 | Journal of Molecular Cell Biology2014，8，6： | 15 |
| 2 | Varying coefficient analysis for indeterminate species interactions with non-parametric estimation, exemplifying with a fig-fig wasp system显示文摘Research on species interactions has generally assumed that species have a fixed interaction and therefore linear or non-linear parametric regression models (e.g. exponential, logistic) have been widely used to describe the species interaction. However, these models that describe the relationship between interacting species as a specific functional response might not be appropriate for real biological communities, for instance, in a chaotic system, when the species relationship varies among different situations. To allow a more accurate description of the relationship, we developed a species correlation model with varying coefficient analysis, in which a non-parametric estimation is applied to identify, as a function of related factors, variation in the correlation coefficient. This was applied to a fig-fig wasp model system. When the effect of the factors on the relationship can be described with parameters, the new method reduces to traditional parametric correlation analysis. In this way, the new method is more general and flexible for empirical data analyses, but different by allowing investigation of whether a species interaction varies with respect to factors, and of the factors that maintain or change the species interaction. This method will have important applications in both theoretical and applied research (e.g. epidemiology, community management). | SHI Lei WANG RuiWu ZHU LiXing ZEN WeiMing XU WangLi ZHENG Qi | 2011 | Chinese Science Bulletin2011，56，24： | 9 |
| 3 | High-precision deformation monitoring algorithm for GBSAR system: rail determination phase error compensation显示文摘In recent years, the repeat-pass GBSAR(ground based synthetic aperture radar) system has demonstrated its capacity to acquire deformation. Nevertheless, in a variety of applications, it needs to measure the deformation with the precision up to 0.1 mm, which could not be reached by utilizing the traditional PS(permanent scatterer) algorithm in most cases. Generally, one of the main reasons could be summarized into the phase error caused by the rail determination error, because the precision of rail determination might degrade during long working hours. However, the traditional PS algorithm could not compensate for the phase error caused by the rail determination error. In order to solve the problems, we modify the conventional PS algorithm.Firstly, we deduced the transformation relationship between the rail determination error and its corresponding interferometric phase error. Then, the phase errors caused by the atmosphere and the rail determination error were jointly compensated. The experimental data, which were obtained in Fangshan District in Beijing(China), were used to test and verify the performance of the new algorithm. After the comparison between the results processed by the new algorithm and those processed by the traditional algorithm, the proposed method demonstrated its ability to obtain high-precision deformation. | Cheng HU Mao ZHU Tao ZENG Weiming TIAN Cong MAO | 2016 | Science China(Information Sciences)2016，59，8： | 9 |
| 4 | Whole-genome sequencing provides insights into the genetic diversity and domestication of bitter gourd(Momordica spp.)显示文摘Bitter gourd(Momordica charantia)is a popular cultivated vegetable in Asian and African countries.To reveal the characteristics of the genomic structure,evolutionary trajectory,and genetic basis underlying the domestication of bitter gourd,we performed whole-genome sequencing of the cultivar Dali-11 and the wild small-fruited line TR and resequencing of 187 bitter gourd germplasms from 16 countries.The major gene clusters(Bi clusters)for the biosynthesis of cucurbitane triterpenoids,which confer a bitter taste,are highly conserved in cucumber,melon,and watermelon.Comparative analysis among cucurbit genomes revealed that the Bi cluster involved in cucurbitane triterpenoid biosynthesis is absent in bitter gourd.Phylogenetic analysis revealed that the TR group,including 21 bitter gourd germplasms,may belong to a new species or subspecies independent from M.charantia.Furthermore,we found that the remaining 166 M.charantia germplasms are geographically differentiated,and we identified 710,412,and 290 candidate domestication genes in the South Asia,Southeast Asia,and China populations,respectively.This study provides new insights into bitter gourd genetic diversity and domestication and will facilitate the future genomics-enabled improvement of bitter gourd. | Junjie Cui Yan Yang Shaobo Luo Le Wang Rukui Huang Qingfang Wen Xiaoxia Han Nansheng Miao Jiaowen Cheng Ziji Liu Changyuan Zhang Chengcheng Feng Haisheng Zhu Jianwen Su Xinjian Wan Fang Hu Yu Niu Xiaoming Zheng Yulan Yang Dai Shan Zhensheng Dong Weiming He Narinder P.S.Dhillon Kailin Hu | 2020 | Horticulture Research2020，7，1： | 7 |
| 5 | 溃疡性结肠炎内镜下严重度指数(UCEIS评分)与Mayo内镜评分(MES)用于预测急性重症结肠炎患者行肠切除术的比较研究显示文摘背景溃疡性结肠炎内镜下严重度指数(UCEIS)和Mayo内镜评分(MES)都是溃疡性结肠炎(UC)内镜下严重程度的客观评估方法,然而,对于这两种评分方法能否用于筛选出需要行结肠切除术的急性重症结肠炎患者,目前仍不明了。方法:对2012年1月至2016年5月间连续收治的ASC患者进行回顾性分析。提取并分析入组患者的人口统计资料、既往治疗史、疾病特征资料、实验室指标、药物治疗及内镜评估等资料。主要结局指标是住院和随访期间需行结肠切除术的患者比例。结果:92例患者纳入研究,其中37例(40.2%)需行结肠切除术。多因素分析显示,UCEIS评分是需行结肠切除术的独立预测因素(OR=3.25,95%CI:1.77~5.97;P<0.001)。UCEIS评分的ROC曲线下面积为0.85;以7分作为最佳阈值,其预测需行结肠切除术的敏感度为60.3%,特异度为85.5%。UCEIS评分对于需要行结肠切除术的预测价值优于MES评分,后者曲线下面积仅为0.65。当UCEIS评分≥7分时,有80%的ASC患者最终需行结肠切除术。结论:预测ASC患者的肠切除风险,UCEIS评分优于MES评分。对于USEIS≥7分的患者,由于其药物治疗失败风险较高,因此,可考虑早期行结肠切除术。 | Tingbin Xie Tenghui Zhang Chao Ding Xujie Dai Yi Li Zhen Guo Yao Wei Jianfeng Gong Weiming Zhu Jieshou Li | 2018 | Gastroenterology Report2018，6，1： | 6 |
| 6 | Diallyl trisulfide induces apoptosis and inhibits proliferation of A549 cells in vitro and in vivo显示文摘肺癌症是在整个世界的癌症相关的死亡的领先的原因。在最近的年里,肺的腺癌在频率超过了有鳞的房间癌并且是在许多国家的肺癌症的占优势的形式。流行病学的调查显示出在消费和死亡从许多癌症评估的大蒜(瞀或蒜之类 sativum ) 之间的一种反的关系。Diallyl trisulfide (DATS ) 是导出大蒜的混合物之一(是也知道:organosulfer 混合物,振荡) 。DATS 能导致 apoptosis 并且禁止许多癌症细胞线的生长。我们的学习证明 DATS 导致的 apoptotic 事件是通过导致了 Bax/Bcl-2 和 caspase-3, -8, 和 -9 的活动的比率的起来规定的 anti-apoptotic Bcl-2 的重要减少的线粒体依赖者 caspase 串联。最后, DATS 导致了 apoptosis 并且在一个集中依赖者和时间依赖者举止禁止了增长。由与 A549 异种皮移植建立女 BALB/c 裸体老鼠的一个动物模特儿,没有与控制组相比引起重量损失或任何另外的副作用,而且,我们在裸体老鼠发现 DATS 的那口头的 gavage A549 异种皮移植的显著地延迟的生长。在 vitro 并且在 vivo 的所有证据建议 DATS 能是理想的反癌症药。 | Wenjun Li Hui Tian Lin Li Shuhai Li Weiming Yue Zhitao Chen Lei Qi Wensi Hu Yingchao Zhu Bin Hao Cun Gao Libo Si Fei Gao | 2012 | Acta Biochimica et Biophysica Sinica2012，44，7： | 6 |
| 7 | Effects of fractal surface on rheological behavior and combustion kinetics of modified brown coal water slurries显示文摘 | Zhifang Gao Shuquan Zhu Mingdong Zheng ZhaojinWu Huihong Lu Weiming Liu | 2015 | International Journal of Coal Science & Technology2015，2，3： | 6 |
| 8 | Characterization of the neutralizing activity of three anti-human TNF monoclonal antibodies and prediction of their TNF epitopes by molecular modeling and mutant protein approach显示文摘 | Cansheng Zhu Xuesong Liu Jiannan Feng Wei Zhang Beifen Shen Weiming Ou'yang Yunxin Cao Boquan Jin | 2006 | 中国生物学文摘2006，20，1： | 5 |
| 9 | Antibiotic Metabolites from the Coral-Associated Actinomycete Streptomyces sp. OUCMDZ-1703显示文摘从软联系珊瑚的放射菌类紧张的寡营养的文化, Streptomyces sp。 OUCMDZ-1703 ,我们孤立并且识别我们把 strepchloritides 称为 A 和 B ( 1 和 2 )的二新使氯化的 polyketides ,作为 watasemycin A ( 3 )知道的三 thiazole 衍生物, pulicatin G ( 4 )和 aerugine ( 5 )与 pyrrole-2-carboxamide 一起, furan-2-carboxamide 和1-( 3,5-dihydroxyphenyl ) ethanone 。1 和 2 的新结构被象 1D-NMR 和 2D-NMR 和 MS 分析那样的分光镜的研究决定,当已知的混合物被 NMR 数据的比较在文学与那些识别时。结果证明放射菌类种类 OUCMDZ-1703 能在寡营养的媒介使用氯的相对高比率综合使氯化的自然产品。新混合物 1 和 2 与 9.9 和 20.2 的 IC50 价值对 MCF-7 房间显示了 cytotoxicity ?? 愠杮' 讙贅 H 敮 ???????? 寓?? | Peng Fu Fandong Kong Yuanfei Wang Yi Wang Peipei Liu Guoying Zuo Weiming Zhu | 2013 | Chinese Journal of Chemistry2013，31，1： | 5 |
| 10 | The Antitumor Components from Marine-derived Bacterium Streptoverticillium luteoverticillatum 11014 Ⅱ显示文摘Eight known compounds were isolated from a marine-derived bacterium Streptoverticillium luteoverticillatum 11014 using bioassay-guided fractionations. Their structures were identified by spectral analysis as bis (4-hydroxybenzyl) ether (1), p-hydroxyphenylethyl alcohol (2), N-(4-hydroxyphenethyl) acetamide (3), indole-3 carboxylic acid methyl ester (4), dibenzo[b,e] [1,4]dioxine (5), thymine (6), cytosine deoxyribonucleoside (7) and 2, 3-butanediol (8). These compounds were evaluated for their cytotoxic activities against K562 cell line with the SRB method for the first time. Compounds 2 and 4 showed cytotoxcities with IC50 values of 101.1 and 165.3 μmol L-1, respectively. All compounds were isolated from S. luteoverticillatum 11014 for the first time. | LI Dehai ZHU Tianjiao FANG Yuchun LIU Hongbing GU Qianqun ZHU Weiming | 2007 | Journal of Ocean University of China2007，6，2： | 4 |
| 11 | Introducing tree neighbouring relationship factors in forest pattern spatial analysis:weighted Delaunay triangulation method显示文摘It is important to quantify and analyze forest spatial patterns for studying biological characteristics,population interaction and the relationship between the population and environment.In this study,the forest spatial structure unit was generated based on the Delaunay triangulation model(DTM),and the weights were generated using the comprehensive values of the tree diameter at breast height,total height and crown width.The distance between neighbors determined by the DTM was weighted to transform the original coordinates of trees into logical coordinates.Then,a weighted spatial pattern(WSP)was developed.After weighting,the neighboring trees were replaced,the replacement ratio was 38.3%,and there was 57.4%of the central tree.Correlation analysis showed that the uniform angle index of the WSP was significantly correlated with the tree size standard deviation under uniformity(r=0.932)and randomness(r=0.711).The DTM method not only considers the spatial distance between trees,but also considers the non-spatial attributes of trees.By changing the spatial topological relation between trees,this method further improves the spatial structure measurement of forest. | Jianjun Li Kaiwen Zhu Shuai Liu Dan Li Gui Zhang Xing Liu Weiming Yang | 2021 | Journal of Forestry Research2021，32，5： | 4 |
| 12 | The Cytotoxic Constituents from Marine-derived Streptomyces 3320^(#)显示文摘现在的工作从 marine-derivedstreptomyces 学习化学成分 3320 ~# 并且他们的反肿瘤活动。酵素肉汤 of3320~# 的 n-BuOH 摘录在用 antitoumor 活动分开混合物的硅石胶化, Sephadex LH-20, ODS 列和 HPLC 上被用色层法分离。他们的结构用红外被识别,紫外, NMR, MSspectroscopic 技术并且与出版数据相比。isolates 的反肿瘤活动是用 SRB 方法和流动 cytometry 试金的 assayed,对哺乳动物的 tsFT210 房间在轻显微镜下面与房间的词法观察伴随了。十混合物,出租机动三轮车--(翼列伊) 1 ,出租机动三轮车--( Ala-Ile ) 2 ,出租机动三轮车--( Ala-Val ) 3 ,出租机动三轮车--(Phe-职业人员) 4 ,出租机动三轮车--( Phe-Gly ) 5 ,出租机动三轮车--(列伊职业人员) 6 , 1-methyl-1 , 2 , 3 ,4-tetrahydro-β- carboline-3-carboxylic 酸 7 ,N-( 4-hydroxyphenethyl )乙酰胺 8 ,4-methyoxy-1-( 2-hydroxy )乙醇苯 9 并且 uridine 10 ,从 streptomyces 的酵素肉汤被孤立 3320 ~#。在他们之中,加重 6, 7, 8 和 10 对有 IC_(50 ) 的 tsFT210 房间的显示出的有势力 cytotoxicity 3.6, 7.2, 5.2 和 1.6 mmolL~ 珍视(-1), 分别地。加重 8,在 2.0 mmolL~ 下面的 10 也展出的 apoptosis 导致活动(-1) 。混合物 6,7,8 和 10 是原则简历为海洋的 streptomyces 的 theantitumor 活动负责的活跃成分 3320 ~# 。化合物 7 第一次从这种被孤立。 | REN Hong GU Qianqun CUI Chengbin ZHU Weiming | 2006 | Journal of Ocean University of China2006，5，1： | 4 |
| 13 | Construction of a Metagenomic DNA Library of Sponge Symbionts and Screening of Antibacterial Metabolites显示文摘为了学习简历,活跃代谢物由导出海绵的未耕作的共生者生产了,海绵 Gelliodes gracilis 的共生者的一个 metagenomic DNA 图书馆被构造。DNA 的平均尺寸在图书馆插入是 20kb。这个图书馆用纸圆盘 assaying 为抗菌素活动被屏蔽。二克隆对小球菌 tetragenus 显示了抗菌剂活动。这二克隆的代谢物通过 HPLC 被分析。结果证明他们的代谢物与主人 E 的那些相当不同。包含向量 pHZ132 的关口 i DH5 α和主人。这研究可以介绍一条新途径给探索简历海绵共生者的活跃代谢物。 | CHEN Juan ZHU Tianjiao LI Dehai CUI Chengbin FANG Yuchun LIU Hongbing LIU Peipei GU Qianqun ZHU Weiming | 2006 | Journal of Ocean University of China2006，5，2： | 3 |
| 14 | Grating lobes suppression method for stepped frequency GB-SAR system显示文摘A grating lobes suppression method for chirp-subpulse stepped frequency(CSSF) signals is proposed, which is applied to deformation monitoring using the ground based synthetic aperture radar(GB-SAR) system. This method is based on accurate estimation and correction of the phase and amplitude error along two dimensions(range and azimuth), i.e., the error estimation inside the subpulse(in-subpulse error) and across the stepped frequency subpulses(cross-subpulse error) of transmitted CSSF signals. Validated both with simulated data and experimental data recorded in the deformation monitoring campaign, it can be seen that the method as well as the relative conclusions can be fully and effectively applied to most of the stepped frequency systems. | Tao Zeng Cong Mao Cheng Hu Mao Zhu Weiming Tian Jingjing Ren | 2014 | Journal of Systems Engineering and Electronics2014，25，6： | 3 |
| 15 | Down-regulation of heparanase leads to the inhibition of invasion and proliferation of A549 cells in vitro and in vivo显示文摘Heparanase 是降级的哺乳动物的 endoglycosidase 在房间表面并且在细胞外的矩阵的 heparan 硫酸盐。heparanase 的表示在许多人的恶意的肿瘤被检测并且仔细把侵略,转移,和 angiogenesis 与肿瘤联系了。然而, heparanase 的特定的角色和它调整非小的房间肺癌症(NSCLC ) 的恶意的潜力的机制房间仍然保持不清楚。在现在的学习, heparanase 的表示在由 antisense oligodeoxynucleotide 的 NSCLC 房间线是下面调整的。结果证明 heparanase 的下面规定导致了重要抑制侵略并且在 vitro 并且在 vivo 的 A549 房间的 proliferative 潜力。进一步的研究证明 heparanase 的下面规定显著地禁止了 A549 房间的 angiogenic 潜力,它可能是为在在 vivo 的 BALB/c 裸体老鼠的 A549 房间增长的抑制负责的机制。这些调查结果证明 heparanase 在调整 A549 房间的侵略,增长,和 angiogenesis 起必要作用。 | Zhitao Chen Liangming Zhu Xiaohua Li Hui Tian Yusong Fang Haibo Liu Shuhai Li Lin Li Weiming Yue Wenjun Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 3 |
| 16 | Hundred-Joule-level,nanosecond-pulse Nd:glass laser system with high spatiotemporal beam quality显示文摘A 100-J-level Nd:glass laser system in nanosecond-scale pulse width has been constructed to perform as a standard source of high-fluence-laser science experiments. The laser system, operating with typical pulse durations of 3–5 ns and beam diameter 60 mm, employs a sequence of successive rod amplifiers to achieve 100-J-level energy at 1053 nm at3 ns. The frequency conversion can provide energy of 50-J level at 351 nm. In addition to the high stability of the energy output, the most valuable of the laser system is the high spatiotemporal beam quality of the output, which contains the uniform square pulse waveform, the uniform flat-top spatial fluence distribution and the uniform flat-top wavefront. | Sensen Li Yulei Wang Zhiwei Lu Lei Ding Yi Chen Pengyuan Du Dexin Ba Zhenxing Zheng Xin Wang Hang Yuan Chengyu Zhu Weiming He Dianyang Lin Yongkang Dong Dengwang Zhou Zhenxu Bai Zhaohong Liu Can Cui | 2016 | High Power Laser Science and Engineering2016，4，1： | 3 |
| 17 | Statistical damage detection method for frame structures using a confidence interval显示文摘A novel damage detection method is applied to a 3-story frame structure,to obtain statistical quantification control criterion of the existence,location and identification of damage.The mean,standard deviation,and exponentially weighted moving average(EWMA) are applied to detect damage information according to statistical process control(SPC) theory.It is concluded that the detection is insignificant with the mean and EWMA because the structural response is not independent and is not a normal distribution.On the other hand,the damage information is detected well with the standard deviation because the influence of the data distribution is not pronounced with this parameter.A suitable moderate confidence level is explored for more significant damage location and quantification detection,and the impact of noise is investigated to illustrate the robustness of the method. | Li Weiming,Zhu Hongping~(++),Luo Hanbin~(++) and Xia Yong~(++) School of Civil Engineering and Mechanics,Huazhong University of Science and Technology,Wuhan 430074,China ~+PhD Candidate ++ Professor | 2010 | Earthquake Engineering and Engineering Vibration2010，9，1： | 2 |
| 18 | Restricted peri-operative fluid administration adjusted by serum lactate level improved outcome after major elective surgery for gastrointestinal malignancy显示文摘 | Yu WenKui Li Ning Gong JianFeng Li WeiQin Tang ShaoQiu Tong Zhihui Gao Tao Zhang JuanJuan Xi FengChan Shi Hui Zhu WeiMing Li Jie-Shou | 2010 | Surgery2010，，4： | 2 |
| 19 | Liver TCRγδ + CD3 + CD4 ? CD8 ? T cells contribute to murine hepatitis virus strain 3-induced hepatic injury through a TNF-α-dependent pathway显示文摘 | Yulei Lu Xiaojing Wang Weiming Yan Hongwu Wang Ming Wang Di Wu Lin Zhu Xiaoping Luo Qin Ning | 2012 | Molecular Immunology (-)2012，，3： | 1 |
| 20 | Oxidation of lignin model compounds in water with dioxygen and hydrogen peroxide catalyzed by metallophthalocyanines显示文摘 | Weiming Zhu Warren T Ford | 1993 | Journal of Molecular Catalysis1993，78，： | 1 |
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