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| 1 | Single-operator cholangioscopy for biliary complications in liver transplant recipients显示文摘AIM To evaluate cholangioscopy in addition to endoscopic retrograde cholangiopancreatography(ERCP) for management of biliary complications after liver transplantation(LT).METHODS Twenty-six LT recipients with duct-to-duct biliary reconstruction who underwent ERCP for suspected biliary complications between April and December2016 at the university hospital of Muenster were consecutively enrolled in this observational study. After evaluating bile ducts using fluoroscopy, cholangioscopy using a modern digital single-operator cholangioscopy s y s t e m(S py G la s s D S ?) wa s pe r fo r me d dur ing the same procedure with patients under conscious sedation. All patients received peri-interventional antibiotic prophylaxis and bile was collected during the intervention for microbial analysis and for antibiotic susceptibility testing.RESULTS Thirty-three biliary complications were found in a total of 22 patients, whereas four patients showed normal bile ducts. Anastomotic strictures were evident in 14(53.8%) patients, non-anastomotic strictures in seven(26.9%), biliary cast in three(11.5%), and stones in six(23.1%). A benefit of cholangioscopy was seen in 12(46.2%) patients. In four of them, cholangioscopy was crucial for selective guidewire placement prior to planned intervention. In six patients, biliary cast and/or stones failed to be diagnosed by ERCP and were only detectable through cholangioscopy. In one case, a bile duct ulcer due to fungal infection was diagnosed by cholangioscopy. In another case, signs of bile duct inflammation caused by acute cholangitis were evident. One patient developed post-interventional cholangitis. No further procedure-related complications occurred. Thirty-seven isolates were found in bile. Sixteen of these were gram-positive(43.2%), 12(32.4%) were gram-negative bacteria, and Candida species accounted for 24.3% of all isolated microorganisms. Interestingly, only 48.6% of specimens were sensitive to prophylactic antibiotics.CONCLUSION Single-operator cholangioscopy can provide important diagnostic information, helping endoscopists to plan and perform interventional procedures in LT-related biliary complications. | Anna Hüsing-Kabar Hauke Sebastian Heinzow Hartmut Hans-Jürgen Schmidt Carina Stenger Hans Ulrich Gerth Michele Pohlen Gerold Tholking Christian Wilms Iyad Kabar | 2017 | World Journal of Gastroenterology2017，23，22： | 4 |
| 2 | Paclitaxel-eluting balloon dilation of biliary anastomotic stricture after liver transplantation显示文摘AIM:To investigate the safety and effectiveness of endoscopic therapy with a paclitaxel-eluting balloon(PEB) for biliary anastomotic stricture(AS) after liver transplantation(LT).METHODS:This prospective pilot study enrolled 13 consecutive eligible patients treated for symptomatic AS after LT at the University Hospital of Münster between January 2011 and March 2014.The patients were treated by endoscopic therapy with a PEB and followed up every 8 wk by endoscopic retrograde cholangiopancreatography(ERCP).In cases of re-stenosis,further balloon dilation with a PEB was performed.Follow-up was continued until 24 mo after the last intervention.RESULTS:Initial technical feasibility,defined as successful balloon dilation with a PEB during the initial ERCP procedure,was achieved in 100% of cases.Long-term clinical success(LTCS),defined as no need for further endoscopic intervention for at least 24 mo,was achieved in 12 of the 13 patients(92.3%).The mean number of endoscopic interventions required to achieve LTCS was only 1.7 ± 1.1.Treatment failure,defined as the need for definitive alternative treatment,occurred in only one patient,who developed recurrent stenosis with increasing bile duct dilatation that required stent placement.CONCLUSION:Endoscopic therapy with a PEB is very effective for the treatment of AS after LT,and seems to significantly shorten the overall duration of endoscopic treatment by reducing the number of interventions needed to achieve LTCS. | Anna Hüsing Holger Reinecke Vito R Cicinnati Susanne Beckebaum Christian Wilms Hartmut H Schmidt Iyad Kabar | 2015 | World Journal of Gastroenterology2015，21，3： | 4 |
| 3 | Primary Gastric B-Cell Lymphoma: Results of a Prospective Multicenter Study显示文摘 | Wolfgang Fischbach* Brigitte Dragosics? Maria-Elisabeth Kolve-Goebeler§ Christian Ohmann∥ Axel Greiner? Qin Yang∥ Stephan B?hm? Patrick Verreet∥ Olaf Horstmann# Martin Busch** Eckhart Dühmke** Hans-Konrad Müller-Hermelink? Klaus Wilms§ | 2000 | Gastroenterology2000，，5： | 1 |
| 4 | One Hundred Thirty-Two Consecutive Pediatric Liver Transplants Without Hospital Mortality: Lessons Learned and Outlook for the Future显示文摘 | Dieter C. Broering Jong-Sun Kim Teresa Mueller Lutz Fischer Rainer Ganschow Turan Bicak Lars Mueller Christian Hillert Christian Wilms Bernd Hinrichs Knut Helmke Werner Pothmann Martin Burdelski Xavier Rogiers | 2004 | Annals of Surgery2004，，6： | 1 |
| 5 | Comparative Study of Portal Vein Embolization Versus Portal Vein Ligation for Induction of Hypertrophy of the Future Liver Remnant Using a Mini-Pig Model显示文摘 | Christian Wilms Lars Mueller Christian Lenk Oliver Wittkugel Knut Helmke Gerrit Krupski-Berdien Xavier Rogiers Dieter C. Broering | 2008 | Annals of Surgery2008，，5： | 1 |
| 6 | Quantitative two-photon Ca2+ imaging via fluorescence lifetime analysis显示文摘 | Christian D Wilms Hatmut Schmidt Jens Eilers | | 0，，： | 1 |
| 7 | Comparative Study of Portal Vein Embolization Versus Portal Vein Ligation for Induction of Hypertrophy of the Future Liver Remnant Using a Mini-Pig Model显示文摘 | Christian Wilms Lars Mueller Christian Lenk Oliver Wittkugel Knut Helmke Gerrit Krupski-Berdien Xavier Rogiers Dieter C. Broering | 2008 | Annals of Surgery2008，，5： | 1 |
| 8 | Comparative Study of Portal Vein Embolization Versus Portal Vein Ligation for Induction of Hypertrophy of the Future Liver Remnant Using a Mini-Pig Model显示文摘 | Christian Wilms Lars Mueller Christian Lenk Oliver Wittkugel Knut Helmke Gerrit Krupski-Berdien Xavier Rogiers Dieter C. Broering | 2008 | Annals of Surgery2008，，5： | 1 |
| 9 | Observatory science with eXTP显示文摘In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s. | Jean J.M.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina Baglio David R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous Pere Blay Joao Braga Sφren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien Mauro Orlandini Julian P.Osborne Luigi Pacciani Stéphane Paltani Maurizio Paolillo Iossif E.Papadakis Biswajit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo Reig Alessandro Riggio Jerome Rodriguez Pablo Rodríguez-Gil Patrizia Romano Agata Rózańska Takanori Sakamoto Tuomo Salmi Ruben Salvaterra andrea Sanna andrea Santangelo Tuomas Savolainen Stéphane Schanne Hendrik Schatz LiJing Shao andy Shearer Steven N.Shore Ben W.Stappers Tod E.Strohmayer Valery F.Suleimanov Jirí Svoboda F.-K.Thielemann Francesco Tombesi Diego F.Torres Eleonora Torresi Sara Turriziani andrea Vacchi Stefano Vercellone Jacco Vink Jian-Min Wang JunFeng Wang Anna L.Watts ShanShan Weng Nevin N.Weinberg Peter J.Wheatley Rudy Wijnands Tyrone E.Woods Stan E.Woosley ShaoLin Xiong YuPeng Xu Zhen Yan George Younes WenFei Yu Feng Yuan Luca Zampieri Silvia Zane andrzej A.Zdziarski Shuang-Nan Zhang Shu Zhang Shuo Zhang Xiao Zhang Michael Zingale | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 0 |
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