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| 1 | A proposal for the theoretical analysis of the interactive coupled effects between urbanization and the eco-environment in mega-urban agglomerations显示文摘Mega-urban agglomerations are strategic core areas for national economic development and the main regions of new urbanization. They also have important roles in shifting the global economic center of gravity to China. However, the development of mega-urban agglomerations has triggered the interactive coercion between resources and the eco-environment. The interactive coupled effects between urbanization and the eco-environment in mega-urban agglomerations represent frontier and high-priority research topics in the field of Earth system science over the next decade. In this paper, we carried out systematic theoretical analysis of the interactive coupling mechanisms and coercing effects between urbanization and the eco-environment in mega-urban agglomerations. In detail, we analyzed the nonlinear-coupled relationships and the coupling characteristics between natural and human elements in mega-urban agglomerations. We also investigated the interactive coercion intensities between internal and external elements, and the mechanisms and patterns of local couplings and telecouplings in mega-urban agglomeration systems, which are affected by key internal and external control elements. In addition, we proposed the interactive coupling theory on urbanization and the eco-environment in mega-urban agglomerations. Furthermore, we established a spatiotemporal dynamic coupling model with multi-element, multi-scale, multi-scenario, multi-module and multi-agent integrations, which can be used to develop an intelligent decision support system for sustainable development of mega-urban agglomerations. In general, our research may provide theoretical guidance and method support to solve problems related to mega-urban agglomerations and maintain their sustainable development. | FANG Chuanglin ZHOU Chenghu GU Chaolin CHEN Liding LI Shuangcheng | 2017 | Journal of Geographical Sciences2017，27，12： | 36 |
| 2 | Numerical simulation of topography effects on the “00.7” severe rainfall in Beijing显示文摘In an effort to study the severe rainfall event of 4—5th July 2000 in Beijing (with 24h accumulated precipitation of 240 mm), we perform numerical simulations to investigate this event using the MM5v3.6 model. The model is initialized with the MM5/WRF 3DVAR analysis, which incorporates the ground-based GPS precipitable water vapor, automatic and conventional meteorological observations in its assimilation step. For 24 h accumulated precipitation forecast, the threat scores are 0.72, 0.76, 0.67 and 0.63, for thresholds of 1, 5, 10, and 20 mm, respectively. Holding other factors unchanged, sensitivity experiments were conducted with different topographic resolutions of 110, 50 and 3.7 km to investigate the topographic effects on precipitation over the Beijing area. In these sensitivity experiments, we attempt to preserve the realistic orographic distribution in the model topography under the condition of keeping the dynamic-thermodynamic consistency of the initial model atmosphere to the extent possible. Results indicate that the unique topographic distribution and variations in the Beijing area play an important role in determining the location, distribution and intensity of heavy precipitation. | ZHANG Chaolin JI Chongping KUO Yinghwa FAN Shuiyong XUAN Chunyi CHEN Min | 2005 | Progress in Natural Science:Materials International2005，15，9： | 8 |
| 3 | Towards high-performance lithium metal anodes via the modification of solid electrolyte interphases显示文摘Li metal has been regarded as one of the most promising anodes for high-energy-density storage systems due to its high theoretical capacity and lowest electrochemical potential.Unfortunately,an unstable and non-uniform solid electrolyte interphase(SEI)deriving from the spontaneous reaction between Li metal anode and electrolyte causes uneven Li deposition,resulting in the growth of Li dendrites and low Coulombic efficiency,which have greatly hindered the practical application of Li metal batteries.Thus,the construction of a stable SEI is an effective approach to suppress the growth of Li dendrites and enhance the electrochemical performances of Li metal anode.In this review,we firstly introduce the formation process of inferior SEI of Li metal anode and the corresponding challenges caused by the unstable SEI.Next,recent progresses to modify SEI layer through the regulation of electrolyte compositions and exsitu protective coating are summarized.Finally,the remained issues,challenges,and perspectives are also proposed on the basis of current research status and progress. | Zhen Hou Jiaolong Zhang Wenhui Wang Qianwen Chen Baohua Li Chaolin Li | 2020 | Journal of Energy Chemistry2020，29，6： | 8 |
| 4 | Localization and validation of an urbanized high-resolution land data assimilation system(u-HRLDAS)显示文摘This paper uses an urbanized high-resolution land data assimilation system(u-HRLDAS) to parameterize the urban land surface characteristics.The u-HRLDAS model is localized and developed in order to satisfy the need of the weather forecast in Beijing,China.The remote sensing data used to localize and drive u-HRLDAS include the soil type data and MODIS retrieved leaf area index(LAI) data.The evaporation and water depth for impervious surface in urban area are developed to improve the simulation of u-HRLDAS.The result of the urban weather forecast is used for the comparison based on the rapid update cycle system at Beijing Meteorological Bureau(BJ-RUC) without coupled with u-HRLDAS.The land surface temperature,land surface fluxes,and first layer soil moisture in several single sites and urban Beijing region by BJ-RUC are compared with u-HRLDAS after localization and development.The off-line simulation results indicate that compared with BJ-RUC,after the localization and development,u-HRLDAS can improve the simulation of land surface parameters and fluxes definitely. | MENG ChunLei ZHANG ChaoLin MIAO ShiGuang CHEN Fei | 2013 | Science China Earth Sciences2013，56，6： | 4 |
| 5 | Protecting healthcare personnel from 2019-nCoV infection risks:lessons and suggestions显示文摘The outbreak of a novel coronavirus disease(COVID-19,caused by the 2019-nCoV infection)in December 2019 is one of the most severe public health emergencies since the founding of People’s Republic of China in 1949.Healthcare personnel(HCP)nationwide are facing heavy workloads and high risk of infection,especially those who care for patients in Hubei Province.Sadly,as of February 20,2020,over two thousand COVID-19 cases are confirmed among HCP from 476 hospitals nationwide,with nearly 90%of them from Hubei Province.Based on literature search and interviews with some HCP working at Wuhan,capital city of Hubei,we have summarized some of the effective measures taken to reduce infection among HCP,and also made suggestions for improving occupational safety during an infectious disease outbreak.The experience and lessons learned should be a valuable asset for international health community to contain the ongoing COVID-19 epidemic around the world. | Zhiruo Zhang Shelan Liu Mi Xiang Shijian Li Dahai Zhao Chaolin Huang Saijuan Chen | 2020 | Frontiers of Medicine2020，14，2： | 4 |
| 6 | Antidiabetic effect of an engineered bacterium Lactobacillus plantarum-pMG36e-GLP-1 in monkey model显示文摘Glucagon-like peptide-1(GLP-1)reduces postprandial hyperglycaemia,but its short half-life inhibits clinical application.The aim of the current study was to evaluate the treatment efforts of an engineered strain,Lactobacillus plantarum-pMG36e-GLP-1(L.plantarum-pMG36e-GLP-1),that continuously expresses GLP-1 in spontaneous type 2 diabetes mellitus(T2DM)monkeys.After 7 weeks of oral supplementation with L.plantarum-pMG36e-GLP-1,the fasting blood glucose(FPG)of monkeys was significantly(p<0.05)reduced to a normal level and only a small amount of weight was lost.The results of metagenomic sequencing showed that L.plantarum-pMG36e-GLP-1 caused a substantial(p<0.05)reduction in the intestinal pathogen Prevotella and marked enhancement of butyrate-producing Alistipes genera.According to the functional analysis using Kyoto Encyclopaedia of Genes and Genomes(KEGG)pathways,19 metabolism-related pathways were significantly enriched in T2DM monkeys after treatment with L.plantarum-pMG36e-GLP-1.LC-MS faecal metabolomics analysis found 41 significant differential metabolites(11 higher and 30 lower)in monkeys after treatment pathways linked to the metabolism of cofactors and vitamins were the most relevant.The present study suggests that L.plantarum-pMG36e-GLP-1 had an impact on the gut microbial composition and faecal metabolomic profile in spontaneous T2DM monkeys and may be a novel candidate for diabetes treatment. | Jie Luo Hongfei Zhang Jiachen Lu ChaoLin Ma Tingtao Chen | 2021 | Synthetic and Systems Biotechnology2021，6，4： | 3 |
| 7 | RETRACTED ARTICLE:Human H9N2 Avian Influenza Infection:Epidemiological and Clinical Characterization of 16 Cases in China显示文摘The authors are retracting this paper owing to errors in the reported data.The paper claimed that 16 patient cases were infected with H9N2 virus.However,when the authors recently further investigated all the thirteen sera samples,no anti-H9N2 antibodies were found by the haemagglutination inhibition assay.Moreover,re-sequencing of the remaining five throat swabs showed all five samples were H1N1 virus. | Xuan Dong Jiasong Xiong Chaolin Huang Jie Xiang Wenjuan Wu Nanshan Chen Danning Wen Chao Tu Xueli Qiao Liang Kang Zhongzi Yao Dingyu Zhang Quanjiao Chen | 2021 | Virologica Sinica2021，36，3： | 3 |
| 8 | Digital medical education empowered by intelligent fabric space显示文摘Medical education plays an important role in promoting the development of global medical science.Nevertheless,the intrinsic gap existing between institutional medical teaching and practical clinical tasks causes low education efficiency and students’weak initiative.Recent developments of sensing fabric and embedded computing,along with the advances in artificial intelligence(AI)and digital twin technology are paving the way for the transformation of medical research towards digitization.In this work,we present an intelligent fabric space based on novel functional fabric materials and digital twin networking enabled by 5G and internet of things(IoT)technologies.In this space,medical students can learn knowledge with collaborative mapping of the digital and real world,cyber-physical interaction and real-time tactile feedback.And the proposed service system will evaluate and feedback students’operational behaviors to improve their experimental skills.We provide four typical applications of intelligent fabric space for medical education,including medical education training,health and behavior tracking,operation playback and reproduction,as well as medical knowledge popularization.The proposed intelligent fabric space has the potential to promote innovative technologies for training cutting-edge medical students by effective and efficient ways. | Min Chen Rui Wang Rui Wang Yingting Zhou Zicheng He Xiaojuan Liu Muyao He Jiaxi Wang Chaolin Huang Huamin Zhou Ping Hong Chong Hou Ning Zhou Dingyu Zhang Guangming Tao | 2022 | National Science Open2022，1，1： | 2 |
| 9 | Use of angiotensin-converting enzyme inhibitors and angiotensin Ⅱ receptor blockers in context of COVID-19 outbreak:a retrospective analysis显示文摘The possible effects of angiotensin-converting enzyme inhibitors(ACEIs)or angiotensin Ⅱ receptor blockers(ARBs)on COVID-19 disease severity have generated considerable debate.We performed a single-center,retrospective analysis of hospitalized adult COVID-19 patients in Wuhan,China,who had definite clinical outcome(dead or discharged)by February 15,2020.Patients on anti-hypertensive treatment with or without ACEI/ARB were compared on their clinical characteristics and outcomes.The medical records from 702 patients were screened.Among the 101 patients with a history of hypertension and taking at least one anti-hypertensive medication,40 patients were receiving ACEI/ARB as part of their regimen,and 61 patients were on antihypertensive medication other than ACEI/ARB.We observed no statistically significant differences in percentages of in-hospital mortality(28%vs.34%,P=0.46),ICU admission(20%vs.28%,P=0.37)or invasive mechanical ventilation(18%vs.26%,P=0.31)between patients with or without ACEI/ARB treatment.Further multivariable adjustment of age and gender did not provide evidence for a significant association between ACEI/ARB treatment and severe COVID-19 outcomes.Our findings confirm the lack of an association between chronic receipt of reninangiotensin system antagonists and severe outcomes of COVID-19.Patients should continue previous antihypertensive therapy until further evidence is available. | Jiuyang Xu Chaolin Huang Guohui Fan Zhibo Liu Lianhan Shang Fei Zhou Yeming Wang Jiapei Yu Luning Yang Ke Xie Zhisheng Huang Lixue Huang Xiaoying Gu Hui Li Yi Zhang Yimin Wang Frederick G.Hayden Peter W.Horby Bin Cao Chen Wang | 2020 | Frontiers of Medicine2020，14，5： | 2 |
| 10 | Post-mortem tissue proteomics reveals the pathogenesis of multi-organ injuries of COVID-19显示文摘Multi-organ injuries are a major complication of severe Coronavirus Disease 2019(COVID-19).However,its pathogenesis is barely understood.Herein;we profile host responses to fatal SARS-CoV-2 infection by performing quantitative proteomics of 19 post-mortem samples of 8 different organs or tissues,including lungs,liver,intestine,kidney;spleen,brain,heart and muscle,from 3 deceased COVID-19 victims during the first wave of the pandemic(Supplementary Fig.S1A and B,Tables SI-S3). | Yang Qiu Di Wu Wanshan Ning Jiqian Xu Ting Shu Muhan Huang Rong Chen Jiancheng Zhang Yang Han Qingyu Yang Ruiting Li Xiaobo Yang Yaxin Wang Xiaojing Zou Shangwen Pan Chaolin Huang Yu Xue You Shang Xi Zhou | 2021 | National Science Review2021，8，11： | 1 |
| 11 | Measuring the impact of urban sprawl on natural landscape pattern of the Western Taihu Lake watershed, China显示文摘 | Weizhong Su Chaolin Gu Guishan Yang Shuang Chen Feng Zhen | 2009 | Landscape and Urban Planning2009，，1： | 1 |
| 12 | Measuring the impact of urban sprawl on natural landscape pattern of the Western Taihu Lake watershed, China显示文摘 | Weizhong Su Chaolin Gu Guishan Yang Shuang Chen Feng Zhen | 2009 | Landscape and Urban Planning2009，，1： | 1 |
| 13 | Urban poverty in the transi- tional economy: a case of Nanjing, China显示文摘 | Chen Guo Gu Chaolin Wu Fulong | 2006 | Habitat Interna- tional2006，30，1： | 1 |
| 14 | Patients with Prolonged Positivity of SARS-CoV-2 RNA Benefit from Convalescent Plasma Therapy:A Retrospective Study显示文摘Convalescent plasma therapy has been implemented in a few cases of severe coronavirus disease 2019.No report about convalescent plasma therapy in treating patients with prolonged positivity of SARS-CoV-2 RNA has been published.In this study,we conducted a retrospective observational study in 27 patients with prolonged positivity of SARS-CoV-2 RNA,the clinical benefit of convalescent plasma therapy were analyzed.q RT-PCR test of SARS-CoV-2 RNA turned negative(B 7 days)in a part of patients(early negative group,n=15)after therapy,others(late negative group,n=12)turned negative in more than 7 days.Pulmonary imaging improvement was confirmed in 7 patients in early negative group and 8 in late negative group after CP therapy.Viral load decreased in early negative group compared with late negative group at day 3,5,7 after implementing convalescent plasma therapy.Patients in early negative group had a shorter median length of hospital stay.In conclusion,convalescent plasma therapy might help eliminate virus and shorten length of hospital stay in patients with prolonged positivity of SARS-CoV-2 RNA. | Yongran Wu Ke Hong Lianguo Ruan Xiaobo Yang Jiancheng Zhang Jiqian Xu Shangwen Pan Lehao Ren Lu Chen Chaolin Huang You Shang | 2020 | Virologica Sinica2020，35，6： | 1 |
| 15 | Alterations in Phenotypes and Responses of T Cells Within 6 Months of Recovery from COVID-19: A Cohort Study显示文摘The COVID-19 pandemic,caused by the SARS-CoV-2 infection,is a global health crisis.While many patients have clinically recovered,little is known about long-term alterations in T cell responses of COVID-19 convalescents.In this study,T cell responses in peripheral blood mononuclear cells of a long-time COVID-19 clinically recovered(20–26 weeks)cohort(LCR)were measured via flow cytometry and ELISpot.The T cell responses of LCR were comparatively analyzed against an age and sex matched short-time clinically recovered(4–9 weeks)cohort(SCR)and a healthy donor cohort(HD).All volunteers were recruited from Wuhan Jinyintan Hospital,China.Phenotypic analysis showed that activation marker PD-1 expressing on CD4^(+)T cells of LCR was still significantly lower than that of HD.Functional analysis indicated that frequencies of Tc2,Th2 and Th17 in LCR were comparable to those of HD,but Tc17 was higher than that of HD.In LCR,compared to the HD,there were fewer IFN-c producing T cells but more IL-2 secreting T cells.In addition,the circulating Tfh cells in LCR were still slightly lower compared to HD,though the subsets composition had recovered.Remarkably,SARS-CoV-2 specific T cell responses in LCR were comparable to that of SCR.Collectively,T cell responses experienced long-term alterations in phenotype and functional potential of LCR cohort.However,after clinical recovery,SARS-CoV-2 specific T cell responses could be sustained at least for six months,which may be helpful in resisting re-infection。 | Bali Zhao Maohua Zhong Qingyu Yang Ke Hong Jianbo Xia Xia Li Ying Liu Yao-Qing Chen Jingyi Yang Chaolin Huang Huimin Yan | 2021 | Virologica Sinica2021，36，5： | 1 |
| 16 | Genome-wide transcriptome analysis of roots in two rice varieties in response to alternate wetting and drying irrigation显示文摘Alternate wetting and drying(AWD)irrigation has been widely used as an efficient rice production method to obtain better yield without continuous flooding(CF)of the paddy field.However,how this practice affects gene expression to regulate rice physiology and morphology is largely unknown.In this study,we used two rice varieties,Nipponbare,a lowland rice cultivar,and Gaoshan 1,an upland cultivar,and found that root dry weight(RDW)and root oxidation activity(ROA)in both cultivars substantially increased in response to AWD.We then analyzed the differences in transcriptome profiles of their roots irrigated in AWD vs.CF conditions.AWD responsive genes are mainly involved in lignin biosynthetic pathway and phytohormone signal transduction pathway and belong mainly to b HLH,b ZIP,NAC,WRKY,and HSF transcription factor families.We discussed how these differentially expressed genes may contribute to the morphological adaptations observed in roots exposed to AWD.This analysis also provides useful information to explain the similarities and differences in adaptation to AWD irrigation between the two rice ecotypes. | Tao Song Debatosh Das Feng Yang Moxian Chen Yuan Tian Chaolin Cheng Chao Sun Weifeng Xu Jianhua Zhang | 2020 | The Crop Journal2020，8，4： | 1 |
| 17 | Impact of corticosteroids on initiation and half-year durability of humoral response in COVID-19 survivors显示文摘Background:The impact of corticosteroids on humoral responses in coronavirus disease 2019(COVID-19)sur-vivors during the acute phase and subsequent 6-month period remains unknown.This study aimed to determine how the use of corticosteroids influences the initiation and duration of humoral responses in COVID-19 survivors 6 months after infection onset.Methods:We used kinetic antibody data from the lopinavir-ritonavir trial conducted at Jin Yin-Tan Hospital in January 2020,which involved adults hospitalized with severe COVID-19(LOTUS,ChiCTR2000029308).Anti-body samples were collected from 192 patients during hospitalization,and kinetic antibodies were monitored at all available time points after recruitment.Additionally,plasma samples were collected from 101 COVID-19 survivors for comprehensive humoral immune measurement at the half-year follow-up visit.The main focus was comparing the humoral responses between patients treated with systemic corticosteroid therapy and the non-corticosteroid group.Results:From illness onset to day 30,the median antibody titre areas under the receiver operating characteristic curve(AUCs)of nucleoprotein(N),spike protein(S),and receptor-binding domain(RBD)immunoglobulin G(IgG)were significantly lower in the corticosteroids group.The AUCs of N-,S-,and RBD-IgM as well as neutralizing antibodies(NAbs)were numerically lower in the corticosteroids group compared with the non-corticosteroid group.However,peak titres of N,S,RBD-IgM and-IgG and NAbs were not influenced by corticosteroids.During 6-month follow-up,we observed a delayed decline for most binding antibodies,except N-IgM(��−0.05,95%CI[−0.10,0.00])in the corticosteroids group,though not reaching statistical significance.No significant difference was observed for NAbs.However,for the half-year seropositive rate,corticosteroids significantly accelerated the decay of IgA and IgM but made no difference to N-,S-,and RBD-IgG or NAbs.Additionally,corticosteroids group showed a trend towards delayed viral clearance compared with the non-corticosteroid group,but the results were not statistically significant(adjusted hazard ratio 0.71,95%CI 0.50-1.00;P=0.0508).Conclusion:Our findings suggested that corticosteroid therapy was associated with impaired initiation of the antibody response but this did not compromise the peak titres of binding and neutralizing antibodies.Throughout the decay phase,from the acute phase to the half-year follow-up visit,short-term and low-dose corticosteroids did not significantly affect humoral responses,except for accelerating the waning of short-lived antibodies. | Yeming Wang Li Guo Guohui Fan Yang Han Qiao Zhang Lili Ren Hui Zhang Geng Wang Xueyang Zhang Tingxuan Huang Weiyang Wang Lan Chen Lixue Huang Xiaoying Gu Xinming Wang Jingchuan Zhong Ying Wang Hui Li Jiapei Yu Zhibo Liu Chaolin Huang Bin Cao Jianwei Wang | 2024 | Chinese Medical Journal Pulmonary and Critical Care Medicine2024，2，1： | 0 |
| 18 | Coupling functional anodes with natural air-diffused cathodes enables highly efficient hydrogen peroxide electrosynthesis显示文摘Electrosynthesis of hydrogen peroxide(H_(2)O_(2))is a decentralized production method with excellent application prospects.Coupling anodes with cathodes can achieve highly efficient electrosynthesis of hydrogen peroxide.In this study,we prepared an anode for H_(2)O_(2) electrosynthesis via the two-electron water oxidation reaction(2e-WOR)by modifying carbon fiber paper with self-assembling monolayers.In addition,a natural air-diffused cathode loaded with polytetrafluoroethylene/carbon black using carbon cloth as substrate was prepared to combine with the modified anode to produce H_(2)O_(2) simultaneously.The total current efficiency of the anode and cathode reached 152.9%,and the H_(2)O_(2) production rate was as high as 38μmol/min at 2.8 V vs.reversible hydrogen electrodes(RHE)in a Nafion 117 membrane-separated electrolyzer.This work reported a novel carbon-based 2e-WOR catalyst and laid a theoretical foundation for the simultaneous electrosynthesis of H_(2)O_(2) with an anode and cathode. | Chen LING Aiping LIANG Chaolin LI Wenhui WANG | 2023 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2023，24，4： | 0 |
| 19 | Characteristics of coal resources in China and statistical analysis and preventive measures for coal mine accidents显示文摘In the process of green and smart mine construction under the context of carbon neutrality,China's coal safety situation has been continuously improved in recent years.In order to recognize the development of coal production in China and prepare for future monitoring and prevention of safety incidents,this study mainly elaborated on the basic situation of coal resources and national mining accidents over the past five years(2017-2021),from four dimensions(accident level,type,region,and time),and then proposed the preventive measures based on accident statistical laws.The results show that the storage of coal resources has obvious geographic characteristics,mainly concentrated in the Midwest,with coal resources in Shanxi and Shaanxi accounting for about 49.4%.The proportion of coal consumption has dropped from 70.2%to 56%between 2011 and 2021,but still accounts for more than half of the all.Meanwhile,the accident-prone areas are positively correlated with the amount of coal production.Among different levels of coal mine accidents,general accidents had the highest number of accidents and deaths,with 692 accidents and 783 deaths,accounting for 87.6%and 54.64%respectively.The frequency of roof,gas,and transportation accidents is relatively high,and the number of single fatalities caused by gas accidents is the largest,about 4.18.In terms of geographical distribution of accidents,the safety situation in Shanxi Province is the most severe.From the time distribution of coal mine accidents,the accidents mainly occurred in July and August,and rarely occurred in February and December.Finally,the'4+4'safety management model is proposed,combining the statistical results with coal production in China.Based on the existing health and safety management systems,the manage-ments are divided into four sub-categories,and more specific measures are suggested. | Chaolin Zhang Peizhong Wang Enyuan Wang Dapeng Chen Chao Li | 2023 | International Journal of Coal Science & Technology2023，10，2： | 0 |
| 20 | A Late Comer's Internationalization Strategy for Chinese Firms: A Theoretical Study显示文摘 | Weichu Xu Yue Xi Jian Yu Chaolin Chen | 2014 | China-USA Business Review2014，13，7： | 0 |
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