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| 1 | p38α MAPK pathway:A key factor in colorectal cancer therapy and chemoresistance显示文摘Colorectal cancer(CRC)remains one of the most common malignancies in the world.Although surgical resection combined with adjuvant therapy is effective at the early stages of the disease,resistance to conventional therapies is frequently observed in advanced stages,where treatments become ineffective.Resistance to cisplatin,irinotecan and 5-fluorouracil chemotherapy has been shown to involve mitogen-activated protein kinase(MAPK)signaling and recent studies identified p38αMAPK as a mediator of resistance to various agents in CRC patients.Studies published in the last decade showed a dual role for the p38αpathway in mammals.Its role as a negative regulator of proliferation has been reported in both normal(including cardiomyocytes,hepatocytes,fibroblasts,hematopoietic and lung cells)and cancer cells(colon,prostate,breast,lung tumor cells).This function is mediated by the negative regulation of cell cycle progression and the transduction of some apoptotic stimuli.However,despite its anti-proliferative and tumor suppressor activity in some tissues,the p38αpathway may also acquire an oncogenic role involving cancer related-processes such as cell metabolism,invasion,inflammation and angiogenesis.In this review,we summarize current knowledge about the predominant role of the p38αMAPK pathway in CRC development and chemoresistance.In our view,this might help establish the therapeutic potential of the targeted manipulation of this pathway in clinical settings. | Valentina Grossi Alessia Peserico Tugsan Tezil Cristiano Simone | 2014 | World Journal of Gastroenterology2014，20，29： | 20 |
| 2 | Reduction of relapses of atopic dermatitis with methylprednisolone aceponate cream twice weekly in addition to maintenance treatment with emollient: a multicentre, randomized, double-blind, controlled study显示文摘 | Peserico A Stadtler G Sebastian M | 2008 | Br J Dermatol2008，158，： | 1 |
| 3 | Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models显示文摘 | Fulvio Chiacchiera Valentina Grossi Marianna Cappellari Alessia Peserico Marta Simonatto Aldo Germani Silvana Russo Mary P. Moyer Nicoletta Resta Stefania Murzilli Cristiano Simone | 2012 | Cancer Letters2012，，1： | 1 |
| 4 | Reduction of relaps- es of atopic dermatitis with methylprednisolone aceponate cream twice weekly in addition to maintenance treatment with emollient : a muhicentre, randomized, double-blind, con- trolled study显示文摘 | Peserico A Stadtler G Sebastian M | 2008 | Br J Dermatol2008，158，： | 1 |
| 5 | A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels 显示文摘 | PESERICO A CHIAUCHIERA F GROSSI V | 2013 | Cell Mol Life Sci2013，70，11： | 1 |
| 6 | A novel AMPK-depend- ent FoxO3 A-SIRT3 intramitochondrial complex sensing glucose lev- els 显示文摘 | Peserico A Chiacchiera F Grossi V | 2013 | Cell Mol Life Sci2013，70，11： | 1 |
| 7 | Physical and functional HAT/HDACs interplay regulates protein acetylation balance 显示文摘 | Peserico A Simone C | 2011 | J Biomed Biotechnol2011，832，： | 1 |
| 8 | Physical and functional HAT/HDACinterplay regulates protein acetylation balance显示文摘 | Peserico A Simone C | 2011 | J Biomed Biotechnol2011，1，2011： | 1 |
| 9 | Erythroderma in the era of biological therapies 显示文摘 | Zattra E Belloni FA Peserico A | 2012 | Eur J Dermatol2012，22，2： | 1 |
| 10 | Reduction of relapses ofatopic dermatitis with methylprednisolone aceponate cream twiceweekly in addition to maintenance treatment with emollient: amulticentre, randomized, double-blind, controlled study 显示文摘 | Peserico A Stadtler G Sebastian M | 2008 | Br JDermatol2008，158，4： | 1 |
| 11 | Reduction of relapses of atopic dermatitis with methylprednisolone acclimate cream twice weekly in addition to maintenance treatment with emollient: a multicentre, randomized, double-blind, controlled study 显示文摘 | Peserico A Stadtler G Sebastian M | 2008 | Br J Dermatol2008，158，： | 1 |
| 12 | Electrical programmable multilevel nonvolatile photonic random-access memory显示文摘Photonic Random-Access Memories(P-RAM)are an essential component for the on-chip non-von Neumann photonic computing by eliminating optoelectronic conversion losses in data links.Emerging Phase-Change Materials(PCMs)have been showed multilevel memory capability,but demonstrations still yield relatively high optical loss and require cumbersome WRITE-ERASE approaches increasing power consumption and system package challenges.Here we demonstrate a multistate electrically programmed low-loss nonvolatile photonic memory based on a broadband transparent phase-change material(Ge2Sb2Se5,GSSe)with ultralow absorption in the amorphous state.A zero-staticpower and electrically programmed multi-bit P-RAM is demonstrated on a silicon-on-insulator platform,featuring efficient amplitude modulation up to 0.2 dB/μm and an ultralow insertion loss of total 0.12 dB for a 4-bit memory showing a 100×improved signal to loss ratio compared to other phase-change-materials based photonic memories.We further optimize the positioning of dual microheaters validating performance tradeoffs.Experimentally we demonstrate a half-a-million cyclability test showcasing the robust approach of this material and device.Low-loss photonic retention-of-state adds a key feature for photonic functional and programmable circuits impacting many applications including neural networks,LiDAR,and sensors for example. | Jiawei Meng Yaliang Gui Behrouz Movahhed Nouri Xiaoxuan Ma Yifei Zhang Cosmin-Constantin Popescu Myungkoo Kang Mario Miscuglio Nicola Peserico Kathleen Richardson Juejun Hu Hamed Dalir Volker J.Sorger | 2023 | Light(Science & Applications)2023，12，11： | 0 |
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