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142篇 您的检索式：作者名="Do Y Lee"

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	题名	作者	年代	出处	被引量
1	4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells.	Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon	2017	Cellular & Molecular Immunology2017，14，9：	6
2	Multiple primary cancers in patients with non-Uodgkin's lymphoma显示文摘	Song H Do Y Lee W	2006	J Clin Oncol2006，，17：	1
3	Tumor necrosis factor α-induced interleukin-32 is positively regulated via the Syk/protein kinase Cδ/JNK pathway in rheumatoid synovial fibroblasts显示文摘	Mun S H Kim J W Nah S S Ko N Y Lee J H Kim J D Kim do K Kim H S Choi J D Kim S H Lee C K Park S H Kim B K Kim H S Kim Y M and Choi W S		0，，03：	1
4	ERK1/2 activation attenuates TRAIL-induced apoptosis through the regulation of mitochondria-dependent pathway显示文摘	Lee do y Lee MW Lee HJ	2006	Toxicol In Vitro2006，20，6：	1
5	Uterine arterial embolization for the treatment of uterine leiomyomas显示文摘	Jang JB Lee do Y	2002	Yonsei Med J2002，43，3：	1
6	Structural effects of n-aromatic acyl-aminoacid conjugates on their deconjugation in the cecal contentsof rats: implication in design of a colon-specific prodrugwith controlled conversion rate at the target site 显示文摘	Kong H Kim H Do H Lee Y Hong S Yoon J H JungY Kim Y M	2011	Bio pharmaceutics Drug Disposition2011，32，6：	1
7	Ovarian expression of melatonin Me(Ia)receptor mRNA during mouse development显示文摘	DO B R Lee Y H	2001	Mol Reprod Dev2001，59，2：	1
8	Fate of donor mitochondrial DNA in cloned bovine embryos produced by microinjection of cumulus cells显示文摘	Do J T Lee J W Lee B Y	2002	Biol Reprod2002，67，2：	1
9	ERK1/2 activation at- tenuates TRAIL-induced apoptosis through the regulation of mitochondria-dependent pathway显示文摘	Lee do Y Lee MW Lee HJ	2006	Toxicol in Vitro2006，20，6：	1
10	EUC- guided transural cholecystostomy as rescue manage- ment for acute cholecystitis in elderly or high-risk pa- tients: a prospective feasibility study 显示文摘	LEE S S PARK DO H HWANG C Y	2007	Gastrointest Endos2007，66，：	1
11	Uterine arterial embolization for the treatment of uterine leiomyomas显示文摘	Bai SW Jang JB Lee do Y	2002	Yonsei Med J2002，43，3：	1
12	Early on-treatment predictions of clinical outcomes using alpha-fetoprotein and des-gamma-carboxy prothrombin responses in patients with advanced hepatocellular carcinoma 显示文摘	Lee M I-I Kim S U Kim do Y	2011	J Gastroen- terol Hepatol2011，27，2：	1
13	Long-term adefovir dipivoxil monotherapy for up to 5 years in lamivudineresistant chronic hepatitis B显示文摘	Lee JM Park JY Kim do Y	2010	Antivir Ther2010，15，2：	1
14	Long-term adefovir dipivoxil monotherapy for up to 5 years in lamivudine-resistant chronic hepatitis B显示文摘	Lee JM Park JY Kim do Y	2010	Antivir Ther2010，15，2：	1
15	The effect of WO3 on the photo - catalytic activity of TiO2显示文摘	DO Y R LEE W DWIGHT K	1994	Journal of Solid State Chemistry1994，108，1：	1
16	Preoperative localization of early colorectal cancer or a malignant polyp by using the patient' s own blood 显示文摘	Lee SH Kim do Y Oh SY	2014	Ann Coloproctol2014，30，：	1
17	Percutaneous modular stent grafts in the treatment of abdominal aortic aneurysms显示文摘	Kang SG Choi D	2003	Endovase Ther2003，10，：	1
18	The effect of W03 on the photocatalytic activity of TiO2 显示文摘	Do Y R Lee W Dwight K	1994	J Solid State Chem1994，108，1：	1
19	Angiopoietin-I suppresses choroidal neovascularization and vascular leakage 显示文摘	Lee J Park DY Park do Y Park I Chang W Nakaoka Y	2014	Invest Ophthalmol Vis Sci2014，55，8：	1
20	The effect of WO3 on the photocatalytic activity of TiO2显示文摘	Y R Do Lee W Dwight K	1994	Journal of Solid State Chemistry1994，108，1：	1

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