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| 1 | 脑静脉血栓形成的诊断和处理 美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘背景本指南旨在对脑静脉窦血栓形成(cerebral venous sinus thrombosis,CVT)进行概述,并提供其诊断、处理和治疗的推荐意见,目标读者为涉及CVT患者诊断和处理的临床医生和其他医疗工作者。方法和结果作为不同专业领域的代表,专家小组成员由美国心脏协会(American Heart Association,AHA)卒中委员会科学声明监督委员会任命。专家小组回顾了相关文献,重点为1966年以来公开发表的报道,并使用AHA证据水平分级方案对证据进行评定并制定推荐意见。本指南经专家小组认可后,由AHA科学咨询和协调委员会进行同行评议并批准。结论本指南为CVT的诊断、处理和复发的预防提供了循证推荐,同时还提供了妊娠期妇女和儿童CVT评估和处理的推荐意见,对临床并发症(痫性发作、脑积水、颅内压增高和神经功能恶化)的处理进行了总结,并描述了CVT患者诊断和治疗的流程图。 | Gustavo Saposnik Femando Barinagarrementeria Robert D. Brown Cheryl D. Bushnell Brett Cucchiara Mary Cushman Gabrielle deVeber Jose M. Ferro Fong Y. Tsai 张沈阳(译) 韩丽娟(译) 叶丹(译) 徐运(译) | 2011 | 国际脑血管病杂志2011，19，10： | 197 |
| 2 | 急性缺血性卒中静脉阿替普酶溶栓后出血转化的治疗和结局:美国心脏协会/美国卒中协会科学声明显示文摘急性缺血性卒中发病4.5 h内给予静脉阿替普酶溶栓治疗可改善预后。尽管阿替普酶的有效性被证实,但因增加出血风险,尤其是症状性颅内出血(symptomatic intracranial hemorrhage,sICH),其应用受到限制。sICH的发生率在不同患者和不同sICH定义中不同,一般波动于2%~7%。 | Yaghi S Willey JZ Cucchiara B 蒋芳 赵文博 吴川杰 李传辉 任明 吉训明 | 2018 | 中国脑血管病杂志2018，15，7： | 17 |
| 3 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 4 | A pediatric non-protein losing Menetrier's disease successfully treated with octreotide long acting release显示文摘Pediatric Menetrier's disease (MD) is an uncommon, acute, self-limited hypertrophic gastropathy characterized by enlarged gastric folds associated with epithelial hyperplasia and usually accompanied by protein losing gastropathy. Gastric cytomegalovirus infection is found in one third of MD children and its treatment is often associated with remission. Diagnosis often requires fullthickness biopsy due to inability to detect typical histological findings with conventional endoscopic biopsy. We report an uncommon case of non self-limited pediatric MD needing endoscopic mucosal resection for diagnosis which was then successfully treated with octreotide long-acting release (LAR). To the best of our knowledge, this is the first pediatric MD case successfully treated with octreotide LAR. Our experience suggests octreotide LAR as treatment for refractory MD before gastrectomy. | Giovanni Di Nardo Salvatore Oliva Marina Aloi Federica Ferrari Simone Frediani Adriana Marcheggiano Salvatore Cucchiara | 2012 | World Journal of Gastroenterology2012，18，21： | 6 |
| 5 | Capsule endoscopy in pediatrics: A 10-years journey显示文摘Video capsule endoscopy(CE) for evaluation the esophagus(ECE), small bowel(SBCE) and the colon(CCE) is particularly useful in pediatrics, because this imaging modality does not require ionizing radiation, deep sedation or general anesthesia. The risk of capsule retention appears to be dependent on indication rather than age and parallels the adult experience by indication, making SBCE a relatively safe procedure with a significant diagnostic yield. The newest indication, assessment of mucosal change, greatly enhances and expands its potential benefit. The diagnostic role of CE extends beyond the SB. The use of ECE also may enhance our knowledge of esophageal disease and assist patient care. Colon CCE is a novel minimally invasive and painless endoscopic technique allowing exploration of the colon without need for sedation, rectal intubation and gas insufflation. The limited data on ECE and CCE in pediatrics does not yet allow the same conclusions regarding efficacy; however, both appear to provide safe methods to assess and monitor mucosal change in their respective areas with little discomfort. Moreover, although experience has been limited, the patency capsule may help lessen the potential of capsule retention; and newly researched protocols for bowel cleaning may further enhance CE's diagnostic yield. However, further research is needed to optimize the use of the various CE procedures in pediatric populations. | Salvatore Oliva Stanley A Cohen Giovanni Di Nardo Gianfranco Gualdi Salvatore Cucchiara Emanuele Casciani | 2014 | World Journal of Gastroenterology2014，20，44： | 6 |
| 6 | Enteric neuropathology of congenital intestinal obstruction:A case report显示文摘试验性的证据显示肠的长期的机械亚吸藏可以损坏伤寒神经系统(ENS ) ,尽管在人的数据正在缺乏。我们这里描述伤寒的第一诉讼与内脏的先天的阻塞有关的退化神经病。3 年的 A 和老女孩开始抱怨了呕吐的 9 瞬间,腹的扩张,有空气液体的便秘在飞机铺平腹的辐射学。她的随后的病历被 3 操作描绘:首先显示出的扩大 duodeno-jejunal 当闭塞的损害不在时循环;第二(2 年以后) 被执行获得扩大的肠的环的完整厚度的活体检视并且在组织病理学说揭示了 hyperganglionosis;第三(在 hyperganglionosis 以后的 9 年被识别) 揭示了 Ladd 被移开的乐队,联系内脏旋转不良被改正。完整厚度的活体检视显示出的重复 intraoperative 与 Cajal 的减少的空隙的房间一起的退化神经病在 Ladd 的乐队下面在阻塞和正常的神经与肌的层上面在扩大的环联网的伤寒。病人容忍了的在最近的外科以后的一年口头的喂并且很好,建议那先天(部分) 在人的小肠的机械阻塞能唤起类似于在肠的机械吸藏的动物模型发现的那些的 ENS 的进步适应变化。如此的 ENS 变化模仿在肠的伪阻塞观察的神经元畸形。 | Giovanni Di Nardo Vincenzo Stanghellini Salvatore Cucchiara Giovanni Barbara Gianandrea Pasquinelli Donatella Santini Cristina Felicani Gianluca Grazi Antonio D Pinna Rosanna Cogliandro Cesare Cremon Alessandra Gori Roberto Corinaldesi Kenton M Sanders Roberto De Giorgio | 2006 | World Journal of Gastroenterology2006，12，32： | 4 |
| 7 | Usefulness of ω-3 fatty acid supplementation in addition to mesalazine in maintaining remission in pediatric Crohn's disease: A double-blind, randomized, placebo-controlled study显示文摘AIM: To assess the value of long-chain ω-3 fatty acids (FAs) supplementation in addition to amino-salicylic-acid (5-ASA) in pediatric patients with Crohn's disease (CD).METHODS: Thirty-eight patients (20 males and 18females, mean age 10.13 years, range 5-16 years)with CD in remission were randomized into two groups and treated for 12 mo. Group Ⅰ (18 patients) received 5-ASA (50 mg/kg/d)+ω-3 FAs as triglycerides in gastroresistant capsules, 3 g/d (eicosapentanoic acid, EPA, 400mg/g, docosahexaenoic acid, DHA, 200 mg/g). Group Ⅱ (20 patients) received 5-ASA (50 mg/kg/d)+olive oil placebo capsules. Patients were evaluated for fatty acid incorporation in red blood cell membranes by gas chromatography at baseline 6 and 12 mo after the treatment.RESUJLTS: The number of patients who relapsed at 1year was significantly lower in group Ⅰ than in group Ⅱ(P<0.001). Patients in group Ⅰ had a significant increase in the incorporation of EPA and DHA (P<0.001) and a decrease in the presence of arachidonic acids.CONCLUSION: Enteric-coated ω-3 FAs in addition to treatment with 5-ASA are effective in maintaining remission of pediatric CD. | C Romano S Cucchiara A Barabino V Annese C Sferlazzas SIGENP Italian Study Group of Pediatric Inflammatory Bowel Diseases | 2005 | World Journal of Gastroenterology2005，11，45： | 4 |
| 8 | Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult-and pediatric-onset inflammatory bowel disease in Italy显示文摘AIM: To investigate gene variants in a large Italian inflammatory bowel disease (IBD) cohort, and to analyze the correlation of sub-phenotypes (including age at diagnosis) and epistatic interaction with other IBD genes. METHODS: Total of 763 patients with Crohn's disease (CD, 189 diagnosed at age < 19 years), 843 with ulcerative colitis (UC, 179 diagnosed <19 years), 749 healthy controls, and 546 healthy parents (273 trios) were included in the study. The rs2241880 [autophagy-related 16-like 1 (ATG16L1)], rs11209026 and rs7517847 [interleukin 23 receptor (IL23R)], rs2066844, rs2066845, rs2066847 (CARD15), rs1050152 (OCTN1), and rs2631367 (OCTN2) gene variants were genotyped. RESULTS: The frequency of G allele of ATG16L1 SNP (Ala197Thr) was increased in patients with CD compared with controls (59% vs 54% respectively) (OR = 1.25, CI = 1.08-1.45, P = 0.003), but not in UC (55%). The frequency of A and G (minor) alleles of Arg381Gln, rs11209026 and rs7517847 variants of IL23R were reduced significantly in CD (4%, OR = 0.62, CI = 0.45-0.87, P = 0.005; 28%, OR = 0.64, CI = 0.55-0.75, P < 0.01), compared with controls (6% and 38%, respectively). The A allele (but not G) was also reduced signifi cantly in UC (4%, OR = 0.69, CI = 0.5-0.94, P = 0.019). No association was demonstrated with sub-phenotypes and interaction with CARD15 , and OCTN1/2 genes, although both gene variants were associated with pediatric-onset disease. CONCLUSION: The present study confirms the association of IL23R polymorphisms with IBD, and ATG16L1 with CD, in both adult- and pediatric-onset subsets in our study population. | Anna Latiano Orazio Palmieri Maria Rosa Valvano Renata D'Incà Salvatore Cucchiara Gabriele Riegler Anna Maria Staiano Sandro Ardizzone Salvatore Accomando Gian Luigi de Angelis Giuseppe Corritore Fabrizio Bossa Vito Annese | 2008 | World Journal of Gastroenterology2008，14，29： | 3 |
| 9 | Imaging of the small bowel:Crohn's disease in paediatric patients显示文摘In more than 20% of all patients, the Crohn's diseasepresents before the age of 18 years. The diagnosisand management of Crohn's disease in children haschanged dramatically over the last decade, mainly dueto increased awareness, availability of newer diagnosticmodalities such as magnetic resonance imaging(MRI)and newer, more powerful treatments such as biolog-ics. Imaging of the small bowel is needed for diagno-sis, management, follow-up and also evaluation of thedisease in terms of location, extent, activity and com-plications. We review all the methods(barium exami-nations, ultrasonography, computed tomography, MR,and computed tomography- positron emission tomog-raphy) commonly used for imaging the small bowel inpaediatric patients with Crohn's disease analyzing theadvantages and disadvantages of each modality, withparticular emphasis on MR imaging. | Emanuele Casciani Chiara De Vincentiis Elisabetta Polettini Gabriele Masselli Giovanni Di Nardo Fortunata Civitelli Salvatore Cucchiara Gian Franco Gualdi | 2014 | World Journal of Radiology2014，6，6： | 2 |
| 10 | Diagnosis and Management of Cerebral Venous Thrombosis: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | Gustavo Saposnik Fernando Barinagarrementeria Robert D. Brown Cheryl D. Bushnell Brett Cucchiara Mary Cushman Gabrielle deVeber Jose M. Ferro Fong Y. Tsai | 2011 | Stroke2011，，4： | 2 |
| 11 | Narrow band imaging combined with water immersion technique in the diagnosis of celiac disease显示文摘 | Francesco Valitutti Salvatore Oliva Donatella Iorfida Marina Aloi Silvia Gatti Chiara Maria Trovato Monica Montuori Antonio Tiberti Salvatore Cucchiara Giovanni Di Nardo | 2014 | Digestive and Liver Disease2014，，： | 2 |
| 12 | Small Intestine Contrast Ultrasonography in Pediatric Crohn’s Disease显示文摘 | Nadia Pallotta Fortunata Civitelli Giovanni Di Nardo Giuseppina Vincoli Marina Aloi Franca Viola Paolo Capocaccia Enrico Corazziari Salvatore Cucchiara | 2013 | The Journal of Pediatrics2013，，： | 2 |
| 13 | Detecting moving objects,ghosts,and shadows in video streams显示文摘 | Cucchiara R Piccardi M Prati A | 2003 | IEEE Transactions on Pattern Analysis and Machine Intelligence2003，25，10： | 1 |
| 14 | Prior antiplatelet use does not affect hemorrhage growth or outcome after ICH 显示文摘 | Sansing LH Messe SR Cucchiara BL | 2009 | Neurolagy2009，72，16： | 1 |
| 15 | Detecting moving objects,ghosts,and shadows in video streams显示文摘 | Cucchiara R Piccardi M Prati A | 2003 | IEEE Transactions on Pattern Analysis and Machine Intelligence2003，25，10： | 1 |
| 16 | Detecting objects, sahdows and ghosts in video streams by exploiting color and motion information显示文摘 | Cucchiara R Grana C Piccardi M | 2001 | Proceedings of the IEEE Int''l Conference on Image Analysis and Processing2001，，： | 1 |
| 17 | Evaluation and management of stroke显示文摘 | CUCCHIARA B L | 2009 | Hematology Am Soc Hematol Educ Program2009，，： | 1 |
| 18 | Prophylactic antiepileptic drug use is associated with poor outcome following ICH显示文摘 | Messe S R Sansing L H Cucchiara B L | 2009 | Neurocrit Care2009，11，1： | 1 |
| 19 | An Integrated Framework for Semantic Annotation and Adaptation显示文摘 | Bertini M Cucchiara R Prati A | | 0，，03： | 1 |
| 20 | Childhood functional gastrointestinal disorders 显示文摘 | Rasquin - Weber A Hyman PE Cucchiara S | 1999 | Gut1999，45，2： | 1 |
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