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| 1 | 原发灶切除在无症状的、同时性的、转移灶不可切除的结直肠癌患者中的作用:一项多中心随机对照试验显示文摘目的:我们在同时性的、转移灶不可切除的无症状Ⅳ期结直肠癌患者中,评估接受原发灶切除术(primary tumor resection,PTR)续贯化疗的患者相比接受单纯化疗的患者的生存优势。方法:这是一项开放的前瞻性随机对照试验(ClnicalTrials.gov注册号:NCT01978249)。从2013年5月至2016年4月,在12所三级医院中将48例诊断为转移灶不可切除的、原发灶无症状的结直肠癌患者按1:1比例进行随机化分组,其中PTR组26例、化疗组22例。主要终点是两年总生存率,次要终点为与原发灶、PTR相关的并发症发生率以及转变为可切除状态的转化率。 | 卓长华 陈功 PARK E J BAEK J H CHOI G S | 2020 | 结直肠肛门外科2020，26，5： | 8 |
| 2 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 3 | Second-look endoscopy with prophylactic hemostasis is still effective after endoscopic submucosal dissection for gastric neoplasm显示文摘AIM: The clinical value of second-look endoscopy(SLE) after endoscopic submucosal dissection(ESD) has been doubted continuously. The aim of this study was to assess the effectiveness of SLE based on the risk of delayed bleeding after ESD. METHODS: A total of 310 lesions of gastric epithelial neoplasms treated by ESD were reviewed. The lesions were divided into two groups based on the risk of postprocedural bleeding estimated by Forrest classification. The high risk of rebleeding group(Forrest?Ⅰa,?Ⅰb and Ⅱa) required endoscopic treatment, while the low risk of rebleeding group(Forrest Ⅱb, Ⅱc and Ⅲ) did not. Delayed bleeding after ESD was investigated. RESULTS: Sixty-six lesions were included in the high risk of rebleeding group and 244 lesions in the low risk of rebleeding group. There were no significant differences in delayed bleeding between the high risk group(1/66) and the low risk group(1/244)(P = 0.38). The high risk of rebleeding group tended to be located more often in the mid-third and had higher appearance of flat or depressed shape than the low risk group(P = 0.004 and P = 0.006, respectively). CONCLUSION: SLE with pre-emptive prophylactic endoscopic treatment is still effective in preventing delayed bleeding after ESD. | Ji Hye Jung Beom Jin Kim Chang Hwan Choi Jae G Kim | 2015 | World Journal of Gastroenterology2015，21，48： | 3 |
| 4 | The quality of reconstructed 3D images in mutidetector-row helical CT: experimental study involving scan parameters显示文摘 | Shin J H Lee H K Choi C G | 2002 | Korean J Radiol2002，3，1： | 2 |
| 5 | All-optical clock recovery from NRZ data with simple NRZ-to-PRZ converter based on self-modulation of semiconductor optical amplifier显示文摘 | Lee H J Kim H G Choi J Y | 1999 | Electronics Letters1999，35，12： | 2 |
| 6 | Evaluation of seismic performance of multistory building structures based on the equivalent responses 显示文摘 | LEE D G CHOI W H CHEONG M C | 2006 | Engineering Structures2006，28，6： | 1 |
| 7 | A generalized ordering and recovery policy for reusable items显示文摘 | CHOI DW HWANG H KOH S G | 2007 | European Journal of Operational Research2007，182，2： | 1 |
| 8 | Low expression of p27(Kip1) in advanced mucoepidermoid carcinoma of head and neck显示文摘 | Choi G Jung KY | 2001 | Head Neck2001，23，4： | 1 |
| 9 | Random sequence analy-sis of genomie DNA of a hyperthemophile:Aquifex pyrophilus显示文摘 | Kim S S Ryu J R | 1997 | Extremophiles1997，1，3： | 1 |
| 10 | Antifungal activity of the methanol extract of Myristica malabarica fruit rinds and the active ingredients malabaricones against phytopathogenic fungi 显示文摘 | Choi H N Choi J G Jang S K | 2008 | Plant Pathol2008，24，3： | 1 |
| 11 | AtMYB21,a gene encoding a flower-specific transcription factor,is regulated by COP1显示文摘 | Shin B Choi G Yi H | 2002 | The Plant Journal2002，30，1： | 1 |
| 12 | Improvement of 4I11/2→4I13/2 transition rate and thermal stabilities in Er3+-doped TeO2-B2O3-(GeO2)ZnO-K2O Glasses 显示文摘 | Cho D H Choi Y G Kim K H | 2001 | ETRI Joural(S1225-6463)2001，2，4： | 1 |
| 13 | Protective effects of extract with phenolics from Camellia (Camellia japonica) leaf against oxidative stress- induced neurotoxicity显示文摘 | JEONG C H KIM J H CHOI G N | 2010 | Food Sci Biotechnol2010，19，5： | 1 |
| 14 | Relationship be- tween psychological factors and quality of life in subtypes of gastroesophageal reflux disease显示文摘 | Oh J H Kim T S Choi M G | 2009 | Gut Liver2009，3，4： | 1 |
| 15 | The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference显示文摘 | CHOI D S CASCINI M G MAILLIARD W | 2004 | Nat Neurosci2004，7，8： | 1 |
| 16 | Over expression of CD24:association with invasiveness in urothelial carcinoma of bladder显示文摘 | Choi Y L Lee S H Kwon G Y | 2007 | Arch Pathol Lab Med2007，131，2： | 1 |
| 17 | The relationship betweeninflammation and the coagulation system显示文摘 | Choi G Scbultz MJ Levi M | 2006 | SWISS MEDWKLY2006，136，910： | 1 |
| 18 | Underwater autonomous manipulation for intervention missions AUVs 显示文摘 | Marani G Choi S K Yuh J | 2009 | Ocean Engineering2009，36，1： | 1 |
| 19 | B7-H4,a molecule of the B7 family, negatively regulates T cell immunity显示文摘 | Sica GL Choi IH Zhu G | 2003 | Immunity2003，18，6： | 1 |
| 20 | Virtual Prototyping Simulation for Design of Mechanical Systems显示文摘 | HAUG E J CHOI K K ZZJ G Kuhl | 1995 | Transactions of the ASME Special 50th Anniversary DesignIssue1995，117，： | 1 |
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