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| 1 | Whole-genome sequencing provides insights into the genetic diversity and domestication of bitter gourd(Momordica spp.)显示文摘Bitter gourd(Momordica charantia)is a popular cultivated vegetable in Asian and African countries.To reveal the characteristics of the genomic structure,evolutionary trajectory,and genetic basis underlying the domestication of bitter gourd,we performed whole-genome sequencing of the cultivar Dali-11 and the wild small-fruited line TR and resequencing of 187 bitter gourd germplasms from 16 countries.The major gene clusters(Bi clusters)for the biosynthesis of cucurbitane triterpenoids,which confer a bitter taste,are highly conserved in cucumber,melon,and watermelon.Comparative analysis among cucurbit genomes revealed that the Bi cluster involved in cucurbitane triterpenoid biosynthesis is absent in bitter gourd.Phylogenetic analysis revealed that the TR group,including 21 bitter gourd germplasms,may belong to a new species or subspecies independent from M.charantia.Furthermore,we found that the remaining 166 M.charantia germplasms are geographically differentiated,and we identified 710,412,and 290 candidate domestication genes in the South Asia,Southeast Asia,and China populations,respectively.This study provides new insights into bitter gourd genetic diversity and domestication and will facilitate the future genomics-enabled improvement of bitter gourd. | Junjie Cui Yan Yang Shaobo Luo Le Wang Rukui Huang Qingfang Wen Xiaoxia Han Nansheng Miao Jiaowen Cheng Ziji Liu Changyuan Zhang Chengcheng Feng Haisheng Zhu Jianwen Su Xinjian Wan Fang Hu Yu Niu Xiaoming Zheng Yulan Yang Dai Shan Zhensheng Dong Weiming He Narinder P.S.Dhillon Kailin Hu | 2020 | Horticulture Research2020，7，1： | 7 |
| 2 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 3 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 4 | High-risk phenotypes of genetic disease in a Neonatal Intensive Care Unit population显示文摘To the Editor: Genetic diseases contribute to 35% of deaths during the first year of life and are a significant cause of intensive care.[1] A previous study based on the China Neonatal Genomes Project investigated the genetic causes of early infant deaths and found that >25% of deceased neonates with genetic diagnoses can be cured if diagnosed in time.[2] Therefore, it is crucial to target and diagnose neonates with genetic diseases as early as possible. According to our experience, the typical phenotypes, such as special facial features or multiple congenital anomalies (MCAs), indicate a high risk of genetic disease and lead physicians to perform genetic testing in neonates as early as possible. However, in practice, infants without typical phenotypes typically undergo a long and costly diagnostic process before genetic diagnoses are confirmed. Moreover, a recent survey by the American College of Medical Genetics and Genomics (ACMG) and other national professional organizations indicated that there are insufficient numbers of qualified geneticists to fulfil genetic service needs.[3] The ACMG published the general clinical features for genetic testing indications. For example, patients with phenotypes or family history data that strongly implicate a genetic cause may undergo genetic testing.[1] However, the study indicated that many genetic conditions arise de novo or are inherited with no family history.[1] A previous study attempted to apply the non-phenotype-driven panel approach in neonates admitted to the neonate intensive care unit (NICU).[4] However, at present, the diagnostic yield is only 3.45% (1/29).[4] In addition, the economic and ethical issues associated with genomic screening remain challenging. Therefore, the available indications for genetic testing may improve the management of genetic diseases. | Tiantian Xiao Qi Ni Huiyao Chen Huijun Wang Lin Yang Bingbing Wu Yun Cao Guoqiang Cheng Laishuan Wang Liyuan Hu Hongfang Mei Yulan Lu Mengchun Gong Xinran Dong Wenhao Zhou | 2022 | Chinese Medical Journal2022，，5： | 2 |
| 5 | Development and application of ex-situ presulfurization technology for hydrotreating catalysts in China显示文摘The development and application of ex-situ presulfurization(EPRES)technology for hydrotreating catalysts has been reviewed in the present article.The studies in laboratory scale and commercial practice indicated that the adoption of the EPRES catalyst in industrial application can significantly enhance the degree of presulfurization of metal oxide components,shorten the start-up period,and effectively reduce the environmental impact as well as the danger of start-up procedure in industrial hydrotreating unit.This catalyst has been proved to be versatile for different types of hydrogenation reactions.Different types of active site models are also discussed for better understanding the nature of presulfur-ized catalysts. | Yulan GAO Xiangchen FANG Zhenmin CHENG | 2011 | Frontiers of Chemical Science and Engineering2011，5，3： | 2 |
| 6 | Endoglin promoter hypermethylation identifies a field defect in human primary esophageal cancer显示文摘 | Zhe Jin Zhenfu Zhao Yulan Cheng Ming Dong Xiaojing Zhang Liang Wang Xinmin Fan Xianling Feng Yuriko Mori Stephen J. Meltzer | 2013 | Cancer2013，，20： | 2 |
| 7 | The Study of Relationships between the Damage of Visual Function and Hemorrheology, Ocular Rheography, as well as Other Related Factors in Patients with Primary Open Angle Glaucoma (POAG)显示文摘Researches of glaucoma visual function damage, hemorrheololgy, ocular rheography and other related multiplex factors, with computed multifactorial stepwise regresion analysis, indicate that the elevation of intraocular pressure (IOP) is not the only factor to induce visual impairment. POAG patients are shown to have markedly reduced diastolic purfussion pressure in ophthalmic artery, besides prolonged filling time of the retinal artery and vein, diminished erythrocyte deformability and increased platele... | Jian Ge, Wenbing Zhou National Ophthalmological Laboratories, Ministry of Public Health, China, Zhongshan Ophthalmic Center, Sun Yat-Sen University of Medical Sciences, Guangzhou 510060, China Jiancu Zhu, Anheng Cheng, Yulan Lin, Hongyan Tong, Lin Lian, Zhixing Chen Institute of Cardiovascular Diseases of Guangdong Province, Guangzhou 510080, China | 1993 | 眼科学报1993，9，1： | 1 |
| 8 | Hypomethylation of Noncoding DNA Regions and Overexpression of the Long Noncoding RNA, AFAP1-AS1 , in Barrett’s Esophagus and Esophageal Adenocarcinoma显示文摘 | Wenjing Wu Tushar D. Bhagat Xue Yang Jee Hoon Song Yulan Cheng Rachana Agarwal John M. Abraham Sariat Ibrahim Matthias Bartenstein Zulfiqar Hussain Masako Suzuki Yiting Yu Wei Chen Charis Eng John Greally Amit Verma Stephen J. Meltzer | 2013 | Gastroenterology2013，，5： | 1 |
| 9 | Selenium-enriched Cardamine violifolia protects against sepsis-induced intestinal injury by regulating mitochondrial fusion in weaned pigs显示文摘Sepsis is a life-threatening organ dysfunction caused by the dysregulated response of the host to an infection, and treatments are limited. Recently, a novel selenium source, selenium-enriched Cardamine violifolia(SEC) has attracted much attention due to its anti-inflammatory and antioxidant properties, but little is known about its role in the treatment of sepsis. Here, we found that SEC alleviated LPS-induced intestinal damage, as indicated by improved intestinal morphology, and increased disaccharidase activity and tight junction protein expression. Moreover, SEC ameliorated the LPS-induced release of pro-inflammatory cytokines, as indicated by decreased IL-6 level in the plasma and jejunum. Moreover, SEC improved intestinal antioxidant functions by regulating oxidative stress indicators and selenoproteins. In vitro, TNF-α-challenged IPEC-1 cells were examined and showed that selenium-enriched peptides, which are the main functional components extracted from Cardamine violifolia(CSP), increased cell viability, decreased lactate dehydrogenase activity and improved cell barrier function. Mechanistically, SEC ameliorated LPS/TNF-α-induced perturbations in mitochondrial dynamics in the jejunum and IPEC-1 cells. Moreover, CSPmediated cell barrier function is primarily dependent on the mitochondrial fusion protein MFN2 but not MFN1. Taken together,these results indicate that SEC mitigates sepsis-induced intestinal injury, which is associated with modulating mitochondrial fusion. | Dan Wang Yanling Kuang Qingqing Lv Wenshuai Xie Xiao Xu Huiling Zhu Yue Zhang Xin Cong Shuiyuan Cheng Yulan Liu | 2023 | Science China(Life Sciences)2023，66，9： | 1 |
| 10 | Single molecular insight into steric effect on C-terminal amino acids with various hydrogen bonding sites显示文摘Amino acids are basic units to construct a protein with the assistance of various interactions.During this building process,steric hindrance derived from amino acid side groups or side chains is a factor that could not be ignored.In this contribution,adsorption behaviors of C-terminal amino acid derivatives with amino acid residues fused in 3,4,9,10-perylenetetracarboxylic dianhydride were investigated by scanning tunneling microscopy(STM)and density functional theory(DFT)calculations at various liquid/solid interfaces.STM results at 1-phenyloctane/HOPG interface show that N,N'-3,4,9,10-perylenedicarboximide(GP)and N,N'-methyl-3,4,9,10-perylenedicarboximide(AP)formed linear and herringbone structures,respectively.The driving force could be attributed to different H-bonding sites induced by steric hindrance at side groups.N,N'-Benzyl-3,4,9,10-perylenedicarboximide(PP)generates both linear and herringbone structures because steric hindrance changes the H-bonding sites between PP molecules,whereas N,N'-isopropyl-3,4,9,10-perylenedicarboximide(LP)failed to be imaged because of strong steric hindrance coming from larger side group.To further investigate the impact of steric hindrance,we utilized octanoic acid(OA)as solvent to capture the adsorption details of LP and PP.We found that OA molecules drag PP and LP molecules in a different direction to generate linear structure,impeding the molecular rotation.The structure–solvent relationship shows that the steric hindrance is brought by the large side group,which makes it easier to recognize OA molecules at the interface.These results demonstrate that steric effect plays a significant role in altering interaction sites of the compounds during the adsorption process at the liquid/solid interface. | Yunzhi Xie Chunhua Liu Linxiu Cheng Yulan Fan Huifang Li Wei Liu Lei Zhu Xun Li Ke Deng Qingdao Zeng Shoufa Han | 2022 | Chinese Chemical Letters2022，33，10： | 1 |
| 11 | The miR-106b-25 Polycistron, Activated by Genomic Amplification, Functions as an Oncogene by Suppressing p21 and Bim显示文摘 | Takatsugu Kan Fumiaki Sato Tetsuo Ito Nobutoshi Matsumura Stefan David Yulan Cheng Rachana Agarwal Bogdan C. Paun Zhe Jin Alexandru V. Olaru Florin M. Selaru James P. Hamilton Jian Yang John M. Abraham Yuriko Mori Stephen J. Meltzer | 2009 | Gastroenterology2009，，5： | 1 |
| 12 | A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis显示文摘 | Li‐Dong Wang Xiuli Bi Xin Song Nicole M. Pohl Yulan Cheng Yixing Zhou Stephen Shears Emmanuel Ansong Mengtao Xing Shaomeng Wang Xiao‐Chun Xu Peng Huang Liyan Xu Liang Wang Zongmin Fan Xueke Zhao Huali Dong Stephen J. Meltzer Ivan Ding Wancai Yang | 2013 | Mol Carcinog2013，，1： | 1 |
| 13 | Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization显示文摘 | Chaturvedi R Cheng Yulan Asim M | 2004 | J Biol Chem2004，279，40： | 1 |
| 14 | The rice WUSCHEL -related homeobox genes are involved in reproductive organ development, hormone signaling and abiotic stress response显示文摘 | Saifeng Cheng Yulan Huang Ning Zhu Yu Zhao | 2014 | Gene2014，，2： | 1 |
| 15 | Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage:implications for gastric carcinogenesis显示文摘 | Xu Hangxiu Chaturvedi R Cheng Yulan | 2004 | Cancer Res2004，64，23： | 1 |
| 16 | Hypomethylation of Noncoding DNA Regions and Overexpression of the Long Noncoding RNA, AFAP1-AS1 , in Barrett’s Esophagus and Esophageal Adenocarcinoma显示文摘 | Wenjing Wu Tushar D. Bhagat Xue Yang Jee Hoon Song Yulan Cheng Rachana Agarwal John M. Abraham Sariat Ibrahim Matthias Bartenstein Zulfiqar Hussain Masako Suzuki Yiting Yu Wei Chen Charis Eng John Greally Amit Verma Stephen J. Meltzer | 2013 | Gastroenterology2013，，5： | 1 |
| 17 | SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infection显示文摘The long-term immunity and functional recovery after SARS-CoV-2 infection have implications in preventive measures and patient quality of life.Here we analyzed a prospective cohort of 121 recovered COVID-19 patients from Xiangyang,China at 1-year after diagnosis.Among them,chemiluminescence immunoassay-based screening showed 99%(95%CI,98–100%)seroprevalence 10–12 months after infection,comparing to 0.8%(95%CI,0.7–0.9%)in the general population.Total anti-receptor-binding domain(RBD)antibodies remained stable since discharge,while anti-RBD IgG and neutralization levels decreased over time.A predictive model estimates 17%(95%CI,11–24%)and 87%(95%CI,80–92%)participants were still 50%protected against detectable and severe re-infection of WT SARS-CoV-2,respectively,while neutralization levels against B.1.1.7 and B.1.351 variants were significantly reduced.All non-severe patients showed normal chest CT and 21%reported COVID-19-related symptoms.In contrast,53%severe patients had abnormal chest CT,decreased pulmonary function or cardiac involvement and 79%were still symptomatic.Our findings suggest long-lasting immune protection after SARS-CoV-2 infection,while also highlight the risk of immune evasive variants and long-term consequences for COVID-19 survivors. | Yan Zhan Yufang Zhu Shanshan Wang Shijun Jia Yunling Gao Yingying Lu Caili Zhou Ran Liang Dingwen Sun Xiaobo Wang Zhibing Hou Qiaoqiao Hu Peng Du Hao Yu Chang Liu Miao Cui Gangling Tong Zhihua Zheng Yunsheng Xu Linyu Zhu Jin Cheng Feng Wu Yulan Zheng Peijun Liu Peng Hong | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 0 |
| 18 | Bioassay of Carcinoembryonic Antigens by Organic Field-effect Transistors Based on D-A Type Conjugated Polymer显示文摘Biosensors based on organic field-effect transistors(OFETs)are one of the most promising electronic devices for emerging bioanalytical applications.The selection of organic semiconductors(OSCs)is essential to improve the sensitivity and reliability of this kind of biosensors.Given the good field effect performance and tunable structures of D-A type conjugated polymers,here,we design two D-A type copolymers[P(BDT-co-DPP2T-ThC_(2))and P(BDT-co-DPP2T-Th)],which are applied as the OSC layers.With carcinoembryonic antigen antibody(anti-CEA)adsorbed onto the OSC layers as the recognition sites,OFETs based biosensors for CEA detection are developed.The experimental findings support that the attachment of ester side groups onto the polymer backbone[as for P(BDT-co-DPP2T-ThC_(2))]is favorable for improved solubility and filming properties of the polymer.The introduction of ester side groups affects molecular stacking and enhances intermolecular forces.The resultant devices show high charge mobility and antibody adsorption ability,both of which are critical for sensitive and facile detection of CEA biomarkers.The reliable determination of CEA down to the picomolar level is determined.It is expected that this kind of biosensors fabricated by D-A type conducting polymers will open new avenues toward the early diagnosis,real-time monitoring and treatment of future cancer diseases. | LYU Xiaomeng DUAN Yuchen CHEN Yulan CHENG Shanshan | 2023 | Chemical Research in Chinese Universities2023，39，6： | 0 |
| 19 | Recent progress of inverted organic-inorganic halide perovskite solar cells显示文摘In recent years,inverted perovskite solar cells(IPSCs)have attracted significant attention due to their low-temperature and cost-effective fabrication processes,hysteresis-free properties,excellent stability,and wide application.The efficiency gap between IPSCs and regular structures has shrunk to less than 1%.Over the past few years,IPSC research has mainly focused on optimizing power conversion efficiency to accelerate the development of IPSCs.This review provides an overview of recent improvements in the efficiency of IPSCs,including interface engineering and novel film production techniques to overcome critical obstacles.Tandem and integrated applications of IPSCs are also summarized.Furthermore,prospects for further development of IPSCs are discussed,including the development of new materials,methods,and device structures for novel IPSCs to meet the requirements of commercialization. | Dongyang Li Yulan Huang Zhiwei Ren Abbas Amini Aleksandra B.Djurišic Chun Cheng Gang Li | 2023 | Journal of Energy Chemistry2023，，4： | 0 |
| 20 | Health Status of Left-Behind Children and Parenting Behaviors of Caregivers in Poor Rural Areas-6 Provinces,China,2018显示文摘What is already known about this topic?China has a significant population of left-behind children,and their health and living environments remain a major public health challenge.Children under 6 years old are especially vulnerable to poor health knowledge and behaviors of their caregivers.What is added by this report?The prevalence of stunting,being underweight,and often sick were 13%,3.4%,and 5%,respectively.Only 53.9%of left-behind children could eat meat often,and 59.5%could control their intake of sugary drinks.The proportions of children who had a safe home environment,a safe play environment,and no family violence were 22.5%,75.3%,and 45.9%,respectively.The percentages of caregivers who ensured that they rarely left their children alone and were always in their sight are 76.1%and 92.4%,respectively.What are the implications for public health practice?The implementation of early home visits is necessary to improve the physical health and safety of the living environment of left-behind children.Primary health workers should pay attention to improving the health knowledge and behaviors of caregivers. | Feifei Jin Zhengkui Liu Yufang Liu Chen Yao Yulan Cheng | 2021 | China CDC weekly2021，3，3： | 0 |
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