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| 1 | p38α MAPK pathway:A key factor in colorectal cancer therapy and chemoresistance显示文摘Colorectal cancer(CRC)remains one of the most common malignancies in the world.Although surgical resection combined with adjuvant therapy is effective at the early stages of the disease,resistance to conventional therapies is frequently observed in advanced stages,where treatments become ineffective.Resistance to cisplatin,irinotecan and 5-fluorouracil chemotherapy has been shown to involve mitogen-activated protein kinase(MAPK)signaling and recent studies identified p38αMAPK as a mediator of resistance to various agents in CRC patients.Studies published in the last decade showed a dual role for the p38αpathway in mammals.Its role as a negative regulator of proliferation has been reported in both normal(including cardiomyocytes,hepatocytes,fibroblasts,hematopoietic and lung cells)and cancer cells(colon,prostate,breast,lung tumor cells).This function is mediated by the negative regulation of cell cycle progression and the transduction of some apoptotic stimuli.However,despite its anti-proliferative and tumor suppressor activity in some tissues,the p38αpathway may also acquire an oncogenic role involving cancer related-processes such as cell metabolism,invasion,inflammation and angiogenesis.In this review,we summarize current knowledge about the predominant role of the p38αMAPK pathway in CRC development and chemoresistance.In our view,this might help establish the therapeutic potential of the targeted manipulation of this pathway in clinical settings. | Valentina Grossi Alessia Peserico Tugsan Tezil Cristiano Simone | 2014 | World Journal of Gastroenterology2014，20，29： | 20 |
| 2 | Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models显示文摘 | Fulvio Chiacchiera Valentina Grossi Marianna Cappellari Alessia Peserico Marta Simonatto Aldo Germani Silvana Russo Mary P. Moyer Nicoletta Resta Stefania Murzilli Cristiano Simone | 2012 | Cancer Letters2012，，1： | 1 |
| 3 | Special Agents Hunting Down Women Silent Killer: The Emerging Role of the p38 α Kinase显示文摘 | Valentina Grossi Cristiano Simone Ritu Salani | 2012 | Journal of Oncology2012，，： | 1 |
| 4 | p38α Is Required for Ovarian Cancer Cell Metabolism and Survival显示文摘 | Antonio Matrone Valentina Grossi Fulvio Chiacchiera Emanuela Fina Marianna Cappellari Anna Maria Caringella Edoardo Di Naro Giuseppe Loverro Cristiano Simone | 2010 | International Journal of Gynecological Cancer2010，，2： | 1 |
| 5 | A Predictive Model Identifies Patients Most Likely to Have Inadequate Bowel Preparation for Colonoscopy显示文摘 | Cesare Hassan Lorenzo Fuccio Mario Bruno Nico Pagano Cristiano Spada Silvia Carrara Chiara Giordanino Emanuele Rondonotti Gabriele Curcio Pietro Dulbecco Carlo Fabbri Domenico Della Casa Stefania Maiero Adriana Simone Federico Iacopini Giuseppe Feliciange | 2012 | Clinical Gastroenterology and Hepatology2012，，5： | 1 |
| 6 | 689 Evaluation of the Second Generation Colon Capsule Endoscopy (CCE-2) in Pediatric Ulcerative Colitis (UC)显示文摘 | Salvatore Oliva Giovanni Di Nardo Cristiano Spada Cesare Hassan Marina Aloi Federica Ferrari Fortunata Civitelli Simone Frediani Guido Costamagna Salvatore Cucchiara | 2013 | Gastroenterology2013，，5： | 1 |
| 7 | A Predictive Model Identifies Patients Most Likely to Have Inadequate Bowel Preparation for Colonoscopy显示文摘 | Cesare Hassan Lorenzo Fuccio Mario Bruno Nico Pagano Cristiano Spada Silvia Carrara Chiara Giordanino Emanuele Rondonotti Gabriele Curcio Pietro Dulbecco Carlo Fabbri Domenico Della Casa Stefania Maiero Adriana Simone Federico Iacopini Giuseppe Feliciange | 2012 | Clinical Gastroenterology and Hepatology2012，，5： | 1 |
| 8 | Influence of threshold value in the use of statistical methods for groundwater vulnerability assessment显示文摘 | Marco Masetti Simone Sterlacchini Cristiano Ballabio Alessandro Sorichetta Simone Poli | 2009 | Science of the Total Environment2009，，12： | 1 |
| 9 | Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes显示文摘Familial adenomatous polyposis(FAP)and MUTYH-associ-ated polyposis(MAP)are colon cancer predisposition syn-dromes.FAP is an autosomal dominant inherited condition caused by germline mutations in the adenomatous polyposis coli(APC)gene and characterized by hundreds to thousands of colorectal adenomas. | Giovanna Forte Filomena Cariola Antonia Lucia Buonadonna Anna Filomena Guglielmi Andrea Manghisi Katia De Marco Valentina Grossi Candida Fasano Martina Lepore Signorile Paola Sanese Rosanna Bagnulo Nicoletta Resta b Vittoria Disciglio Cristiano Simone | 2023 | Genes & Diseases2023，10，4： | 0 |
| 10 | Monitoring gully erosion in the European Union: A novel approach based on the Land Use/Cover Area frame survey (LUCAS)显示文摘The European Commission's Thematic Strategy for Soil Protection(COM(2012)46)identified soil erosion as an important threat to European Union's(EU)soil resources.Gully erosion is an important but hitherto poorly understood component of this threat.Here we present the results of an unprecedented attempt to monitor the occurrence of gully erosion across the EU and UK.We integrate a soil erosion module into the 2018 LUCAS Topsoil Survey,which was conducted to monitor the soil health status across the EU and to support actions to prevent soil degradation.We discuss and explore opportunities to further improve this method.The 2018 LUCAS Topsoil Survey consisted of soil sampling(0-20 cm depth)and erosion observations conducted in ca.10%(n=24,759)of the 238,077 Land Use/Cover Area frame Survey(LUCAS)2018 in-field survey sites.Gully erosion channels were detected for ca.1%(211 sites)of the visited LUCAS Topsoil sites.Commission(false positives,2.5%)and omission errors(false negatives,5.6%)were found to be low and at a level that could not compromise the representativeness of the gully erosion survey.Overall,the findings indicate that the tested 2018 LUCAS Topsoil in-field gully erosion monitoring system is effective for detecting the incidence of gully erosion.The morphogenesis of the mapped gullies suggests that the approach is an effective tool to map permanent gullies,whereas it appears less effective to detect short-lived forms like ephemeral gullies.Spatial patterns emerging from the LUCAS Topsoil field observations provide new insights on typical gully formation sites across the EU and UK.This can help to design further targeted research activities.An extension of this approach to all LUCAS sites of 2022 would significantly enhance our understanding of the geographical distribution of gully erosion processes across the EU.Repeated every three years,LUCAS soil erosion surveys would contribute to assess the state of gully erosion in the EU over time.It will also enable monitoring and eventually predicting the dynamics of gully erosion.Data collected were part of the publicly available Gully Erosion LUCAS visual assessment(GE-LUCAS v1.0)inventory. | Pasquale Borrelli Jean Poesen Matthias Vanmaercke Cristiano Ballabio Javier Hervas Michael Maerker Simone Scarpa Panos Panagos | 2022 | International Soil and Water Conservation Research2022，10，1： | 0 |
| 11 | A novel STK11 gene mutation (c.388dupG,p.Glu130Glyfs∗33) in a Peutz-Jeghers family and evidence of higher gastric cancer susceptibility associated with alterations in STK11 region aa 107-170显示文摘Peutz-Jeghers syndrome(PJS)is a rare autosomal dominant disorder characterized by mucocutaneous pigmentation and gastrointestinal(GI)hamartomatous polyposis and is associated with an increased risk of gastrointestinal,breast,gynecologic and other extra-GI malignancies.The serine/threonine kinase 11(STK11)gene has been identi-fied as a pathogenic factor in PJS.STK11 is a tumor sup-pressor gene located on chromosome 19p13.3 and includes 9 coding exons.1 The STK11 protein is composed of 433 amino acids(aa)and comprises a kinase catalytic region(aa 49e309)as well as N-and C-terminal regulatory domains. | Giovanna Forte Filomena Cariola Katia De Marco Andrea Manghisi Filomena Anna Guglielmi Raffaele Armentano Giuseppe Lippolis Pietro Giorgio Cristiano Simone Vittoria Disciglio | 2022 | Genes & Diseases2022，9，2： | 0 |
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